Peripheral neuropathies are chronic painful syndromes characterized by allodynia,hyperalgesia and altered nerve functionality.Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathi...Peripheral neuropathies are chronic painful syndromes characterized by allodynia,hyperalgesia and altered nerve functionality.Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathies.Aimed to improve the therapeutic possibilities,this study investigated the hypersensitivity and the neuromorphological alterations related to the loose ligation of the sciatic nerve in rats.Effects elicited by treatment with acetyl-L-carnitine（ALCAR） in comparison to gabapentin were assessed.Axonal injury,reduction of myelin deposition and accumulation of inflammatory cells were detected in damaged nerve.A decrease of phosphorylated 200-k Da neurofilament（NFP） immunoreactivity and a redistribution in small clusters of myelin basic like-protein（MBP） were observed in ipsilateral nerves.Treatment with ALCAR（100 mg/kg intraperitoneally-i.p.） and gabapentin（70 mg/kg i.p.） administered bis in die for 14 days induced a significant pain relieving effect.ALCAR,but not gabapentin,significantly countered neuromorphological changes and increased axonal NFP immunoreactivity.These findings indicate that both ALCAR and gabapentin significantly decreased the hypersensitivity related to neuropathic lesions.The observation of the positive ALCAR effect on axonal and myelin sheath alterations in damaged nerve supports its use as neurorestorative agent against neuropathies through mechanism（s） consistent to those focused in this study.展开更多
Aim:The aim of this literature review is to evaluate the efficacy of microneedling treatment with injectable platelet-rich fibrin(i-PRF)for facial skin rejuvenation applications,using an objective skin analysis system...Aim:The aim of this literature review is to evaluate the efficacy of microneedling treatment with injectable platelet-rich fibrin(i-PRF)for facial skin rejuvenation applications,using an objective skin analysis system and validated patient-reported outcome measures.Methods:The search approach involved the exploration of electronic databases.An advanced search option was applied to filter our search line,i.e.,from February 2011 to April 2021.We performed a search on Medline,Scopus,Embase,and Web of Science,while improving the accessed articles via Ovid interface.Our keywords were chiefly aligned with a combination of MeSH terms and text words.All retrieved articles were written in English.Results:The search yielded 73 studies.After reviewing their title and summary,nine of them were found to meet the inclusion criteria and,next,the full-text articles were reviewed.Of these,three studies were excluded from systematic research,as they would no longer meet the inclusion criteria.In total,six studies were considered for review.Conclusion:Microneedling treatments combined with blood concentrates are increasingly being utilized as autologous products for aesthetic purposes.Few works can be found on i-PRF in facial rejuvenation,and even fewer on i-PRF along with microneedling.Combined applications seem to be promising and minimally invasive.Further research on PRP and PRF is warranted to better elucidate their functional roles in medical cosmetic rejuvenation.展开更多
基金funded by the Italian Ministry of Instruction,University and Research(MIUR)the Universities of Florence and Camerino
文摘Peripheral neuropathies are chronic painful syndromes characterized by allodynia,hyperalgesia and altered nerve functionality.Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathies.Aimed to improve the therapeutic possibilities,this study investigated the hypersensitivity and the neuromorphological alterations related to the loose ligation of the sciatic nerve in rats.Effects elicited by treatment with acetyl-L-carnitine（ALCAR） in comparison to gabapentin were assessed.Axonal injury,reduction of myelin deposition and accumulation of inflammatory cells were detected in damaged nerve.A decrease of phosphorylated 200-k Da neurofilament（NFP） immunoreactivity and a redistribution in small clusters of myelin basic like-protein（MBP） were observed in ipsilateral nerves.Treatment with ALCAR（100 mg/kg intraperitoneally-i.p.） and gabapentin（70 mg/kg i.p.） administered bis in die for 14 days induced a significant pain relieving effect.ALCAR,but not gabapentin,significantly countered neuromorphological changes and increased axonal NFP immunoreactivity.These findings indicate that both ALCAR and gabapentin significantly decreased the hypersensitivity related to neuropathic lesions.The observation of the positive ALCAR effect on axonal and myelin sheath alterations in damaged nerve supports its use as neurorestorative agent against neuropathies through mechanism（s） consistent to those focused in this study.
基金supported by an institutional grant of the University of Camerino.
文摘Aim:The aim of this literature review is to evaluate the efficacy of microneedling treatment with injectable platelet-rich fibrin(i-PRF)for facial skin rejuvenation applications,using an objective skin analysis system and validated patient-reported outcome measures.Methods:The search approach involved the exploration of electronic databases.An advanced search option was applied to filter our search line,i.e.,from February 2011 to April 2021.We performed a search on Medline,Scopus,Embase,and Web of Science,while improving the accessed articles via Ovid interface.Our keywords were chiefly aligned with a combination of MeSH terms and text words.All retrieved articles were written in English.Results:The search yielded 73 studies.After reviewing their title and summary,nine of them were found to meet the inclusion criteria and,next,the full-text articles were reviewed.Of these,three studies were excluded from systematic research,as they would no longer meet the inclusion criteria.In total,six studies were considered for review.Conclusion:Microneedling treatments combined with blood concentrates are increasingly being utilized as autologous products for aesthetic purposes.Few works can be found on i-PRF in facial rejuvenation,and even fewer on i-PRF along with microneedling.Combined applications seem to be promising and minimally invasive.Further research on PRP and PRF is warranted to better elucidate their functional roles in medical cosmetic rejuvenation.
