Objective To explore the application effect of time tracking platform in improving the reperfusion treatment of patients with acute ischemic stroke in primary hospitals. Methods and Results Patients with acute ischemi...Objective To explore the application effect of time tracking platform in improving the reperfusion treatment of patients with acute ischemic stroke in primary hospitals. Methods and Results Patients with acute ischemic stroke who carried out emergency intravenous thrombolysis and arterial thrombectomy in our hospital in 2021, 2022 and 2023 were selected. The time tracking mode was implemented, and the patients were recorded at each time node of the hospital and the whole-process digital management was conducted. Compared the mean DNT (Door to Needle Time) of intravenous thrombolysis in emergency stroke patients in 2021, 2022 and 2023, the total number of hospital cases within 4.5 h of onset, the total number of thrombolysis cases within 4.5 h of onset, the number of intravenous thrombolysis in 60 minutes of acute ischemic stroke, and the number of thrombolysis cases. The results show that from 2021 to 2023 our emergency stroke patients with intravenous thrombolysis average DNT shortened year by year, to the hospital within 4.5 h after the onset of the difference is statistically significant (all P < 0.05) conclusion through the application of stroke time tracking platform, is beneficial to shorten the treatment time of each link, can effectively reduce the hospital time delay, improve the rate of thrombolysis, improve the reperfusion of stroke centers in primary hospitals.展开更多
The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MVO).However,studies performed in the isolated perfused he...The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MVO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this phenomenon.The intracoronary administration of alteplase has been found to have no effect on the occurrence of MVO in patients with acute myocardial infarction.Consequently,the major events preceding the appearance of MVO in coronary arteries are independent of microthrombi,platelets,and neutrophils.Endothelial cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary arteries.However,reperfusion triggers more pronounced damage,possibly mediated by pyroptosis.MVO and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial remodeling.Therefore,pharmacological agents used to treat MVO should prevent endothelial injury and induce relaxation of smooth muscles.Ischemic conditioning protocols have been shown to prevent MVO,with L-type Ca2+channel blockers appearing the most effective in treating MVO.展开更多
The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 years.It has been demonstrated that reperfusion triggers a multiple increase in free radi...The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 years.It has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated heart.Antioxidants were found to have the ability to mitigate I/R injury of the heart.However,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial tissues.Since high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other molecules.It has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic preconditioning.Consequently,there is evidence that ROS protect the heart against the I/R injury.展开更多
By combining the photochemical reaction and liquid–liquid extraction(PODS), we studied desulfurization of model fuel and FCC gasoline. The effects of air flow, illumination time, extractants, volume ratios of extract...By combining the photochemical reaction and liquid–liquid extraction(PODS), we studied desulfurization of model fuel and FCC gasoline. The effects of air flow, illumination time, extractants, volume ratios of extractant/fuel, and catalyst amounts on the desulfurization process of PODS were analyzed in detail. Under the conditions with the air as oxidant(150 ml·min^(-1)), the mixture of DMF–water as extractant(the volume ratio of extractant/oil of 0.5) and photo-irradiation time of 2 h, the sulfur removal rate reached only 42.63% and 39.54% for the model and FCC gasoline, respectively. Under the same conditions, the sulfur removal rate increased significantly up to79% for gasoline in the presence of Cu_2O catalyst(2 g·L^(-1)). The results suggest that the PODS combined with a Cu_2O catalyst seems to be a promising alternative for sulfur removal of gasoline.展开更多
The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new app...The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these methods.Chronic hypoxia exerts both positive and adverse effects.The positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in reperfusion.The adverse effects are pulmonary hypertension and right ventricular hypertrophy.This review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/reperfusion.It is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.展开更多
Revealing the dynamic reconfiguration of catalysts and the evolution of active species during catalysis,elucidating and regulating the reconfiguration mechanism are paramount to the development of highperformance elec...Revealing the dynamic reconfiguration of catalysts and the evolution of active species during catalysis,elucidating and regulating the reconfiguration mechanism are paramount to the development of highperformance electrochemical nitrate reduction(NO_(3)RR)to ammonia.In-situ characterizations can precisely track reaction process and unveil the origin of activity enhancement.Here,in-situ reconstruction of pre-catalyst Co_(3)O_(4)fabricates a stable heterojunction Co(OH)_(2)/Co_(3)O_(4)to boost NO_(3)RR to ammonia.Insitu generated heterojunction accelerates the transformation of^(*)NO_(3)to^(*)NO_(2),while Co(OH)_(2)promotes the dissociation of water to active*H species for the hydrogenation of^(*)N species,and thereby improving the deoxygenation and hydrogenation ability of NO_(3)RR to NH_(3)and achieving a high Faradaic efficiency(FE)about 96.2%and a high NH_(3)production rate of 218.5μmol h^(-1)mg_(cat)^(-1)at-0.3 V.Density functional theory(DFT)calculations verified that in-situ formed active species Co(OH)_(2)on Co_(3)O_(4)markedly decreased the energy barrier of^(*)NO_(3)→^(*)NO_(2)and accelerated the hydrogenation step of^(*)NH→^(*)NH_(2)→^(*)NH_(3).Co(OH)_(2)/Co_(3)O_(4)heterostructure-based Zn-NO_(3)^(-)cell achieves excellent energy supply(1.22 V),a high ammonia yield rate(48.9μmol h^(-1)cm^(-2)),and a high FE(91%).The establishment of the structure-activity relationship during NO_(3)RR provides guidance for designing advanced electrode materials,and the in-situ evolution of species on the electrode surface unveils the intrinsic nature of improved catalytic performance.展开更多
文摘Objective To explore the application effect of time tracking platform in improving the reperfusion treatment of patients with acute ischemic stroke in primary hospitals. Methods and Results Patients with acute ischemic stroke who carried out emergency intravenous thrombolysis and arterial thrombectomy in our hospital in 2021, 2022 and 2023 were selected. The time tracking mode was implemented, and the patients were recorded at each time node of the hospital and the whole-process digital management was conducted. Compared the mean DNT (Door to Needle Time) of intravenous thrombolysis in emergency stroke patients in 2021, 2022 and 2023, the total number of hospital cases within 4.5 h of onset, the total number of thrombolysis cases within 4.5 h of onset, the number of intravenous thrombolysis in 60 minutes of acute ischemic stroke, and the number of thrombolysis cases. The results show that from 2021 to 2023 our emergency stroke patients with intravenous thrombolysis average DNT shortened year by year, to the hospital within 4.5 h after the onset of the difference is statistically significant (all P < 0.05) conclusion through the application of stroke time tracking platform, is beneficial to shorten the treatment time of each link, can effectively reduce the hospital time delay, improve the rate of thrombolysis, improve the reperfusion of stroke centers in primary hospitals.
基金supported by the Russian Science Foundation(Grant No.23-65-10017)The mini-chapter on treatment of MVO was supported by state assignment 122020300042-4.
文摘The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MVO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this phenomenon.The intracoronary administration of alteplase has been found to have no effect on the occurrence of MVO in patients with acute myocardial infarction.Consequently,the major events preceding the appearance of MVO in coronary arteries are independent of microthrombi,platelets,and neutrophils.Endothelial cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary arteries.However,reperfusion triggers more pronounced damage,possibly mediated by pyroptosis.MVO and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial remodeling.Therefore,pharmacological agents used to treat MVO should prevent endothelial injury and induce relaxation of smooth muscles.Ischemic conditioning protocols have been shown to prevent MVO,with L-type Ca2+channel blockers appearing the most effective in treating MVO.
文摘The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 years.It has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated heart.Antioxidants were found to have the ability to mitigate I/R injury of the heart.However,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial tissues.Since high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other molecules.It has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic preconditioning.Consequently,there is evidence that ROS protect the heart against the I/R injury.
基金Supported by the National Natural Science Foundation of China(Grant No.21766039)the Natural Science Foundation of Shaanxi Province(Grant No.14JS111)+1 种基金the Major Project of Yan'an Science and Technology Bureau(Grant No.2016CGZH-10)the Project of Yan'an University(YDT2017-2)
文摘By combining the photochemical reaction and liquid–liquid extraction(PODS), we studied desulfurization of model fuel and FCC gasoline. The effects of air flow, illumination time, extractants, volume ratios of extractant/fuel, and catalyst amounts on the desulfurization process of PODS were analyzed in detail. Under the conditions with the air as oxidant(150 ml·min^(-1)), the mixture of DMF–water as extractant(the volume ratio of extractant/oil of 0.5) and photo-irradiation time of 2 h, the sulfur removal rate reached only 42.63% and 39.54% for the model and FCC gasoline, respectively. Under the same conditions, the sulfur removal rate increased significantly up to79% for gasoline in the presence of Cu_2O catalyst(2 g·L^(-1)). The results suggest that the PODS combined with a Cu_2O catalyst seems to be a promising alternative for sulfur removal of gasoline.
基金supported by the Russian Science Foundation grant 22-15-00048The section dedicated to the role of kinases in the cardioprotective effect of CH is framed within the framework of state assignments 122020300042-4.
文摘The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these methods.Chronic hypoxia exerts both positive and adverse effects.The positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in reperfusion.The adverse effects are pulmonary hypertension and right ventricular hypertrophy.This review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/reperfusion.It is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.
基金supported by National Natural Science Foundation of China(22162025)the Youth Innovation Team of Shaanxi Universities+2 种基金the Open and Innovation Fund of Hubei Three Gorges Laboratory(SK232001)the Regional Innovation Capability Leading Program of Shaanxi(2022QFY07-03,2022QFY07-06)the Shaanxi Province Training Program of Innovation and Entrepreneurship for Undergraduates(S202210719108)。
文摘Revealing the dynamic reconfiguration of catalysts and the evolution of active species during catalysis,elucidating and regulating the reconfiguration mechanism are paramount to the development of highperformance electrochemical nitrate reduction(NO_(3)RR)to ammonia.In-situ characterizations can precisely track reaction process and unveil the origin of activity enhancement.Here,in-situ reconstruction of pre-catalyst Co_(3)O_(4)fabricates a stable heterojunction Co(OH)_(2)/Co_(3)O_(4)to boost NO_(3)RR to ammonia.Insitu generated heterojunction accelerates the transformation of^(*)NO_(3)to^(*)NO_(2),while Co(OH)_(2)promotes the dissociation of water to active*H species for the hydrogenation of^(*)N species,and thereby improving the deoxygenation and hydrogenation ability of NO_(3)RR to NH_(3)and achieving a high Faradaic efficiency(FE)about 96.2%and a high NH_(3)production rate of 218.5μmol h^(-1)mg_(cat)^(-1)at-0.3 V.Density functional theory(DFT)calculations verified that in-situ formed active species Co(OH)_(2)on Co_(3)O_(4)markedly decreased the energy barrier of^(*)NO_(3)→^(*)NO_(2)and accelerated the hydrogenation step of^(*)NH→^(*)NH_(2)→^(*)NH_(3).Co(OH)_(2)/Co_(3)O_(4)heterostructure-based Zn-NO_(3)^(-)cell achieves excellent energy supply(1.22 V),a high ammonia yield rate(48.9μmol h^(-1)cm^(-2)),and a high FE(91%).The establishment of the structure-activity relationship during NO_(3)RR provides guidance for designing advanced electrode materials,and the in-situ evolution of species on the electrode surface unveils the intrinsic nature of improved catalytic performance.
