Objective:To evaluate the efficacy of montelukast sodium orally dissolving films combined with triple nebulization in the treatment of pediatric asthmatic bronchopneumonia.Methods:A total of 60 pediatric patients with...Objective:To evaluate the efficacy of montelukast sodium orally dissolving films combined with triple nebulization in the treatment of pediatric asthmatic bronchopneumonia.Methods:A total of 60 pediatric patients with asthmatic bronchopneumonia who visited the hospital from December 2021 to December 2024 were selected as samples and randomly divided into two groups.Group A received combined therapy with montelukast sodium orally dissolving films,while Group B received triple nebulization therapy.The time to symptom relief,serum inflammatory factors,and adverse reactions were compared between the two groups.Results:The duration of asthma,cough,and wheezing,as well as the length of hospital stay,were shorter in Group A than in Group B(P<0.05).The levels of C-reactive protein(CRP),white blood cell count(WBC),and serum amyloid A(SAA)were lower in Group A than in Group B(P<0.05).The incidence of adverse reactions was lower in Group A than in Group B(P<0.05).Conclusion:The combination therapy of montelukast sodium orally dissolving films and triple nebulization for pediatric asthmatic bronchopneumonia can effectively inhibit inflammation,shorten the duration of symptoms,and is safe and efficient.展开更多
The plant hormone abscisic acid(ABA)is crucial for plant seed germination and abiotic stress tolerance.However,the association between ABA sensitivity and plant abiotic stress tolerance remains largely unknown.In this...The plant hormone abscisic acid(ABA)is crucial for plant seed germination and abiotic stress tolerance.However,the association between ABA sensitivity and plant abiotic stress tolerance remains largely unknown.In this study,436 rice accessions were assessed for their sensitivity to ABA during seed germination.The considerable diversity in ABA sensitivity among rice germplasm accessions was primarily reflected by the differentiation between the Xian(indica)and Geng(japonica)subspecies and between the upland-Geng and lowland-Geng ecotypes.The upland-Geng accessions were most sensitive to ABA.Genome-wide association analyses identified four major quantitative trait loci containing21 candidate genes associated with ABA sensitivity of which a basic helix-loop-helix transcription factor gene,OsbHLH38,was the most important for ABA sensitivity.Comprehensive functional analyses using knockout and overexpression transgenic lines revealed that OsbHLH38 expression was responsive to multiple abiotic stresses.Overexpression of OsbHLH38 increased seedling salt tolerance,while knockout of OsbHLH38 increased sensitivity to salt stress.A salt-responsive transcription factor,OsDREB2A,interacted with OsbHLH38 and was directly regulated by OsbHLH38.Moreover,OsbHLH38 affected rice abiotic stress tolerance by mediating the expression of a large set of transporter genes of phytohormones,transcription factor genes,and many downstream genes with diverse functions,including photosynthesis,redox homeostasis,and abiotic stress responsiveness.These results demonstrated that OsbHLH38 is a key regulator in plant abiotic stress tolerance.展开更多
文摘Objective:To evaluate the efficacy of montelukast sodium orally dissolving films combined with triple nebulization in the treatment of pediatric asthmatic bronchopneumonia.Methods:A total of 60 pediatric patients with asthmatic bronchopneumonia who visited the hospital from December 2021 to December 2024 were selected as samples and randomly divided into two groups.Group A received combined therapy with montelukast sodium orally dissolving films,while Group B received triple nebulization therapy.The time to symptom relief,serum inflammatory factors,and adverse reactions were compared between the two groups.Results:The duration of asthma,cough,and wheezing,as well as the length of hospital stay,were shorter in Group A than in Group B(P<0.05).The levels of C-reactive protein(CRP),white blood cell count(WBC),and serum amyloid A(SAA)were lower in Group A than in Group B(P<0.05).The incidence of adverse reactions was lower in Group A than in Group B(P<0.05).Conclusion:The combination therapy of montelukast sodium orally dissolving films and triple nebulization for pediatric asthmatic bronchopneumonia can effectively inhibit inflammation,shorten the duration of symptoms,and is safe and efficient.
基金supported by the National Key Research and Development Program of China(2020YFE0202300)the National Natural Science Foundation of China(31971928)+2 种基金the Hainan Yazhou Bay Seed Lab Project(B23CJ0208,B21HJ0223,and B21HJ0508)the CAAS Innovative Team Award(to BYF and WSW)the National High-level Personnel of Special Support Program(to WSW)。
文摘The plant hormone abscisic acid(ABA)is crucial for plant seed germination and abiotic stress tolerance.However,the association between ABA sensitivity and plant abiotic stress tolerance remains largely unknown.In this study,436 rice accessions were assessed for their sensitivity to ABA during seed germination.The considerable diversity in ABA sensitivity among rice germplasm accessions was primarily reflected by the differentiation between the Xian(indica)and Geng(japonica)subspecies and between the upland-Geng and lowland-Geng ecotypes.The upland-Geng accessions were most sensitive to ABA.Genome-wide association analyses identified four major quantitative trait loci containing21 candidate genes associated with ABA sensitivity of which a basic helix-loop-helix transcription factor gene,OsbHLH38,was the most important for ABA sensitivity.Comprehensive functional analyses using knockout and overexpression transgenic lines revealed that OsbHLH38 expression was responsive to multiple abiotic stresses.Overexpression of OsbHLH38 increased seedling salt tolerance,while knockout of OsbHLH38 increased sensitivity to salt stress.A salt-responsive transcription factor,OsDREB2A,interacted with OsbHLH38 and was directly regulated by OsbHLH38.Moreover,OsbHLH38 affected rice abiotic stress tolerance by mediating the expression of a large set of transporter genes of phytohormones,transcription factor genes,and many downstream genes with diverse functions,including photosynthesis,redox homeostasis,and abiotic stress responsiveness.These results demonstrated that OsbHLH38 is a key regulator in plant abiotic stress tolerance.
