Dr.Feng Chen is a chief medical doctor and the vice chairman of the Department of Radiology in Zhong Da Hospital at Southeast University,Nanjing,China and a senior researcher in the Department of Radiology at the Cath...Dr.Feng Chen is a chief medical doctor and the vice chairman of the Department of Radiology in Zhong Da Hospital at Southeast University,Nanjing,China and a senior researcher in the Department of Radiology at the Catholic University of Leuven,Belgium.His main areas of interest are translational imaging research including stroke,tumor angiogenesis,assessment of therapeutic response in solid tumors,and magnetic resonance contrast media.Dr.Feng Chen has published 44 scientific papers in peer-reviewed international journals.He and his colleagues have developed an imaging platform which includes animal models,animal preparations and multiparametric magnetic resonance imaging(MRI)protocols for translational animal imaging research using clinical machines.His MRI findings on rodent stroke are considered to"serve as a model for future laboratory investigations of treatment of acutestroke and unify the approaches developed for clinical studies".He and his colleagues have introduced a novel liver tumor model in rodents,in which a series of studies concerning the antitumor activity of vascular disrupting agents have been successively conducted and assessed by in vivo MRI,especially by diffusion weighted imaging as an imaging biomarker.His goal is to provide valuable references for clinical practice and to contribute to the translation of animal imaging research into patient applications.展开更多
Interferon-related genes are involved in antiviral responses,inflammation,and immunity,which are closely related to sepsis-associated acute respiratory distress syndrome(ARDS).We analyzed 1972 participants with genoty...Interferon-related genes are involved in antiviral responses,inflammation,and immunity,which are closely related to sepsis-associated acute respiratory distress syndrome(ARDS).We analyzed 1972 participants with genotype data and 681 participants with gene expression data from the Molecular Epidemiology of ARDS(MEARDS),the Molecular Epidemiology of Sepsis in the ICU(MESSI),and the Molecular Diagnosis and Risk Stratification of Sepsis(MARS)cohorts in a three-step study focusing on sepsis-associated ARDS and sepsis-only controls.First,we identified and validated interferon-related genes associated with sepsis-associated ARDS risk using genetically regulated gene expression(GReX).Second,we examined the association of the confirmed gene(interferon regulatory factor 1,IRF1)with ARDS risk and survival and conducted a mediation analysis.Through discovery and validation,we found that the GReX of IRF1 was associated with ARDS risk(odds ratio[OR_(MEARDS)]=0.84,P=0.008;OR_(MESSI)=0.83,P=0.034).Furthermore,individual-level measured IRF1 expression was associated with reduced ARDS risk(OR=0.58,P=8.67×10^(-4)),and improved overall survival in ARDS patients(hazard ratio[HR_(28-day)]=0.49,P=0.009)and sepsis patients(HR_(28-day)=0.76,P=0.008).Mediation analysis revealed that IRF1 may enhance immune function by regulating the major histocompatibility complex,including HLA-F,which mediated more than 70%of protective effects of IRF1 on ARDS.The findings were validated by in vitro biological experiments including time-series infection dynamics,overexpression,knockout,and chromatin immunoprecipitation sequencing.Early prophylactic interventions to activate IRF1 in sepsis patients,thereby regulating HLA-F,may reduce the risk of ARDS and mortality,especially in severely ill patients.展开更多
This study investigates the frequency-temperature behaviors in AT-cut quartz crystal resonators(QCRs).First,the dispersion relations of an infinite quartz plate are obtained through a semi-analytical finite element(SA...This study investigates the frequency-temperature behaviors in AT-cut quartz crystal resonators(QCRs).First,the dispersion relations of an infinite quartz plate are obtained through a semi-analytical finite element(SAFE)analysis,which explicitly reveals the intrinsic frequency-temperature dependence of different vibration modes.Subsequently,we address practical resonator configurations by examining finite quartz plates,where numerical simulations uncover critical interactions between the operational thickness-shear(TS)mode and coupling modes,i.e.,the flexure(F),face-shear(FS),and extension(E)modes.Through the frequency spectra analysis,we demonstrate that both the plate aspect ratio and thermal variations affect mode-coupling behaviors.Unstable frequency-temperature variations(activity dips)are observed at critical resonator dimensions.Validation through the free-vibration eigen-frequency analysis and forced-vibration admittance characterization confirms the stable or unstable states predicted by the frequency spectra.The established framework not only reveals the origin of temperatureinduced activity dips but also provides the crucial design criteria for suppressing the mode-coupling interference in high-stability resonators.展开更多
多孔硅基负极材料因其在硅脱嵌锂过程中能缓解体积膨胀的优势,在电池技术中展现出巨大的应用潜力。但在长期循环使用时,电极在脱嵌锂过程中不可避免的出现容量下降和结构被破坏等问题。随着研究的深入和技术的进步,保证多孔型电极在循...多孔硅基负极材料因其在硅脱嵌锂过程中能缓解体积膨胀的优势,在电池技术中展现出巨大的应用潜力。但在长期循环使用时,电极在脱嵌锂过程中不可避免的出现容量下降和结构被破坏等问题。随着研究的深入和技术的进步,保证多孔型电极在循环过程不发生开裂,并具有更高的比容量和倍率性能,成为了多孔型硅基负极材料的新突破口。本实验分别以葡萄糖和蔗糖为碳的前驱体进行分阶段碳化,使用预氧化的聚乙烯吡咯烷酮(PVP)作为骨架,运用微电子打印技术构建了新型Si@PVP/葡萄糖和Si@PVP/蔗糖多孔碳骨架结构的Si@C复合电极。分析结果表明:Si@PVP/葡萄糖结构电极循环后电极表面开裂明显更小。以0.1 A·g^(–1)的电流密度放电,Si@PVP/葡萄糖结构电极首圈比容量为1655 m A·h·g^(–1),100圈后比容量为1095 m A·h·g^(–1),可逆容量保持为97.4%;Si@PVP/蔗糖结构电极首圈比容量为1455 m A·h·g^(–1),100圈后比容量为970 m A·h·g^(–1),可逆容量保持为91%。展开更多
基金Supported by Health Bureau of Jiangsu Province,ChinaChinese Scholarship Council+2 种基金National Natural Science Foundation of ChinaEuropean Congress of Radiology 2000,EAR-ECR Research and Education Fund Fellowship GrantEuropean Union Asia-Link Project
文摘Dr.Feng Chen is a chief medical doctor and the vice chairman of the Department of Radiology in Zhong Da Hospital at Southeast University,Nanjing,China and a senior researcher in the Department of Radiology at the Catholic University of Leuven,Belgium.His main areas of interest are translational imaging research including stroke,tumor angiogenesis,assessment of therapeutic response in solid tumors,and magnetic resonance contrast media.Dr.Feng Chen has published 44 scientific papers in peer-reviewed international journals.He and his colleagues have developed an imaging platform which includes animal models,animal preparations and multiparametric magnetic resonance imaging(MRI)protocols for translational animal imaging research using clinical machines.His MRI findings on rodent stroke are considered to"serve as a model for future laboratory investigations of treatment of acutestroke and unify the approaches developed for clinical studies".He and his colleagues have introduced a novel liver tumor model in rodents,in which a series of studies concerning the antitumor activity of vascular disrupting agents have been successively conducted and assessed by in vivo MRI,especially by diffusion weighted imaging as an imaging biomarker.His goal is to provide valuable references for clinical practice and to contribute to the translation of animal imaging research into patient applications.
基金supported by the National Natural Science Foundation of China(Grant No.82220108002 to F.C.and Grant No.82273737 to R.Z.)the U.S.National Institutes of Health(Grant Nos.CA209414,HL060710,and ES000002 to D.C.C.,Grant Nos.CA209414 and CA249096 to Y.L.)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)supported by the Qing Lan Project of the Higher Education Institutions of Jiangsu Province and the Outstanding Young Level Academic Leadership Training Program of Nanjing Medical University.
文摘Interferon-related genes are involved in antiviral responses,inflammation,and immunity,which are closely related to sepsis-associated acute respiratory distress syndrome(ARDS).We analyzed 1972 participants with genotype data and 681 participants with gene expression data from the Molecular Epidemiology of ARDS(MEARDS),the Molecular Epidemiology of Sepsis in the ICU(MESSI),and the Molecular Diagnosis and Risk Stratification of Sepsis(MARS)cohorts in a three-step study focusing on sepsis-associated ARDS and sepsis-only controls.First,we identified and validated interferon-related genes associated with sepsis-associated ARDS risk using genetically regulated gene expression(GReX).Second,we examined the association of the confirmed gene(interferon regulatory factor 1,IRF1)with ARDS risk and survival and conducted a mediation analysis.Through discovery and validation,we found that the GReX of IRF1 was associated with ARDS risk(odds ratio[OR_(MEARDS)]=0.84,P=0.008;OR_(MESSI)=0.83,P=0.034).Furthermore,individual-level measured IRF1 expression was associated with reduced ARDS risk(OR=0.58,P=8.67×10^(-4)),and improved overall survival in ARDS patients(hazard ratio[HR_(28-day)]=0.49,P=0.009)and sepsis patients(HR_(28-day)=0.76,P=0.008).Mediation analysis revealed that IRF1 may enhance immune function by regulating the major histocompatibility complex,including HLA-F,which mediated more than 70%of protective effects of IRF1 on ARDS.The findings were validated by in vitro biological experiments including time-series infection dynamics,overexpression,knockout,and chromatin immunoprecipitation sequencing.Early prophylactic interventions to activate IRF1 in sepsis patients,thereby regulating HLA-F,may reduce the risk of ARDS and mortality,especially in severely ill patients.
基金Project supported by the National Key Research and Development Program of China(No.2023YFE0111000)the National Natural Science Foundation of China(Nos.12102183,12172171,and U24A2005)the Shenzhen Science and Technology Program of China(No.JCYJ20230807142004009)。
文摘This study investigates the frequency-temperature behaviors in AT-cut quartz crystal resonators(QCRs).First,the dispersion relations of an infinite quartz plate are obtained through a semi-analytical finite element(SAFE)analysis,which explicitly reveals the intrinsic frequency-temperature dependence of different vibration modes.Subsequently,we address practical resonator configurations by examining finite quartz plates,where numerical simulations uncover critical interactions between the operational thickness-shear(TS)mode and coupling modes,i.e.,the flexure(F),face-shear(FS),and extension(E)modes.Through the frequency spectra analysis,we demonstrate that both the plate aspect ratio and thermal variations affect mode-coupling behaviors.Unstable frequency-temperature variations(activity dips)are observed at critical resonator dimensions.Validation through the free-vibration eigen-frequency analysis and forced-vibration admittance characterization confirms the stable or unstable states predicted by the frequency spectra.The established framework not only reveals the origin of temperatureinduced activity dips but also provides the crucial design criteria for suppressing the mode-coupling interference in high-stability resonators.
文摘多孔硅基负极材料因其在硅脱嵌锂过程中能缓解体积膨胀的优势,在电池技术中展现出巨大的应用潜力。但在长期循环使用时,电极在脱嵌锂过程中不可避免的出现容量下降和结构被破坏等问题。随着研究的深入和技术的进步,保证多孔型电极在循环过程不发生开裂,并具有更高的比容量和倍率性能,成为了多孔型硅基负极材料的新突破口。本实验分别以葡萄糖和蔗糖为碳的前驱体进行分阶段碳化,使用预氧化的聚乙烯吡咯烷酮(PVP)作为骨架,运用微电子打印技术构建了新型Si@PVP/葡萄糖和Si@PVP/蔗糖多孔碳骨架结构的Si@C复合电极。分析结果表明:Si@PVP/葡萄糖结构电极循环后电极表面开裂明显更小。以0.1 A·g^(–1)的电流密度放电,Si@PVP/葡萄糖结构电极首圈比容量为1655 m A·h·g^(–1),100圈后比容量为1095 m A·h·g^(–1),可逆容量保持为97.4%;Si@PVP/蔗糖结构电极首圈比容量为1455 m A·h·g^(–1),100圈后比容量为970 m A·h·g^(–1),可逆容量保持为91%。
