In continuation of our studies on Aconitum hemsleyanum Pritz. var. pengzhouense, two new norditerpenoid alkaloids, pengshenines A (1) and B (2), have been isolated from the roots of the plants and their structures wer...In continuation of our studies on Aconitum hemsleyanum Pritz. var. pengzhouense, two new norditerpenoid alkaloids, pengshenines A (1) and B (2), have been isolated from the roots of the plants and their structures were elucidated by 1D- and 2D-NMR.展开更多
Details of a biogenetically inspired strategy that led to the synthesis of the hetidine-type C20-diterpenoid alka- loid skeleton are reported in this paper. Key steps of our synthesis include a C-H oxidation to conver...Details of a biogenetically inspired strategy that led to the synthesis of the hetidine-type C20-diterpenoid alka- loid skeleton are reported in this paper. Key steps of our synthesis include a C-H oxidation to convert the atis- ine-type core to the ajaconine skeleton, as well as an aza-Prins cyclization that establishes the hetidine alkaloid skeleton. An unexpected heptacyclic framework bearing a unique tricyclo[3.3.1.02.7]nonane moiety has been ob- tained during our studies, which may represent a new type of C20-diterpenoid alkaloids yet to be discovered.展开更多
文摘In continuation of our studies on Aconitum hemsleyanum Pritz. var. pengzhouense, two new norditerpenoid alkaloids, pengshenines A (1) and B (2), have been isolated from the roots of the plants and their structures were elucidated by 1D- and 2D-NMR.
基金This research was supported by the National Natural Science Foundation of China （Nos. 21321061, 21132006, 21572139 and 21502126）. Xiao-Yu Liu thanks the financial supports from Sichuan University （Nos. YJ201441 and 2016SCU04A09）.
文摘Details of a biogenetically inspired strategy that led to the synthesis of the hetidine-type C20-diterpenoid alka- loid skeleton are reported in this paper. Key steps of our synthesis include a C-H oxidation to convert the atis- ine-type core to the ajaconine skeleton, as well as an aza-Prins cyclization that establishes the hetidine alkaloid skeleton. An unexpected heptacyclic framework bearing a unique tricyclo[3.3.1.02.7]nonane moiety has been ob- tained during our studies, which may represent a new type of C20-diterpenoid alkaloids yet to be discovered.
