Traditional Si-based photoconductive detectors face problems such as low response in the ultraviolet(UV)and infrared regions,high dark current,and low light absorption efficiency,which seriously limit their applicatio...Traditional Si-based photoconductive detectors face problems such as low response in the ultraviolet(UV)and infrared regions,high dark current,and low light absorption efficiency,which seriously limit their applications in the field of high-performance wide-spectrum detection.In this study,a self-powered broadband photodetector based on a Si/TiO_(2)heterojunction is proposed.The detector has a pyramidal structure.By constructing a pyramidal microstructure on the surface of silicon,the light capture and absorption efficiency is significantly improved,representing a breakthrough in response performance in the visible and near-infrared(NIR)bands.In order to further enhance the photoelectric response in the UV band,a TiO_(2)layer was coated on the surface of the silicon pyramid through a simple spin-coating method and annealing process.The introduction of TiO_(2)effectively broadened the spectral response range of the photoelectric detector and further improved the light absorption of the device.Meanwhile,due to the built-in electric field formed by the n-TiO_(2)/p-Si heterojunction,the dark current was effectively reduced,and the responsivity was improved.Experiments showed that the device exhibits high responsivity,high detectivity,and relatively low dark current in the range of 365-1305 nm.Under light at 780 nm,the device’s on-off ratio reached 2.7×10^(3);its specific detectivity,D^(*),was 3.9×10^(11)Jones;and its responsivity reached 0.174 A/W.In addition,this detector does not require the assistance of expensive equipment.Its preparation process is simple and inexpensive,and there is no need for an external power supply,which gives it broad application potential in wearable devices,environmental monitoring,communications,biosensing,and other fields.This study provides a brand-new strategy for the design of new wide-spectrum detectors.展开更多
AIM: To study the therapeutic effect of rapamycin liposome eyedrops on fungal keratitis(FK) and its effect on the expression of monocyte chemotactic protein-1(MCP-1).METHODS: This study adopted the thin film dispersio...AIM: To study the therapeutic effect of rapamycin liposome eyedrops on fungal keratitis(FK) and its effect on the expression of monocyte chemotactic protein-1(MCP-1).METHODS: This study adopted the thin film dispersion method to prepare rapamycin liposomes eyedrops, as well as used the orthogonal design to analyze and study main influencing factors that affected the quality of liposomes. Totally 96 healthy Wistar rats were randomly divided into four groups: normal control group(A), FK blank control group(B), FK blank liposomes control group(C), and 30 FK rapamycin liposome treatment group(D). Groups B, C, and D were first prepared as FK animal models. The corneal response was recorded in details on day 1, 3, 5, 7, and 14 after modeling. Six rats were obtained and immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction(RT-PCR) were used to detect the expression of MCP-1 protein and mRNA, respectively.RESULTS: The severity of corneal lesions in the rapamycin treatment group was reduced, and the clinical score of the slit lamp examination was lower than that of Groups B and C(P<0.01). The expression of MCP-1 in rapamycin treatment group was significantly inhibited, comparing to that of groups B and C(P<0.01).CONCLUSION: Liposome is a good drug carrier for rapamycin. Rapamycin has a good therapeutic effect on FK. It can reduce FK fungal burden and significantly inhibit the expression of MCP-1 protein and mRNA.展开更多
Gray leaf spot(GLS)caused by Cercospora zeae-maydis and C.zeina is an extremely devastating leaf disease that limits maize production annually.The use of GLS-resistant maize hybrids is the most cost-effective approach...Gray leaf spot(GLS)caused by Cercospora zeae-maydis and C.zeina is an extremely devastating leaf disease that limits maize production annually.The use of GLS-resistant maize hybrids is the most cost-effective approach for reducing losses.Resistance to GLS is quantitatively inherited in maize(Zea mays L.)and further sources of resistance remain to be analyzed.Here,we detected qRgls1.06,a major quantitative trait locus for GLS resistance in bin 1.06 that explained approximately 55%of the phenotype variance.Fine mapping over 2 consecutive years localized qRgls1.06 to a 2.38-Mb region.Homozygous qRgls1.06^(WGR/WGR) plants in DZ01 background displayed higher GLS resistance and 100-grain weight than DZ01 plants.The GLS responses of several susceptible elite inbred lines were improved by the introduction of qRgls1.06 by marker-assisted backcrossing.Our findings extend the understanding of the genetic basis of resistance to GLS and provide a set of resistant germplasm for genetic improvement of resistance to GLS in maize.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.51902255 and 51803168)the Natural Science Foundation of Shaanxi Province(Grant No.2023-JC-YB-015)+1 种基金the Shaanxi Province Key Research and Development Projects(Grant No.2022GY-356)the Shaanxi Universities’Youth Innovation Team(Grant No.23JP174).
文摘Traditional Si-based photoconductive detectors face problems such as low response in the ultraviolet(UV)and infrared regions,high dark current,and low light absorption efficiency,which seriously limit their applications in the field of high-performance wide-spectrum detection.In this study,a self-powered broadband photodetector based on a Si/TiO_(2)heterojunction is proposed.The detector has a pyramidal structure.By constructing a pyramidal microstructure on the surface of silicon,the light capture and absorption efficiency is significantly improved,representing a breakthrough in response performance in the visible and near-infrared(NIR)bands.In order to further enhance the photoelectric response in the UV band,a TiO_(2)layer was coated on the surface of the silicon pyramid through a simple spin-coating method and annealing process.The introduction of TiO_(2)effectively broadened the spectral response range of the photoelectric detector and further improved the light absorption of the device.Meanwhile,due to the built-in electric field formed by the n-TiO_(2)/p-Si heterojunction,the dark current was effectively reduced,and the responsivity was improved.Experiments showed that the device exhibits high responsivity,high detectivity,and relatively low dark current in the range of 365-1305 nm.Under light at 780 nm,the device’s on-off ratio reached 2.7×10^(3);its specific detectivity,D^(*),was 3.9×10^(11)Jones;and its responsivity reached 0.174 A/W.In addition,this detector does not require the assistance of expensive equipment.Its preparation process is simple and inexpensive,and there is no need for an external power supply,which gives it broad application potential in wearable devices,environmental monitoring,communications,biosensing,and other fields.This study provides a brand-new strategy for the design of new wide-spectrum detectors.
文摘AIM: To study the therapeutic effect of rapamycin liposome eyedrops on fungal keratitis(FK) and its effect on the expression of monocyte chemotactic protein-1(MCP-1).METHODS: This study adopted the thin film dispersion method to prepare rapamycin liposomes eyedrops, as well as used the orthogonal design to analyze and study main influencing factors that affected the quality of liposomes. Totally 96 healthy Wistar rats were randomly divided into four groups: normal control group(A), FK blank control group(B), FK blank liposomes control group(C), and 30 FK rapamycin liposome treatment group(D). Groups B, C, and D were first prepared as FK animal models. The corneal response was recorded in details on day 1, 3, 5, 7, and 14 after modeling. Six rats were obtained and immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction(RT-PCR) were used to detect the expression of MCP-1 protein and mRNA, respectively.RESULTS: The severity of corneal lesions in the rapamycin treatment group was reduced, and the clinical score of the slit lamp examination was lower than that of Groups B and C(P<0.01). The expression of MCP-1 in rapamycin treatment group was significantly inhibited, comparing to that of groups B and C(P<0.01).CONCLUSION: Liposome is a good drug carrier for rapamycin. Rapamycin has a good therapeutic effect on FK. It can reduce FK fungal burden and significantly inhibit the expression of MCP-1 protein and mRNA.
基金This work was supported by the National Key Laboratory of Crop Genetic Improvement Self-Research Program(ZW18B0101)the China Scholarship Council(201908420122)+1 种基金the Teachers’Scientific Ability Cultivation Foundation of Hubei University of Arts and Science(PYSB20201001)the Xiangyang Youth Science and Technology Talent Development Plan.
文摘Gray leaf spot(GLS)caused by Cercospora zeae-maydis and C.zeina is an extremely devastating leaf disease that limits maize production annually.The use of GLS-resistant maize hybrids is the most cost-effective approach for reducing losses.Resistance to GLS is quantitatively inherited in maize(Zea mays L.)and further sources of resistance remain to be analyzed.Here,we detected qRgls1.06,a major quantitative trait locus for GLS resistance in bin 1.06 that explained approximately 55%of the phenotype variance.Fine mapping over 2 consecutive years localized qRgls1.06 to a 2.38-Mb region.Homozygous qRgls1.06^(WGR/WGR) plants in DZ01 background displayed higher GLS resistance and 100-grain weight than DZ01 plants.The GLS responses of several susceptible elite inbred lines were improved by the introduction of qRgls1.06 by marker-assisted backcrossing.Our findings extend the understanding of the genetic basis of resistance to GLS and provide a set of resistant germplasm for genetic improvement of resistance to GLS in maize.
