Lumbar interbody fusion is essential for treating degenerative lumbar diseases.The disadvantages of open surgery have led to the evolution of minimally invasive spine surgery,including endoscopic techniques such as un...Lumbar interbody fusion is essential for treating degenerative lumbar diseases.The disadvantages of open surgery have led to the evolution of minimally invasive spine surgery,including endoscopic techniques such as unilateral biportal endoscopy(UBE).Leveraging arthroscopic principles,UBE offers superior visualization and flexibility and expands from decompression to fusion(UBE fusion).However,achieving robust UBE fusion presents challenges,such as suboptimal arthrodesis rates and implant-related complications,requiring more than surgical skill alone.Optimizing UBE fusion critically depends on the effective integration of advanced biomaterials with the surgical technique.This minireview assessed recent advances in UBE,focusing on the development of novel biomaterials,such as functionalized porous,expandable,or double-cage designs,to improve bone regeneration outcomes.These advancements address challenges,like washout of bone graft material and biologics,and utilize growth factors,such as recombinant human bone morphogenetic proteins,while exploring pathway modulation to improve outcomes.We also evaluated clinical optimization strategies involving technical refinements,fluid and hemostasis control,key complication mitigation especially concerning dural tears and hematomas,and technologies such as navigation and robotics.While UBE shows promise particularly for early recovery,its long-term success hinges on these biotechnological advancements.High-quality evidence,especially from randomized controlled trials and longterm studies,is needed to validate integrated strategies and define the optimal role of UBE fusion.展开更多
This paper focuses on the optimization of the outlet temperature field of a hydrogen micromixing diffusion combustor for a micro-turbojet engine with a thrust of 20kgf.The joint simulation optimization platform was es...This paper focuses on the optimization of the outlet temperature field of a hydrogen micromixing diffusion combustor for a micro-turbojet engine with a thrust of 20kgf.The joint simulation optimization platform was established combiningWorkbench and UG and the multi-parameter driven optimization design process was developed.The surrogate models and genetic algorithms were employed to investigate the influences of key parameters on the hotspot temperature at the combustor exit.It was found that smaller diameters of the dilution holes and positions further from the exit lead to lower hotspot temperatures.Additionally,an optimal solution for achieving a uniform temperature distribution at the combustor outlet was obtained.This solution involves a single row of dilution holes on both the inner and outer walls of the flame tube,arranged in an alternating axial and angular pattern.Through aerothermal process analysis,it was determined that the outlet temperature distribution coefficient(OTDF)of the combustion chamber is below 0.2.Meanwhile,the axial dimension of the flame is short,approximately one-third of the flame tube length.The conclusions derived from this study provide important guidance for the design of hydrogen micromix diffusion combustor.展开更多
Non-traumatic osteonecrosis of the femoral head(NONFH)is one of the most common orthopedic diseases,influenced by multiple signaling pathways and inflammatory factors.The PI3K/AKT signaling pathway is closely related ...Non-traumatic osteonecrosis of the femoral head(NONFH)is one of the most common orthopedic diseases,influenced by multiple signaling pathways and inflammatory factors.The PI3K/AKT signaling pathway is closely related to various biological processes such as apoptosis,autophagy,and metabolism in cells.Increasing evidence suggests that it plays an important role in the development of femoral head necrosis.This paper aims to explore the mechanism of the PI3K/AKT signaling pathway in the pathogenesis of NONFH by analyzing its regulation of lipid metabolism,cell apoptosis and autophagy,and intravascular coagulation.This study provides new insights for the research of NONFH.展开更多
基金Supported by Joint Traditional Chinese Medicine Science and Technology Projects of National Demonstration Zones for Comprehensive Traditional Chinese Medicine,No.GZY-KJS-SD-2023-031.
文摘Lumbar interbody fusion is essential for treating degenerative lumbar diseases.The disadvantages of open surgery have led to the evolution of minimally invasive spine surgery,including endoscopic techniques such as unilateral biportal endoscopy(UBE).Leveraging arthroscopic principles,UBE offers superior visualization and flexibility and expands from decompression to fusion(UBE fusion).However,achieving robust UBE fusion presents challenges,such as suboptimal arthrodesis rates and implant-related complications,requiring more than surgical skill alone.Optimizing UBE fusion critically depends on the effective integration of advanced biomaterials with the surgical technique.This minireview assessed recent advances in UBE,focusing on the development of novel biomaterials,such as functionalized porous,expandable,or double-cage designs,to improve bone regeneration outcomes.These advancements address challenges,like washout of bone graft material and biologics,and utilize growth factors,such as recombinant human bone morphogenetic proteins,while exploring pathway modulation to improve outcomes.We also evaluated clinical optimization strategies involving technical refinements,fluid and hemostasis control,key complication mitigation especially concerning dural tears and hematomas,and technologies such as navigation and robotics.While UBE shows promise particularly for early recovery,its long-term success hinges on these biotechnological advancements.High-quality evidence,especially from randomized controlled trials and longterm studies,is needed to validate integrated strategies and define the optimal role of UBE fusion.
基金Advanced Jet Propulsion Innovation Center,AEAC(Project ID.HKCX2021-01-021)The Fundamental Research Funds for the Central Universities(Project ID.501XTCX2023146001)Science Center for Gas Turbine Project(P2022-A-II-006-001)。
文摘This paper focuses on the optimization of the outlet temperature field of a hydrogen micromixing diffusion combustor for a micro-turbojet engine with a thrust of 20kgf.The joint simulation optimization platform was established combiningWorkbench and UG and the multi-parameter driven optimization design process was developed.The surrogate models and genetic algorithms were employed to investigate the influences of key parameters on the hotspot temperature at the combustor exit.It was found that smaller diameters of the dilution holes and positions further from the exit lead to lower hotspot temperatures.Additionally,an optimal solution for achieving a uniform temperature distribution at the combustor outlet was obtained.This solution involves a single row of dilution holes on both the inner and outer walls of the flame tube,arranged in an alternating axial and angular pattern.Through aerothermal process analysis,it was determined that the outlet temperature distribution coefficient(OTDF)of the combustion chamber is below 0.2.Meanwhile,the axial dimension of the flame is short,approximately one-third of the flame tube length.The conclusions derived from this study provide important guidance for the design of hydrogen micromix diffusion combustor.
文摘Non-traumatic osteonecrosis of the femoral head(NONFH)is one of the most common orthopedic diseases,influenced by multiple signaling pathways and inflammatory factors.The PI3K/AKT signaling pathway is closely related to various biological processes such as apoptosis,autophagy,and metabolism in cells.Increasing evidence suggests that it plays an important role in the development of femoral head necrosis.This paper aims to explore the mechanism of the PI3K/AKT signaling pathway in the pathogenesis of NONFH by analyzing its regulation of lipid metabolism,cell apoptosis and autophagy,and intravascular coagulation.This study provides new insights for the research of NONFH.
