Recently emerging Type-I photodynamic therapy holds significant promise in addressing the hypoxia challenge encountered by traditional oxygen-dependent Type-II photosensitizers(PSs)in photodynamic oncotherapy.The key ...Recently emerging Type-I photodynamic therapy holds significant promise in addressing the hypoxia challenge encountered by traditional oxygen-dependent Type-II photosensitizers(PSs)in photodynamic oncotherapy.The key hurdle in engineering Type-I PSs lies in enhancing the electron transfer capabilities of these molecules,enabling them to efficiently convert H_(2)O or oxygen-based substrates into reactive oxygen species.Herein,we propose to construct intramolecular electric fields in the second near-infrared(NIR-II)emissive organic PSs to regulate the local electron density for boosting hypoxia-tolerant cancer phototheranostics.Upon introducing the molecular cationization approach and electron programming strategy,the resultant cationic semiconducting architecture achieves electron distribution rearrangement,forms intramolecular electric fields,and facilitates electron transfer path,resulting in a 50-fold amplification of electrostatic potential difference,thereby accelerating the hydroxyl radical(•OH)-dominant Type-I photosensitization process.In vitro studies disclose that the tailor-made nanomaterial selectively targets the mitochondria and causesmitochondria-mediated cancer cell apoptosis under laser irradiation.Notably,this as-prepared nanoplatform enables NIR-II fluorescence imaging-assisted phototherapy and exhibits in vivo antitumor efficacy on 4T1-bearing mouse models.We believe that this contribution will launch the future of NIR-II emitting Type-I PSs and enlighten scientific researchers to exploit high-efficiency phototheranostic agents for cancer therapy.展开更多
Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influen...Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influenza risk in China warrants cautious assessment.We conducted a cross-sectional,seroepidemiological study in Shandong Province,Northern China in mid-2021.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic.The overall seroprevalence values against A/H1N1pdm09,A/H3N2,B/Victoria,and B/Yamagata were 17.8%(95%CI 16.2%–19.5%),23.5%(95%CI 21.7%–25.4%),7.6%(95%CI 6.6%–8.7%),and 15.0(95%CI 13.5%–16.5%),respectively,in the study period.The overall vaccination rate was extremely low(2.6%).Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals(P<0.001).Notably,the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic(P<0.01).Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.展开更多
Optical imaging possesses important implications for early disease diagnosis,timely disease treatment,and basic medical as well as biological research.Compared with the traditionary near-infrared(NIR-I)window(650-950 ...Optical imaging possesses important implications for early disease diagnosis,timely disease treatment,and basic medical as well as biological research.Compared with the traditionary near-infrared(NIR-I)window(650-950 nm)optical imaging,the emerging second near-infrared(NIR-II)window optical imaging technology owns the great superiorities of non-invasiveness,nonionizing radiation,and real-time dynamic imaging with the low biological interference,can significantly improve the tissue penetration depth and detection sensitivity,thus expecting to achieve accurate and precise diagnosis of major diseases.Inspired by the conspicuous superiorities,an increasing number of versatile NIR-II fluorophores have been legitimately designed and engineered for precisely deep-tissue mapping-mediated theranostics of life-threatening diseases.Organic semiconducting nanomaterials(OSNs)are derived from organic conjugated molecules withπ-electron delocalized skeletons,which show greatly preponderant prospects in the biomedicine field due to the excellent photoelectric property,tunable energy bands,and fine biocompatibility.In this review,the superiorities of NIR-II fluorescence imaging using OSNs for brilliant visualization various of diseases,including tongue cancer,ovarian cancer,osteosarcoma,bacteria or pathogens infection,kidney dysfunction,rheumatoid arthritis,liver injury,and cerebrovascular function,are emphatically summarized.Finally,the reasonable prospects and persistent efforts for repurposing OSNs to facilitate the clinical translation of NIR-II fluorescence phototheranostics are outlined.展开更多
基金the National Natural Science Foundation of China(grant nos.82302257,82302356,62288102,and 22465015)the Natural Science Foundation of Jiangxi Province(grant nos.20232BAB203049,20243BCE51136,20212BAB214005,and 20224BAB204007)+2 种基金the project funded by China Postdoctoral Science Foundation(grant no.2023M730603)the Natural Science Foundation of Fujian Province(grant no.2023J01529)the innovation team of photoelectric functional materials and devices for biomedical theranostics of Fujian Normal University(grant no.Y07204080K13).
文摘Recently emerging Type-I photodynamic therapy holds significant promise in addressing the hypoxia challenge encountered by traditional oxygen-dependent Type-II photosensitizers(PSs)in photodynamic oncotherapy.The key hurdle in engineering Type-I PSs lies in enhancing the electron transfer capabilities of these molecules,enabling them to efficiently convert H_(2)O or oxygen-based substrates into reactive oxygen species.Herein,we propose to construct intramolecular electric fields in the second near-infrared(NIR-II)emissive organic PSs to regulate the local electron density for boosting hypoxia-tolerant cancer phototheranostics.Upon introducing the molecular cationization approach and electron programming strategy,the resultant cationic semiconducting architecture achieves electron distribution rearrangement,forms intramolecular electric fields,and facilitates electron transfer path,resulting in a 50-fold amplification of electrostatic potential difference,thereby accelerating the hydroxyl radical(•OH)-dominant Type-I photosensitization process.In vitro studies disclose that the tailor-made nanomaterial selectively targets the mitochondria and causesmitochondria-mediated cancer cell apoptosis under laser irradiation.Notably,this as-prepared nanoplatform enables NIR-II fluorescence imaging-assisted phototherapy and exhibits in vivo antitumor efficacy on 4T1-bearing mouse models.We believe that this contribution will launch the future of NIR-II emitting Type-I PSs and enlighten scientific researchers to exploit high-efficiency phototheranostic agents for cancer therapy.
基金supported by the Academic Promotion Programme of Shandong First Medical University(No.2019QL006)the Natural Science Foundation of Shandong Province(Nos.ZR2020QH133,ZR2020MH339,and ZR2021MC001).
文摘Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influenza risk in China warrants cautious assessment.We conducted a cross-sectional,seroepidemiological study in Shandong Province,Northern China in mid-2021.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic.The overall seroprevalence values against A/H1N1pdm09,A/H3N2,B/Victoria,and B/Yamagata were 17.8%(95%CI 16.2%–19.5%),23.5%(95%CI 21.7%–25.4%),7.6%(95%CI 6.6%–8.7%),and 15.0(95%CI 13.5%–16.5%),respectively,in the study period.The overall vaccination rate was extremely low(2.6%).Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals(P<0.001).Notably,the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic(P<0.01).Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.
基金supported by the Natural Science Foundation of Jiangxi Province(Nos.20212BAB214005 and 20212ACB214002)the Research startup fund of East China Jiaotong University(No.465).
文摘Optical imaging possesses important implications for early disease diagnosis,timely disease treatment,and basic medical as well as biological research.Compared with the traditionary near-infrared(NIR-I)window(650-950 nm)optical imaging,the emerging second near-infrared(NIR-II)window optical imaging technology owns the great superiorities of non-invasiveness,nonionizing radiation,and real-time dynamic imaging with the low biological interference,can significantly improve the tissue penetration depth and detection sensitivity,thus expecting to achieve accurate and precise diagnosis of major diseases.Inspired by the conspicuous superiorities,an increasing number of versatile NIR-II fluorophores have been legitimately designed and engineered for precisely deep-tissue mapping-mediated theranostics of life-threatening diseases.Organic semiconducting nanomaterials(OSNs)are derived from organic conjugated molecules withπ-electron delocalized skeletons,which show greatly preponderant prospects in the biomedicine field due to the excellent photoelectric property,tunable energy bands,and fine biocompatibility.In this review,the superiorities of NIR-II fluorescence imaging using OSNs for brilliant visualization various of diseases,including tongue cancer,ovarian cancer,osteosarcoma,bacteria or pathogens infection,kidney dysfunction,rheumatoid arthritis,liver injury,and cerebrovascular function,are emphatically summarized.Finally,the reasonable prospects and persistent efforts for repurposing OSNs to facilitate the clinical translation of NIR-II fluorescence phototheranostics are outlined.
