AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induc...AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induced by diethyln-itrosamine in 14 rats of test group. Rats in control group were bred with pure water. From the 1st to 12th wk after the test group was intervened, both groups were studied every week with CTP. CTP parameters of liver parenchyma in different periods and pathologic changes in two groups were compared and analyzed. RESULTS: The process of hepatic diffuse lesions in test groups was classified into three stages or periods according to the pathologic alterations, namely hepatitis, hepatic fibrosis, and cirrhosis. During this period, hepatic artery flow (HAF) of control group declined slightly, mean transit time (MTT), blood flow (BF) and volume (BV) increased, but there were no significant differences between different periods. In test group, HAF tended to increase gradually, MTT prolonged obviously, BV and BF decreased at the same time. The results of statistical analysis revealed that the difference in the HAF ratio of test group to control group was significant. The ratio of BV and BF in test group to control group in stage of hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis was significantly different, but there was no significant difference between hepatitis and hepatic fibrosis. The main pathological changes in stage of hepatitis were swelling of hepatic cells, while sinusoid capillarization and deposition of collagen aggravated gradually in the extravascular Disse's spaces in stage of fibrosis and early stage of cirrhosis. CONCLUSION: The technique could reflect some early changes of hepatic blood perfusion in rat with liver diffuse disease and is valuable for their early diagnosis.展开更多
Objective To explore the correlation between serum, heavy metal and semen quality in normal Chinese young menMethods This study was designed as a multi-center cross-sectional investigation. The subjects consisted of 5...Objective To explore the correlation between serum, heavy metal and semen quality in normal Chinese young menMethods This study was designed as a multi-center cross-sectional investigation. The subjects consisted of 562 male vomunteers who had undergone premarital physical examination in maternal and children health centers in 7 provinces in China. Results Results from Spearman rank correlation analysis (partial variable: region) show that serum lead and cadmium are negatively related to percentage of morphological normal sperm, but canonical correlation between semen quality and serum heavy metal are not significant. Canonical correlation analysis among the subjects from Guizhou shows cadmium is harmful to sperm morphology. In Henan, furthermore, results show lead and cadmium could negatively affect sperm viability and morphology. Conclusion Among all study subjects, canonical correlation between semen quality and serum heavy metal were not significant; however, results in some region showed serum cadmium and lead might be harmful to sperm quality.展开更多
The reported new U-Pb age by sensitive high-resolution ion microprobe (SHRIMP Ⅱ) on zircon was obtained from a tuff sample at the basal Doushantuo Formation in the Jiuqunao section, which situated at the western limb...The reported new U-Pb age by sensitive high-resolution ion microprobe (SHRIMP Ⅱ) on zircon was obtained from a tuff sample at the basal Doushantuo Formation in the Jiuqunao section, which situated at the western limb of the Huangling anticline in the Yangtze Gorges in Zigui, Hubei, South China. Eighteen spots of zircons were analyzed and they form two clusters: one includes three spots, with an inherited age of 784+ 15 Ma (MSWD=0.05); the other consists of 15 spots and gives a weighted mean ^206pb/^238U age of 628.3±5.8 Ma (MSWD=0.86). It is the first SHRIMP U-Pb zircon age obtained nearly the base of the Doushantuo Formation of Ediacaran and represents a maximum age of the Doushantuo Formation It also forms an age constraint on the upper limit age of the Nantuo (Marinoantype) glaciation.展开更多
The extracts from 7 species of bamboo were tested for larvicidal activity against Culex pipiens pallens. At the tested concentration, the extracts of selected bamboo had different degree of toxic effects on the fourth...The extracts from 7 species of bamboo were tested for larvicidal activity against Culex pipiens pallens. At the tested concentration, the extracts of selected bamboo had different degree of toxic effects on the fourth instar larvae of Culex pipiens pallens. Among them,the extracts of Pleioblastus juxianensis, Brachystachyum albostriatum, Phyllostachys platyglossa and Pleioblastus amarus were found to be effective with LC50values at 24h of 30.65mg/L,53.94mg/L, 41.21 mg/L and 54.49 mg/L respectively, against Culex pipiens pallens larvae. The extract of Pleioblastus juxianensis by Soxhlet method showed stronger activity than the extract obtained by interval-shaking, the LC50 of which were 30.65 mg/L and 48.34 mg/L, respectively.The diethyl ether extract of Pleioblastus juxianensis exhibited better larvicidal activity than the methanol extract and the petroleum ether extract. The results would help to provide the basis for the study of environment acceptable pesticide for mosquito control, and also help to comprehensively utilize the source of bamboo.展开更多
基金Supported by a Grant from the Ministry of Public Health of China, No. 20011420
文摘AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induced by diethyln-itrosamine in 14 rats of test group. Rats in control group were bred with pure water. From the 1st to 12th wk after the test group was intervened, both groups were studied every week with CTP. CTP parameters of liver parenchyma in different periods and pathologic changes in two groups were compared and analyzed. RESULTS: The process of hepatic diffuse lesions in test groups was classified into three stages or periods according to the pathologic alterations, namely hepatitis, hepatic fibrosis, and cirrhosis. During this period, hepatic artery flow (HAF) of control group declined slightly, mean transit time (MTT), blood flow (BF) and volume (BV) increased, but there were no significant differences between different periods. In test group, HAF tended to increase gradually, MTT prolonged obviously, BV and BF decreased at the same time. The results of statistical analysis revealed that the difference in the HAF ratio of test group to control group was significant. The ratio of BV and BF in test group to control group in stage of hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis was significantly different, but there was no significant difference between hepatitis and hepatic fibrosis. The main pathological changes in stage of hepatitis were swelling of hepatic cells, while sinusoid capillarization and deposition of collagen aggravated gradually in the extravascular Disse's spaces in stage of fibrosis and early stage of cirrhosis. CONCLUSION: The technique could reflect some early changes of hepatic blood perfusion in rat with liver diffuse disease and is valuable for their early diagnosis.
文摘Objective To explore the correlation between serum, heavy metal and semen quality in normal Chinese young menMethods This study was designed as a multi-center cross-sectional investigation. The subjects consisted of 562 male vomunteers who had undergone premarital physical examination in maternal and children health centers in 7 provinces in China. Results Results from Spearman rank correlation analysis (partial variable: region) show that serum lead and cadmium are negatively related to percentage of morphological normal sperm, but canonical correlation between semen quality and serum heavy metal are not significant. Canonical correlation analysis among the subjects from Guizhou shows cadmium is harmful to sperm morphology. In Henan, furthermore, results show lead and cadmium could negatively affect sperm viability and morphology. Conclusion Among all study subjects, canonical correlation between semen quality and serum heavy metal were not significant; however, results in some region showed serum cadmium and lead might be harmful to sperm quality.
文摘The reported new U-Pb age by sensitive high-resolution ion microprobe (SHRIMP Ⅱ) on zircon was obtained from a tuff sample at the basal Doushantuo Formation in the Jiuqunao section, which situated at the western limb of the Huangling anticline in the Yangtze Gorges in Zigui, Hubei, South China. Eighteen spots of zircons were analyzed and they form two clusters: one includes three spots, with an inherited age of 784+ 15 Ma (MSWD=0.05); the other consists of 15 spots and gives a weighted mean ^206pb/^238U age of 628.3±5.8 Ma (MSWD=0.86). It is the first SHRIMP U-Pb zircon age obtained nearly the base of the Doushantuo Formation of Ediacaran and represents a maximum age of the Doushantuo Formation It also forms an age constraint on the upper limit age of the Nantuo (Marinoantype) glaciation.
文摘The extracts from 7 species of bamboo were tested for larvicidal activity against Culex pipiens pallens. At the tested concentration, the extracts of selected bamboo had different degree of toxic effects on the fourth instar larvae of Culex pipiens pallens. Among them,the extracts of Pleioblastus juxianensis, Brachystachyum albostriatum, Phyllostachys platyglossa and Pleioblastus amarus were found to be effective with LC50values at 24h of 30.65mg/L,53.94mg/L, 41.21 mg/L and 54.49 mg/L respectively, against Culex pipiens pallens larvae. The extract of Pleioblastus juxianensis by Soxhlet method showed stronger activity than the extract obtained by interval-shaking, the LC50 of which were 30.65 mg/L and 48.34 mg/L, respectively.The diethyl ether extract of Pleioblastus juxianensis exhibited better larvicidal activity than the methanol extract and the petroleum ether extract. The results would help to provide the basis for the study of environment acceptable pesticide for mosquito control, and also help to comprehensively utilize the source of bamboo.
