Coal mine underground reservoirs help address the severe water imbalance in ecologically fragile mining regions of western China,but evaluating their storage capacity remains challenging due to the coupled effects of ...Coal mine underground reservoirs help address the severe water imbalance in ecologically fragile mining regions of western China,but evaluating their storage capacity remains challenging due to the coupled effects of gangue deformation,saturation,and goaf geometry.This study investigates the deformation and void evolution of fragmented gangue with varying lithologies,particle sizes,and water contents through an independent-developed testing system and theoretical model.A planar micro-unit model and a three-dimensional spatial structure model are proposed to quantify the storage coefficient and total reservoir capacity of underground water storage structures.These models incorporate the effects of stratified lithologies,saturation-induced softening,and spatially distributed stress conditions.The methodology is applied to the underground reservoir in Chahasu coal mine,and the results show that under increasing stress,storage coefficients decline exponentially,with pronounced differences between single-and double-lithology structures.The storage coefficient in the spatial model demonstrate greater resilience to stress concentration compared to planar models,and further analysis identifies critical thresholds in roof fracture distances and stress-recovery times affecting long-term storage performance.This research provides a comprehensive framework for evaluating underground reservoir storage potential,offering theoretical support and engineering guidance for the sustainable utilization of mine water.展开更多
Iptakalim is a new ATP-sensitive potassium （KATp） channel opener, and it inhibits the proliferation of pulmonary arterial smooth muscle cells （PASMCs） and pulmonary vascular remodeling. However, the underlying mec...Iptakalim is a new ATP-sensitive potassium （KATp） channel opener, and it inhibits the proliferation of pulmonary arterial smooth muscle cells （PASMCs） and pulmonary vascular remodeling. However, the underlying mechanism remains unclear. In the present study, we found that iptakalim significantly decreased pulmonary artery pressure, inhibited pulmonary ariery remodeling and PKC-α overexpression in chronic hypoxia in a rat pulmonary hypertension model. Iptakalim reduced hypoxia-induced expression of PKC-α, and abolished the effect of hypoxia on PASMC proliferation significantly in a dose-dependent manner in vitro. Moreover, these effects were abol- ished by glibenclamide, a selective KArp channel antagonist. These results indicate that iptakalim inhibits PASMC proliferation and pulmonary vascular remodeling induced by hypoxia through downregulating the expression of PKC-α. Iptakalim can serve as a novel promising treatment for hypoxic pulmonary hypertension.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52404153,52504157 and 52504156)the Natural Science Foundation of Jiangsu Province(No.BK20241649).
文摘Coal mine underground reservoirs help address the severe water imbalance in ecologically fragile mining regions of western China,but evaluating their storage capacity remains challenging due to the coupled effects of gangue deformation,saturation,and goaf geometry.This study investigates the deformation and void evolution of fragmented gangue with varying lithologies,particle sizes,and water contents through an independent-developed testing system and theoretical model.A planar micro-unit model and a three-dimensional spatial structure model are proposed to quantify the storage coefficient and total reservoir capacity of underground water storage structures.These models incorporate the effects of stratified lithologies,saturation-induced softening,and spatially distributed stress conditions.The methodology is applied to the underground reservoir in Chahasu coal mine,and the results show that under increasing stress,storage coefficients decline exponentially,with pronounced differences between single-and double-lithology structures.The storage coefficient in the spatial model demonstrate greater resilience to stress concentration compared to planar models,and further analysis identifies critical thresholds in roof fracture distances and stress-recovery times affecting long-term storage performance.This research provides a comprehensive framework for evaluating underground reservoir storage potential,offering theoretical support and engineering guidance for the sustainable utilization of mine water.
基金supported by the National Natural Science Foundation of China (No.30971319)the "Six Talent Peak" Project of Jiangsu Province (No.08-B)the grant from Open Project Program of the Key Disciplines of the Public Health Department of Jiangsu Province (No. XK13_200902)
文摘Iptakalim is a new ATP-sensitive potassium （KATp） channel opener, and it inhibits the proliferation of pulmonary arterial smooth muscle cells （PASMCs） and pulmonary vascular remodeling. However, the underlying mechanism remains unclear. In the present study, we found that iptakalim significantly decreased pulmonary artery pressure, inhibited pulmonary ariery remodeling and PKC-α overexpression in chronic hypoxia in a rat pulmonary hypertension model. Iptakalim reduced hypoxia-induced expression of PKC-α, and abolished the effect of hypoxia on PASMC proliferation significantly in a dose-dependent manner in vitro. Moreover, these effects were abol- ished by glibenclamide, a selective KArp channel antagonist. These results indicate that iptakalim inhibits PASMC proliferation and pulmonary vascular remodeling induced by hypoxia through downregulating the expression of PKC-α. Iptakalim can serve as a novel promising treatment for hypoxic pulmonary hypertension.
