Here we report the binding of the diruthenium complex[Ru_(2)Cl(D-p-CNPhF)(O_(2)CCH_(3))_(3)]_(n)(D-p-CNPhF-=N,N’-bis(4-cyanophenyl)formamidinate)to the model protein bovine pancreatic ribonuclease(RNase A),investigat...Here we report the binding of the diruthenium complex[Ru_(2)Cl(D-p-CNPhF)(O_(2)CCH_(3))_(3)]_(n)(D-p-CNPhF-=N,N’-bis(4-cyanophenyl)formamidinate)to the model protein bovine pancreatic ribonuclease(RNase A),investigated for the first time by means of X-ray crystallography and Quantum Chemistry.The crystal structure reveals that the compound binds a histidine side chain with the diruthenium core anchored to RNase A at the axial site.展开更多
基金supported by the Human Frontier Science Program(Grant Number RGY0056/2022)A.M.thanks MIUR PRIN 2022-Cod.2022JMFC3X,“Protein Metalation by Anticancer Metal-based Drugs”for financial support.Comunidad de Madrid(Project S2017/BMD-3770-CM)+2 种基金Complutense University of Madrid(GRFN32/23 and Program PR3/23)are gratefully acknowledged for financial supportA.T.also acknowledges the Complutense University for a Predoctoral Grant(CT63/19-CT64/19)Research Stay Grant(EB25/22)and the Spanish Ministry of Science and Innovation for a Postgraduate Fellowship at Residencia de Estudiantes(2021-2022)。
文摘Here we report the binding of the diruthenium complex[Ru_(2)Cl(D-p-CNPhF)(O_(2)CCH_(3))_(3)]_(n)(D-p-CNPhF-=N,N’-bis(4-cyanophenyl)formamidinate)to the model protein bovine pancreatic ribonuclease(RNase A),investigated for the first time by means of X-ray crystallography and Quantum Chemistry.The crystal structure reveals that the compound binds a histidine side chain with the diruthenium core anchored to RNase A at the axial site.
