To editor:The EBF3(early B cytokine 3)gene encodes early and highly conserved B cytokine transcription factors that play crucial roles in B lymphocyte differentiation,skeletal phylogeny,and the genesis and differentia...To editor:The EBF3(early B cytokine 3)gene encodes early and highly conserved B cytokine transcription factors that play crucial roles in B lymphocyte differentiation,skeletal phylogeny,and the genesis and differentiation of neurons.These transcription factors are highly expressed in the developing nervous system.Heterozygous mutations or deletions of the EBF3 gene can lead to autosomal dominant HADDS(Hypotonia,Ataxia,and Delayed Development Syndrome),characterized by intellectual disability,neurodevelopmental disorders(NDDs),and facial malformations.1 Written informed consent has been obtained for the publication.展开更多
基金supported by the Medical Research Project of the Chengdu Health Commission(202321).
文摘To editor:The EBF3(early B cytokine 3)gene encodes early and highly conserved B cytokine transcription factors that play crucial roles in B lymphocyte differentiation,skeletal phylogeny,and the genesis and differentiation of neurons.These transcription factors are highly expressed in the developing nervous system.Heterozygous mutations or deletions of the EBF3 gene can lead to autosomal dominant HADDS(Hypotonia,Ataxia,and Delayed Development Syndrome),characterized by intellectual disability,neurodevelopmental disorders(NDDs),and facial malformations.1 Written informed consent has been obtained for the publication.
