Aims:To explore the point-wise correlations between 10-2 visual field(VF)metrics and macular vessel density,as measured by optical coherence tomography angiography(OCTA),in patients with early open-angle glaucoma(OAG)...Aims:To explore the point-wise correlations between 10-2 visual field(VF)metrics and macular vessel density,as measured by optical coherence tomography angiography(OCTA),in patients with early open-angle glaucoma(OAG)and healthy controls.Methods:This is a cross-sectional study that retrospectively analyzed data from 54 participants(18 early OAG patients and 36 healthy controls)from the Zhongshan Ophthalmic Center.All participants underwent comprehensive ophthalmic examinations,10-2 VF,and macular OCTA imaging.The correlation between capillary density(CD)in macular subregions and light sensitivity(LS)at corresponding VF test points was analyzed using Pearson's correlation coefficients.Results:The analysis revealed a significant reduction in CD within the inferior macular regions of glaucomatous eyes.Notably,there were strong point-wise correlations between CD and 10-2 VF,particularly in the inferior region of outer ring(peak r=0.534,P<0.001).Conclusion:The point-wise correlation between 10-2 VF and macular CD demonstrates the potential for using CD to predict central VF damage in glaucoma,emphasizing the importance of macular microcirculation in early disease screening.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2502800)the National Natural Science Foundation of China(82070955)the Science and Technology Program of Guangzhou,China(2024A03J0250).
文摘Aims:To explore the point-wise correlations between 10-2 visual field(VF)metrics and macular vessel density,as measured by optical coherence tomography angiography(OCTA),in patients with early open-angle glaucoma(OAG)and healthy controls.Methods:This is a cross-sectional study that retrospectively analyzed data from 54 participants(18 early OAG patients and 36 healthy controls)from the Zhongshan Ophthalmic Center.All participants underwent comprehensive ophthalmic examinations,10-2 VF,and macular OCTA imaging.The correlation between capillary density(CD)in macular subregions and light sensitivity(LS)at corresponding VF test points was analyzed using Pearson's correlation coefficients.Results:The analysis revealed a significant reduction in CD within the inferior macular regions of glaucomatous eyes.Notably,there were strong point-wise correlations between CD and 10-2 VF,particularly in the inferior region of outer ring(peak r=0.534,P<0.001).Conclusion:The point-wise correlation between 10-2 VF and macular CD demonstrates the potential for using CD to predict central VF damage in glaucoma,emphasizing the importance of macular microcirculation in early disease screening.
