The summer Asian-Pacific Oscillation （APO） is a major teleconnection pattern that reflects the zonal thermal contrast between East Asia and the North Pacific in the upper troposphere. The performance of Beijing Clim...The summer Asian-Pacific Oscillation （APO） is a major teleconnection pattern that reflects the zonal thermal contrast between East Asia and the North Pacific in the upper troposphere. The performance of Beijing Climate Center Climate System Models （BCC_CSMs） with different horizontal resolutions, i.e., BCC_CSM1.1 and BCC_CSM1.1 （m）, in reproducing APO interannual variability, APO-related precipitation anomalies, and associated atmospheric circulation anomalies, is evaluated. The results show that BCC_CSMI.I（m） can successfully capture the interannual variability of the summer APO index. It is also more capable in reproducing the APO＇s spatial pattern, compared to BCC_CSMI.1, due to its higher horizontal resolution. Associated with a positive APO index, the northward-shifted and intensified South Asian high, strengthened extratropical westerly jet, and tropical easterly jet in the upper troposphere, as well as the southwesterly monsoonal flow over North Africa and the Indian Ocean in the lower troposphere, are realistically represented by BCC_CSM1.1 （m）, leading to an improvement in reproducing the increased precipitation over tropical North Africa, South Asia, and East Asia, as well as the decreased precipitation over subtropical North Africa, Japan, and North America. In contrast, these features are less consistent with observations when simulated by BCC_CSM1.1. Regression analysis further indicates that surface temperature anomalies over the North Pacific and the southern and western flanks of the Tibetan Plateau are reasonably reproduced by BCC_CSM 1.1 （m）, which contributes to the substantial improvement in the simulation of the characteristics of summer APO compared to that of BCC_CSM1.1.展开更多
L-tyrosine,an aromatic amino acid,is an important upstream precursor for the synthesis of a series of valuable natural products such as flavonoids and phenolic acids.In recent years,regulation of the L‑tyrosine metabo...L-tyrosine,an aromatic amino acid,is an important upstream precursor for the synthesis of a series of valuable natural products such as flavonoids and phenolic acids.In recent years,regulation of the L‑tyrosine metabolic pathway has been devoted to enhancing the production of L-tyrosine and the derived bioactive compounds in microorganisms,usually by increasing the supply of precursors,blocking competitive routes,and modulating the transport system.Here,we reviewed the strategies to promote L-tyrosine production in microbial hosts and the common strategies to produce bioactive compounds in engineered Escherichia coli and Saccharomyces cerevisiae to better understand and utilize the L-tyrosine metabolic pathway for microbial overproduction of diverse valuable aromatic compounds in the future.展开更多
基金jointly supported by the State Key Program of the National Natural Science of China(Grant No.41130963)the National Natural Science Foundation of China(Grant No.41575071)
文摘The summer Asian-Pacific Oscillation （APO） is a major teleconnection pattern that reflects the zonal thermal contrast between East Asia and the North Pacific in the upper troposphere. The performance of Beijing Climate Center Climate System Models （BCC_CSMs） with different horizontal resolutions, i.e., BCC_CSM1.1 and BCC_CSM1.1 （m）, in reproducing APO interannual variability, APO-related precipitation anomalies, and associated atmospheric circulation anomalies, is evaluated. The results show that BCC_CSMI.I（m） can successfully capture the interannual variability of the summer APO index. It is also more capable in reproducing the APO＇s spatial pattern, compared to BCC_CSMI.1, due to its higher horizontal resolution. Associated with a positive APO index, the northward-shifted and intensified South Asian high, strengthened extratropical westerly jet, and tropical easterly jet in the upper troposphere, as well as the southwesterly monsoonal flow over North Africa and the Indian Ocean in the lower troposphere, are realistically represented by BCC_CSM1.1 （m）, leading to an improvement in reproducing the increased precipitation over tropical North Africa, South Asia, and East Asia, as well as the decreased precipitation over subtropical North Africa, Japan, and North America. In contrast, these features are less consistent with observations when simulated by BCC_CSM1.1. Regression analysis further indicates that surface temperature anomalies over the North Pacific and the southern and western flanks of the Tibetan Plateau are reasonably reproduced by BCC_CSM 1.1 （m）, which contributes to the substantial improvement in the simulation of the characteristics of summer APO compared to that of BCC_CSM1.1.
基金supported by the National Natural Science Foundation of China(No.81673540,82173924)“Synthetic Biology-based biosynthesis of salvianolic acids”.
文摘L-tyrosine,an aromatic amino acid,is an important upstream precursor for the synthesis of a series of valuable natural products such as flavonoids and phenolic acids.In recent years,regulation of the L‑tyrosine metabolic pathway has been devoted to enhancing the production of L-tyrosine and the derived bioactive compounds in microorganisms,usually by increasing the supply of precursors,blocking competitive routes,and modulating the transport system.Here,we reviewed the strategies to promote L-tyrosine production in microbial hosts and the common strategies to produce bioactive compounds in engineered Escherichia coli and Saccharomyces cerevisiae to better understand and utilize the L-tyrosine metabolic pathway for microbial overproduction of diverse valuable aromatic compounds in the future.
