Although a variety of cancers are initially susceptible to chemotherapy,they eventually develop multidrug resistance.To overcome this situation,more effective and selective treatments are necessary using anti-tumour a...Although a variety of cancers are initially susceptible to chemotherapy,they eventually develop multidrug resistance.To overcome this situation,more effective and selective treatments are necessary using anti-tumour agents that act in two or more ways and offer greater therapeutic benefits over singlemechanism entities.In this study,we report on treating cancer with Na[3,3’-^(57)Fe(1,2-C_(2)B_(9)H_(11))_(2)],which offers the possibility of dual action(radiation-drug combinations)to improve the clinical benefits and reduce healthy tissue toxicity.展开更多
Correction for‘The Mössbauer effect using ^(57)Fe-ferrabisdicarbollide([o-^(57)FESAN]−):a glance into the potential of a low-dose approach for glioblastoma radiotherapy’by Ana B.Buades et al.,Inorg.Chem.Front.,...Correction for‘The Mössbauer effect using ^(57)Fe-ferrabisdicarbollide([o-^(57)FESAN]−):a glance into the potential of a low-dose approach for glioblastoma radiotherapy’by Ana B.Buades et al.,Inorg.Chem.Front.,2022,9,1490–1503,https://doi.org/10.1039/D1QI01513C.展开更多
基金supported by the Spanish Ministerio de Economía y Competitividad(PID2019-106832RB-100)the Generalitat de Catalunya(2017SGR1720)+2 种基金by the Fundação para a Ciência e Tecnologia(FCT/MEC)for projects UID/MULTI/04349/2020,PTDC/BTM-TEC/29256/2017,UIDB/04565/2020,UIDP/04565/2020(iBB/IST),LA/P/0140/2020(Associate Laboratory Institute for Health and Bioeconomy-i4HB)PTDC/QUI-QIN/32240/2017,LISBOA-01-0145-FEDER-022096(National Infrastructure Roadmap,LTHMFL-NECL)and GCT grant to A.C.Cerdeira(BL156/2019_IST-ID)A.B.Buades was enrolled in the PhD program of the UAB.C.I.G.Pinto is enrolled in the PhD scholarship 689 DFA/BD/07119/2020.The authors thank Dr Moulay Sougrati,Charles Gerhardt Institute,ICGM UMR 5253,Montpellier,France for a kind gift of^(57)FeCl_(2).The LMRI(Metrology Laboratory of Ionizing Radiation)team is acknowledged for their support in the X-ray irradiation setup.
文摘Although a variety of cancers are initially susceptible to chemotherapy,they eventually develop multidrug resistance.To overcome this situation,more effective and selective treatments are necessary using anti-tumour agents that act in two or more ways and offer greater therapeutic benefits over singlemechanism entities.In this study,we report on treating cancer with Na[3,3’-^(57)Fe(1,2-C_(2)B_(9)H_(11))_(2)],which offers the possibility of dual action(radiation-drug combinations)to improve the clinical benefits and reduce healthy tissue toxicity.
文摘Correction for‘The Mössbauer effect using ^(57)Fe-ferrabisdicarbollide([o-^(57)FESAN]−):a glance into the potential of a low-dose approach for glioblastoma radiotherapy’by Ana B.Buades et al.,Inorg.Chem.Front.,2022,9,1490–1503,https://doi.org/10.1039/D1QI01513C.
