目的系统评价推拿治疗2型糖尿病(T2DM)的临床疗效,为T2DM治疗的临床实践提供参考。方法计算机检索中国期刊网、万方、中国生物医学文献库、维普及Pub Med等数据库,所有文献检索时限截止至2016年11月。根据纳入和排除标准,由2位评价者独...目的系统评价推拿治疗2型糖尿病(T2DM)的临床疗效,为T2DM治疗的临床实践提供参考。方法计算机检索中国期刊网、万方、中国生物医学文献库、维普及Pub Med等数据库,所有文献检索时限截止至2016年11月。根据纳入和排除标准,由2位评价者独立进行文献筛选和资料提取,并对纳入文献的质量进行评价,采用Rev Man 5.0软件进行Meta分析。结果纳入8个临床随机对照试验共998例患者。Meta分析结果显示,推拿联合常规药物治疗T2DM(观察组)的总有效率、显效率高于常规药物治疗组(对照组)(P<0.05),观察组无效率低于对照组(P<0.05);观察组与对照组的有效率、改善率比较,差异无统计学意义(P>0.05)。结论推拿治疗T2DM安全有效,但因纳入文献数量较少、质量较低,还需开展大样本、高质量的随机对照试验证实其有效性。展开更多
One-stage partial nitrification coupled with anammox(PN/A)technology effectively reduces the energy consumption of a biological nitrogen removal system.Inhibiting nitrite-oxidizing bacteria(NOB)is essential for this t...One-stage partial nitrification coupled with anammox(PN/A)technology effectively reduces the energy consumption of a biological nitrogen removal system.Inhibiting nitrite-oxidizing bacteria(NOB)is essential for this technology to maintain efficient nitrogen removal performance.Initial ammonium concentration(IAC)affects the degree of inhibited NOB.In this study,the effect of the IAC on a PN/A biofilm was investigated in a moving bed biofilm reactor.The results showed that nitrogen removal efficiency decreased from 82.49%±1.90%to 64.57%±3.96%after the IAC was reduced from 60 to 20 mg N/L,while the nitrate production ratio increased from 13.87%±0.90%to 26.50%±3.76%.NOB activity increased to1,133.86 mg N/m^(2)/day after the IAC decreased,approximately 4-fold,indicating that the IAC plays an important inhibitory role in NOB.The rate-limiting step in the mature biofilm of the PN/A system is the nitritation process and is not shifted by the IAC.The analysis of the microbial community structure in the biofilm indicates that the IAC was the dominant factor in changes in community structure.Ca.Brocadia and Ca.Jettenia were the main anammox bacteria,and Nitrosomonas and Nitrospira were the main AOB and NOB,respectively.IAC did not affect the difference in growth between Ca.Brocadia and Ca.Jettenia.Thus,modulating the IAC promoted the PN/A process with efficient nitrogen removal performance at medium to low ammonium concentrations.展开更多
In this study,a new series of zinc oxide(ZnO)with high specific surface area and narrow energy band gap are prepared using a facile microwave-induced method.The corresponding formation mechanism is also discussed for ...In this study,a new series of zinc oxide(ZnO)with high specific surface area and narrow energy band gap are prepared using a facile microwave-induced method.The corresponding formation mechanism is also discussed for the first time.Due to the introduction of C,these ZnO can be excited by long wave temperature light without harmful short wave radiation,and play an efficient photocatalytic activity.This valuable property fundamentally improves the biological safety of its photocatalytic application.Herein,taking teeth whitening as an example,the photocatalytic performance of ZnO is evaluated.The“pure”yellow light-emitting diode(PYLED)with high biological safety is used as the excitation source.It is found that this method could effectively remove pigment on the tooth surface through physical adsorption.In addition,these ZnO could generate active oxygen to degrade the pigment on the tooth surface under the irradiation of yellow light.Some further optimization of these“warm light”responsive ZnO is also discussed in this systematical study,which could open up new opportunities in biomedical field.展开更多
Michelia alba DC is a highly valuable ornamental plant of the Magnoliaceae family.This evergreen tropical tree commonly grows in Southeast Asia and is adored for its delightful fragrance.Our study assembled the M.alba...Michelia alba DC is a highly valuable ornamental plant of the Magnoliaceae family.This evergreen tropical tree commonly grows in Southeast Asia and is adored for its delightful fragrance.Our study assembled the M.alba haplotype genome MC and MM by utilizing Nanopore ultralong reads,Pacbio Hifi long reads and parental second-generation data.Moreover,the first methylation map of Magnoliaceae was constructed based on the methylation site data obtained using Nanopore data.Metabolomic datasets were generated from the flowers of three different species to assess variations in pigment and volatile compound accumulation.Finally,transcriptome data were generated to link genomic,methylation,and morphological patterns to reveal the reasons underlying the differences between M.alba and its parental lines in petal color,flower shape,and fragrance.We found that the AP1 and AP2 genes are crucial in M.alba petal formation,while the 4CL,PAL,and C4H genes control petal color.The data generated in this study serve as a foundation for future physiological and biochemical research on M.alba,facilitate the targeted improvement of M.alba varieties,and offer a theoretical basis for molecular research on Michelia L.展开更多
文摘目的系统评价推拿治疗2型糖尿病(T2DM)的临床疗效,为T2DM治疗的临床实践提供参考。方法计算机检索中国期刊网、万方、中国生物医学文献库、维普及Pub Med等数据库,所有文献检索时限截止至2016年11月。根据纳入和排除标准,由2位评价者独立进行文献筛选和资料提取,并对纳入文献的质量进行评价,采用Rev Man 5.0软件进行Meta分析。结果纳入8个临床随机对照试验共998例患者。Meta分析结果显示,推拿联合常规药物治疗T2DM(观察组)的总有效率、显效率高于常规药物治疗组(对照组)(P<0.05),观察组无效率低于对照组(P<0.05);观察组与对照组的有效率、改善率比较,差异无统计学意义(P>0.05)。结论推拿治疗T2DM安全有效,但因纳入文献数量较少、质量较低,还需开展大样本、高质量的随机对照试验证实其有效性。
基金supported by the National Natural Science Foundation of China(Nos.52070153,52200175)the Key Research and Development Program of Shaanxi,China(No.2023-YBSF-283)。
文摘One-stage partial nitrification coupled with anammox(PN/A)technology effectively reduces the energy consumption of a biological nitrogen removal system.Inhibiting nitrite-oxidizing bacteria(NOB)is essential for this technology to maintain efficient nitrogen removal performance.Initial ammonium concentration(IAC)affects the degree of inhibited NOB.In this study,the effect of the IAC on a PN/A biofilm was investigated in a moving bed biofilm reactor.The results showed that nitrogen removal efficiency decreased from 82.49%±1.90%to 64.57%±3.96%after the IAC was reduced from 60 to 20 mg N/L,while the nitrate production ratio increased from 13.87%±0.90%to 26.50%±3.76%.NOB activity increased to1,133.86 mg N/m^(2)/day after the IAC decreased,approximately 4-fold,indicating that the IAC plays an important inhibitory role in NOB.The rate-limiting step in the mature biofilm of the PN/A system is the nitritation process and is not shifted by the IAC.The analysis of the microbial community structure in the biofilm indicates that the IAC was the dominant factor in changes in community structure.Ca.Brocadia and Ca.Jettenia were the main anammox bacteria,and Nitrosomonas and Nitrospira were the main AOB and NOB,respectively.IAC did not affect the difference in growth between Ca.Brocadia and Ca.Jettenia.Thus,modulating the IAC promoted the PN/A process with efficient nitrogen removal performance at medium to low ammonium concentrations.
基金This work was supported by the National Natural Science Foundation of China(No.31860263 to Xiaolei Wang)Science Foundation of Jiangxi Provincial Department of Science and Technology(20182BCB22019 to Xigao Cheng)+1 种基金Science Foundation of Jiangxi Provincial Department of Education(KJLD14010,20153BCB23035,20161ACB21002,20165BCB19002 to Xiaolei Wang)Nanchang University Seed Grant for Biomedicine.
文摘In this study,a new series of zinc oxide(ZnO)with high specific surface area and narrow energy band gap are prepared using a facile microwave-induced method.The corresponding formation mechanism is also discussed for the first time.Due to the introduction of C,these ZnO can be excited by long wave temperature light without harmful short wave radiation,and play an efficient photocatalytic activity.This valuable property fundamentally improves the biological safety of its photocatalytic application.Herein,taking teeth whitening as an example,the photocatalytic performance of ZnO is evaluated.The“pure”yellow light-emitting diode(PYLED)with high biological safety is used as the excitation source.It is found that this method could effectively remove pigment on the tooth surface through physical adsorption.In addition,these ZnO could generate active oxygen to degrade the pigment on the tooth surface under the irradiation of yellow light.Some further optimization of these“warm light”responsive ZnO is also discussed in this systematical study,which could open up new opportunities in biomedical field.
基金supported by a project on Hainan Provincial Project of Science and Technology(ZDYF2022XDNY149)Developing Bioinformatics Platform in Hainan Yazhou Bay Seed Lab(B21HJ0001)+1 种基金Supported by the PhD Scientific Research and Innovation Foundation of Sanya Yazhou Bay Science and Technology City(HSPHDSRF-2023-12-007)Hainan University Startup Fund(KYQD(ZR)-20101).
文摘Michelia alba DC is a highly valuable ornamental plant of the Magnoliaceae family.This evergreen tropical tree commonly grows in Southeast Asia and is adored for its delightful fragrance.Our study assembled the M.alba haplotype genome MC and MM by utilizing Nanopore ultralong reads,Pacbio Hifi long reads and parental second-generation data.Moreover,the first methylation map of Magnoliaceae was constructed based on the methylation site data obtained using Nanopore data.Metabolomic datasets were generated from the flowers of three different species to assess variations in pigment and volatile compound accumulation.Finally,transcriptome data were generated to link genomic,methylation,and morphological patterns to reveal the reasons underlying the differences between M.alba and its parental lines in petal color,flower shape,and fragrance.We found that the AP1 and AP2 genes are crucial in M.alba petal formation,while the 4CL,PAL,and C4H genes control petal color.The data generated in this study serve as a foundation for future physiological and biochemical research on M.alba,facilitate the targeted improvement of M.alba varieties,and offer a theoretical basis for molecular research on Michelia L.
