BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis th...BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.展开更多
Background:Q uantifying the rich home-c age activities of tree shrews provides a reliable basis for understanding their daily routines and building disease models.However,due to the lack of effective behavioral method...Background:Q uantifying the rich home-c age activities of tree shrews provides a reliable basis for understanding their daily routines and building disease models.However,due to the lack of effective behavioral methods,most efforts on tree shrew behavior are limited to simple measures,resulting in the loss of much behavioral information.Methods:T o address this issue,we present a deep learning(DL)approach to achieve markerless pose estimation and recognize multiple spontaneous behaviors of tree shrews,including drinking,eating,resting,and staying in the dark house,etc.Results:T his high-t hroughput approach can monitor the home-cage activities of 16 tree shrews simultaneously over an extended period.Additionally,we demonstrated an innovative system with reliable apparatus,paradigms,and analysis methods for investigating food grasping behavior.The median duration for each bout of grasping was 0.20 s.Conclusion:T his study provides an efficient tool for quantifying and understand tree shrews'natural behaviors.展开更多
Supercapacitors,also known as ultracapacitors or electrochemical capacitors,possess intriguing merits of high power density(10-100 times higher than that of batteries),long life expectancy(millions of cycles),wide ope...Supercapacitors,also known as ultracapacitors or electrochemical capacitors,possess intriguing merits of high power density(10-100 times higher than that of batteries),long life expectancy(millions of cycles),wide operation temperature range (-40℃ to 70℃),environmental friendliness.展开更多
The Li-ion capacitors(LICs)develop rapidly due to their double-high features of high-energy density and high-power density.However,the relative low capacity of cathode and sluggish kinetics of anode seriously impede t...The Li-ion capacitors(LICs)develop rapidly due to their double-high features of high-energy density and high-power density.However,the relative low capacity of cathode and sluggish kinetics of anode seriously impede the development of LICs.Herein,the precisely pore-engineered and heteroatomtailored defective hierarchical porous carbons(DHPCs)as large-capacity cathode and high-rate anode to construct high-performance dual-carbon LICs have been developed.The DHPCs are prepared based on triple-activation mechanisms by direct pyrolysis of sustainable lignin with urea to generate the interconnected hierarchical porous structure and plentiful heteroatominduced defects.Benefiting from these advanced merits,DHPCs show the well-matched high capacity and fast kinetics of both cathode and anode,exhibiting large capacities,superior rate capability and long-term lifespan.Both experimental and computational results demonstrate the strong synergistic effect of pore and dopants for Li storage.Consequently,the assembled dual-carbon LIC exhibits high voltage of 4.5 V,high-energy density of 208 Wh kg^(−1),ultrahigh power density of 53.4 kW kg^(−1)and almost zerodecrement cycling lifetime.Impressively,the full device with high mass loading of 9.4 mg cm^(−2)on cathode still outputs high-energy density of 187 Wh kg^(−1),demonstrative of their potential as electrode materials for high-performance electrochemical devices.展开更多
Porous structure and heteroatom doping are two key parameters for significantly boosting the capacitive performance of graphene-based materials.Herein,we report a facile approach to prepare onedimensional(ID) nitrogen...Porous structure and heteroatom doping are two key parameters for significantly boosting the capacitive performance of graphene-based materials.Herein,we report a facile approach to prepare onedimensional(ID) nitrogen-doped holey graphene nanoscrolls(NHGNSs) through cold quenching treatment of two-dimensional graphene oxide sheets,followed by thermal annealing in the successive atmosphere of NH3 and air.Benefiting from the synergy of the unique 1D tubular morphology,abundant nanoholes and nitrogen doping,the NHGNSs exhibit a high specific capacitance of 126 F/g at 1 A/g in ionic liquid electrolyte and excellent rate capability with 81% of the capacitance retained at 20 A/g.Furthermore,the fabricated symmetric supercapacitors based on NHGNSs achieve both high energy density of 53.5 Wh/kg at 875 W/kg and high power density of 17.5 kW/kg at 43.4 Wh/kg.The simple synthetic process and superior electrochemical performance suggest the great potential of NHGNSs for supercapacitor application.展开更多
Based on X-ray diffraction, microscopic and magnetic analysis, the structure and magnetic properties of Co77Zr18W5 melt-spun ribbons were studied in this paper. A new element to stabilize the metastable Co5Zr phase wa...Based on X-ray diffraction, microscopic and magnetic analysis, the structure and magnetic properties of Co77Zr18W5 melt-spun ribbons were studied in this paper. A new element to stabilize the metastable Co5Zr phase was found and the coercivity observed in Co-Zr alloys can be obviously enhanced by proper tungsten substitution. The Curie temperature of Co77Zr18W5 ribbons is 475℃ which suggests that W doped Co-Zr alloys may become an attractive candidate perma- nent magnets for practical applications in high temperature. Annealing of the Co77Zr18W5 ribbons results in a decrease of the coercivity which confirmed that the hard magnetic phase is Co5Zr phase in 77Zr18W5 melt-spun ribbons.展开更多
基金Supported by The National Natural Science Foundation of China,No.82350127 and No.82241013the Shanghai Natural Science Foundation,No.20ZR1411600+2 种基金the Shanghai Shenkang Hospital Development Center,No.SHDC2020CR4039the Bethune Ethicon Excellent Surgery Foundation,No.CESS2021TC04Xuhui District Medical Research Project of Shanghai,No.SHXH201805.
文摘BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
基金supported by grants from the National Key Research and Development Program of China(2023YFF0724902)the China Postdoctoral Science Foundation(2020?M670027,2023TQ0183)the Local Standards Research of BeiJing Laboratory Tree Shrew(CHYX-2023-DGB001)。
文摘Background:Q uantifying the rich home-c age activities of tree shrews provides a reliable basis for understanding their daily routines and building disease models.However,due to the lack of effective behavioral methods,most efforts on tree shrew behavior are limited to simple measures,resulting in the loss of much behavioral information.Methods:T o address this issue,we present a deep learning(DL)approach to achieve markerless pose estimation and recognize multiple spontaneous behaviors of tree shrews,including drinking,eating,resting,and staying in the dark house,etc.Results:T his high-t hroughput approach can monitor the home-cage activities of 16 tree shrews simultaneously over an extended period.Additionally,we demonstrated an innovative system with reliable apparatus,paradigms,and analysis methods for investigating food grasping behavior.The median duration for each bout of grasping was 0.20 s.Conclusion:T his study provides an efficient tool for quantifying and understand tree shrews'natural behaviors.
基金financially supported by the National Natural Science Foundation of China (Grants 51872283, 21805273)National Key R&D Program of China (Grant 2016YFA0200200)+4 种基金Liaoning BaiQianWan Talents Program, LiaoNing Revitalization Talents Program (Grant XLYC1807153)Natural Science Foundation of Liaoning Province, Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science (Grant 20180510038)DICP (DICP ZZBS201708, DICP ZZBS201802)DICP&QIBEBT (Grant DICP&QIBEBT UN201702)DNL Cooperation Fund, CAS (DNL180310, DNL180308, DNL201912, DNL201915)。
文摘Supercapacitors,also known as ultracapacitors or electrochemical capacitors,possess intriguing merits of high power density(10-100 times higher than that of batteries),long life expectancy(millions of cycles),wide operation temperature range (-40℃ to 70℃),environmental friendliness.
基金financialy supported by National Natural Science Foundation of China(Grants 22005298,22125903,51872283,22075279,22279137)Dalian Innovation Support Plan for High Level Talents(2019RT09)+3 种基金Dalian National Laboratory For Clean Energy(DNL),CAS,DNL Cooperation Fund,CAS(DNL201912,DNL201915,DNL202016,DNL202019),DICP(DICP I2020032)The Joint Fund of the Yulin University and the Dalian National Laboratory for Clean Energy(YLUDNL Fund 2021002,YLU-DNL Fund 2021009)Suzhou University Scientific Research Platform(2021XJPT07)China Postdoctoral Science Foundation(2019 M661141)
文摘The Li-ion capacitors(LICs)develop rapidly due to their double-high features of high-energy density and high-power density.However,the relative low capacity of cathode and sluggish kinetics of anode seriously impede the development of LICs.Herein,the precisely pore-engineered and heteroatomtailored defective hierarchical porous carbons(DHPCs)as large-capacity cathode and high-rate anode to construct high-performance dual-carbon LICs have been developed.The DHPCs are prepared based on triple-activation mechanisms by direct pyrolysis of sustainable lignin with urea to generate the interconnected hierarchical porous structure and plentiful heteroatominduced defects.Benefiting from these advanced merits,DHPCs show the well-matched high capacity and fast kinetics of both cathode and anode,exhibiting large capacities,superior rate capability and long-term lifespan.Both experimental and computational results demonstrate the strong synergistic effect of pore and dopants for Li storage.Consequently,the assembled dual-carbon LIC exhibits high voltage of 4.5 V,high-energy density of 208 Wh kg^(−1),ultrahigh power density of 53.4 kW kg^(−1)and almost zerodecrement cycling lifetime.Impressively,the full device with high mass loading of 9.4 mg cm^(−2)on cathode still outputs high-energy density of 187 Wh kg^(−1),demonstrative of their potential as electrode materials for high-performance electrochemical devices.
基金financially supported by the National Natural Science Foundation of China (Nos.51872283,21805273)National Key R&D Program of China (Nos.2016YBF0100100, 2016YFA0200200)+5 种基金Liaoning BaiQianWan Talents ProgramLiaoNing Revitalization Talents Program (No.XLYC1807153)Natural Science Foundation of Liaoning Province,Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science (No. 20180510038)DICP (Nos.DICP ZZBS201708,DICP ZZBS201802)DICP&QIBEBT (No.DICP&QIBEBT UN201702)DNL Cooperation Fund,CAS (Nos.DNL180310,DNL180308,DNL201912,DNL201915)。
文摘Porous structure and heteroatom doping are two key parameters for significantly boosting the capacitive performance of graphene-based materials.Herein,we report a facile approach to prepare onedimensional(ID) nitrogen-doped holey graphene nanoscrolls(NHGNSs) through cold quenching treatment of two-dimensional graphene oxide sheets,followed by thermal annealing in the successive atmosphere of NH3 and air.Benefiting from the synergy of the unique 1D tubular morphology,abundant nanoholes and nitrogen doping,the NHGNSs exhibit a high specific capacitance of 126 F/g at 1 A/g in ionic liquid electrolyte and excellent rate capability with 81% of the capacitance retained at 20 A/g.Furthermore,the fabricated symmetric supercapacitors based on NHGNSs achieve both high energy density of 53.5 Wh/kg at 875 W/kg and high power density of 17.5 kW/kg at 43.4 Wh/kg.The simple synthetic process and superior electrochemical performance suggest the great potential of NHGNSs for supercapacitor application.
文摘Based on X-ray diffraction, microscopic and magnetic analysis, the structure and magnetic properties of Co77Zr18W5 melt-spun ribbons were studied in this paper. A new element to stabilize the metastable Co5Zr phase was found and the coercivity observed in Co-Zr alloys can be obviously enhanced by proper tungsten substitution. The Curie temperature of Co77Zr18W5 ribbons is 475℃ which suggests that W doped Co-Zr alloys may become an attractive candidate perma- nent magnets for practical applications in high temperature. Annealing of the Co77Zr18W5 ribbons results in a decrease of the coercivity which confirmed that the hard magnetic phase is Co5Zr phase in 77Zr18W5 melt-spun ribbons.
