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Chimeric antigen receptor-T cell therapy for lung cancer:The tumor microenvironment bottleneck and remedies to circumvent it
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作者 Qi Zhou fengfei sun Xinhui Wang 《Chinese Medical Journal Pulmonary and Critical Care Medicine》 2025年第3期145-148,共4页
Edited by:Peifang Wei Lung cancer is the most lethal solid malignancy in adults worldwide.1 Chimeric antigen receptor(CAR)-T cell therapy has emerged as a promising approach for anti-tumor immunotherapy.2 As of Novemb... Edited by:Peifang Wei Lung cancer is the most lethal solid malignancy in adults worldwide.1 Chimeric antigen receptor(CAR)-T cell therapy has emerged as a promising approach for anti-tumor immunotherapy.2 As of November 2024,the United States Food and Drug Administration has granted market authorization to seven CAR-T products for treating relapsed or refractory hematological neoplasms;however,extending this platform to lung cancer faces formidable obstacles. 展开更多
关键词 lung cancer solid malignancy treating relapsed refractory hematological neoplasmshoweverextending chimeric antigen receptor t cell therapy hematological neoplasms tumor microenvironment market authorization
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