Objective:To describe the Chinese experience of natural orifice transluminal endoscopic surgery(NOTES)in urology.Methods:From December 2008 to May 2017,35 animal experiments and 305 clinical surgeries of NOTES or natu...Objective:To describe the Chinese experience of natural orifice transluminal endoscopic surgery(NOTES)in urology.Methods:From December 2008 to May 2017,35 animal experiments and 305 clinical surgeries of NOTES or natural orifices specimen extractions(NOSE)were performed in China.The animal experiments included five kidney biopsies,24 nephrectomies and six partial nephrectomies.The clinical surgeries included 12 transvaginal NOSE(TV-NOSE),266 hybrid transvaginal NOTES(TV-NOTES)and 27 pure TV-NOTES.The TV-NOSE procedure was performed in five transumbilical laparoendoscopic single-site(U-LESS)nephrectomies,four suprapubic-assisted laparoendoscopic single-site surgery(SA-LESS)nephroureterectomies,and three laparoscopic radical cystectomies.The hybrid TV-NOTES procedure included 210 nephrectomies,31 adrenalectomies,eight nephroureterectomies,13 partial nephrectomies,and four heminephrectomies.The pure TV-NOTES procedure included five renal cyst decortications and 22 nephrectomies.Results:A total of 29 animal experiments were successfully performed.One partial nephrectomy was converted to standard laparoscopic surgery.Two kidney biopsies and two nephrectomies were unsuccessful.A total of 297 clinical surgeries were successfully performed.Six patients who underwent hybrid TV-NOTES were converted to open surgery.Two patients who underwent pure TV-NOTES were converted to SA-LESS.There were 22 major complications,16 occurred intraoperatively and six postoperatively.The mean visual analog score(VAS)of 48 h after the operation was 2.5 points in TV-NOSE,2.3 points in hybrid TV-NOTES and 1.7 points in pure TV-NOTES.The mean follow-up of 50.6(3.0-87.0)months showed that all patients were in good condition.The umbilicus scars were nearly invisible in TV-NOSE and hybrid TV-NOTES.The vaginal incision healed well.Conclusions:TV-NOSE and TV-NOTES are feasible,safe,and effective with little injury,low pain,fast recovery,and good cosmetic outcomes in properly selected patients.They are worth consideration for urological clinical practice.展开更多
Objective:The purpose of this study was to analyze the clinical disadvantages of non-standard surgical treatment for parotid gland cancer and probe the re-operative indication following non-standard surgical treatment...Objective:The purpose of this study was to analyze the clinical disadvantages of non-standard surgical treatment for parotid gland cancer and probe the re-operative indication following non-standard surgical treatment.Methods: Data of 58 cases suffered parotid gland cancer who received non-standard operation at other hospital and received re-operation in tumor hospital of Ganzhou from June 1998 to October 2010 were retrospectively reviewed.Results: In all cases,parotid gland cancer were residual in 46 cases,the facial nerve remaining rate was 81.0% (47/58),facial nerve branches injury rate was 3.5% (2/58),facial nerve partial resection rate was 8.6% (5/58) and total resection rate was 6.9% (4/58).The sensitivity of residual tumor was 83.3%,scanned by contrast-enhanced CT and the CT positive predictive value was 86.9%. Conclusion: Consideration of the higher residual tumor rate in patients who received non-standard operations,the re-operations were necessary.Contrast-enhanced CT positive predictive value was high for residual tumor and it was important for re-operation.展开更多
Microbial electrosynthesis is a promising alternative to directly convert CO_(2)into long-chain compounds by coupling inorganic electrocatalysis with biosynthetic systems.However,problems arose that the conventional e...Microbial electrosynthesis is a promising alternative to directly convert CO_(2)into long-chain compounds by coupling inorganic electrocatalysis with biosynthetic systems.However,problems arose that the conventional electrocatalysts for hydrogen evolution may produce extensive by-products of reactive oxygen species and cause severe metal leaching,both of which induce strong toxicity toward microorganisms.Moreover,poor stability of electrocatalysts cannot be qualified for long-term operation.These problems may result in poor biocompatibility between electrocatalysts and microorganisms.To solve the bottleneck problem,Co anchored on porphyrinic triazine-based frameworks was synthesized as the electrocatalyst for hydrogen evolution and further coupled with Cupriavidus necator H16.It showed high selectivity for a four-electron pathway of oxygen reduction reaction and low production of reactive oxygen species,owing to the synergistic effect of Co–Nx modulating the charge distribution and adsorption energy of intermediates.Additionally,low metal leaching and excellent stability were observed,which may be attributed to low content of Co and the stabilizing effect of metalloporphyrins.Hence,the electrocatalyst exhibited excellent biocompatibility.Finally,the microbial electrosynthesis system equipped with the electrocatalyst successfully converted CO_(2)to poly-β-hydroxybutyrate.This work drew up a novel strategy for enhancing the biocompatibility of electrocatalysts in microbial electrosynthesis system.展开更多
基金the National High Technology Research and Development Program(“863”Program)of China(2012AA021100)Ganpo 555 Talents Program of Jiangxi Province+2 种基金the Major Science and Technology Support Project from the Department of Science and Technology of Jiangxi Province(20132BAB205007)the Science and Technology Floor Project from the Department of Education of Jiangxi Province(KJLD12044)the Science and Technology Program from the Department of Health of Jiangxi Province(20121095).
文摘Objective:To describe the Chinese experience of natural orifice transluminal endoscopic surgery(NOTES)in urology.Methods:From December 2008 to May 2017,35 animal experiments and 305 clinical surgeries of NOTES or natural orifices specimen extractions(NOSE)were performed in China.The animal experiments included five kidney biopsies,24 nephrectomies and six partial nephrectomies.The clinical surgeries included 12 transvaginal NOSE(TV-NOSE),266 hybrid transvaginal NOTES(TV-NOTES)and 27 pure TV-NOTES.The TV-NOSE procedure was performed in five transumbilical laparoendoscopic single-site(U-LESS)nephrectomies,four suprapubic-assisted laparoendoscopic single-site surgery(SA-LESS)nephroureterectomies,and three laparoscopic radical cystectomies.The hybrid TV-NOTES procedure included 210 nephrectomies,31 adrenalectomies,eight nephroureterectomies,13 partial nephrectomies,and four heminephrectomies.The pure TV-NOTES procedure included five renal cyst decortications and 22 nephrectomies.Results:A total of 29 animal experiments were successfully performed.One partial nephrectomy was converted to standard laparoscopic surgery.Two kidney biopsies and two nephrectomies were unsuccessful.A total of 297 clinical surgeries were successfully performed.Six patients who underwent hybrid TV-NOTES were converted to open surgery.Two patients who underwent pure TV-NOTES were converted to SA-LESS.There were 22 major complications,16 occurred intraoperatively and six postoperatively.The mean visual analog score(VAS)of 48 h after the operation was 2.5 points in TV-NOSE,2.3 points in hybrid TV-NOTES and 1.7 points in pure TV-NOTES.The mean follow-up of 50.6(3.0-87.0)months showed that all patients were in good condition.The umbilicus scars were nearly invisible in TV-NOSE and hybrid TV-NOTES.The vaginal incision healed well.Conclusions:TV-NOSE and TV-NOTES are feasible,safe,and effective with little injury,low pain,fast recovery,and good cosmetic outcomes in properly selected patients.They are worth consideration for urological clinical practice.
文摘Objective:The purpose of this study was to analyze the clinical disadvantages of non-standard surgical treatment for parotid gland cancer and probe the re-operative indication following non-standard surgical treatment.Methods: Data of 58 cases suffered parotid gland cancer who received non-standard operation at other hospital and received re-operation in tumor hospital of Ganzhou from June 1998 to October 2010 were retrospectively reviewed.Results: In all cases,parotid gland cancer were residual in 46 cases,the facial nerve remaining rate was 81.0% (47/58),facial nerve branches injury rate was 3.5% (2/58),facial nerve partial resection rate was 8.6% (5/58) and total resection rate was 6.9% (4/58).The sensitivity of residual tumor was 83.3%,scanned by contrast-enhanced CT and the CT positive predictive value was 86.9%. Conclusion: Consideration of the higher residual tumor rate in patients who received non-standard operations,the re-operations were necessary.Contrast-enhanced CT positive predictive value was high for residual tumor and it was important for re-operation.
基金This project was supported by the National Natural Science Foundation of China(Grant Nos.22122812,22075245 and 21961160742)。
文摘Microbial electrosynthesis is a promising alternative to directly convert CO_(2)into long-chain compounds by coupling inorganic electrocatalysis with biosynthetic systems.However,problems arose that the conventional electrocatalysts for hydrogen evolution may produce extensive by-products of reactive oxygen species and cause severe metal leaching,both of which induce strong toxicity toward microorganisms.Moreover,poor stability of electrocatalysts cannot be qualified for long-term operation.These problems may result in poor biocompatibility between electrocatalysts and microorganisms.To solve the bottleneck problem,Co anchored on porphyrinic triazine-based frameworks was synthesized as the electrocatalyst for hydrogen evolution and further coupled with Cupriavidus necator H16.It showed high selectivity for a four-electron pathway of oxygen reduction reaction and low production of reactive oxygen species,owing to the synergistic effect of Co–Nx modulating the charge distribution and adsorption energy of intermediates.Additionally,low metal leaching and excellent stability were observed,which may be attributed to low content of Co and the stabilizing effect of metalloporphyrins.Hence,the electrocatalyst exhibited excellent biocompatibility.Finally,the microbial electrosynthesis system equipped with the electrocatalyst successfully converted CO_(2)to poly-β-hydroxybutyrate.This work drew up a novel strategy for enhancing the biocompatibility of electrocatalysts in microbial electrosynthesis system.
