The excessive use of nonrenewable energy has brought about serious greenhouse effect.Converting CO_(2) into high-value-added chemicals is undoubtedly the best choice to solve energy problems.Due to the excellent cost-...The excessive use of nonrenewable energy has brought about serious greenhouse effect.Converting CO_(2) into high-value-added chemicals is undoubtedly the best choice to solve energy problems.Due to the excellent cost-effectiveness and dramatic catalytic performance,nickel-based catalysts have been considered as the most promising candidates for the electrocatalytic CO_(2) reduction reaction(eCO_(2)RR).In this work,the electrocatalytic reduction mechanism of CO_(2) over Ni-based materials is reviewed.The strategies to improve the eCO_(2)RR performance are emphasized.Moreover,the research on Ni-based materials for syngas generation is briefly summarized.Finally,the prospects of nickel-based materials in the eCO_(2)RR are provided with the hope of improving transition-metal-based electrocatalysts for eCO_(2)RR in the future.展开更多
Chaenomeles speciosa(2n=34),a medicinal and edible plant in the Rosaceae,is commonly used in traditional Chinese medicine.To date,the lack of genomic sequence and genetic studies has impeded efforts to improve its med...Chaenomeles speciosa(2n=34),a medicinal and edible plant in the Rosaceae,is commonly used in traditional Chinese medicine.To date,the lack of genomic sequence and genetic studies has impeded efforts to improve its medicinal value.Herein,we report the use of an integrative approach involving PacBio HiFi(third-generation)sequencing and Hi-C scaffolding to assemble a high-quality telomere-to-telomere genome of C.speciosa.The genome comprised 650.4 Mb with a contig N50 of 35.5 Mb.Of these,632.3 Mb were anchored to 17 pseudo-chromosomes,in which 12,4,and 1 pseudo-chromosomes were represented by a single contig,two contigs,and four contigs,respectively.Eleven pseudo-chromosomes had telomere repeats at both ends,and four had telomere repeats at a single end.Repetitive sequences accounted for 49.5%of the genome,while a total of 45515 protein-coding genes have been annotated.The genome size of C.speciosa was relatively similar to that of Malus domestica.Expanded or contracted gene families were identified and investigated for their association with different plant metabolisms or biological processes.In particular,functional annotation characterized gene families that were associated with the biosynthetic pathway of oleanolic and ursolic acids,two abundant pentacyclic triterpenoids in the fruits of C.speciosa.Taken together,this telomere-to-telomere and chromosome-level genome of C.speciosa not only provides a valuable resource to enhance understanding of the biosynthesis of medicinal compounds in tissues,but also promotes understanding of the evolution of the Rosaceae.展开更多
The mismatch in thermal expansion coefficients between the fiber-rich and resin-rich regions of a shape memory polymer composite(SMPC)laminate,along with the residual strain during SMPC fabrication,results in buckling...The mismatch in thermal expansion coefficients between the fiber-rich and resin-rich regions of a shape memory polymer composite(SMPC)laminate,along with the residual strain during SMPC fabrication,results in buckling deformation of the inhomogeneous laminate.This paper presents a macroscopic model for buckling of an inhomogeneous SMPC laminate under initial biaxial prestrains.Both linear and nonlinear buckling analyses are carried out using the energy method.The influences of prestrain biaxiality,temperature,and ply angle on the buckling wavelength,critical buckling prestrain,and buckling amplitude are calculated.The results demonstrate that the critical buckling wavelength of the SMPC laminate is independent of the prestrain,while the amplitude is almost independent of temperature.In addition,the optimal fiber stacking configuration with the maximum critical buckling prestrains of inhomogeneous SMPC laminates is determined by a genetic algorithm.展开更多
For developing and utilizing near-infrared(NIR)energy in sunlight,NaYF4:Yb,Tm(NYFYT)up-conversion Iuminescent powder was combined with Ag_(3)PO_(4)(AP)and Ag_(3)PO_(4)/Pt nanoparticles(AP/PtNPs)as a photocatalyst.Driv...For developing and utilizing near-infrared(NIR)energy in sunlight,NaYF4:Yb,Tm(NYFYT)up-conversion Iuminescent powder was combined with Ag_(3)PO_(4)(AP)and Ag_(3)PO_(4)/Pt nanoparticles(AP/PtNPs)as a photocatalyst.Driven by NIR light,NYFYT produces up-conversion emission at 348,364,453 and 478 nm,effectively stimulating the photocatalytic degradation performance of AP and AP/PtNPs,Under xenon lamp irradiation,the apparent rate constants(k)for Ag_(3)PO_(4)/Pt nanoparticles-NaYF4:Yb,Tm(AP/PtNPs-NYFYT)in photocatalytic degradation of rhodamine B(Rh B)and phenol are 5.51 and 12.82 times higher than those of AP and 1.90 and 2.37 times higher than those of AP-NYFYT-50 wt%,respectively.In addition,under 980nm laser irradiation,rate constants are 3.26 and 4.16 times higher than those of AP-NYFYT-50 wt%,respectively.These results indicate that the combination of NYFYT and AP expands the absorption range of the composite photocatalyst and facilitates the NIR-driven photocatalytic process.The introduction of PtNPs effectively prevents the electron-hole recombination and the reduction of Ag+,accelerating the redox reaction and promoting the photocatalytic activity and stability of AP.展开更多
Copper is one of the essential trace elements for living beings,influencing several critical processes like cellular energy production,antioxidant defense,communication within cells,and the functioning of enzymes[1].T...Copper is one of the essential trace elements for living beings,influencing several critical processes like cellular energy production,antioxidant defense,communication within cells,and the functioning of enzymes[1].The daily intake of copper is 0.7−3.0 mg/d,and copper homeostasis is strictly regulated by physiological processes,including duodenal and small intestinal uptake,blood transport,liver storage and release,and bile excretion,thereby maintaining copper homeostasis in the body[2],and many studies have confirmed that copper disorders in the body are associated with neurodegenerative,metabolic,and genetic diseases[3].展开更多
In order to effectively improve the afterglow properties of CaAl_(2)O_(4):Eu^(2+),Nd^(3+) phosphors,a series of Ca_(0.982-x)Al_(2)O_(4):0.012 Eu^(2+),0.006 Nd^(3+),xGd^(3+)(x=0,0.012,0.024,0.036,0.048,0.060 mol) phosp...In order to effectively improve the afterglow properties of CaAl_(2)O_(4):Eu^(2+),Nd^(3+) phosphors,a series of Ca_(0.982-x)Al_(2)O_(4):0.012 Eu^(2+),0.006 Nd^(3+),xGd^(3+)(x=0,0.012,0.024,0.036,0.048,0.060 mol) phosphors were prepared by a high-temperature solid-phase approach.Crystalline composition and microstructure were characterized by XRD,TEM,HRTEM,and XPS,luminescence properties were systematically analyzed by fluorescence spectra,afterglow decay curves and TL glow curve.Results show that all of Ca_(0.982-x)Al_(2)O_(4):0.012 Eu^(2+),0.006 Nd^(3+),xGd^(3+)phosphors belong to monoclinic CaAl_(2)O_(4),without other cystalline phase.The blue emission at 442 nm is observed,which is assigned to the 4f^(6)5 d→4f^(7) transition of Eu^(2+) ions.Doping with appropriate amount of Gd^(3+) ions(x=0.036 mol) significantly improves the afterglow properties of phosphors,but the excessive doping of Gd^(3+) induces the fluorescent quenching.The doping of moderate Gd^(3+) changes the traps states,the trap depth varies from 0.598 to 0.644 eV and the trap concentration is also greatly improved,thus significantly improving afterglow performance.展开更多
Kirigami arts have provided a more promising method for building multiscale structures,which can shape two-dimensional(2D)sheets into three-dimensional(3D)configurations by cutting and folding.Here,we first carried ou...Kirigami arts have provided a more promising method for building multiscale structures,which can shape two-dimensional(2D)sheets into three-dimensional(3D)configurations by cutting and folding.Here,we first carried out a theoretical analysis of the mechanical properties of 2D honeycomb lattice structures and experimental verification combined with finite element(FE)simulation.Furthermore,a series of thick-walled 3D kirigami-inspired honeycomb(TW3KH)structures with different mechanical properties were designed and fabricated on the exploration and optimization of geometric parameters of 2D honeycomb structures.The investigations of folding feasibility,self-expansion,and self-folding performance experimentally showed that our designed four-dimensional(4D)printing structure had good programmability and shape memory capability and a large volume change ratio during shape change.Meanwhile,research on its compression deformation behavior found that the TW3KH structures can recover load-bearing capacity very well when the angle is positive.Therefore,these TW3KH structures have great advantages in space-saving smart load-bearing equipment.展开更多
Lipid metabolism disorders contribute to hyperlipidemia and hepatic steatosis.It is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic steatosis.Nitazoxanide is an FDA-approved oral antiprot...Lipid metabolism disorders contribute to hyperlipidemia and hepatic steatosis.It is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic steatosis.Nitazoxanide is an FDA-approved oral antiprotozoal drug with excellent pharmacokinetic and safety profile.We found that nitazoxanide and its metabolite tizoxanide induced mild mitochondrial uncoupling and subsequently activated AMPK in Hep G2 cells.Gavage administration of nitazoxanide inhibited high-fat diet(HFD)-induced increases of liver weight,blood and liver lipids,and ameliorated HFD-induced renal lipid accumulation in hamsters.Nitazoxanide significantly improved HFD-induced histopathologic changes of hamster livers.In the hamsters with pre-existing hyperlipidemia and hepatic steatosis,nitazoxanide also showed therapeutic effect.Gavage administration of nitazoxanide improved HFD-induced hepatic steatosis in C57BL/6J mice and western diet(WD)-induced hepatic steatosis in Apoe-/-mice.The present study suggests that repurposing nitazoxanide as a drug for hyperlipidemia and hepatic steatosis treatment is promising.展开更多
The deployable structures based on shape memory polymer com-posites(SMPCs)have been developed for its unique properties,such as high reliability,low-cost,lightweight,and self-deployment without complex mechanical devi...The deployable structures based on shape memory polymer com-posites(SMPCs)have been developed for its unique properties,such as high reliability,low-cost,lightweight,and self-deployment without complex mechanical devices compared with traditional deployable structures.In order to increase the inflatable structure system’s robustness and light the weight of it,a cubic deployable support structure based on SMPC is designed and analyzed pre-liminarily.The cubic deployable support structure based on SMPC consists of four dependent spatial cages,each spatial cage is composed of 12 three-longeron SMPC truss booms and end con-nections.The shape recovery of arc-shaped deployable laminates drive the three-longeron SMPC truss booms to unfold,thus realize the expansion of the deployable support structure.The concept and operation of the cubic deployable support structure are described in detail.A series of experiments are performed on the three-longeron deployable laminates unit and the simplified cubic deployable support structure to investigate the shape recovery behavior in the deployment process.Results indicate that the cubic deployable support structure has a high deployment-tgo-stowage volume ratio and can achieve self-deployment,package,and deploy without complex mechanical devices.展开更多
In the present study,nanocomplexes composed of perilla seed protein isolate(PSPI)and pectin(PEC)were assembled for the delivery of curcumin(Cur)based on the pH-driven self-assembly method.The encapsulation efficiency ...In the present study,nanocomplexes composed of perilla seed protein isolate(PSPI)and pectin(PEC)were assembled for the delivery of curcumin(Cur)based on the pH-driven self-assembly method.The encapsulation efficiency of Cur was 87.77%,and the PSPI-Cur-PEC exhibited controlled release of Cur during the in vitro digestion.Moreover,the PSPI-Cur-PEC possessed efficient antioxidant activity and provided greater defense for Cur against thermal treatment and ultraviolet irradiation.Fourier transform infrared spectroscopy,fluorescence spectroscopy and X-ray diffraction results indicated that entrapped Cur was existed in the form of amorphous state in PSPI-PEC,and the process was driven by hydrophobic effects,hydrogen bonding and electrostatic in-teractions.Scanning electron microscopy images revealed substantial morphological changes of the nano-complexes throughout the process,while transmission electron microscopy images observed the core-shell structure of PSPI-Cur-PEC nanocomplexes.Furthermore,PSPI-PEC exhibited excellent biocompatibility by the in vitro cytotoxicity assay on Caco-2 cells,and the intermolecular interactions and possible formation mechanism of PSPI-Cur-PEC were further determined by molecular docking.This work elucidated that PSPI-PEC nano-complexes assembled by a green and energy-efficient pH-driven method was feasible to protect sensitive hy-drophobic bioactive components and provided a possible utilization of perilla seed protein in delivery system for nutraceuticals.展开更多
Heterogeneously catalyzed liquid oxidation of olefins with O_(2) provides an alternative way for synthesizing high-value added chemicals.Herein,we report a straightforward urea-redox and sol-gel process for synthesizi...Heterogeneously catalyzed liquid oxidation of olefins with O_(2) provides an alternative way for synthesizing high-value added chemicals.Herein,we report a straightforward urea-redox and sol-gel process for synthesizing LaCo_(x)Cu_(1−x)O_(3) for aerobic photooxidation of cyclohexene.Our research highlights a marked increase in the proportions of Co^(2+) and Cu+species in a low chemical state,as well as enhanced visible light absorption through this method.Mechanistic investigations suggest that the catalytic process,particularly with LaCo_(0.7)Cu_(0.3)O_(3),involves a radical pathway mediated by reactive oxygen species.The presence of Cu+/Co^(2+) species and surface oxygen vacancies is proposed to boost O_(2) adsorption and activation on the catalyst,facilitating the formation of 2-cyclohexene-1-hydroperoxides.Furthermore,Cu^(2+)/Co^(3+) species are thought to aid in generating cyclohexenederived radical species.The efficient aerobic oxidation of cyclohexene on LaCo_(0.7)Cu_(0.3)O_(3) catalyst relies on the formation of reactive oxygen species and carbon radicals,facilitated by its strong visible light illumination.It achieves a cyclohexene conversion of 89.4% and selectivity to cyclohex-2-ene-1-one of 72.2%,along with stable recyclability after six reuses.The creation of nano-structured LaCo_(x)Cu_(1−x)O_(3) through the urea-redox and sol-gel process offers a promising avenue for the development of highly efficient catalysts for the aerobic photo-oxidation of cyclohexene to cyclohex-2-ene-1-one in the future.展开更多
O_(x)idative couplings of aliphatic alkynes are crucial for the production of naturally occurring 1,3-diynes.Herein we report the novel approach for effective synthesis of unsaturated coordinated N doped copper oxides...O_(x)idative couplings of aliphatic alkynes are crucial for the production of naturally occurring 1,3-diynes.Herein we report the novel approach for effective synthesis of unsaturated coordinated N doped copper oxides(N-CuO_(x))catalyst,and uncover that N-CuO_(x) catalyst as an additive-free and cost-effective heterogeneous catalyst has highly catalytic performance for directly oxidative coupling of aliphatic alkynes.The key to achieve efficient oxidative coupling of aliphatic alkynes is the synergistic effect of N species and uncoordinated O/Cu species caused by N dopants,which undergoes the Langmuir–Hinshelwood reaction mechanism.The N-CuO_(x) catalyst displays~89.1%yield for hexadeca-7,9-diyne under mild conditions and stable reusability(5 cycles),showing significant advances compared with the traditionally copper oxides.These findings highlight the heteroatom dopants that provide a new methodology for designing efficient copper catalysts in synthesis of naturally occurring 1,3-diynes.展开更多
Rational design of earth-abundant transition metal oxides catalysts is highly desirable for developing sustainable chemical processes.Herein,we demonstrate a prospective interstitial nitrogen engineering for fabricati...Rational design of earth-abundant transition metal oxides catalysts is highly desirable for developing sustainable chemical processes.Herein,we demonstrate a prospective interstitial nitrogen engineering for fabricating oxygen vacancies(OVs)-rich nitrogen-doped-Mn_(x)Co_(3-x)O_(4)(N-Mn_(x)Co_(3-x)O_(4))oxide catalyst,in which the ratio of OVs concentration of N-Mn_(x)Co_(3-x)O_(4)to Mn species is as high as 1:1,according to the characterizations of X-ray absorption(XAS)and X-ray photoelectron(XPS)spectroscopies.The promising strategy of interstitial nitrogen engineering through lattice distortion caused by the Jahn-Teller effect can significantly increase the amount of interstitial nitrogen.The resulting catalyst enables an additive-free aerobic dehydrogenation coupling of aromatic amine to afford azo compounds with>99%yield and>99%selectivity at 60☆.We observed the superb catalytic activity is promoted by the enhanced oxygen mobility in OVs,which were created by the interstitial nitrogen in the catalyst matrix.The presence of interstitial nitrogen in transition metal oxides in this study shows how the manipulation of catalyst matrix can increase the OV sites to promote aerobic oxidation reaction.展开更多
Background The current prevention and control strategy forAedes albopictus heavily relies on comprehensive management, such as environmental management and chemical control. However, the wide application of pyrethroid...Background The current prevention and control strategy forAedes albopictus heavily relies on comprehensive management, such as environmental management and chemical control. However, the wide application of pyrethroids has facilitated the development of insecticide resistance, primarily via mutations in the voltage-gated sodium channel (VGSC) gene. This study aims to develop a novel strategy for detecting mutations in the VGSC gene inAe. albopictus using multiplex PCR-mass spectrometry (MPCR-MS) minisequencing technology.Methods We established a new strategy for detecting mutations in the VGSC gene inAe. albopictus using MPCR-MS minisequencing technology. MPCR amplification and mass probe extension (MPE) were first used, followed by single nucleotide polymorphism (SNP) typing mass spectrometry, which allows the simultaneous detection of multiple mutation sites of the VGSC gene in 96 samples ofAe. albopictus. A total of 70 wild-collectedAe. albopictus were used to evaluate the performance of the method by comparing it with other methods.Results Three target sites (1016, 1532, 1534) in the VGSC gene can be detected simultaneously by double PCR amplification combined with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry, achieving a detection limit of 20 fg/μl. We applied this method to 70 wild-collectedAe. albopictus, and the obtained genotypes were consistent with the routine sequencing results, suggesting the accuracy of our method.Conclusions MPCR-MS minisequencing technology provides a sensitive and high-throughput approach toAe. albopictus VGSC gene mutation screening. Compared with conventional sequencing, this method is economical and time-saving. It is of great value for insecticide resistance surveillance in areas with a high risk of vector-borne disease.展开更多
The proportion of steel produced using electric arc furnaces(EAFs)is increasing.In this study,polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)concentrations and patterns in stack gas samples from three typ...The proportion of steel produced using electric arc furnaces(EAFs)is increasing.In this study,polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)concentrations and patterns in stack gas samples from three typical EAFs in steelmaking plants were determined to allow the contributions of EAFs in steelmaking plants to PCDD/Fs emissions in China to be assessed.Samples collection was accomplished by adopting the automatic isokinetic sampling technique,then the PCDD/Fs congeners concentrations were analyzed qualitatively and quantitatively by isotope dilution high-resolution gas chromatography high-resolution mass spectrometry(HRGC-HRMS).The mean PCDD/Fs mass concentrations in stack gases emitted during the scrap preheating phase of plants E1,E2,and E3 were 0.48,385.55,and 0.34 ng Nm^-3,respectively,and the total toxic equivalent(WHO2005-TEQ)concentrations were 0.05,33.16,and 0.03 ng Nm^-3,respectively.The PCDD/Fs mass concentration in stack gases emitted during the melting phase at plant E3 was 0.12 ng Nm^-3(0.02 ng WHO2005-TEQ Nm^-3).The operational temperature of the bag filter of the preheating in the E2 EAF was as high as 230℃,which is conducive to the generation of PCDD/Fs,whether the temperature in the bag filter of E1(150℃)and E3(120℃)are not.Moreover,the bag filter temperature is suggested to be best controlled to below 150℃.The emission factors(EF)for PCDD/Fs released into the air during the scrap preheating phase for plants E1,E2,and E3 were 0.13,52,and 0.10 mg WHO2005-TEQ t1,respectively,and the EF for the smelting phase from plant E3 was 0.14 mg WHO2005-TEQ t1.The emission factor in E2 is 5 times higher than the highest current UNEP toolkit factor for EAFs(10 mg TEQ/tonne steel).Therefore,an update for the UNEP toolkit emission factor for a few case plants is suggested.Several congeners,including 2,3,7,8-TeCDF,1,2,3,4,6,7,8-HpCDF,and 1,2,3,4,6,7,8-HpCDD,were dominant during the preheating phase,while 2,3,7,8-TeCDF,1,2,3,7,8-PeCDF,and 2,3,4,7,8-PeCDF were dominant during the smelting phase.The monitoring data from the case plants helps to better understand the PCDD/Fs emissions of EAFs using preheating process stages.However,a more complete emission inventory requires more case investigations on the PCDD/Fs emissions from representative EAFs steelmaking plants.展开更多
基金support from the National Natural Science Foundation of China(52072389,52311530113)the Science and Technology Commission of Shanghai Municipality(22DZ1205600,20520760900)+2 种基金the Program of Shanghai Academic Research Leader(20XD1424300)for financial support.The authors also would like to express their gratitude to Tangshan Basic Research Funding Projects(23130210E),Hebei Province High-level Talent(Postdoctor)Funding Project(B2022003025)Key R&D projects of North China University of Science and Technology(ZD-ST-202301)Tangshan Talent Funding Project(A202202007)for their financial support.
文摘The excessive use of nonrenewable energy has brought about serious greenhouse effect.Converting CO_(2) into high-value-added chemicals is undoubtedly the best choice to solve energy problems.Due to the excellent cost-effectiveness and dramatic catalytic performance,nickel-based catalysts have been considered as the most promising candidates for the electrocatalytic CO_(2) reduction reaction(eCO_(2)RR).In this work,the electrocatalytic reduction mechanism of CO_(2) over Ni-based materials is reviewed.The strategies to improve the eCO_(2)RR performance are emphasized.Moreover,the research on Ni-based materials for syngas generation is briefly summarized.Finally,the prospects of nickel-based materials in the eCO_(2)RR are provided with the hope of improving transition-metal-based electrocatalysts for eCO_(2)RR in the future.
基金This work was supported by the Key Industries Innovation Chain Major Project,Hubei Province(2021ACA004 and 2022 AC003-01-003).
文摘Chaenomeles speciosa(2n=34),a medicinal and edible plant in the Rosaceae,is commonly used in traditional Chinese medicine.To date,the lack of genomic sequence and genetic studies has impeded efforts to improve its medicinal value.Herein,we report the use of an integrative approach involving PacBio HiFi(third-generation)sequencing and Hi-C scaffolding to assemble a high-quality telomere-to-telomere genome of C.speciosa.The genome comprised 650.4 Mb with a contig N50 of 35.5 Mb.Of these,632.3 Mb were anchored to 17 pseudo-chromosomes,in which 12,4,and 1 pseudo-chromosomes were represented by a single contig,two contigs,and four contigs,respectively.Eleven pseudo-chromosomes had telomere repeats at both ends,and four had telomere repeats at a single end.Repetitive sequences accounted for 49.5%of the genome,while a total of 45515 protein-coding genes have been annotated.The genome size of C.speciosa was relatively similar to that of Malus domestica.Expanded or contracted gene families were identified and investigated for their association with different plant metabolisms or biological processes.In particular,functional annotation characterized gene families that were associated with the biosynthetic pathway of oleanolic and ursolic acids,two abundant pentacyclic triterpenoids in the fruits of C.speciosa.Taken together,this telomere-to-telomere and chromosome-level genome of C.speciosa not only provides a valuable resource to enhance understanding of the biosynthesis of medicinal compounds in tissues,but also promotes understanding of the evolution of the Rosaceae.
基金supported by the National Natural Science Foundation of China(Grant Nos.12102107 and 12272113)China National Postdoctoral Program for Innovative Talents(No.BX2021090).
文摘The mismatch in thermal expansion coefficients between the fiber-rich and resin-rich regions of a shape memory polymer composite(SMPC)laminate,along with the residual strain during SMPC fabrication,results in buckling deformation of the inhomogeneous laminate.This paper presents a macroscopic model for buckling of an inhomogeneous SMPC laminate under initial biaxial prestrains.Both linear and nonlinear buckling analyses are carried out using the energy method.The influences of prestrain biaxiality,temperature,and ply angle on the buckling wavelength,critical buckling prestrain,and buckling amplitude are calculated.The results demonstrate that the critical buckling wavelength of the SMPC laminate is independent of the prestrain,while the amplitude is almost independent of temperature.In addition,the optimal fiber stacking configuration with the maximum critical buckling prestrains of inhomogeneous SMPC laminates is determined by a genetic algorithm.
基金Project supported by Hebei Province High-level Talent(Postdoctor)Funding Project(B2022003025)。
文摘For developing and utilizing near-infrared(NIR)energy in sunlight,NaYF4:Yb,Tm(NYFYT)up-conversion Iuminescent powder was combined with Ag_(3)PO_(4)(AP)and Ag_(3)PO_(4)/Pt nanoparticles(AP/PtNPs)as a photocatalyst.Driven by NIR light,NYFYT produces up-conversion emission at 348,364,453 and 478 nm,effectively stimulating the photocatalytic degradation performance of AP and AP/PtNPs,Under xenon lamp irradiation,the apparent rate constants(k)for Ag_(3)PO_(4)/Pt nanoparticles-NaYF4:Yb,Tm(AP/PtNPs-NYFYT)in photocatalytic degradation of rhodamine B(Rh B)and phenol are 5.51 and 12.82 times higher than those of AP and 1.90 and 2.37 times higher than those of AP-NYFYT-50 wt%,respectively.In addition,under 980nm laser irradiation,rate constants are 3.26 and 4.16 times higher than those of AP-NYFYT-50 wt%,respectively.These results indicate that the combination of NYFYT and AP expands the absorption range of the composite photocatalyst and facilitates the NIR-driven photocatalytic process.The introduction of PtNPs effectively prevents the electron-hole recombination and the reduction of Ag+,accelerating the redox reaction and promoting the photocatalytic activity and stability of AP.
基金supported by grants from the Health Commission of Weifang(No.WFWSJK-2023-155 to Q.W.)the Natural Science Foundation of Shandong Province(No.ZR2024MH147 to G.D.)the National Natural Science Foundation of China(No.81570945 to G.D.).
文摘Copper is one of the essential trace elements for living beings,influencing several critical processes like cellular energy production,antioxidant defense,communication within cells,and the functioning of enzymes[1].The daily intake of copper is 0.7−3.0 mg/d,and copper homeostasis is strictly regulated by physiological processes,including duodenal and small intestinal uptake,blood transport,liver storage and release,and bile excretion,thereby maintaining copper homeostasis in the body[2],and many studies have confirmed that copper disorders in the body are associated with neurodegenerative,metabolic,and genetic diseases[3].
基金the National Natural Science Fund of China(51772099,51572069,51872091)Scientific and Technological Research Projects of Colleges and Universities in Hebei Province(QN2019049)the Doctoral Initiation Fund(BS2017025)。
文摘In order to effectively improve the afterglow properties of CaAl_(2)O_(4):Eu^(2+),Nd^(3+) phosphors,a series of Ca_(0.982-x)Al_(2)O_(4):0.012 Eu^(2+),0.006 Nd^(3+),xGd^(3+)(x=0,0.012,0.024,0.036,0.048,0.060 mol) phosphors were prepared by a high-temperature solid-phase approach.Crystalline composition and microstructure were characterized by XRD,TEM,HRTEM,and XPS,luminescence properties were systematically analyzed by fluorescence spectra,afterglow decay curves and TL glow curve.Results show that all of Ca_(0.982-x)Al_(2)O_(4):0.012 Eu^(2+),0.006 Nd^(3+),xGd^(3+)phosphors belong to monoclinic CaAl_(2)O_(4),without other cystalline phase.The blue emission at 442 nm is observed,which is assigned to the 4f^(6)5 d→4f^(7) transition of Eu^(2+) ions.Doping with appropriate amount of Gd^(3+) ions(x=0.036 mol) significantly improves the afterglow properties of phosphors,but the excessive doping of Gd^(3+) induces the fluorescent quenching.The doping of moderate Gd^(3+) changes the traps states,the trap depth varies from 0.598 to 0.644 eV and the trap concentration is also greatly improved,thus significantly improving afterglow performance.
基金This work was supported by the National Natural Science Foundation of China(Nos.12072094 and 12172106).
文摘Kirigami arts have provided a more promising method for building multiscale structures,which can shape two-dimensional(2D)sheets into three-dimensional(3D)configurations by cutting and folding.Here,we first carried out a theoretical analysis of the mechanical properties of 2D honeycomb lattice structures and experimental verification combined with finite element(FE)simulation.Furthermore,a series of thick-walled 3D kirigami-inspired honeycomb(TW3KH)structures with different mechanical properties were designed and fabricated on the exploration and optimization of geometric parameters of 2D honeycomb structures.The investigations of folding feasibility,self-expansion,and self-folding performance experimentally showed that our designed four-dimensional(4D)printing structure had good programmability and shape memory capability and a large volume change ratio during shape change.Meanwhile,research on its compression deformation behavior found that the TW3KH structures can recover load-bearing capacity very well when the angle is positive.Therefore,these TW3KH structures have great advantages in space-saving smart load-bearing equipment.
基金supported by the National Natural Science Foundation of China(Nos.81773725 and 91739102)。
文摘Lipid metabolism disorders contribute to hyperlipidemia and hepatic steatosis.It is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic steatosis.Nitazoxanide is an FDA-approved oral antiprotozoal drug with excellent pharmacokinetic and safety profile.We found that nitazoxanide and its metabolite tizoxanide induced mild mitochondrial uncoupling and subsequently activated AMPK in Hep G2 cells.Gavage administration of nitazoxanide inhibited high-fat diet(HFD)-induced increases of liver weight,blood and liver lipids,and ameliorated HFD-induced renal lipid accumulation in hamsters.Nitazoxanide significantly improved HFD-induced histopathologic changes of hamster livers.In the hamsters with pre-existing hyperlipidemia and hepatic steatosis,nitazoxanide also showed therapeutic effect.Gavage administration of nitazoxanide improved HFD-induced hepatic steatosis in C57BL/6J mice and western diet(WD)-induced hepatic steatosis in Apoe-/-mice.The present study suggests that repurposing nitazoxanide as a drug for hyperlipidemia and hepatic steatosis treatment is promising.
基金This work is supported by the National Natural Science Foundation of China(Grant No.11225211,No.11272106,No.11102052).
文摘The deployable structures based on shape memory polymer com-posites(SMPCs)have been developed for its unique properties,such as high reliability,low-cost,lightweight,and self-deployment without complex mechanical devices compared with traditional deployable structures.In order to increase the inflatable structure system’s robustness and light the weight of it,a cubic deployable support structure based on SMPC is designed and analyzed pre-liminarily.The cubic deployable support structure based on SMPC consists of four dependent spatial cages,each spatial cage is composed of 12 three-longeron SMPC truss booms and end con-nections.The shape recovery of arc-shaped deployable laminates drive the three-longeron SMPC truss booms to unfold,thus realize the expansion of the deployable support structure.The concept and operation of the cubic deployable support structure are described in detail.A series of experiments are performed on the three-longeron deployable laminates unit and the simplified cubic deployable support structure to investigate the shape recovery behavior in the deployment process.Results indicate that the cubic deployable support structure has a high deployment-tgo-stowage volume ratio and can achieve self-deployment,package,and deploy without complex mechanical devices.
基金supported by the Discipline-Team of Northeast Agri-cultural University,“Storage,processing and demonstration of charac-teristic fruits and vegetables”(107-54941312)the“Research and development of Perilla series products’related technologies”from en-terprise cooperationand the“Young Talents”Project of Northeast Agricultural University(206-54980112).
文摘In the present study,nanocomplexes composed of perilla seed protein isolate(PSPI)and pectin(PEC)were assembled for the delivery of curcumin(Cur)based on the pH-driven self-assembly method.The encapsulation efficiency of Cur was 87.77%,and the PSPI-Cur-PEC exhibited controlled release of Cur during the in vitro digestion.Moreover,the PSPI-Cur-PEC possessed efficient antioxidant activity and provided greater defense for Cur against thermal treatment and ultraviolet irradiation.Fourier transform infrared spectroscopy,fluorescence spectroscopy and X-ray diffraction results indicated that entrapped Cur was existed in the form of amorphous state in PSPI-PEC,and the process was driven by hydrophobic effects,hydrogen bonding and electrostatic in-teractions.Scanning electron microscopy images revealed substantial morphological changes of the nano-complexes throughout the process,while transmission electron microscopy images observed the core-shell structure of PSPI-Cur-PEC nanocomplexes.Furthermore,PSPI-PEC exhibited excellent biocompatibility by the in vitro cytotoxicity assay on Caco-2 cells,and the intermolecular interactions and possible formation mechanism of PSPI-Cur-PEC were further determined by molecular docking.This work elucidated that PSPI-PEC nano-complexes assembled by a green and energy-efficient pH-driven method was feasible to protect sensitive hy-drophobic bioactive components and provided a possible utilization of perilla seed protein in delivery system for nutraceuticals.
基金supported by the National Natural Science Foundation of China(No.22302001)Key Projects of the Department of Education of Anhui Province of China(No.2022AH050314)Key Program for International S&T Cooperation Projects of China(No.2017YFE0124300).
文摘Heterogeneously catalyzed liquid oxidation of olefins with O_(2) provides an alternative way for synthesizing high-value added chemicals.Herein,we report a straightforward urea-redox and sol-gel process for synthesizing LaCo_(x)Cu_(1−x)O_(3) for aerobic photooxidation of cyclohexene.Our research highlights a marked increase in the proportions of Co^(2+) and Cu+species in a low chemical state,as well as enhanced visible light absorption through this method.Mechanistic investigations suggest that the catalytic process,particularly with LaCo_(0.7)Cu_(0.3)O_(3),involves a radical pathway mediated by reactive oxygen species.The presence of Cu+/Co^(2+) species and surface oxygen vacancies is proposed to boost O_(2) adsorption and activation on the catalyst,facilitating the formation of 2-cyclohexene-1-hydroperoxides.Furthermore,Cu^(2+)/Co^(3+) species are thought to aid in generating cyclohexenederived radical species.The efficient aerobic oxidation of cyclohexene on LaCo_(0.7)Cu_(0.3)O_(3) catalyst relies on the formation of reactive oxygen species and carbon radicals,facilitated by its strong visible light illumination.It achieves a cyclohexene conversion of 89.4% and selectivity to cyclohex-2-ene-1-one of 72.2%,along with stable recyclability after six reuses.The creation of nano-structured LaCo_(x)Cu_(1−x)O_(3) through the urea-redox and sol-gel process offers a promising avenue for the development of highly efficient catalysts for the aerobic photo-oxidation of cyclohexene to cyclohex-2-ene-1-one in the future.
基金supported by the“Key Program for International S&T Cooperation Projects of China”(No.2017YFE0124300)Anhui Provincial Natural Science Foundation of China(No.2008085M47)+1 种基金Key Projects of the Department of Education of Anhui Province of China(No.RZ2000003450)The authors thank the beamline BL14W1 at Shanghai Synchrotron Radiation Facility(SSRF).
文摘O_(x)idative couplings of aliphatic alkynes are crucial for the production of naturally occurring 1,3-diynes.Herein we report the novel approach for effective synthesis of unsaturated coordinated N doped copper oxides(N-CuO_(x))catalyst,and uncover that N-CuO_(x) catalyst as an additive-free and cost-effective heterogeneous catalyst has highly catalytic performance for directly oxidative coupling of aliphatic alkynes.The key to achieve efficient oxidative coupling of aliphatic alkynes is the synergistic effect of N species and uncoordinated O/Cu species caused by N dopants,which undergoes the Langmuir–Hinshelwood reaction mechanism.The N-CuO_(x) catalyst displays~89.1%yield for hexadeca-7,9-diyne under mild conditions and stable reusability(5 cycles),showing significant advances compared with the traditionally copper oxides.These findings highlight the heteroatom dopants that provide a new methodology for designing efficient copper catalysts in synthesis of naturally occurring 1,3-diynes.
基金supported by the Anhui Provincial Natural Science Foundation of China(2008085M47)“Key Program for International S&T Cooperation Projects of China”(No.2017YFE0124300)Anhui Provincial Science Fund for Excellent Young Scholars(gxyqZD2018034).
文摘Rational design of earth-abundant transition metal oxides catalysts is highly desirable for developing sustainable chemical processes.Herein,we demonstrate a prospective interstitial nitrogen engineering for fabricating oxygen vacancies(OVs)-rich nitrogen-doped-Mn_(x)Co_(3-x)O_(4)(N-Mn_(x)Co_(3-x)O_(4))oxide catalyst,in which the ratio of OVs concentration of N-Mn_(x)Co_(3-x)O_(4)to Mn species is as high as 1:1,according to the characterizations of X-ray absorption(XAS)and X-ray photoelectron(XPS)spectroscopies.The promising strategy of interstitial nitrogen engineering through lattice distortion caused by the Jahn-Teller effect can significantly increase the amount of interstitial nitrogen.The resulting catalyst enables an additive-free aerobic dehydrogenation coupling of aromatic amine to afford azo compounds with>99%yield and>99%selectivity at 60☆.We observed the superb catalytic activity is promoted by the enhanced oxygen mobility in OVs,which were created by the interstitial nitrogen in the catalyst matrix.The presence of interstitial nitrogen in transition metal oxides in this study shows how the manipulation of catalyst matrix can increase the OV sites to promote aerobic oxidation reaction.
基金National Science and Technology Major Project of China(No. 2018ZX10101002-002)。
文摘Background The current prevention and control strategy forAedes albopictus heavily relies on comprehensive management, such as environmental management and chemical control. However, the wide application of pyrethroids has facilitated the development of insecticide resistance, primarily via mutations in the voltage-gated sodium channel (VGSC) gene. This study aims to develop a novel strategy for detecting mutations in the VGSC gene inAe. albopictus using multiplex PCR-mass spectrometry (MPCR-MS) minisequencing technology.Methods We established a new strategy for detecting mutations in the VGSC gene inAe. albopictus using MPCR-MS minisequencing technology. MPCR amplification and mass probe extension (MPE) were first used, followed by single nucleotide polymorphism (SNP) typing mass spectrometry, which allows the simultaneous detection of multiple mutation sites of the VGSC gene in 96 samples ofAe. albopictus. A total of 70 wild-collectedAe. albopictus were used to evaluate the performance of the method by comparing it with other methods.Results Three target sites (1016, 1532, 1534) in the VGSC gene can be detected simultaneously by double PCR amplification combined with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry, achieving a detection limit of 20 fg/μl. We applied this method to 70 wild-collectedAe. albopictus, and the obtained genotypes were consistent with the routine sequencing results, suggesting the accuracy of our method.Conclusions MPCR-MS minisequencing technology provides a sensitive and high-throughput approach toAe. albopictus VGSC gene mutation screening. Compared with conventional sequencing, this method is economical and time-saving. It is of great value for insecticide resistance surveillance in areas with a high risk of vector-borne disease.
基金the National Natural Science Foundation of China(grant nos.21936007 and 21906165)the CAS Interdisciplinary Innovation Team(grant no.JCTD-2019-03)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(grant no.2016038).
文摘The proportion of steel produced using electric arc furnaces(EAFs)is increasing.In this study,polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)concentrations and patterns in stack gas samples from three typical EAFs in steelmaking plants were determined to allow the contributions of EAFs in steelmaking plants to PCDD/Fs emissions in China to be assessed.Samples collection was accomplished by adopting the automatic isokinetic sampling technique,then the PCDD/Fs congeners concentrations were analyzed qualitatively and quantitatively by isotope dilution high-resolution gas chromatography high-resolution mass spectrometry(HRGC-HRMS).The mean PCDD/Fs mass concentrations in stack gases emitted during the scrap preheating phase of plants E1,E2,and E3 were 0.48,385.55,and 0.34 ng Nm^-3,respectively,and the total toxic equivalent(WHO2005-TEQ)concentrations were 0.05,33.16,and 0.03 ng Nm^-3,respectively.The PCDD/Fs mass concentration in stack gases emitted during the melting phase at plant E3 was 0.12 ng Nm^-3(0.02 ng WHO2005-TEQ Nm^-3).The operational temperature of the bag filter of the preheating in the E2 EAF was as high as 230℃,which is conducive to the generation of PCDD/Fs,whether the temperature in the bag filter of E1(150℃)and E3(120℃)are not.Moreover,the bag filter temperature is suggested to be best controlled to below 150℃.The emission factors(EF)for PCDD/Fs released into the air during the scrap preheating phase for plants E1,E2,and E3 were 0.13,52,and 0.10 mg WHO2005-TEQ t1,respectively,and the EF for the smelting phase from plant E3 was 0.14 mg WHO2005-TEQ t1.The emission factor in E2 is 5 times higher than the highest current UNEP toolkit factor for EAFs(10 mg TEQ/tonne steel).Therefore,an update for the UNEP toolkit emission factor for a few case plants is suggested.Several congeners,including 2,3,7,8-TeCDF,1,2,3,4,6,7,8-HpCDF,and 1,2,3,4,6,7,8-HpCDD,were dominant during the preheating phase,while 2,3,7,8-TeCDF,1,2,3,7,8-PeCDF,and 2,3,4,7,8-PeCDF were dominant during the smelting phase.The monitoring data from the case plants helps to better understand the PCDD/Fs emissions of EAFs using preheating process stages.However,a more complete emission inventory requires more case investigations on the PCDD/Fs emissions from representative EAFs steelmaking plants.
