Dear Editor,Obesity is an increasingly prevalent global metabolic disorder,yet effctive long-term interventions remain elusive.Recent studies have highlighted a novel peptide,Urocortin 3(UCN3),which shows potential fo...Dear Editor,Obesity is an increasingly prevalent global metabolic disorder,yet effctive long-term interventions remain elusive.Recent studies have highlighted a novel peptide,Urocortin 3(UCN3),which shows potential for obesity intervention[1].展开更多
Objective Accurately identifying the key influencing factors of psychological birth trauma in primiparous women is crucial for implementing effective preventive and intervention measures.This study aimed to develop an...Objective Accurately identifying the key influencing factors of psychological birth trauma in primiparous women is crucial for implementing effective preventive and intervention measures.This study aimed to develop and validate an interpretable machine learning prediction model for identifying the key influencing factors of psychological birth trauma in primiparous women.Methods A multicenter cross-sectional study was conducted on primiparous women in four tertiary hospitals in Sichuan Province,southwestern China,from December 2023 to March 2024.The Childbirth Trauma Index was used in assessing psychological birth trauma in primiparous women.Data were collected and randomly divided into a training set(80%,n=289)and a testing set(20%,n=73).Six different machine learning models were trained and tested.Training and prediction were conducted using six machine learning models included Linear Regression,Support Vector Regression,Multilayer Perceptron Regression,eXtreme Gradient Boosting Regression,Random Forest Regression,and Adaptive Boosting Regression.The optimal model was selected based on various performance metrics,and its predictive results were interpreted using SHapley Additive exPlanations(SHAP)and accumulated local effects(ALE).Results Among the six machine learning models,the Multilayer Perceptron Regression model exhibited the best overall performance in the testing set(MAE=3.977,MSE=24.832,R2=0.507,EVS=0.524,RMSE=4.983).In the testing set,the R2 and EVS of the Multilayer Perceptron Regression model increased by 8.3%and 1.2%,respectively,compared to the traditional linear regression model.Meanwhile,the MAE,MSE,and RMSE decreased by 0.4%,7.3%,and 3.7%,respectively,compared to the traditional linear regression model.The SHAP analysis indicated that intrapartum pain,anxiety,postpartum pain,resilience,and planned pregnancy are the most critical influencing factors of psychological birth trauma in primiparous women.The ALE analysis indicated that higher intrapartum pain,anxiety,and postpartum pain scores are risk factors,while higher resilience scores are protective factors.Conclusions Interpretable machine learning prediction models can identify the key influencing factors of psychological birth trauma in primiparous women.SHAP and ALE analyses based on the Multilayer Perceptron Regression model can help healthcare providers understand the complex decision-making logic within a prediction model.This study provides a scientific basis for the early prevention and personalized intervention of psychological birth trauma in primiparous women.展开更多
OBJECTIVE:To verify the effects of perilla oil on the regulation of blood lipid levels in patients with hyperlipidemia.METHODS:Blood was taken from patients prior to and 8 weeks following treatment with perilla oil.Di...OBJECTIVE:To verify the effects of perilla oil on the regulation of blood lipid levels in patients with hyperlipidemia.METHODS:Blood was taken from patients prior to and 8 weeks following treatment with perilla oil.Different ways to test for indexes which correlate to hyperlipidemia were performed.Some indexes,which correlate with inflammation and injury to endothelial cells,were tested using enzyme linked immunosorbent assays.RESULTS:Serum lipid levels [triglyceride(TG),total cholesterol(TC),and low-density lipoprotein-cholesterol(LDL-C)] changed significantly after 56 days of treatment.Differences were noted as early as 28 days after treatment began(P<0.05).Treatment with perilla oil showed statistically significant recovery levels of high-density lipoprotein-cholesterol(HDL-C) after 28 and 56 days of treatment.Plasma lipids levels were significantly lower after 56 days of treatment(P<0.05).Perilla oil reduced blood lipid levels in patients,and the regulation of cell signaling factor levels had no adverse effects on patients' liver or kidney function,or blood routine examinations.CONCLUSION:Perilla oil treatment is safe in clinical use,can regulate blood lipid levels and protects the function of endothelial cells.展开更多
OBJECTIVE： To investigate the effect of Qiguiyish- en decoction （QGYS） on the severity of nephropa- thy. METHODS： Twenty-four rats were randomly divid- ed into four groups （ Ⅰ,Ⅱ,Ⅲ, IV） according to the random...OBJECTIVE： To investigate the effect of Qiguiyish- en decoction （QGYS） on the severity of nephropa- thy. METHODS： Twenty-four rats were randomly divid- ed into four groups （ Ⅰ,Ⅱ,Ⅲ, IV） according to the random number table. Group I as control group did not establish nephropathy model. Groups Ⅱ, Ⅲ, and IV were intravenously administered Adria- mycin （7.5 mg/kg） through the tail vein to establish nephropathy model. QGYS was prepared with the extracts of Huangqi （RadixAstragali Mongolici）, Dan- ggui （Radix Angelicae Sinensis）, Niuxi （Radix Achyran-this Bidentatae）, and Chuanxiong （Rhizoma Chuanx- iong）. Group IV was administered QGYS （2 mL. kg^-1· d^-1）, groupⅢ was administered benazepril （10 mL. kg^-1·d^-1）, and group ⅠⅡ was administered water （2 mL. kg·^-1. d^-1） once daily for eight weeks. RESULTS： QGYS reduced the excretion of urinary protein and N-acetyH3-D-glucosaminidase and alle- viated the accumulation of extracellular matrix （ECM） in renal tissue. Additionally, QGYS effectively regulated the levels of transforming growth factor, tissue inhibitor of matrix metalloproteinase, and matrix metalloproteinases in the kidney of the rats. CONCLUSION-＂ QGYS may reduce the accumulation of ECM in the kidneys of rats with Adriamycin-in- duced nephropathy.展开更多
Suppose V ∪S W is a strongly irreducible Heegaard splitting of a compact connected orientable 3-manifold M and F1 and F2 are pairwise disjoint homeomorphic essential subsurfaces in ?V. In this paper,we give a suffici...Suppose V ∪S W is a strongly irreducible Heegaard splitting of a compact connected orientable 3-manifold M and F1 and F2 are pairwise disjoint homeomorphic essential subsurfaces in ?V. In this paper,we give a sufficient condition such that the self-amalgamation of V ∪S W along F1 and F2 is unstabilized and uncritical.展开更多
The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two han...The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two handlebodies H1 and H2 is a handlebody if and only if the core curve of A is a longitude for either H1 or H2;(2)Let H=H1∪Sg,b H2 be a surface sum of two handlebodies H1 and H2 along a connected surface S=Sg,b,b 1,ni=g(Hi)2,i=1,2.Suppose that S is incompressible in both H1 and H2.Then H is a handlebody if and only if there exists a basis J={J1,...,Jm}with a partition(J1,J2)of J such that J1 is primitive in H1 and J2 is primitive in H2.展开更多
Let M be a compact connected 3-submanifold of the 3-sphere S^3 with one boundary component F such that there exists a collection of n pairwise disjoint connected orientable surfaces S = {S_1, ···, S_n} ...Let M be a compact connected 3-submanifold of the 3-sphere S^3 with one boundary component F such that there exists a collection of n pairwise disjoint connected orientable surfaces S = {S_1, ···, S_n} properly embedded in M, ?S = {?S_1, ···, ?S_n}is a complete curve system on F. We call S a complete surface system for M, and ?S a complete spanning curve system for M. In the present paper, the authors show that the equivalent classes of complete spanning curve systems for M are unique, that is, any complete spanning curve system for M is equivalent to ?S. As an application of the result,it is shown that the image of the natural homomorphism from the mapping class group M(M) to M(F) is a subgroup of the handlebody subgroup Hn.展开更多
In this paper,the authors systematically discuss orbit braids in M×I with regards to orbit configuration space FG(M,n),where M is a connected topological manifold of dimension at least 2 with an effective action ...In this paper,the authors systematically discuss orbit braids in M×I with regards to orbit configuration space FG(M,n),where M is a connected topological manifold of dimension at least 2 with an effective action of a finite group G.These orbit braids form a group,named orbit braid group,which enriches the theory of ordinary braids.The authors analyze the substantial relations among various braid groups associated to those configuration spaces FG(M,n),F(M/G,n)and F(M,n).They also consider the presentations of orbit braid groups in terms of orbit braids as generators by choosing M=C with typical actions of Zpand(Z_(2))^(2).展开更多
基金supported by the Major Project of the Science and Technology Innovation 2030 of China(2021ZD0202103)the National Natural Science Foundation of China(82425023,82171492,and 32300846)+2 种基金Guangdong Basic and Applied Basic Research Foundation(2023B1515040009)the Technology and Innovation Commission of Shenzhen(RCJC20200714114556103,ZDSYS20190902093601675 and JCYJ20230807120302004)the Yunnan Technological Innovation Centre of Drug Addiction Medicine(202305AK340001).
文摘Dear Editor,Obesity is an increasingly prevalent global metabolic disorder,yet effctive long-term interventions remain elusive.Recent studies have highlighted a novel peptide,Urocortin 3(UCN3),which shows potential for obesity intervention[1].
基金supported by the Sichuan Province Nursing Scientific Research Project Plan(H23022)the 2022 Municipal-University Science and Technology Strategic Cooperation Special Fund of Nanchong Science and Technology Bureau(22SXQT0222)。
文摘Objective Accurately identifying the key influencing factors of psychological birth trauma in primiparous women is crucial for implementing effective preventive and intervention measures.This study aimed to develop and validate an interpretable machine learning prediction model for identifying the key influencing factors of psychological birth trauma in primiparous women.Methods A multicenter cross-sectional study was conducted on primiparous women in four tertiary hospitals in Sichuan Province,southwestern China,from December 2023 to March 2024.The Childbirth Trauma Index was used in assessing psychological birth trauma in primiparous women.Data were collected and randomly divided into a training set(80%,n=289)and a testing set(20%,n=73).Six different machine learning models were trained and tested.Training and prediction were conducted using six machine learning models included Linear Regression,Support Vector Regression,Multilayer Perceptron Regression,eXtreme Gradient Boosting Regression,Random Forest Regression,and Adaptive Boosting Regression.The optimal model was selected based on various performance metrics,and its predictive results were interpreted using SHapley Additive exPlanations(SHAP)and accumulated local effects(ALE).Results Among the six machine learning models,the Multilayer Perceptron Regression model exhibited the best overall performance in the testing set(MAE=3.977,MSE=24.832,R2=0.507,EVS=0.524,RMSE=4.983).In the testing set,the R2 and EVS of the Multilayer Perceptron Regression model increased by 8.3%and 1.2%,respectively,compared to the traditional linear regression model.Meanwhile,the MAE,MSE,and RMSE decreased by 0.4%,7.3%,and 3.7%,respectively,compared to the traditional linear regression model.The SHAP analysis indicated that intrapartum pain,anxiety,postpartum pain,resilience,and planned pregnancy are the most critical influencing factors of psychological birth trauma in primiparous women.The ALE analysis indicated that higher intrapartum pain,anxiety,and postpartum pain scores are risk factors,while higher resilience scores are protective factors.Conclusions Interpretable machine learning prediction models can identify the key influencing factors of psychological birth trauma in primiparous women.SHAP and ALE analyses based on the Multilayer Perceptron Regression model can help healthcare providers understand the complex decision-making logic within a prediction model.This study provides a scientific basis for the early prevention and personalized intervention of psychological birth trauma in primiparous women.
文摘OBJECTIVE:To verify the effects of perilla oil on the regulation of blood lipid levels in patients with hyperlipidemia.METHODS:Blood was taken from patients prior to and 8 weeks following treatment with perilla oil.Different ways to test for indexes which correlate to hyperlipidemia were performed.Some indexes,which correlate with inflammation and injury to endothelial cells,were tested using enzyme linked immunosorbent assays.RESULTS:Serum lipid levels [triglyceride(TG),total cholesterol(TC),and low-density lipoprotein-cholesterol(LDL-C)] changed significantly after 56 days of treatment.Differences were noted as early as 28 days after treatment began(P<0.05).Treatment with perilla oil showed statistically significant recovery levels of high-density lipoprotein-cholesterol(HDL-C) after 28 and 56 days of treatment.Plasma lipids levels were significantly lower after 56 days of treatment(P<0.05).Perilla oil reduced blood lipid levels in patients,and the regulation of cell signaling factor levels had no adverse effects on patients' liver or kidney function,or blood routine examinations.CONCLUSION:Perilla oil treatment is safe in clinical use,can regulate blood lipid levels and protects the function of endothelial cells.
基金Supported by the Natural Science Foundation of China,Through Cell Signaling Pathway to Treat Chronic Kidney Disease by Chinese Herbs Modified Jiaweidangguibuxue Decottion(No.81273723)Jiangsu Administration of Traditional Chinese Medicine(No.LZ13235)the Natural Science Foundation of Bureau of Science and Technology of Suzhou(No.SYS201016)
文摘OBJECTIVE： To investigate the effect of Qiguiyish- en decoction （QGYS） on the severity of nephropa- thy. METHODS： Twenty-four rats were randomly divid- ed into four groups （ Ⅰ,Ⅱ,Ⅲ, IV） according to the random number table. Group I as control group did not establish nephropathy model. Groups Ⅱ, Ⅲ, and IV were intravenously administered Adria- mycin （7.5 mg/kg） through the tail vein to establish nephropathy model. QGYS was prepared with the extracts of Huangqi （RadixAstragali Mongolici）, Dan- ggui （Radix Angelicae Sinensis）, Niuxi （Radix Achyran-this Bidentatae）, and Chuanxiong （Rhizoma Chuanx- iong）. Group IV was administered QGYS （2 mL. kg^-1· d^-1）, groupⅢ was administered benazepril （10 mL. kg^-1·d^-1）, and group ⅠⅡ was administered water （2 mL. kg·^-1. d^-1） once daily for eight weeks. RESULTS： QGYS reduced the excretion of urinary protein and N-acetyH3-D-glucosaminidase and alle- viated the accumulation of extracellular matrix （ECM） in renal tissue. Additionally, QGYS effectively regulated the levels of transforming growth factor, tissue inhibitor of matrix metalloproteinase, and matrix metalloproteinases in the kidney of the rats. CONCLUSION-＂ QGYS may reduce the accumulation of ECM in the kidneys of rats with Adriamycin-in- duced nephropathy.
基金supported by National Natural Science Foundation of China(Grant Nos.11601209,11671064,11471151,11401069,11329101 and 11431009)Scientific Research Foundation for Doctors of Liaoning Province(Grant No.201601239)+1 种基金Scientific Research Fund of Liaoning Provincial Education Department(Grant No.L201683660)the Fundamental Research Funds for the Central Universities(Grant No.DUT16LK40)
文摘Suppose V ∪S W is a strongly irreducible Heegaard splitting of a compact connected orientable 3-manifold M and F1 and F2 are pairwise disjoint homeomorphic essential subsurfaces in ?V. In this paper,we give a sufficient condition such that the self-amalgamation of V ∪S W along F1 and F2 is unstabilized and uncritical.
基金supported by National Natural Science Foundation of China(Grant Nos.11431009 and 11671064)the Fundamental Research Funds for the Central Universities(Grant No.DUT19LK15)Ministry of Science and Education of Russia(Grant No.1.13557.2019/13.1)。
文摘The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two handlebodies H1 and H2 is a handlebody if and only if the core curve of A is a longitude for either H1 or H2;(2)Let H=H1∪Sg,b H2 be a surface sum of two handlebodies H1 and H2 along a connected surface S=Sg,b,b 1,ni=g(Hi)2,i=1,2.Suppose that S is incompressible in both H1 and H2.Then H is a handlebody if and only if there exists a basis J={J1,...,Jm}with a partition(J1,J2)of J such that J1 is primitive in H1 and J2 is primitive in H2.
基金supported by the National Natural Science Foundation of China(Nos.11329101,11431009,11329101,11471151,11401069)the grant of the Fundamental Research Funds for the Central Universities(No.DUT14LK12)
文摘Let M be a compact connected 3-submanifold of the 3-sphere S^3 with one boundary component F such that there exists a collection of n pairwise disjoint connected orientable surfaces S = {S_1, ···, S_n} properly embedded in M, ?S = {?S_1, ···, ?S_n}is a complete curve system on F. We call S a complete surface system for M, and ?S a complete spanning curve system for M. In the present paper, the authors show that the equivalent classes of complete spanning curve systems for M are unique, that is, any complete spanning curve system for M is equivalent to ?S. As an application of the result,it is shown that the image of the natural homomorphism from the mapping class group M(M) to M(F) is a subgroup of the handlebody subgroup Hn.
基金supported by the National Natural Science Foundation of China(No.11971112)。
文摘In this paper,the authors systematically discuss orbit braids in M×I with regards to orbit configuration space FG(M,n),where M is a connected topological manifold of dimension at least 2 with an effective action of a finite group G.These orbit braids form a group,named orbit braid group,which enriches the theory of ordinary braids.The authors analyze the substantial relations among various braid groups associated to those configuration spaces FG(M,n),F(M/G,n)and F(M,n).They also consider the presentations of orbit braid groups in terms of orbit braids as generators by choosing M=C with typical actions of Zpand(Z_(2))^(2).
