Periodontitis is the leading cause of tooth loss in adults.Unfortunately,inflammation remains poorly controlled and prone to relapse,even after removing the initial plaque biofilm.The unique metabolic properties of mi...Periodontitis is the leading cause of tooth loss in adults.Unfortunately,inflammation remains poorly controlled and prone to relapse,even after removing the initial plaque biofilm.The unique metabolic properties of mitochondria in the periodontal microenvironment provide a promising target for novel therapeutic strategies against periodontitis.Here,we integrate meta-bolomics and network biology to elucidate the potential role of nuclear factor E2-related factor 2/mitochondrial transcription factor(Nrf2/TFAM)in regulating mitochondrial metabolism in periodontitis.Based on this discovery,it is crucial to develop an innovative nanomedicine capable of effectively modulating the mitochondrial metabolism in periodontitis.Recently,itaconate(ITA),a key metabolite linking mitochondrial metabolism and inflammation,has emerged as a powerhouse in regulating immunity through Nrf2;however,its limited permeability hinders its application in biological systems.Therefore,we synthesize ITA-based nano cocktail(INC)with cell permeability and improved biological functions.At the cellular level,INC activates Nrf2/TFAM to remodel mitochondrial metabolism and regulate macrophage immune homeostasis.In mouse models of peri-odontitis,INC successfully reprograms mitochondrial metabolism within the gingiva,leading to an improved inflammatory microenvironment.Our study elucidates the role of INC in modulating mitochondrial metabolism,thereby offering an inno-vative therapeutic strategy for the management of periodontitis and other clinical conditions resulting from mitochondrial abnormalities.展开更多
Strain gauge plays vital roles in various fields as structural health monitoring,aerospace engineering,and civil infrastructure.However,traditional flexible strain gauge inevitably brings the pseudo-signal caused by t...Strain gauge plays vital roles in various fields as structural health monitoring,aerospace engineering,and civil infrastructure.However,traditional flexible strain gauge inevitably brings the pseudo-signal caused by the substrate temperature effect and determines its accuracy.Here,we present an anisotropic composite substrate designed to modify the thermal expansion performance via Micro-electro-mechanical System(MEMS)technology,which facilitates the development of strain gauges that are minimally affected by substrate temperature-induced effect.Compared to the isotropic flexible substrate,the simulated expansion displacement in the thermal insensitive direction is reduced by 53.6%via introducing an anisotropic thermal expansion structure.The developed strain gauge exhibits significantly reduced sensitivity to temperature-induced effect,with a temperature coefficient of resistance decreasing from 87.3%to 10%,along with a notable 47.1%improvement in TCR stability.In addition,the strain gauge displays a sensitivity of 1.99 and boasts a wide strain operational range of 0-6000μe,while maintaining excellent linearity.Furthermore,stress response conducted on a model of an aircraft wing illustrates the rapid monitoring of the strain gauge,which can detect strain as low as 100μe.This study strongly highlights the potential applicability of the developed strain gauge in the aircraft,ships,and bridges for monitoring stress.展开更多
基金supported by the National Natural Science Foundation of China(82301131)the Jilin Province Development and Reform Commission(2023C041-3)+1 种基金the Science,Technology Project of Jilin Provincial Department of Finance(JCSZ2023481-14)the Bethune Project of Jilin University(2023B27).
文摘Periodontitis is the leading cause of tooth loss in adults.Unfortunately,inflammation remains poorly controlled and prone to relapse,even after removing the initial plaque biofilm.The unique metabolic properties of mitochondria in the periodontal microenvironment provide a promising target for novel therapeutic strategies against periodontitis.Here,we integrate meta-bolomics and network biology to elucidate the potential role of nuclear factor E2-related factor 2/mitochondrial transcription factor(Nrf2/TFAM)in regulating mitochondrial metabolism in periodontitis.Based on this discovery,it is crucial to develop an innovative nanomedicine capable of effectively modulating the mitochondrial metabolism in periodontitis.Recently,itaconate(ITA),a key metabolite linking mitochondrial metabolism and inflammation,has emerged as a powerhouse in regulating immunity through Nrf2;however,its limited permeability hinders its application in biological systems.Therefore,we synthesize ITA-based nano cocktail(INC)with cell permeability and improved biological functions.At the cellular level,INC activates Nrf2/TFAM to remodel mitochondrial metabolism and regulate macrophage immune homeostasis.In mouse models of peri-odontitis,INC successfully reprograms mitochondrial metabolism within the gingiva,leading to an improved inflammatory microenvironment.Our study elucidates the role of INC in modulating mitochondrial metabolism,thereby offering an inno-vative therapeutic strategy for the management of periodontitis and other clinical conditions resulting from mitochondrial abnormalities.
基金This work was supported by the National Key Research and Development Program of China(Grant No.2020YFB2008503)Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(grant no.SL2022ZD203)National Natural Science Foundation of China(No.62274108).
文摘Strain gauge plays vital roles in various fields as structural health monitoring,aerospace engineering,and civil infrastructure.However,traditional flexible strain gauge inevitably brings the pseudo-signal caused by the substrate temperature effect and determines its accuracy.Here,we present an anisotropic composite substrate designed to modify the thermal expansion performance via Micro-electro-mechanical System(MEMS)technology,which facilitates the development of strain gauges that are minimally affected by substrate temperature-induced effect.Compared to the isotropic flexible substrate,the simulated expansion displacement in the thermal insensitive direction is reduced by 53.6%via introducing an anisotropic thermal expansion structure.The developed strain gauge exhibits significantly reduced sensitivity to temperature-induced effect,with a temperature coefficient of resistance decreasing from 87.3%to 10%,along with a notable 47.1%improvement in TCR stability.In addition,the strain gauge displays a sensitivity of 1.99 and boasts a wide strain operational range of 0-6000μe,while maintaining excellent linearity.Furthermore,stress response conducted on a model of an aircraft wing illustrates the rapid monitoring of the strain gauge,which can detect strain as low as 100μe.This study strongly highlights the potential applicability of the developed strain gauge in the aircraft,ships,and bridges for monitoring stress.
