Pain is an unpleasant sensory and emotional experience associated with,or resembling that associated with,actual or potential tissue damage.The processing of pain involves complicated modulation at the levels of the p...Pain is an unpleasant sensory and emotional experience associated with,or resembling that associated with,actual or potential tissue damage.The processing of pain involves complicated modulation at the levels of the periphery,spinal cord,and brain.The pathogenesis of chronic pain is still not fully understood,which makes the clinical treatment challenging.Optogenetics,which combines optical and genetic technologies,can precisely intervene in the activity of specific groups of neurons and elements of the related circuits.Taking advantage of optogenetics,researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission,pain modulation,and chronic pain both in the periphery and the central nervous system.In this review,we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.展开更多
Dear Editor,Neuropathic pain(NeuP)is known as a common and notorious neurological disease,characterized by spontaneous pain and evoked abnormal pain that includes hypersensitivity to external innocuous(allodynia)and n...Dear Editor,Neuropathic pain(NeuP)is known as a common and notorious neurological disease,characterized by spontaneous pain and evoked abnormal pain that includes hypersensitivity to external innocuous(allodynia)and noxious stimulation(hyperalgesia).Allodynia is especially torturous because gentle touch may trigger pain.展开更多
基金supported by grants from the National Natural Science Foundation of China(82073819 and 81872843)Fundamental Research Funds for the Central Universities of China(2021QNA7005).
文摘Pain is an unpleasant sensory and emotional experience associated with,or resembling that associated with,actual or potential tissue damage.The processing of pain involves complicated modulation at the levels of the periphery,spinal cord,and brain.The pathogenesis of chronic pain is still not fully understood,which makes the clinical treatment challenging.Optogenetics,which combines optical and genetic technologies,can precisely intervene in the activity of specific groups of neurons and elements of the related circuits.Taking advantage of optogenetics,researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission,pain modulation,and chronic pain both in the periphery and the central nervous system.In this review,we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.
基金This work was supported by grants from National Natural Science Foundation of China(81872843,81673404,and 81821091).
文摘Dear Editor,Neuropathic pain(NeuP)is known as a common and notorious neurological disease,characterized by spontaneous pain and evoked abnormal pain that includes hypersensitivity to external innocuous(allodynia)and noxious stimulation(hyperalgesia).Allodynia is especially torturous because gentle touch may trigger pain.
