Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We eval...Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We evaluated whether:(i)the level of sleep loss correlates with pruritus and(ii)the level of pruritus correlates with the extent or severity of AD in children according to the SCORing Atopic Dermatitis(SCORAD)index.Method:Patients with AD younger than 18 years old were recruited from the pediatric dermatology clinic of a university teaching hospital,and AD severity was evaluated by the SCORAD index.Results:One hundred and eighty-two Chinese children with AD(107 boys and 75 girls)[mean(SD)age of 9.6(4.2)years] were recruited.Their mean(SD)overall SCORAD was 30.1(19.2).Sleep loss was strongly correlated with pruritus(r=0.57,P < 0.001).However,the two subjective symptoms were only weakly correlated with the objective signs(extent and intensity)of AD.The correlations between pruritus and extent and intensity were 0.42(P < 0.001)and 0.38(P < 0.001),respectively,and the correlations between sleep loss and extent and intensity were 0.38(P < 0.001)and 0.34(P < 0.001),respectively.Conclusion:We speculate that the lack of a better correlation was either because pruritus and sleep loss as reported by parents were imprecise,or that mechanisms other than disease extent or severity are responsible for the pathogenesis of these subjective symptoms.展开更多
Background: Disturbed growth of the trunk may result in abnormal sternocostal relationship and a variety of pectus deformities. Aims: The purposes of this study were to establish norms of trunk anthropometry for dysmo...Background: Disturbed growth of the trunk may result in abnormal sternocostal relationship and a variety of pectus deformities. Aims: The purposes of this study were to establish norms of trunk anthropometry for dysmorphology identification in the newborns and to evaluate chest circumference as a predictor for low birth weight for outborn infants where weighing scales were unavailable. Study design and subjects: A total of 10,339 Chinese infants (5478 males, 4861 females) with gestation 24-42 weeks from 12 hospitals were included. The anthropometric measurements analyzed included chest circumference, inter-nipple distance, sternal length and abdominal circumference. Outcome measures: The LMS method using maximum penalized likelihood was used to perform model fitting of the anthropometric centiles for these physical parameters. Results: References tables of the four physical parameters for newborns were constructed. Chest circumference showed the highest correlation with birth weight (male: r = 0.866, female: r = 0.883). The cut-off points for chest circumference of 295 (male) and 299 mm (female) were the best predictor for low birth weight. There were also racial differences in these parameters. When compared with French infants, Chinese newborns had smaller chest circumference. Conclusion: These physical parameters provide useful references and aid dysmorphology diagnosis in newborns of ethnic Chinese origin.展开更多
文摘Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We evaluated whether:(i)the level of sleep loss correlates with pruritus and(ii)the level of pruritus correlates with the extent or severity of AD in children according to the SCORing Atopic Dermatitis(SCORAD)index.Method:Patients with AD younger than 18 years old were recruited from the pediatric dermatology clinic of a university teaching hospital,and AD severity was evaluated by the SCORAD index.Results:One hundred and eighty-two Chinese children with AD(107 boys and 75 girls)[mean(SD)age of 9.6(4.2)years] were recruited.Their mean(SD)overall SCORAD was 30.1(19.2).Sleep loss was strongly correlated with pruritus(r=0.57,P < 0.001).However,the two subjective symptoms were only weakly correlated with the objective signs(extent and intensity)of AD.The correlations between pruritus and extent and intensity were 0.42(P < 0.001)and 0.38(P < 0.001),respectively,and the correlations between sleep loss and extent and intensity were 0.38(P < 0.001)and 0.34(P < 0.001),respectively.Conclusion:We speculate that the lack of a better correlation was either because pruritus and sleep loss as reported by parents were imprecise,or that mechanisms other than disease extent or severity are responsible for the pathogenesis of these subjective symptoms.
文摘Background: Disturbed growth of the trunk may result in abnormal sternocostal relationship and a variety of pectus deformities. Aims: The purposes of this study were to establish norms of trunk anthropometry for dysmorphology identification in the newborns and to evaluate chest circumference as a predictor for low birth weight for outborn infants where weighing scales were unavailable. Study design and subjects: A total of 10,339 Chinese infants (5478 males, 4861 females) with gestation 24-42 weeks from 12 hospitals were included. The anthropometric measurements analyzed included chest circumference, inter-nipple distance, sternal length and abdominal circumference. Outcome measures: The LMS method using maximum penalized likelihood was used to perform model fitting of the anthropometric centiles for these physical parameters. Results: References tables of the four physical parameters for newborns were constructed. Chest circumference showed the highest correlation with birth weight (male: r = 0.866, female: r = 0.883). The cut-off points for chest circumference of 295 (male) and 299 mm (female) were the best predictor for low birth weight. There were also racial differences in these parameters. When compared with French infants, Chinese newborns had smaller chest circumference. Conclusion: These physical parameters provide useful references and aid dysmorphology diagnosis in newborns of ethnic Chinese origin.
