Background:Foreign bodies within the sinuses,orbit,and skull base (FBSOS) are rare;hence,diagnosis and management guidelines are lacking.Endoscopic sinus surgery (ESS) removal is preferred because of the less invasive...Background:Foreign bodies within the sinuses,orbit,and skull base (FBSOS) are rare;hence,diagnosis and management guidelines are lacking.Endoscopic sinus surgery (ESS) removal is preferred because of the less invasiveness and minimal morbidity.This study was designed to summarize clinical experience with ESS management of FBSOS.Methods:We retrospectively reviewed clinical manifestations,imaging findings,treatment,and outcomes in consecutive patients with ESS removal of FBSOS between 2004 and 2015 at a tertiary academic medical center.The Chi-square test was performed to compare the infection rate between wooden and nonwooden FBSOS.Results:There were 23 male and five female patients,with median age of 11 years.FBSOS were located within the sinuses (86%),orbit (75%),and skull base/intracranial region (46%).Wooden FBSOS had a significantly higher risk of infection (78%) compared with nonwooden FBSOS (5%,P 〈 0.05).Contrast-enhanced computed tomography (CT) plus three-dimensional reconstruction was sensitive in all cases.Twenty-seven (96%) FBSOS were removed by ESS alone,while 1 (4%) FBSOS was removed using the combined ESS and lateral cervical approach.Four of the nine intracranial penetrating FBSOS patients had intraoperative cerebrospinal fluid (CSF) leak and received endoscopic CSF leak repair.Twelve (43%) patients suffered complications (meningitis,diplopia,and vision loss).Conclusions:ESS is a minimally invasive,safe,and promising surgical approach for FBSOS removal.Contrast-enhanced CT is effective in preoperative diagnosis and intraoperative guidance.Wooden FBSOS had higher risk of infection,thus antibiotics are recommended.展开更多
Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China....Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.展开更多
基金Project supported by the Innovation Foundation of the State Key State Key Laboratory of Fluid Power and Mechatronic Systems(No.GZKF-201406),Zhejiang University,China
基金This work was supported by grants from the Natural Science Foundation of Guangdong Province, China (No. 2015A030310236) Medical Scientific Research Foundation of Guangdong Province, China (No. A2013192).
文摘Background:Foreign bodies within the sinuses,orbit,and skull base (FBSOS) are rare;hence,diagnosis and management guidelines are lacking.Endoscopic sinus surgery (ESS) removal is preferred because of the less invasiveness and minimal morbidity.This study was designed to summarize clinical experience with ESS management of FBSOS.Methods:We retrospectively reviewed clinical manifestations,imaging findings,treatment,and outcomes in consecutive patients with ESS removal of FBSOS between 2004 and 2015 at a tertiary academic medical center.The Chi-square test was performed to compare the infection rate between wooden and nonwooden FBSOS.Results:There were 23 male and five female patients,with median age of 11 years.FBSOS were located within the sinuses (86%),orbit (75%),and skull base/intracranial region (46%).Wooden FBSOS had a significantly higher risk of infection (78%) compared with nonwooden FBSOS (5%,P 〈 0.05).Contrast-enhanced computed tomography (CT) plus three-dimensional reconstruction was sensitive in all cases.Twenty-seven (96%) FBSOS were removed by ESS alone,while 1 (4%) FBSOS was removed using the combined ESS and lateral cervical approach.Four of the nine intracranial penetrating FBSOS patients had intraoperative cerebrospinal fluid (CSF) leak and received endoscopic CSF leak repair.Twelve (43%) patients suffered complications (meningitis,diplopia,and vision loss).Conclusions:ESS is a minimally invasive,safe,and promising surgical approach for FBSOS removal.Contrast-enhanced CT is effective in preoperative diagnosis and intraoperative guidance.Wooden FBSOS had higher risk of infection,thus antibiotics are recommended.
基金National High Level Hospital Clinical Research Funding,Grant/Award Number:2022-NHLHCRF-YGJE-02Natural Science Foundation of Beijing Municipality,Grant/Award Number:7212090。
文摘Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.
