Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low b...Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low bio-availability,and potential toxicity.Nanocarriers,such as liposomes,polymeric nanoparticles,inorganic nanoparticles,and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations.This article summarizes the recent progress in nanocarrier-based delivery systems.Nanotechnology can broaden the scope of applications of traditional Chinese medicine.The concept of nano-traditional Chinese medicine(nano-TCM)is introduced,and the progress of nanomedicine,the advantages,and the development direction of nano-TCM are reviewed,providing new ideas for the development of nano-TCM.展开更多
The layout effects and optimization of runoff storage and filtration facilities are crucial to the efficiency and management of the cost of runoff control, but related research is still lacking. In this study, scenari...The layout effects and optimization of runoff storage and filtration facilities are crucial to the efficiency and management of the cost of runoff control, but related research is still lacking. In this study, scenarios with different layouts were simulated using the storm water management model(SWMM), to investigate the layout effects on control efficiency with different precipitations. In a rainfall event with 50 mm of precipitation in two hours, 1820 scenarios with different layouts of four facilities constructed in 16 sub-catchments were simulated, the reduction rates of internal flow presented a standard deviation of 10.9%, and the difference between the maximum and minimum reduction rates reached59.7%. Based on weighting analysis, an integrated ranking index was obtained and used to determine the optimal layout scenarios considering different rainfall events. In the optimal scenario(storage and filtration facilities constructed in sub-catchments 14, 12, 7, and 2), the reduction rates of the total outflow reached 31.4%, 26.4%, and 14.7%, respectively, with 30, 50, and 80 mm of precipitation. The reduction rate of the internal outflow reached 95% with 50 mm of precipitation and approximately 56% with 80 mm of precipitation.展开更多
Acute acalculous cholecystitis(AAC)is a rare complication of gastric surgery.The most commonly accepted concepts regarding its pathogenesis are bile stasis,sepsis and ischemia,but it has not been well described how to...Acute acalculous cholecystitis(AAC)is a rare complication of gastric surgery.The most commonly accepted concepts regarding its pathogenesis are bile stasis,sepsis and ischemia,but it has not been well described how to identify and manage this disease in the early stage.We report three cases of AAC in elderly patients immediately after gastric surgery,which were treated with three different strategies.One patient died 42 d after emergency cholecystectomy,and the other two finally recovered through timely cholecystostomy and percutaneous transhepatic gallbladder drainage,respectively.These cases informed us of the value of early diagnosis and proper treatment for perioperative AAC after gastric surgery.We further reviewed reported cases of AAC immediately after gastric operation,which may expand our knowledge of this disease.展开更多
Aryl sulfonyl radical triggered cascade cyclization of phenyl-linked 1,6-enynes for the synthesis of biologically important indenes containing alkenyl C—X bonds and 10a,11-dihydro-10H-benzo[b]fluorines is presented.I...Aryl sulfonyl radical triggered cascade cyclization of phenyl-linked 1,6-enynes for the synthesis of biologically important indenes containing alkenyl C—X bonds and 10a,11-dihydro-10H-benzo[b]fluorines is presented.In these radical cascade processes,three new chemical bonds,including C—S,C—C,and C—X bonds,and three C—C bonds are formed in one step.The method is attractive and valuable due to its metal-free,mild reaction conditions,broad substrate scope and good functional group tolerance.展开更多
To the Editor:Gastric cancer is one of the most common cancers in China.It is mainly found in the middle/lower part of the stomach,[1]where it commonly metastasizes from the infrapyloric lymph node(No.6).Previous stud...To the Editor:Gastric cancer is one of the most common cancers in China.It is mainly found in the middle/lower part of the stomach,[1]where it commonly metastasizes from the infrapyloric lymph node(No.6).Previous studies reported that the risk of No.6 lymph node metastasis was different based on tumor locations.In lower gastric cancer patients,the metastatic rate of No.6 lymph node can reach up to 18.7%,and in upper gastric cancer,the rate is merely 1.9%.[2]The distance between the primary tumor and the pylorus was proved to be related to No.6 lymph node metastasis.However,most of the studies were retrospective and their lymph nodes dissection’s quality control was controversial.展开更多
基金supported by Young Talent Program of The Affiliated Hospital of Xuzhou Medical University,Advanced Program of The Affiliated Hospital of Xuzhou Medical University(PYJH2024210)Medical Research Project of Jiangsu Provincial Health Commission(H2023050)National Natural Science Foundation of China(No.32301278).
文摘Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low bio-availability,and potential toxicity.Nanocarriers,such as liposomes,polymeric nanoparticles,inorganic nanoparticles,and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations.This article summarizes the recent progress in nanocarrier-based delivery systems.Nanotechnology can broaden the scope of applications of traditional Chinese medicine.The concept of nano-traditional Chinese medicine(nano-TCM)is introduced,and the progress of nanomedicine,the advantages,and the development direction of nano-TCM are reviewed,providing new ideas for the development of nano-TCM.
基金supported by the Major Science and Technology Program for Water Pollution Control and Management of China(Grant No.2011ZX07301-002)
文摘The layout effects and optimization of runoff storage and filtration facilities are crucial to the efficiency and management of the cost of runoff control, but related research is still lacking. In this study, scenarios with different layouts were simulated using the storm water management model(SWMM), to investigate the layout effects on control efficiency with different precipitations. In a rainfall event with 50 mm of precipitation in two hours, 1820 scenarios with different layouts of four facilities constructed in 16 sub-catchments were simulated, the reduction rates of internal flow presented a standard deviation of 10.9%, and the difference between the maximum and minimum reduction rates reached59.7%. Based on weighting analysis, an integrated ranking index was obtained and used to determine the optimal layout scenarios considering different rainfall events. In the optimal scenario(storage and filtration facilities constructed in sub-catchments 14, 12, 7, and 2), the reduction rates of the total outflow reached 31.4%, 26.4%, and 14.7%, respectively, with 30, 50, and 80 mm of precipitation. The reduction rate of the internal outflow reached 95% with 50 mm of precipitation and approximately 56% with 80 mm of precipitation.
基金Supported by Zhongshan Hospital,Fudan University,Shanghai,China
文摘Acute acalculous cholecystitis(AAC)is a rare complication of gastric surgery.The most commonly accepted concepts regarding its pathogenesis are bile stasis,sepsis and ischemia,but it has not been well described how to identify and manage this disease in the early stage.We report three cases of AAC in elderly patients immediately after gastric surgery,which were treated with three different strategies.One patient died 42 d after emergency cholecystectomy,and the other two finally recovered through timely cholecystostomy and percutaneous transhepatic gallbladder drainage,respectively.These cases informed us of the value of early diagnosis and proper treatment for perioperative AAC after gastric surgery.We further reviewed reported cases of AAC immediately after gastric operation,which may expand our knowledge of this disease.
基金the National Natural Science Foundation of China(No.21861043)the Yunnan Fundamental Research Projects(No.2019FB016)Scientific and Technological Innovation Team of Optical Functional Materials of Yunnan Provincial Education Department forfinancial support.
文摘Aryl sulfonyl radical triggered cascade cyclization of phenyl-linked 1,6-enynes for the synthesis of biologically important indenes containing alkenyl C—X bonds and 10a,11-dihydro-10H-benzo[b]fluorines is presented.In these radical cascade processes,three new chemical bonds,including C—S,C—C,and C—X bonds,and three C—C bonds are formed in one step.The method is attractive and valuable due to its metal-free,mild reaction conditions,broad substrate scope and good functional group tolerance.
文摘To the Editor:Gastric cancer is one of the most common cancers in China.It is mainly found in the middle/lower part of the stomach,[1]where it commonly metastasizes from the infrapyloric lymph node(No.6).Previous studies reported that the risk of No.6 lymph node metastasis was different based on tumor locations.In lower gastric cancer patients,the metastatic rate of No.6 lymph node can reach up to 18.7%,and in upper gastric cancer,the rate is merely 1.9%.[2]The distance between the primary tumor and the pylorus was proved to be related to No.6 lymph node metastasis.However,most of the studies were retrospective and their lymph nodes dissection’s quality control was controversial.
