Background:Ketone body metabolism can improve cardiomyocytes metabolism and reduce myocardial oxygen consumption;however,its role in the short-term prognosis of patients with acute myocardial infarction combined with ...Background:Ketone body metabolism can improve cardiomyocytes metabolism and reduce myocardial oxygen consumption;however,its role in the short-term prognosis of patients with acute myocardial infarction combined with heart failure has not been clearly elucidated.The aim of this study was to investigate the effect ofβ-hydroxybutyric acid,the main component of ketone bodies,on the shortterm prognosis of patients with acute myocardial infarction combined with heart failure.Methods:This was a retrospective observational study that enrolled patients admitted to the Qilu Hospital of Shandong University for acute myocardial infarction combined with heart failure between January 1,2019,and December 31,2022.According to whetherβ-hydroxybutyric acid was elevated or not,subjects were divided into aβ-hydroxybutyric acid elevated and nonelevated groups,to observe the difference in cardiac function improvement between the two groups.Results:This study included a total of 260 patients,of which 170 exhibited elevated levels ofβ-hydroxybutyric acid.Compared to the patients in the nonelevated group,patients in the elevatedβ-hydroxybutyric acid group had higher plasma levels of creatine kinase myocardial band and greater Gensini scores.Multivariate logistic regression analysis indicated that an increase inβ-hydroxybutyric acid levels(odds ratio:3.076;95%confidence intervals:1.479–6.395;P=0.003)is an independent protective factor affecting the prognosis of cardiac function in patients with acute myocardial infarction combined with heart failure.Conclusion:In patients with acute myocardial infarction combined with heart failure,plasmaβ-hydroxybutyric acid serves as an independent protective factor for short-term improvement in cardiac function.展开更多
Lodging is a major yield-limiting factor of quinoa production.In 2018 and 2019,the orthogonal field experiments were conducted to investigate the responses of quinoa lodging risk and yield to irrigation threshold(soil...Lodging is a major yield-limiting factor of quinoa production.In 2018 and 2019,the orthogonal field experiments were conducted to investigate the responses of quinoa lodging risk and yield to irrigation threshold(soil matric potential of−15,−25 and−55 kPa),nitrogen rate(80,160 and 240 kg·ha^(−1))and planting density(20,30 and 40 plants m^(−2)).Results showed that high irrigation thresholds and nitrogen rates significantly(P<0.05)increased plant height and fresh weight per plant,and high planting densities reduced stem diameter and strength,all of those led to significantly(P<0.05)high lodging risks.The−15 and−55 kPa treatments gave the lowest actual yield(P<0.05)in 2018 and 2019,respectively.Higher lodging rate with a nitrogen rate of 240 kg·ha^(−1) resulted in a lower actual yield than 80 and 160 kg·ha^(−1) in both years.Planting density of 30 plants m^(−2) gave a significantly(P<0.05)greater estimated yield than 20 plants m^(−2) and had a lower lodging rate than 40 plants m^(−2),resulting in the maximum actual yield among planting densities.In conclusion,a moderate irrigation threshold of−25 kPa,a nitrogen rate of 80−160 kg·ha^(−1) and an intermediate planting density of 30 plants m−2 were determined to be best for quinoa cultivation in North-western China.In addition,the lower-stem lodging index(quarter plant height)could evaluate lodging risk more accurately than middle-stem(half plant height)or upper-stem(three quarters plant height)lodging indexes.展开更多
基金supported by the State Key Program of the National Natural Science Foundation of China(82030059)National Natural Science Foundation of China(82172178,82072144,81873950,81873953,81300219,81671951)+6 种基金National Key R&D Program of China(2020YFC1512700,2020YFC1512705,2020YFC1512703)National S&T Fundamental Resources Investigation Project(2018FY100600,2018FY100602)Natural Science Foundation of Shandong Province(ZR2022MH078)Key R&D Program of Shandong Province(2019GSF108131)Taishan Pandeng Scholar Program of Shandong Province(tspd20181220)Taishan Young Scholar Program of Shandong Province(tsqn202103173,tsqn20161065,tsqn201812129)Youth Top-Talent Project of National Ten Thousand Talents Plan,and Qilu Young Scholar Program.
文摘Background:Ketone body metabolism can improve cardiomyocytes metabolism and reduce myocardial oxygen consumption;however,its role in the short-term prognosis of patients with acute myocardial infarction combined with heart failure has not been clearly elucidated.The aim of this study was to investigate the effect ofβ-hydroxybutyric acid,the main component of ketone bodies,on the shortterm prognosis of patients with acute myocardial infarction combined with heart failure.Methods:This was a retrospective observational study that enrolled patients admitted to the Qilu Hospital of Shandong University for acute myocardial infarction combined with heart failure between January 1,2019,and December 31,2022.According to whetherβ-hydroxybutyric acid was elevated or not,subjects were divided into aβ-hydroxybutyric acid elevated and nonelevated groups,to observe the difference in cardiac function improvement between the two groups.Results:This study included a total of 260 patients,of which 170 exhibited elevated levels ofβ-hydroxybutyric acid.Compared to the patients in the nonelevated group,patients in the elevatedβ-hydroxybutyric acid group had higher plasma levels of creatine kinase myocardial band and greater Gensini scores.Multivariate logistic regression analysis indicated that an increase inβ-hydroxybutyric acid levels(odds ratio:3.076;95%confidence intervals:1.479–6.395;P=0.003)is an independent protective factor affecting the prognosis of cardiac function in patients with acute myocardial infarction combined with heart failure.Conclusion:In patients with acute myocardial infarction combined with heart failure,plasmaβ-hydroxybutyric acid serves as an independent protective factor for short-term improvement in cardiac function.
基金supported by the Ministry of Water Resources(201501017)the Foundation for Innovative Research Groups of the National Natural Science Foundation(51621061)the Major Program of the National Natural Science Foundation(51439006)of China.
文摘Lodging is a major yield-limiting factor of quinoa production.In 2018 and 2019,the orthogonal field experiments were conducted to investigate the responses of quinoa lodging risk and yield to irrigation threshold(soil matric potential of−15,−25 and−55 kPa),nitrogen rate(80,160 and 240 kg·ha^(−1))and planting density(20,30 and 40 plants m^(−2)).Results showed that high irrigation thresholds and nitrogen rates significantly(P<0.05)increased plant height and fresh weight per plant,and high planting densities reduced stem diameter and strength,all of those led to significantly(P<0.05)high lodging risks.The−15 and−55 kPa treatments gave the lowest actual yield(P<0.05)in 2018 and 2019,respectively.Higher lodging rate with a nitrogen rate of 240 kg·ha^(−1) resulted in a lower actual yield than 80 and 160 kg·ha^(−1) in both years.Planting density of 30 plants m^(−2) gave a significantly(P<0.05)greater estimated yield than 20 plants m^(−2) and had a lower lodging rate than 40 plants m^(−2),resulting in the maximum actual yield among planting densities.In conclusion,a moderate irrigation threshold of−25 kPa,a nitrogen rate of 80−160 kg·ha^(−1) and an intermediate planting density of 30 plants m−2 were determined to be best for quinoa cultivation in North-western China.In addition,the lower-stem lodging index(quarter plant height)could evaluate lodging risk more accurately than middle-stem(half plant height)or upper-stem(three quarters plant height)lodging indexes.
