目的从安全性、有效性两方面比较腹腔镜下经胆囊管胆总管探查术(laparoscopic transcystic common bile duct exploration,LTCBDE)与腹腔镜胆总管探查术(laparoscopic common bile duct exploration,LCBDE)治疗胆总管结石治疗的疗效。...目的从安全性、有效性两方面比较腹腔镜下经胆囊管胆总管探查术(laparoscopic transcystic common bile duct exploration,LTCBDE)与腹腔镜胆总管探查术(laparoscopic common bile duct exploration,LCBDE)治疗胆总管结石治疗的疗效。方法采用前瞻随机对照试验方法选取同济大学附属普陀人民医院普外科2022年6月—2024年1月53例胆总管结石患者,将这些患者根据数字表随机方法进行随机分组,分为研究组(LTCBDE,n=26)和对照组(LCBDE,n=27),两组均行腹腔镜下胆囊切除术;比较两组的手术时间、术后住院天数、住院总金额、术前与术后胃肠病生活质量指数(gastrointestinal quality of life index)和术后并发症发生率等。结果两组患者的单次结石清除成功率、术中出血量、术后并发症发生率和胆总管结石复发率差异均无统计学意义;研究组手术平均时间[(145.80±47.60)min vs(174.20±51.22)min]、术后离床活动时间[(22.88±3.42)h vs(31.72±3.71)h],术后首次肛门排气时间[(22.51±3.65)h vs(28.02±2.81)h],术后住院天数[(8.44±1.19)d vs(10.76±2.13)d],住院金额[(28241±11300)元vs(36233±12220)元]均低于对照组。结论LTCBDE联合腹腔镜下胆囊切除术治疗胆总管结石术后恢复较快,生活质量高、有效、安全,值得推广。展开更多
Imines play a pivotal role as multifunctional intermediates in pharmaceutical and biological applications,and their selective synthesis under mild conditions has attracted increasing interest.In this study,a covalent-...Imines play a pivotal role as multifunctional intermediates in pharmaceutical and biological applications,and their selective synthesis under mild conditions has attracted increasing interest.In this study,a covalent-organic frameworks(COFs)modified with CeO_(2)quantum dots(QDs)were prepared through a simple chemical reaction using LZU1 COFs and Ce(NO_(3))_(3)·6H_(2)O serving as precursors.The optimized5CeO_(2)QDs@LZU1 decorated with about 3.9 wt%CeO_(2)QDs demonstrates excellent performance in the photocatalytic selective oxidative of amines in visible light conditions,achieving nearly 100%benzylamine conversion and over 99%imine selectivity within 6 h,which is significantly superior to that of pure LZU1 and CeO_(2).The remarkable enhancement in activity is mainly attributed to the fact that the interaction between CeO_(2)QDs and LZU1 COF in 5CeO_(2)QDs@LZU1 improves the visible light response and concurrently promotes the separation efficiency of photogenerated e-and h+pairs.Broad substrate scope also provides a prospect for the industrial synthesis of various imines.Our findings not only expand the application range of COFs by incorporating QDs but also lay the groundwork for their further rational design and optimization.展开更多
Photocatalytic oxidative desulfurization(PODS)over efficient earth-abundant catalysts to obtain clean fuel oil is of great importance for the environmental protection.In this work,a series of Ce-doped MIL-125-NH_(2)ph...Photocatalytic oxidative desulfurization(PODS)over efficient earth-abundant catalysts to obtain clean fuel oil is of great importance for the environmental protection.In this work,a series of Ce-doped MIL-125-NH_(2)photocatalysts were successfully prepared via a simple in-situ doping method and exhibited superior PODS performance of dibenzothiophene(DBT)under mild reaction conditions.The 1.0 mol%Ce/MIL-125-NH_(2)catalyst achieved 100%sulfur removal within 22 min at 30℃ under visible light illumination,which is mainly attributed to the high surface area and the formation of Ce-Ti-oxo clusters due to electronic coupling.The valence transformation of Ce^(4+)/Ce^(3+)and Ti^(4+)/Ti^(3+)redox mediators could not only expose abundant Lewis acid sites,but also promote the separation and transfer of photogenerated charges.In addition,increasing the reaction temperature has been demonstrated to be effective in promoting the PODS performance.Additionally,a thermo-enhanced PODS mechanism was proposed over Ce/MIL-125-NH_(2),demonstrating the great potential of thermal energy to promote the desulfurization activity.展开更多
This paper addresses a dynamic lot sizing problem with bounded inventory and stockout where both no backlogging and backlogging allowed cases are considered. The stockout option means that there is outsourcing in a pe...This paper addresses a dynamic lot sizing problem with bounded inventory and stockout where both no backlogging and backlogging allowed cases are considered. The stockout option means that there is outsourcing in a period only when the inventory level at that period is non-positive. The production capacity is unlimited and production cost functions are linear but with fixed charges. The problem is that of satisfying all demands in the planning horizon at minimal total cost. We show that the no backlogging case can be solved in O（T^2） time with general concave inventory holding and outsourcing cost functions where T is the length of the planning horizon. The complexity can be reduced to O（T） when the inventory holding cost functions are also linear and have some realistic properties, even if the outsourcing cost functions remain general concave functions. When the inventory holding and outsourcing cost functions are linear, the backlogging case can be solved in O（ T^3 logT） time whether the outsourcing level at each period is bounded by the sum of the demand of that period and backlogging level from previous periods, or only by the demand of that period.展开更多
O-linkedβ-N-acetylglucosaminylation(O-GlcNAcylation)is a highly dynamic and widespread post-translational modification(PTM)that regulates the activity,subcellular localization,and stability of target proteins.O-GlcNA...O-linkedβ-N-acetylglucosaminylation(O-GlcNAcylation)is a highly dynamic and widespread post-translational modification(PTM)that regulates the activity,subcellular localization,and stability of target proteins.O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes:O-linked N-acetylglucosamine transferase and O-GlcNAcase.Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity,inflammatory signaling,and cancer development.O-GlcNAcylation usually occurs on serine/threonine residues,where it interacts with other PTMs,such as phosphorylation.Thus,it likely has a broad regulatory scope.This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation.A more comprehensive understanding ofO-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer.展开更多
文摘目的从安全性、有效性两方面比较腹腔镜下经胆囊管胆总管探查术(laparoscopic transcystic common bile duct exploration,LTCBDE)与腹腔镜胆总管探查术(laparoscopic common bile duct exploration,LCBDE)治疗胆总管结石治疗的疗效。方法采用前瞻随机对照试验方法选取同济大学附属普陀人民医院普外科2022年6月—2024年1月53例胆总管结石患者,将这些患者根据数字表随机方法进行随机分组,分为研究组(LTCBDE,n=26)和对照组(LCBDE,n=27),两组均行腹腔镜下胆囊切除术;比较两组的手术时间、术后住院天数、住院总金额、术前与术后胃肠病生活质量指数(gastrointestinal quality of life index)和术后并发症发生率等。结果两组患者的单次结石清除成功率、术中出血量、术后并发症发生率和胆总管结石复发率差异均无统计学意义;研究组手术平均时间[(145.80±47.60)min vs(174.20±51.22)min]、术后离床活动时间[(22.88±3.42)h vs(31.72±3.71)h],术后首次肛门排气时间[(22.51±3.65)h vs(28.02±2.81)h],术后住院天数[(8.44±1.19)d vs(10.76±2.13)d],住院金额[(28241±11300)元vs(36233±12220)元]均低于对照组。结论LTCBDE联合腹腔镜下胆囊切除术治疗胆总管结石术后恢复较快,生活质量高、有效、安全,值得推广。
基金Project supported by the National Natural Science Foundation of China(22176054,22306060)China Postdoctoral Science Foundation(2022M721134)the Fundamental Research Funds for the Central Universities(2023MS060)。
文摘Imines play a pivotal role as multifunctional intermediates in pharmaceutical and biological applications,and their selective synthesis under mild conditions has attracted increasing interest.In this study,a covalent-organic frameworks(COFs)modified with CeO_(2)quantum dots(QDs)were prepared through a simple chemical reaction using LZU1 COFs and Ce(NO_(3))_(3)·6H_(2)O serving as precursors.The optimized5CeO_(2)QDs@LZU1 decorated with about 3.9 wt%CeO_(2)QDs demonstrates excellent performance in the photocatalytic selective oxidative of amines in visible light conditions,achieving nearly 100%benzylamine conversion and over 99%imine selectivity within 6 h,which is significantly superior to that of pure LZU1 and CeO_(2).The remarkable enhancement in activity is mainly attributed to the fact that the interaction between CeO_(2)QDs and LZU1 COF in 5CeO_(2)QDs@LZU1 improves the visible light response and concurrently promotes the separation efficiency of photogenerated e-and h+pairs.Broad substrate scope also provides a prospect for the industrial synthesis of various imines.Our findings not only expand the application range of COFs by incorporating QDs but also lay the groundwork for their further rational design and optimization.
基金supported by the National Key Research and Development Program of China(No.2021YFB3500700)the National Natural Science Foundation of China(No.21976054)Fundamental Research Funds for the Central Universities(No.FRFTP-20-005A3)。
文摘Photocatalytic oxidative desulfurization(PODS)over efficient earth-abundant catalysts to obtain clean fuel oil is of great importance for the environmental protection.In this work,a series of Ce-doped MIL-125-NH_(2)photocatalysts were successfully prepared via a simple in-situ doping method and exhibited superior PODS performance of dibenzothiophene(DBT)under mild reaction conditions.The 1.0 mol%Ce/MIL-125-NH_(2)catalyst achieved 100%sulfur removal within 22 min at 30℃ under visible light illumination,which is mainly attributed to the high surface area and the formation of Ce-Ti-oxo clusters due to electronic coupling.The valence transformation of Ce^(4+)/Ce^(3+)and Ti^(4+)/Ti^(3+)redox mediators could not only expose abundant Lewis acid sites,but also promote the separation and transfer of photogenerated charges.In addition,increasing the reaction temperature has been demonstrated to be effective in promoting the PODS performance.Additionally,a thermo-enhanced PODS mechanism was proposed over Ce/MIL-125-NH_(2),demonstrating the great potential of thermal energy to promote the desulfurization activity.
基金Acknowledgments This work is supported by the National Natural Science Foundation of China （No. 71171072, 71301040）. The authors are thankful to two anonymous referees and the editor for their constructive comments, which resulted in the subsequent improvement of this article.
文摘This paper addresses a dynamic lot sizing problem with bounded inventory and stockout where both no backlogging and backlogging allowed cases are considered. The stockout option means that there is outsourcing in a period only when the inventory level at that period is non-positive. The production capacity is unlimited and production cost functions are linear but with fixed charges. The problem is that of satisfying all demands in the planning horizon at minimal total cost. We show that the no backlogging case can be solved in O（T^2） time with general concave inventory holding and outsourcing cost functions where T is the length of the planning horizon. The complexity can be reduced to O（T） when the inventory holding cost functions are also linear and have some realistic properties, even if the outsourcing cost functions remain general concave functions. When the inventory holding and outsourcing cost functions are linear, the backlogging case can be solved in O（ T^3 logT） time whether the outsourcing level at each period is bounded by the sum of the demand of that period and backlogging level from previous periods, or only by the demand of that period.
基金The current work was supported by a special program from the Ministry of Science and Technology of China(2021YFA1101000)the National Natural Science Foundation of China(U20A20393,32125016,31871405,31925013,31870902,and 32070907)+1 种基金Jiangsu National Science Foundation(19KJA550003)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘O-linkedβ-N-acetylglucosaminylation(O-GlcNAcylation)is a highly dynamic and widespread post-translational modification(PTM)that regulates the activity,subcellular localization,and stability of target proteins.O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes:O-linked N-acetylglucosamine transferase and O-GlcNAcase.Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity,inflammatory signaling,and cancer development.O-GlcNAcylation usually occurs on serine/threonine residues,where it interacts with other PTMs,such as phosphorylation.Thus,it likely has a broad regulatory scope.This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation.A more comprehensive understanding ofO-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer.
