Superhydrophobic surfaces have attracted extensive interests and researches into their fundamentals and potential applications.Laser texturing provides the convenience to fabricate the hierarchical micro/nanostructure...Superhydrophobic surfaces have attracted extensive interests and researches into their fundamentals and potential applications.Laser texturing provides the convenience to fabricate the hierarchical micro/nanostructures for superhydrophobicity.However,after laser texturing,long wettability transition time from superhydrophilicity to superhydrophobicity is a barrier to mass production and practical industrial applications.External stimuli have been applied to change the surface composition and/or the surface morphology to reduce wettability transition time.Herein,by temperature tuning,wettability transition of laser textured brass surfaces is investigated.Scanning electron microscopy and surface contact angle measurement are employed to characterize the surface morphology and wettability behavior of the textured brass surfaces.By low-temperature heating(100℃~150℃),partial deoxidation of the top Cu O layer occurs to form hydrophobic Cu_2O.Therefore,superhydrophobicity without any chemical coating and surface modification could be achieved in a short time.Furthermore,after low-temperature heating,the low adhesive force between the water droplet and the sample surface is demonstrated for the laser textured brass surface.This study provides a simple method to fabricate the micro/nanostructure surfaces with controllable wettability for the potential applications.展开更多
Isocitrate dehydrogenase(IDH)is an essential metabolic enzyme in the tricarboxylic acid cycle(TAC).The high mutation frequency of the IDH gene plays a complicated role in gliomas.In addition to affecting gliomas direc...Isocitrate dehydrogenase(IDH)is an essential metabolic enzyme in the tricarboxylic acid cycle(TAC).The high mutation frequency of the IDH gene plays a complicated role in gliomas.In addition to affecting gliomas directly,mutations in IDH can also alter their immune microenvironment and can change immune-cell function in direct and indirect ways.IDH mutations mediate immune-cell infiltration and function by modulating immune-checkpoint gene expression and chemokine secretion.In addition,IDH mutation-derived D2-hydroxyglutarate can be absorbed by surrounding immune cells,also affecting their functioning.In this review,we summarize current knowledge about the effects of IDH mutations as well as other gene mutations on the immune microenvironment of gliomas.We also describe recent preclinical and clinical data related to IDH-mutant inhibitors for the treatment of gliomas.Finally,we discuss different types of immunotherapy and the immunotherapeutic potential of IDH mutations in gliomas.展开更多
Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human...Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human organs and integrated photonic circuits are extraordinary attractive as they can promote the current technology to a new level.Among all the 3D printing methods available,two-photon polymerization(2PP)is very competitive as it is the unique method to achieve sub-micron resolution to make any desired tiny structures.For the conventional 2PP,the building block is the photoresist.However,the requirement for the building block is different for different purposes.It is very necessary to investigate and improve the photoresist properties according to different requirements.In this paper,we presented one hybrid method to modify the mechanical strength and light trapping efficiency of the photoresist,which transfers the photoresist into the micro-concretes.The micro-concrete structure can achieve±22%strength modification via a silica nano-particles doping.The structures doped with gold nano-particles show tunable plasmonic absorption.Dye doped hybrid structure shows great potential to fabricate 3D micro-chip laser.展开更多
What is known about this topic?Global human cases of zoonotic influenza A(H5N6)have increased significantly in recent years,primarily due to widespread circulation of clade 2.3.4.4b virus since 2020.Concurrent with th...What is known about this topic?Global human cases of zoonotic influenza A(H5N6)have increased significantly in recent years,primarily due to widespread circulation of clade 2.3.4.4b virus since 2020.Concurrent with this trend,sporadic human infections with clade 2.3.4.4h H5N6 avian influenza virus continue to occur.The high mortality rate associated with H5N6 virus infections has emerged as a critical public health concern.What is added by this report?Through comprehensive field epidemiological investigations and laboratory analyses,we identified the infection sources for these cases and conclusively ruled out human-to-human transmission.Genetic analyses revealed that while the virus maintains its avian host tropism,it has acquired mutations that may enhance human receptor binding affinity,viral replication capacity,pathogenicity,and neuraminidase inhibitor resistance.What are the implications for public health practice?The ongoing viral mutations increase the potential for H5 subtype avian influenza viruses to overcome species barriers and cause human epidemics.Enhanced surveillance strategies incorporating advanced technologies,such as metagenomic sequencing,are essential for early risk detection and management.Special attention should be directed toward cancer patients and immunocompromised individuals,who demonstrate increased susceptibility to avian influenza virus infections and require targeted prevention and control measures.展开更多
基金supported by the National Natural Science Foundation of China (U1609209)Open Program of Laser Precision Machining Engineering Technology Research Center of Fujian Province (2016JZA001)
文摘Superhydrophobic surfaces have attracted extensive interests and researches into their fundamentals and potential applications.Laser texturing provides the convenience to fabricate the hierarchical micro/nanostructures for superhydrophobicity.However,after laser texturing,long wettability transition time from superhydrophilicity to superhydrophobicity is a barrier to mass production and practical industrial applications.External stimuli have been applied to change the surface composition and/or the surface morphology to reduce wettability transition time.Herein,by temperature tuning,wettability transition of laser textured brass surfaces is investigated.Scanning electron microscopy and surface contact angle measurement are employed to characterize the surface morphology and wettability behavior of the textured brass surfaces.By low-temperature heating(100℃~150℃),partial deoxidation of the top Cu O layer occurs to form hydrophobic Cu_2O.Therefore,superhydrophobicity without any chemical coating and surface modification could be achieved in a short time.Furthermore,after low-temperature heating,the low adhesive force between the water droplet and the sample surface is demonstrated for the laser textured brass surface.This study provides a simple method to fabricate the micro/nanostructure surfaces with controllable wettability for the potential applications.
基金supported by the Translational Medicine Research Fund of Zhongnan Hospital of Wuhan University(ZLYNXM202011 and ZNLH201901)the National Health Commission of China(2018ZX-07S-011).
文摘Isocitrate dehydrogenase(IDH)is an essential metabolic enzyme in the tricarboxylic acid cycle(TAC).The high mutation frequency of the IDH gene plays a complicated role in gliomas.In addition to affecting gliomas directly,mutations in IDH can also alter their immune microenvironment and can change immune-cell function in direct and indirect ways.IDH mutations mediate immune-cell infiltration and function by modulating immune-checkpoint gene expression and chemokine secretion.In addition,IDH mutation-derived D2-hydroxyglutarate can be absorbed by surrounding immune cells,also affecting their functioning.In this review,we summarize current knowledge about the effects of IDH mutations as well as other gene mutations on the immune microenvironment of gliomas.We also describe recent preclinical and clinical data related to IDH-mutant inhibitors for the treatment of gliomas.Finally,we discuss different types of immunotherapy and the immunotherapeutic potential of IDH mutations in gliomas.
基金financially supported by A*STAR, SERC 2014 Public Sector Research Funding (PSF) (Grant: SERC Project, 1421200080)973 Program of China (2013CBA01700)Chinese Nature Science Grant (61675207, U1609209)
文摘Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human organs and integrated photonic circuits are extraordinary attractive as they can promote the current technology to a new level.Among all the 3D printing methods available,two-photon polymerization(2PP)is very competitive as it is the unique method to achieve sub-micron resolution to make any desired tiny structures.For the conventional 2PP,the building block is the photoresist.However,the requirement for the building block is different for different purposes.It is very necessary to investigate and improve the photoresist properties according to different requirements.In this paper,we presented one hybrid method to modify the mechanical strength and light trapping efficiency of the photoresist,which transfers the photoresist into the micro-concretes.The micro-concrete structure can achieve±22%strength modification via a silica nano-particles doping.The structures doped with gold nano-particles show tunable plasmonic absorption.Dye doped hybrid structure shows great potential to fabricate 3D micro-chip laser.
基金Supported by the Fujian Natural Science Foundation(2021J01351)the Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province,China(Grant No.2021ZQNZD006).
文摘What is known about this topic?Global human cases of zoonotic influenza A(H5N6)have increased significantly in recent years,primarily due to widespread circulation of clade 2.3.4.4b virus since 2020.Concurrent with this trend,sporadic human infections with clade 2.3.4.4h H5N6 avian influenza virus continue to occur.The high mortality rate associated with H5N6 virus infections has emerged as a critical public health concern.What is added by this report?Through comprehensive field epidemiological investigations and laboratory analyses,we identified the infection sources for these cases and conclusively ruled out human-to-human transmission.Genetic analyses revealed that while the virus maintains its avian host tropism,it has acquired mutations that may enhance human receptor binding affinity,viral replication capacity,pathogenicity,and neuraminidase inhibitor resistance.What are the implications for public health practice?The ongoing viral mutations increase the potential for H5 subtype avian influenza viruses to overcome species barriers and cause human epidemics.Enhanced surveillance strategies incorporating advanced technologies,such as metagenomic sequencing,are essential for early risk detection and management.Special attention should be directed toward cancer patients and immunocompromised individuals,who demonstrate increased susceptibility to avian influenza virus infections and require targeted prevention and control measures.
