BACKGROUND Neonatal hyperbilirubinemia is a common problem faced by pediatricians.The role of genetic factors in neonatal jaundice has been gradually recognized.This study aims to identify genetic variants that influe...BACKGROUND Neonatal hyperbilirubinemia is a common problem faced by pediatricians.The role of genetic factors in neonatal jaundice has been gradually recognized.This study aims to identify genetic variants that influence the bilirubin level in five patients using next-generation sequencing(NGS).CASE SUMMARY Five neonates with severe hyperbilirubinemia were retrospectively studied.They exhibited bilirubin encephalopathy,hypothyroidism,ABO blood type incompatibility hemolysis,glucose-6-phosphate dehydrogenase(G6PD)deficiency and premature birth,respectively.A customized 22-gene panel was designed,and NGS was carried out for these neonates.Eight variations(G6PD c.G1388A,HBA2 c.C369G,ABCC2 c.C3825G,UGT1A1 c.G211A,SPTB c.A1729G,EPB41 c.G520A,c.1213-4T>G and c.A1474G)were identified in these five neonates.Genetic mutations of these genes are associated with G6PD deficiency,thalassemia,Dubin-Johnson syndrome,Gilbert syndrome,hereditary spherocytosis,and hereditary elliptocytosis.One of the neonates was found to have compound variants of the EPB41 splice site c.1213-4T>G and c.G520A(p.E174K),but no elliptocyte was seen on his blood smear of 4 years old.CONCLUSION Pathological factors of severe neonatal hyperbilirubinemia are complicated.Genetic variants may play an important role in an increased risk of neonatal hyperbilirubinemia,and severe jaundice in neonates may be related to a cumulative effect of genetic variants.展开更多
Overtaking accidents caused by improper operations performed by a driver occur frequently. However, most stud?ies on overtaking safety have neglected research into driver control input. A novel method is proposed to o...Overtaking accidents caused by improper operations performed by a driver occur frequently. However, most stud?ies on overtaking safety have neglected research into driver control input. A novel method is proposed to obtain the driver control input during the overtaking process. Meanwhile, to improve the safety of overtaking, two types of safe distances, and the time of the overtaking are considered. Path constraints are established when considering the two types of safe distances. An optimal control model is established to solve the minimum time maneuver under multiple constraints. Using the Gauss pseudospectral method, the optimal control problem is converted into a nonlinear pro?gramming problem, which is then solved through sequential quadratic programming(SQP). In addition, the e ective?ness of the proposed method is verified based on the results of a Carsim simulation. The simulation results show that by adopting an inverse dynamics method to solve the manipulation problem of the vehicle’s minimum overtaking time, the manipulation capability of a vehicle in completing an overtaking safely within the minimum time can be obtained. This method can provide a reference for research into the active safety of manned and unmanned vehicles.展开更多
BACKGROUND Coronary heart disease(CHD)is a prominent cause of mortality and disability worldwide.Like most complex diseases,the risk of CHD in individuals is regulated by the interaction between genetic factors and li...BACKGROUND Coronary heart disease(CHD)is a prominent cause of mortality and disability worldwide.Like most complex diseases,the risk of CHD in individuals is regulated by the interaction between genetic factors and lifestyle.APOE and SLCO1B1 genetic polymorphisms and LPA KIV-2 copy number variation may influence the development and progression of CHD.Clarifying gene polymor-phisms can guide clinical precision and prevention,thereby improving treatment outcomes.AIM To investigate the influence of APOE and SLCO1B1 gene polymorphisms,as well as LPA KIV-2 copy number variation on CHD in the Teochew population.METHODS A total of 324 patients with CHD and 143 control participants were involved in this study.Single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene,and rs2306283 and rs4149056 in the SLCO1B1 gene were analyzed via high-resolution melting curve analysis.Additionally,PCR was performed to detect KIV-2 copy number variations.Clinical risk factors and potential effects on CHD patients were subsequently assessed.RESULTS In the CHD group,the frequencies of APOE alleleε2,ε3,ε4 were 8.02%,82.97%,and 9.10%,respectively.Compared to the control groups(13.29%,79.37%,and 7.34%,respectively),theε2 allele frequency showed a significant difference(8.02%vs 13.29%,P=0.012).SLCO1B1 allele frequencies in the CHD group were not significantly different from those in the control group(*1a:26.69%vs 25.52%,*1b:61.17%vs 65.38%,*5:0.15%vs 0.35%,*15:11.83%vs 8.74%).The number of copies of the KIV-2 gene was significantly lower in the CHD group when compared to controls(23.35±8.78 vs 27.21±9.48;P<0.01).Logistic regression analysis revealed that sex,age,hypertension,diabetes,smoking,theε2 allele and KIV-2 copy number were factors influencing the presence of CHD.CONCLUSION In the Teochew population,the APOEε2 allele and a higher KIV-2 copy number were associated with a reduced risk of CHD.In contrast,the APOEε4 allele and SLCO1B1 gene were not associated with CHD.展开更多
Non-pneumatic wheels inherently offer explosion-proof advantages compared to pneumatic wheel.Our team innovatively proposed an“elastic ring-hinge group”type non-pneumatic mechanical elastic wheel(ME-Wheel).To analyz...Non-pneumatic wheels inherently offer explosion-proof advantages compared to pneumatic wheel.Our team innovatively proposed an“elastic ring-hinge group”type non-pneumatic mechanical elastic wheel(ME-Wheel).To analyze the gas flow characteristics around the ME-Wheel,this study analyzed the aerodynamic characteristics of the MEWheel for the first time by using CFD calculation method,and studied the influences of speed,steering angle,camber angle and hinge group on the aerodynamic characteristics of the wheel.Compared with camber angle,steering angle has a more significant effect on the aerodynamic characteristics of non-pneumatic mechanical elastic wheels in terms of lift and drag.Speed has no significant effect on the wheel drag coefficient and lift coefficient.The number of hinge groups has a significant effect on wheel aerodynamic characteristics.The deviations between the maximum and minimum values of drag,lift,drag coefficient,and lift coefficient are 6.06%,8.57%,6.05%,and 8.6%,respectively.This study addresses a critical gap in the design optimization of ME-Wheel,provides a theoretical basis for the aerodynamic optimization of ME-Wheel,and has strong practical significance for the commercial development of nonpneumatic mechanical elastic wheels.展开更多
The current research of autonomous vehicle motion control mainly focuses on trajectory tracking and velocity tracking. However, numerous studies deal with trajectory tracking and velocity tracking separately, and the ...The current research of autonomous vehicle motion control mainly focuses on trajectory tracking and velocity tracking. However, numerous studies deal with trajectory tracking and velocity tracking separately, and the yaw stability is seldom considered during trajectory tracking. In this research, a combination of the longitudinal–lateral control method with the yaw stability in the trajectory tracking for autonomous vehicles is studied. Based on the vehicle dynamics, considering the longitudinal and lateral motion of the vehicle, the velocity tracking and trajectory tracking problems can be attributed to the longitudinal and lateral control. A sliding mode variable structure control method is used in the longitudinal control. The total driving force is obtained from the velocity error in order to carry out velocity tracking. A linear time-varying model predictive control method is used in the lateral control to predict the required front wheel angle for trajectory tracking. Furthermore, a combined control framework is established to control the longitudinal and lateral motions and improve the reliability of the longitudinal and lateral direction control. On this basis, the driving force of a tire is allocated reasonably by using the direct yaw moment control, which ensures good yaw stability of the vehicle when tracking the trajectory. Simulation results indicate that the proposed control strategy is good in tracking the reference velocity and trajectory and improves the performance of the stability of the vehicle.展开更多
The accurate estimation of road friction coeffi- cient in the active safety control system has become increasingly prominent. Most previous studies on road friction estimation have only used vehicle longitudinal or la...The accurate estimation of road friction coeffi- cient in the active safety control system has become increasingly prominent. Most previous studies on road friction estimation have only used vehicle longitudinal or lateral dynamics and often ignored the load transfer, which tends to cause inaccurate of the actual road friction coef- ficient. A novel method considering load transfer of front and rear axles is proposed to estimate road friction coef- ficient based on braking dynamic model of two-wheeled vehicle. Sliding mode control technique is used to build the ideal braking torque controller, which control target is to control the actual wheel slip ratio of front and rear wheels tracking the ideal wheel slip ratio. In order to eliminate the chattering problem of the sliding mode controller, integral switching surface is used to design the sliding mode sur- face. A second order linear extended state observer is designed to observe road friction coefficient based on wheel speed and braking torque of front and rear wheels. The proposed road friction coefficient estimation schemes are evaluated by simulation in ADAMS/Car. The results show that the estimated values can well agree with the actual values in different road conditions. The observer can estimate road friction coefficient exactly in real-time andresist external disturbance. The proposed research provides a novel method to estimate road friction coefficient with strong robustness and more accurate.展开更多
BACKGROUND Neonatal hyperbilirubinemia is one of the common diseases of newborns that typically presents with yellow staining of skin,resulting in sequelaes such as hearing loss,motor and intellectual development diso...BACKGROUND Neonatal hyperbilirubinemia is one of the common diseases of newborns that typically presents with yellow staining of skin,resulting in sequelaes such as hearing loss,motor and intellectual development disorders,and even death.The pathogenic factors of neonatal hyperbilirubinemia are complex.Different cases of hyperbilirubinemia may have a single or mixed etiology.AIM To explore the etiological characteristics of severe hyperbilirubinemia in term newborns of eastern Guangdong of China.METHODS Term newborns with severe hyperbilirubinemia in one hospital from January 2012 to December 2021 were retrospectively analyzed.The etiology was determined according to the laboratory results and clinical manifestations.RESULTS Among 1602 term newborns with hyperbilirubinemia in eastern Guangdong of China,32.20%(580/1602)was severe hyperbilirubinemia.Among the causes of severe hyperbilirubinemia,neonatal hemolysis accounted for 15.17%,breast milk jaundice accounted for 12.09%,infection accounted for 10.17%,glucose-6-phosphate dehydrogenase(G6PD)deficiency accounted for 9.14%,and the coexistence of multiple etiologies accounted for 6.55%,unknown etiology accounted for 41.72%.ABO hemolysis and G6PD deficiency were the most common causes in the 20 cases with bilirubin encephalopathy.94 severe hyperbilirubinemia newborns were tested for uridine diphosphate glucuronosyl transferase 1A1(UGT1A1)*6 variant(rs4148323,c.211G>A,p.Arg71Gly),9 cases were 211 G to A homozygous variant,37 cases were 211 G to A heterozygous variant,and 48 cases were wild genotypes.CONCLUSION The main cause for severe hyperbilirubinemia and bilirubin encephalopathy in eastern Guangdong of China were the hemolytic disease of the newborns,G6PD deficiency and infection.UGT1A1 gene variant was also a high-risk factor for neonatal hyperbilirubinemia.Targeted prevention and treatment according to the etiology may reduce the occurrence of bilirubin encephalopathy and kernicterus.展开更多
Machining and installation errors are unavoidable in mechanical structures. However, the effect of errors on radial stiffness of the mechanical elastic wheel(ME-Wheel) is not considered in previous studies. To this en...Machining and installation errors are unavoidable in mechanical structures. However, the effect of errors on radial stiffness of the mechanical elastic wheel(ME-Wheel) is not considered in previous studies. To this end, the interval mathematical model and interval finite element model of the ME-Wheel were both established and compared with bench test results. The intercomparison of the influence of the machining and installation errors on the ME-Wheel radial stiffness revealed good consistency among the interval mathematical analysis, interval finite element simulation,and bench test results. Within the interval range of the ME-Wheel machining and installation errors, parametric analysis of the combined elastic rings was performed at different initial radial rigidity values. The results showed that the initial radial stiffness of the flexible tire body significantly influenced the ME-Wheel radial stiffness, and the inverse relationship between the hinge unit length or suspension hub and the radial stiffness was nonlinear. The radial stiffness of the ME-Wheel is predicted by using the interval algorithm for the first time, and the regularity of the radial stiffness between the error and the load on the ME-Wheel is studied, which will lay the foundation for the exact study of the ME-Wheel dynamic characteristics in the future.展开更多
Aiming at the independent development of tracked vehicles,it is urgent to improve its mobility,passability and ride comfort,a new type of flexible road wheel with a“wheel-hinge-hub”combined structure is proposed in ...Aiming at the independent development of tracked vehicles,it is urgent to improve its mobility,passability and ride comfort,a new type of flexible road wheel with a“wheel-hinge-hub”combined structure is proposed in this study.The vibration model characteristics of the flexible road wheel were studied by the combination of numerical simulation and experiments.The superelasticity of rubber is obtained through uniaxial tensile experiment of the material and a detail three-dimensional nolinear finite element model of the flexible road wheel is established through finite element software ABAQUS.The free vibration equation of the flexible road wheel is solved by Lanczos vector direct superposition method,and its predicted modes and natural frequencies are compared with experimental results,which verifies the accuracy and reliability of the established finite element model.On this basis,the effects of various key structural or material factors on the natural frequencies of the flexible road wheel are studied using orthogonal experimental design method.Besides,the vibration modal characteristics of the flexible road wheel are also compared with those of the rigid road wheel.The research results provide a theoretical basis for the vibration and noise reduction of flexible road wheel.展开更多
The presence of defects and detrimental reactions at NiO_(x)/perovskite interface extremely limit the efficiency performance and long-term stability of the perovskite solar cells(PSCs) based on NiO_(x).Herein,an amphi...The presence of defects and detrimental reactions at NiO_(x)/perovskite interface extremely limit the efficiency performance and long-term stability of the perovskite solar cells(PSCs) based on NiO_(x).Herein,an amphipathic molecule Triton X100(Triton) is modified on the NiO_(x)surface.The hydrophilic chain of Triton as a Lewis base additive can coordinate with the Ni3+on the NiO_(x)surface which can passivate the interfacial defects and hinder the detrimental reactions at the NiO_(x)/perovskite interface.Additionally,the hydrophobic chain of Triton protrudes from the NiO_(x)surface to prevent moisture from penetrating into the NiO_(x)/perovskite interface.Consequently,the NiO_(x)/Triton-based devices(MAPbI3as absorbing layer) show superior moisture and thermal stability,retaining 88.4% and 64.3% of the initial power conversion efficiency after storage in air(40%-50% relative humidity(RH)) at 25 ℃ for 1070 h and in N2at 85℃ for 800 h,respectively.Moreover,the efficiency increases from 17.59% to 19.89% because of the passivation defect and enhanced hole-extraction capability.Besides,the NiO_(x)/Triton-based PSCs with Cs_(0.05)(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))3perovskite as the light-absorbing layer also exhibits better moisture and thermal stability compared to the control devices,indicating the viability of our strategies.Of particular note,a champion PCE of 22.35% and 20.46% was achieved for small-area(0.1 cm^(2)) and large-area(1.2 cm^(2)) NiO_(x)/Triton-based devices,respectively.展开更多
Electron transport layers(ETLs)are crucial for achieving efficient and stable planar perovskite solar cells(PSCs).Reports on versatile inorganic ETLs using a simple film fabrication method and applicability for both l...Electron transport layers(ETLs)are crucial for achieving efficient and stable planar perovskite solar cells(PSCs).Reports on versatile inorganic ETLs using a simple film fabrication method and applicability for both low-cost planar regular and inverted PSCs with excellent efficiencies(>22%)and high stability are very limited.Herein,we employ a novel inorganic ZnSe as ETL for both regular and inverted PSCs to improve the efficiency and stability using a simple thermal evaporation method.The TiO_(2)-ZnSe-FAPbl_(3)heterojunction could be formed,resulting in an improved charge collection and a decreased carrier recombination further proved through theoretical calculations.The optimized regular PSCs based on TiO_(2)/ZnSe have achieved 23.25%efficiency with negligible hysteresis.In addition,the ZnSe ETL can also effectively replace the unstable bathocuproine(BCP)in inverted PSCs.Consequently,the ZnSe-based inverted device realizes a champion efficiency of 22.54%.Moreover,the regular device comprising the TiO_(2)/ZnSe layers retains 92%of its initial PCE after 10:00 h under 1 Sun continuous illumination and the inverted device comprising the C_(60)/ZnSe layers maintains over 85%of its initial PCE at 85℃for 10:00 h.This highlights one of the best results among universal ETLs in both regular and inverted perovskite photovoltaics.展开更多
Enhancing ride comfort has always constituted a crucial focus in the design and research of modern tracked vehicles,heavily reliant on the driving system's performance.While the road wheel is a key component of th...Enhancing ride comfort has always constituted a crucial focus in the design and research of modern tracked vehicles,heavily reliant on the driving system's performance.While the road wheel is a key component of the driving system,traditional road wheels predominantly adopt a solid structure,exhibiting subpar adhesion performance and damping effects,thereby falling short of meeting the demands for high-speed,stable,and long-distance driving in tracked vehicles.Addressing this issue,this paper proposes a novel type of flexible road wheel(FRW)characterized by a catenary construction.The study investigates the ride comfort of tracked vehicles equipped with flexible road wheels by integrating finite element and vehicle dynamic.First,three-dimensional(3D)finite element(FE)models of both flexible and rigid road wheels are established,considering material and contact nonlinearities.These models are validated through a wheel radial loading test.Based on the validated FE model,the paper uncovers the relationship between load and radial deformation of the road wheel,forming the basis for a nonlinear mathematical model.Subsequently,a half-car model of a tracked vehicle with seven degrees of freedom is established using Newton's second law.A random road model,considering the track effect and employing white noise,is constructed.The study concludes by examining the ride comfort of tracked vehicles equipped with flexible and rigid road wheels under various speeds and road grades.The results demonstrate that,in comparison to the rigid road wheel(RRW),the flexible road wheel enhances the ride comfort of tracked vehicles on randomly uneven roads.This research provides a theoretical foundation for the implementation of flexible road wheels in tracked vehicles.展开更多
The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite interface.In this study,a novel microstructure-control technology is ...The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite interface.In this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination agent.The synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite interface.Consequently,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FTO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.This study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.展开更多
Scrub typhus is a significant public health issue with a wide distribution and is influenced by various determinants.However,in order to effectively eradicate scrub typhus,it is crucial to identify the specific factor...Scrub typhus is a significant public health issue with a wide distribution and is influenced by various determinants.However,in order to effectively eradicate scrub typhus,it is crucial to identify the specific factors that contribute to its incidence at a detailed level.Therefore,the objective of our study is to identify these influencing factors,examine the spatial variations in incidence,and analyze the interplay of two factors on scrub typhus incidence,so as to provide valuable experience for the prevention and treatment of scrub typhus in Gannan and to alleviate the economic burden of the local population.This study employed spatial autocorrelation analyses to examine the dependent variable and ordinary least squares model residuals.Additionally,spatial regression modelling and geographical detector were used to analyze the factors influencing the annual mean 14-year incidence of scrub typhus in the streets/townships of Gannan region from 2008 to 2021.The results of spatial1 autocorrelation analyses indicated the presence of spatial correlation.Among the global spatial regression models,the spatial lag model was found to be the best fitting model(log likelihood ratio?319.3029,AIC?666.6059).The results from the SLM analysis indicated that DEM,mean temperature,and mean wind speed were the primary factors influencing the occurrence of scrub typhus.For the local spatial regression models,the multiscale geographically weighted regression was determined to be the best fitting model(adjusted R2?0.443,AICc?726.489).Further analysis using the MGWR model revealed that DEM had a greater impact in Xinfeng and Longnan,while the southern region was found to be more susceptible to scrub typhus due to mean wind speed.The geographical detector results revealed that the incidence of scrub typhus was primarily influenced by annual average normalized difference vegetation index.Additionally,the interaction between GDP and the percentage of grassland area had a significant impact on the incidence of scrub typhus(q?0.357).This study illustrated the individual and interactive effects of natural environmental factors and socio-economic factors on the incidence of scrub typhus;and elucidated the specific factors affecting the incidence of scrub typhus in various streets/townships.The findings of this study can be used to develop effective interventions for the prevention and control of scrub typhus.展开更多
Gelatin as one kind of nano-drug carrier is a polysaccharide which can be absorbed after releasing all nano-drugs.Poly(ethylene glycol)as a polymer material that can modify nano-drugs is able to extend circulatory tim...Gelatin as one kind of nano-drug carrier is a polysaccharide which can be absorbed after releasing all nano-drugs.Poly(ethylene glycol)as a polymer material that can modify nano-drugs is able to extend circulatory time of doxorubicin and aspirin,enhance stability and reduce toxicity.At precancerous,aspirin will be released slowly to resist inflammation.When tumor cell appears at a more advance stage,doxorubicin release from Gel to achieve anti-tumor effect.After all those steps,poly(ethylene glycol)could be expelled from body.In brief,the nano-drug that has doxorubicin and aspirin is able to prevent the growth of tumor cells and kill them when they appear more precisely.展开更多
Metal halide perovskites possess appealing optoelectronic properties and have been widely applied for solar energy harvesting and light emitting.Although perovskite solar cells(PeSCs)and perovskite light-emitting diod...Metal halide perovskites possess appealing optoelectronic properties and have been widely applied for solar energy harvesting and light emitting.Although perovskite solar cells(PeSCs)and perovskite light-emitting diodes(PeLEDs)have been developed rapidly in recent years,there are still no universal rules for the selection of perovskites to achieve high-performance optoelectronic devices.In this review,the working mechanisms of PeSCs and PeLEDs are first demonstrated with the discussion on the factors which determine the device performance.We then examine the optoelectronic properties of perovskites with structures modulated from 3D,2D,1D to 0D,and analyze the corresponding structure-property relationships in terms of photo-electric and electric-photo conversion processes.Based on the unique optoelectronic properties of structurally modulated perovskites,we put forward the concept of structural assembling engineering that integrate the merits of different types of perovskites within one matrix and elaborate their excellent properties for applications of both PeSCs and PeLEDs.Finally,we discuss the potential challenges and provide our perspectives on the structural assembling engineering of perovskites for future optoelectronic applications.展开更多
Hepatic stellate cells(HSCs)are the primary fibrogenic cells in the liver,and their activation plays a crucial role in the development and progression of hepatic fibrosis.Here,we report that retinoid X receptor-alpha(...Hepatic stellate cells(HSCs)are the primary fibrogenic cells in the liver,and their activation plays a crucial role in the development and progression of hepatic fibrosis.Here,we report that retinoid X receptor-alpha(RXRα),a unique member of the nuclear receptor superfamily,is a key modulator of HSC activation and liver fibrosis.RXRαexerts its effects by modulating calcium/calmodulin-dependent protein kinase kinaseβ(CaMKKβ)-mediated activation of AMP-activated protein kinase-alpha(AMPKα).In addition,we demonstrate that K-80003,which binds RXRαby a unique mechanism,effectively suppresses HSC activation,proliferation,and migration,thereby inhibiting liver fibrosis in the CCl4 and amylin liver NASH(AMLN)diet animal models.The effect is mediated by AMPKαactivation,promoting mitophagy in HSCs.Mechanistically,K-80003 activates AMPKαby inducing RXRαto form condensates with CaMKKβand AMPKαvia a two-phase process.The formation of RXRαcondensates is driven by its N-terminal intrinsic disorder region and requires phosphorylation by CaMKKβ.Our results reveal a crucial role of RXRαin liver fibrosis regulation through modulating mitochondrial activities in HSCs.Furthermore,they suggest that K-80003 and related RXRαmodulators hold promise as therapeutic agents for fibrosis-related diseases.展开更多
Scrub typhus poses a serious public health risk globally.Forecasting the occurrence of the disease is essential for policymakers to develop prevention and control strategies.This study investigated the application of ...Scrub typhus poses a serious public health risk globally.Forecasting the occurrence of the disease is essential for policymakers to develop prevention and control strategies.This study investigated the application of modelling techniques to predict the occurrence of scrub typhus and establishes an early warning system aimed at providing a foundational reference for its effective prevention and control.In this study,the monthly occurrence of scrub typhus in Ganzhou City from January 2008 to December 2022 was utilized as the training set for the first part of the analysis,while the data from January 2008 to December 2019 served as the training set for the second part.Based1 on these data,the SARIMA model,the BPNN model,and the combined SARIMA-BPNN model were developed and validated using data from January to December 2023.The most effective model was then selected to predict the number of occurrences of scrub typhus for the years 2024 and 2025,respectively.The root mean square error(RMSE)and mean absolute error(MAE)of the BPNN(3-9-1)model,developed using data from January 2008 to December 2022,were 8.472 and 6.4,respectively.In contrast,the RMSE and MAE of the combined SARIMA-BPNN(1-9-1)model,constructed using data from January 2008 to December 2019,were 19.361 and 16.178,respectively.In addition,the BPNN(3-9-1)model predicted 284 cases of scrub typhus in Ganzhou City for 2024,and 163 cases for 2025.The BPNN(3-9-1)model demonstrated strong applicability in predicting the monthly occurrence of scrub typhus.Furthermore,incorporating three years of data on the occurrence of new crown outbreaks when developing a predictive model for infectious diseases can substantially enhance prediction accuracy.展开更多
This paper proposes an adaptive-neural-network based robust hierarchical path-tracking controller for autonomous fourwheel-independent-drive electric vehicles(4WID-EVs)with parametric uncertainties and external distur...This paper proposes an adaptive-neural-network based robust hierarchical path-tracking controller for autonomous fourwheel-independent-drive electric vehicles(4WID-EVs)with parametric uncertainties and external disturbances.Firstly,considering the uncertain tire cornering stiffness and longitudinal speed,a control-oriented mismatched norm bounded uncertain system model of 4WID-EVs is established by using Takagi–Sugeno(T–S)fuzzy modeling approach.Secondly,an adaptive integral sliding mode controller combined with radial basis function neural network(RBFNN)is proposed,in which an improved RBFNN is used to approximate uncertain dynamics to improve tracking performance and reduce chattering.A sufficient condition for the asymptotic stability of sliding mode dynamics is given based on linear matrix inequality.According to Lyapunov theory,it has been proved that the estimation errors are bounded and finally converge near the origin.Further,a novel torque vectoring algorithm is introduced to allocate longitudinal driving force and additional yaw moment,aiming to reduce tire load rate and slip energy consumption,in which the weights assigned to the two objective functions are determined by taking into account the customized vehicle stability index and slip rate.Finally,the simulation results conducted on the CarSim-Simulink platform confirm the outstanding tracking and energy-efficient performance of the proposed controller.展开更多
文摘BACKGROUND Neonatal hyperbilirubinemia is a common problem faced by pediatricians.The role of genetic factors in neonatal jaundice has been gradually recognized.This study aims to identify genetic variants that influence the bilirubin level in five patients using next-generation sequencing(NGS).CASE SUMMARY Five neonates with severe hyperbilirubinemia were retrospectively studied.They exhibited bilirubin encephalopathy,hypothyroidism,ABO blood type incompatibility hemolysis,glucose-6-phosphate dehydrogenase(G6PD)deficiency and premature birth,respectively.A customized 22-gene panel was designed,and NGS was carried out for these neonates.Eight variations(G6PD c.G1388A,HBA2 c.C369G,ABCC2 c.C3825G,UGT1A1 c.G211A,SPTB c.A1729G,EPB41 c.G520A,c.1213-4T>G and c.A1474G)were identified in these five neonates.Genetic mutations of these genes are associated with G6PD deficiency,thalassemia,Dubin-Johnson syndrome,Gilbert syndrome,hereditary spherocytosis,and hereditary elliptocytosis.One of the neonates was found to have compound variants of the EPB41 splice site c.1213-4T>G and c.G520A(p.E174K),but no elliptocyte was seen on his blood smear of 4 years old.CONCLUSION Pathological factors of severe neonatal hyperbilirubinemia are complicated.Genetic variants may play an important role in an increased risk of neonatal hyperbilirubinemia,and severe jaundice in neonates may be related to a cumulative effect of genetic variants.
基金Supported by National Natural Science Foundation of China(Grant No.11672127)Fundamental Research Funds for the Central Universities of China(Grant No.NP2016412)
文摘Overtaking accidents caused by improper operations performed by a driver occur frequently. However, most stud?ies on overtaking safety have neglected research into driver control input. A novel method is proposed to obtain the driver control input during the overtaking process. Meanwhile, to improve the safety of overtaking, two types of safe distances, and the time of the overtaking are considered. Path constraints are established when considering the two types of safe distances. An optimal control model is established to solve the minimum time maneuver under multiple constraints. Using the Gauss pseudospectral method, the optimal control problem is converted into a nonlinear pro?gramming problem, which is then solved through sequential quadratic programming(SQP). In addition, the e ective?ness of the proposed method is verified based on the results of a Carsim simulation. The simulation results show that by adopting an inverse dynamics method to solve the manipulation problem of the vehicle’s minimum overtaking time, the manipulation capability of a vehicle in completing an overtaking safely within the minimum time can be obtained. This method can provide a reference for research into the active safety of manned and unmanned vehicles.
基金Supported by Special Research Plan 2023 of Chaozhou,No.202303GY05。
文摘BACKGROUND Coronary heart disease(CHD)is a prominent cause of mortality and disability worldwide.Like most complex diseases,the risk of CHD in individuals is regulated by the interaction between genetic factors and lifestyle.APOE and SLCO1B1 genetic polymorphisms and LPA KIV-2 copy number variation may influence the development and progression of CHD.Clarifying gene polymor-phisms can guide clinical precision and prevention,thereby improving treatment outcomes.AIM To investigate the influence of APOE and SLCO1B1 gene polymorphisms,as well as LPA KIV-2 copy number variation on CHD in the Teochew population.METHODS A total of 324 patients with CHD and 143 control participants were involved in this study.Single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene,and rs2306283 and rs4149056 in the SLCO1B1 gene were analyzed via high-resolution melting curve analysis.Additionally,PCR was performed to detect KIV-2 copy number variations.Clinical risk factors and potential effects on CHD patients were subsequently assessed.RESULTS In the CHD group,the frequencies of APOE alleleε2,ε3,ε4 were 8.02%,82.97%,and 9.10%,respectively.Compared to the control groups(13.29%,79.37%,and 7.34%,respectively),theε2 allele frequency showed a significant difference(8.02%vs 13.29%,P=0.012).SLCO1B1 allele frequencies in the CHD group were not significantly different from those in the control group(*1a:26.69%vs 25.52%,*1b:61.17%vs 65.38%,*5:0.15%vs 0.35%,*15:11.83%vs 8.74%).The number of copies of the KIV-2 gene was significantly lower in the CHD group when compared to controls(23.35±8.78 vs 27.21±9.48;P<0.01).Logistic regression analysis revealed that sex,age,hypertension,diabetes,smoking,theε2 allele and KIV-2 copy number were factors influencing the presence of CHD.CONCLUSION In the Teochew population,the APOEε2 allele and a higher KIV-2 copy number were associated with a reduced risk of CHD.In contrast,the APOEε4 allele and SLCO1B1 gene were not associated with CHD.
基金Supported by National Natural Science Foundation of China(Grant Nos.52472411,52272397)the Key Research&Development and Achievement Transformation Program of Wuhu(Grant No.2023YF010)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX25_0566).
文摘Non-pneumatic wheels inherently offer explosion-proof advantages compared to pneumatic wheel.Our team innovatively proposed an“elastic ring-hinge group”type non-pneumatic mechanical elastic wheel(ME-Wheel).To analyze the gas flow characteristics around the ME-Wheel,this study analyzed the aerodynamic characteristics of the MEWheel for the first time by using CFD calculation method,and studied the influences of speed,steering angle,camber angle and hinge group on the aerodynamic characteristics of the wheel.Compared with camber angle,steering angle has a more significant effect on the aerodynamic characteristics of non-pneumatic mechanical elastic wheels in terms of lift and drag.Speed has no significant effect on the wheel drag coefficient and lift coefficient.The number of hinge groups has a significant effect on wheel aerodynamic characteristics.The deviations between the maximum and minimum values of drag,lift,drag coefficient,and lift coefficient are 6.06%,8.57%,6.05%,and 8.6%,respectively.This study addresses a critical gap in the design optimization of ME-Wheel,provides a theoretical basis for the aerodynamic optimization of ME-Wheel,and has strong practical significance for the commercial development of nonpneumatic mechanical elastic wheels.
基金Supported by National Natural Science Foundation of China(Grant Nos.51575103,11672127,U1664258)Fundamental Research Funds for the Central Universities of China(Grant No.NT2018002)+1 种基金China Postdoctoral Science Foundation(Grant Nos.2017T100365,2016M601799)the Fundation of Graduate Innovation Center in NUAA(Grant No.k j20180207)
文摘The current research of autonomous vehicle motion control mainly focuses on trajectory tracking and velocity tracking. However, numerous studies deal with trajectory tracking and velocity tracking separately, and the yaw stability is seldom considered during trajectory tracking. In this research, a combination of the longitudinal–lateral control method with the yaw stability in the trajectory tracking for autonomous vehicles is studied. Based on the vehicle dynamics, considering the longitudinal and lateral motion of the vehicle, the velocity tracking and trajectory tracking problems can be attributed to the longitudinal and lateral control. A sliding mode variable structure control method is used in the longitudinal control. The total driving force is obtained from the velocity error in order to carry out velocity tracking. A linear time-varying model predictive control method is used in the lateral control to predict the required front wheel angle for trajectory tracking. Furthermore, a combined control framework is established to control the longitudinal and lateral motions and improve the reliability of the longitudinal and lateral direction control. On this basis, the driving force of a tire is allocated reasonably by using the direct yaw moment control, which ensures good yaw stability of the vehicle when tracking the trajectory. Simulation results indicate that the proposed control strategy is good in tracking the reference velocity and trajectory and improves the performance of the stability of the vehicle.
基金Supported by Fundamental Research Funds for the Central Universities(Grant No.NS2015015)
文摘The accurate estimation of road friction coeffi- cient in the active safety control system has become increasingly prominent. Most previous studies on road friction estimation have only used vehicle longitudinal or lateral dynamics and often ignored the load transfer, which tends to cause inaccurate of the actual road friction coef- ficient. A novel method considering load transfer of front and rear axles is proposed to estimate road friction coef- ficient based on braking dynamic model of two-wheeled vehicle. Sliding mode control technique is used to build the ideal braking torque controller, which control target is to control the actual wheel slip ratio of front and rear wheels tracking the ideal wheel slip ratio. In order to eliminate the chattering problem of the sliding mode controller, integral switching surface is used to design the sliding mode sur- face. A second order linear extended state observer is designed to observe road friction coefficient based on wheel speed and braking torque of front and rear wheels. The proposed road friction coefficient estimation schemes are evaluated by simulation in ADAMS/Car. The results show that the estimated values can well agree with the actual values in different road conditions. The observer can estimate road friction coefficient exactly in real-time andresist external disturbance. The proposed research provides a novel method to estimate road friction coefficient with strong robustness and more accurate.
基金Supported by the Natural Science Foundation of Guangdong Province,No.2016A030307035Special Research Plan 2019 of Chaozhou,No.2020xg01High-Level Development Plan of People’s Hospital of Yangjiang,No.G2020007.
文摘BACKGROUND Neonatal hyperbilirubinemia is one of the common diseases of newborns that typically presents with yellow staining of skin,resulting in sequelaes such as hearing loss,motor and intellectual development disorders,and even death.The pathogenic factors of neonatal hyperbilirubinemia are complex.Different cases of hyperbilirubinemia may have a single or mixed etiology.AIM To explore the etiological characteristics of severe hyperbilirubinemia in term newborns of eastern Guangdong of China.METHODS Term newborns with severe hyperbilirubinemia in one hospital from January 2012 to December 2021 were retrospectively analyzed.The etiology was determined according to the laboratory results and clinical manifestations.RESULTS Among 1602 term newborns with hyperbilirubinemia in eastern Guangdong of China,32.20%(580/1602)was severe hyperbilirubinemia.Among the causes of severe hyperbilirubinemia,neonatal hemolysis accounted for 15.17%,breast milk jaundice accounted for 12.09%,infection accounted for 10.17%,glucose-6-phosphate dehydrogenase(G6PD)deficiency accounted for 9.14%,and the coexistence of multiple etiologies accounted for 6.55%,unknown etiology accounted for 41.72%.ABO hemolysis and G6PD deficiency were the most common causes in the 20 cases with bilirubin encephalopathy.94 severe hyperbilirubinemia newborns were tested for uridine diphosphate glucuronosyl transferase 1A1(UGT1A1)*6 variant(rs4148323,c.211G>A,p.Arg71Gly),9 cases were 211 G to A homozygous variant,37 cases were 211 G to A heterozygous variant,and 48 cases were wild genotypes.CONCLUSION The main cause for severe hyperbilirubinemia and bilirubin encephalopathy in eastern Guangdong of China were the hemolytic disease of the newborns,G6PD deficiency and infection.UGT1A1 gene variant was also a high-risk factor for neonatal hyperbilirubinemia.Targeted prevention and treatment according to the etiology may reduce the occurrence of bilirubin encephalopathy and kernicterus.
基金Supported by National Natural Science Foundation of China(Grant No.11672127)Major Exploration Project of the General Armaments Department of China(Grant No.NHA13002)+1 种基金Fundamental Research Funds for the Central Universities of China(Grant No.NP2016412,NP2018403,NT2018002)Jiangsu Provincial Innovation Program for Graduate Education and the Fundamental Research Funds for the Central Universities of China(Grant No.KYLX16_0330)
文摘Machining and installation errors are unavoidable in mechanical structures. However, the effect of errors on radial stiffness of the mechanical elastic wheel(ME-Wheel) is not considered in previous studies. To this end, the interval mathematical model and interval finite element model of the ME-Wheel were both established and compared with bench test results. The intercomparison of the influence of the machining and installation errors on the ME-Wheel radial stiffness revealed good consistency among the interval mathematical analysis, interval finite element simulation,and bench test results. Within the interval range of the ME-Wheel machining and installation errors, parametric analysis of the combined elastic rings was performed at different initial radial rigidity values. The results showed that the initial radial stiffness of the flexible tire body significantly influenced the ME-Wheel radial stiffness, and the inverse relationship between the hinge unit length or suspension hub and the radial stiffness was nonlinear. The radial stiffness of the ME-Wheel is predicted by using the interval algorithm for the first time, and the regularity of the radial stiffness between the error and the load on the ME-Wheel is studied, which will lay the foundation for the exact study of the ME-Wheel dynamic characteristics in the future.
基金the National Natural Science Foundation of China[grant numbers 11672127,51605215]the Advance Research Special Technology Project of Army Equipment[grant number AGA19001]+2 种基金the Army Research and Technology Project[grant number AQA19001],the Innovation Fund Project of China Aerospace 1st Academy[grant number CHC20001]the Special funded project of China Postdoctoral Science Foundation[grant number 2019T120450]the Fundamental Research Funds for the Central Universities[grant number NP2020407].
文摘Aiming at the independent development of tracked vehicles,it is urgent to improve its mobility,passability and ride comfort,a new type of flexible road wheel with a“wheel-hinge-hub”combined structure is proposed in this study.The vibration model characteristics of the flexible road wheel were studied by the combination of numerical simulation and experiments.The superelasticity of rubber is obtained through uniaxial tensile experiment of the material and a detail three-dimensional nolinear finite element model of the flexible road wheel is established through finite element software ABAQUS.The free vibration equation of the flexible road wheel is solved by Lanczos vector direct superposition method,and its predicted modes and natural frequencies are compared with experimental results,which verifies the accuracy and reliability of the established finite element model.On this basis,the effects of various key structural or material factors on the natural frequencies of the flexible road wheel are studied using orthogonal experimental design method.Besides,the vibration modal characteristics of the flexible road wheel are also compared with those of the rigid road wheel.The research results provide a theoretical basis for the vibration and noise reduction of flexible road wheel.
基金supported by the National Key Research and Development Program of China(2018YFA0208701)the National Natural Science Foundation of China(21773308)+7 种基金the Research Funds of Renmin University of China(2017030013,201903020 and 20XNH059)the Fundamental Research Funds for Central Universities(China)supported by the Solar Energy Research Institute of Singapore(SERIS) at the National University of Singapore(NUS)supported by NUSthe National Research Foundation Singapore(NRF)the Energy Market Authority of Singapore(EMA)the Singapore Economic Development Board(EDB)the financial support from the China Scholarship Council(CSC) funding。
文摘The presence of defects and detrimental reactions at NiO_(x)/perovskite interface extremely limit the efficiency performance and long-term stability of the perovskite solar cells(PSCs) based on NiO_(x).Herein,an amphipathic molecule Triton X100(Triton) is modified on the NiO_(x)surface.The hydrophilic chain of Triton as a Lewis base additive can coordinate with the Ni3+on the NiO_(x)surface which can passivate the interfacial defects and hinder the detrimental reactions at the NiO_(x)/perovskite interface.Additionally,the hydrophobic chain of Triton protrudes from the NiO_(x)surface to prevent moisture from penetrating into the NiO_(x)/perovskite interface.Consequently,the NiO_(x)/Triton-based devices(MAPbI3as absorbing layer) show superior moisture and thermal stability,retaining 88.4% and 64.3% of the initial power conversion efficiency after storage in air(40%-50% relative humidity(RH)) at 25 ℃ for 1070 h and in N2at 85℃ for 800 h,respectively.Moreover,the efficiency increases from 17.59% to 19.89% because of the passivation defect and enhanced hole-extraction capability.Besides,the NiO_(x)/Triton-based PSCs with Cs_(0.05)(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))3perovskite as the light-absorbing layer also exhibits better moisture and thermal stability compared to the control devices,indicating the viability of our strategies.Of particular note,a champion PCE of 22.35% and 20.46% was achieved for small-area(0.1 cm^(2)) and large-area(1.2 cm^(2)) NiO_(x)/Triton-based devices,respectively.
基金supported by the Solar Energy Research Institute of Singapore(SERIS)at the National University of Singapore(NUS).SERIS is supported by NUS,the National Research Foundation Singapore(NRF),the Energy Market Authority of Singapore(EMA),and the Singapore Economic Development Board(EDB)support from the Science and Engineering Research Council of Singapore with Grant No.A1898b0043Singapore NRF CRP Grant No.NRF-CRP24-2020-0002.
文摘Electron transport layers(ETLs)are crucial for achieving efficient and stable planar perovskite solar cells(PSCs).Reports on versatile inorganic ETLs using a simple film fabrication method and applicability for both low-cost planar regular and inverted PSCs with excellent efficiencies(>22%)and high stability are very limited.Herein,we employ a novel inorganic ZnSe as ETL for both regular and inverted PSCs to improve the efficiency and stability using a simple thermal evaporation method.The TiO_(2)-ZnSe-FAPbl_(3)heterojunction could be formed,resulting in an improved charge collection and a decreased carrier recombination further proved through theoretical calculations.The optimized regular PSCs based on TiO_(2)/ZnSe have achieved 23.25%efficiency with negligible hysteresis.In addition,the ZnSe ETL can also effectively replace the unstable bathocuproine(BCP)in inverted PSCs.Consequently,the ZnSe-based inverted device realizes a champion efficiency of 22.54%.Moreover,the regular device comprising the TiO_(2)/ZnSe layers retains 92%of its initial PCE after 10:00 h under 1 Sun continuous illumination and the inverted device comprising the C_(60)/ZnSe layers maintains over 85%of its initial PCE at 85℃for 10:00 h.This highlights one of the best results among universal ETLs in both regular and inverted perovskite photovoltaics.
基金Supported by National Natural Science Foundation of China (Grant No.11672127)Innovative Science and Technology Platform Project of Cooperation between Yangzhou City and Yangzhou University of China (Grant No.YZ2020266)+3 种基金Advance Research Special Technology Project of Army Equipment of China (Grant No.AGA19001)Innovation Fund Project of China Aerospace 1st Academy (Grant No.CHC20001)Fundamental Research Funds for the Central Universities of China (Grant No.NP2022408)Jiangsu Provincial Postgraduate Research&Practice Innovation Program of China (Grant No.SJCX23_1903)。
文摘Enhancing ride comfort has always constituted a crucial focus in the design and research of modern tracked vehicles,heavily reliant on the driving system's performance.While the road wheel is a key component of the driving system,traditional road wheels predominantly adopt a solid structure,exhibiting subpar adhesion performance and damping effects,thereby falling short of meeting the demands for high-speed,stable,and long-distance driving in tracked vehicles.Addressing this issue,this paper proposes a novel type of flexible road wheel(FRW)characterized by a catenary construction.The study investigates the ride comfort of tracked vehicles equipped with flexible road wheels by integrating finite element and vehicle dynamic.First,three-dimensional(3D)finite element(FE)models of both flexible and rigid road wheels are established,considering material and contact nonlinearities.These models are validated through a wheel radial loading test.Based on the validated FE model,the paper uncovers the relationship between load and radial deformation of the road wheel,forming the basis for a nonlinear mathematical model.Subsequently,a half-car model of a tracked vehicle with seven degrees of freedom is established using Newton's second law.A random road model,considering the track effect and employing white noise,is constructed.The study concludes by examining the ride comfort of tracked vehicles equipped with flexible and rigid road wheels under various speeds and road grades.The results demonstrate that,in comparison to the rigid road wheel(RRW),the flexible road wheel enhances the ride comfort of tracked vehicles on randomly uneven roads.This research provides a theoretical foundation for the implementation of flexible road wheels in tracked vehicles.
基金supported by the National Key Research and Development Program of China(grant no.2018YFA0208701)National Natural Science Foundation of China(grant no.21773308)+6 种基金Research Funds of Renmin University of China(grant nos.2017030013,201903020,and 20XNH059)Fundamental Research Funds for Central Universities(China)supported by the Solar Energy Research Institute of Singapore(SERIS)at the National University of Singapore(NUS)supported by NUS,the National Research Foundation Singapore(NRF),the Energy Market Authority of Singapore(EMA),and the Singapore Economic Development Board(EDB)the experimental support from Suzhou Fangsheng FS-300funding from Deutsche Forschungsge-meinschaft(DFG)via Germany's Excellence Strategy-EXC 2089/1-390776260(e-conversion)as well as from TUM.solar in the context of the Bavarian Collaborative Research Project Solar Technologies Go Hybrid(SoITech)the China Scholarship Council(CSC)funding
文摘The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite interface.In this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination agent.The synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite interface.Consequently,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FTO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.This study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.
基金provided by the Science and Technology Program of Jiangxi Provincial Health andWellness Commission(Grant No.SKJP220226866).
文摘Scrub typhus is a significant public health issue with a wide distribution and is influenced by various determinants.However,in order to effectively eradicate scrub typhus,it is crucial to identify the specific factors that contribute to its incidence at a detailed level.Therefore,the objective of our study is to identify these influencing factors,examine the spatial variations in incidence,and analyze the interplay of two factors on scrub typhus incidence,so as to provide valuable experience for the prevention and treatment of scrub typhus in Gannan and to alleviate the economic burden of the local population.This study employed spatial autocorrelation analyses to examine the dependent variable and ordinary least squares model residuals.Additionally,spatial regression modelling and geographical detector were used to analyze the factors influencing the annual mean 14-year incidence of scrub typhus in the streets/townships of Gannan region from 2008 to 2021.The results of spatial1 autocorrelation analyses indicated the presence of spatial correlation.Among the global spatial regression models,the spatial lag model was found to be the best fitting model(log likelihood ratio?319.3029,AIC?666.6059).The results from the SLM analysis indicated that DEM,mean temperature,and mean wind speed were the primary factors influencing the occurrence of scrub typhus.For the local spatial regression models,the multiscale geographically weighted regression was determined to be the best fitting model(adjusted R2?0.443,AICc?726.489).Further analysis using the MGWR model revealed that DEM had a greater impact in Xinfeng and Longnan,while the southern region was found to be more susceptible to scrub typhus due to mean wind speed.The geographical detector results revealed that the incidence of scrub typhus was primarily influenced by annual average normalized difference vegetation index.Additionally,the interaction between GDP and the percentage of grassland area had a significant impact on the incidence of scrub typhus(q?0.357).This study illustrated the individual and interactive effects of natural environmental factors and socio-economic factors on the incidence of scrub typhus;and elucidated the specific factors affecting the incidence of scrub typhus in various streets/townships.The findings of this study can be used to develop effective interventions for the prevention and control of scrub typhus.
文摘Gelatin as one kind of nano-drug carrier is a polysaccharide which can be absorbed after releasing all nano-drugs.Poly(ethylene glycol)as a polymer material that can modify nano-drugs is able to extend circulatory time of doxorubicin and aspirin,enhance stability and reduce toxicity.At precancerous,aspirin will be released slowly to resist inflammation.When tumor cell appears at a more advance stage,doxorubicin release from Gel to achieve anti-tumor effect.After all those steps,poly(ethylene glycol)could be expelled from body.In brief,the nano-drug that has doxorubicin and aspirin is able to prevent the growth of tumor cells and kill them when they appear more precisely.
基金Singapore Economic Development BoardEnergy Market Authority of Singapore+3 种基金National Research Foundation SingaporeNational University of SingaporeInternational Postdoctoral Exchange Fellowship Program(Talent-Introduction Program)of ChinaBoya Postdoctoral program of Peking University。
文摘Metal halide perovskites possess appealing optoelectronic properties and have been widely applied for solar energy harvesting and light emitting.Although perovskite solar cells(PeSCs)and perovskite light-emitting diodes(PeLEDs)have been developed rapidly in recent years,there are still no universal rules for the selection of perovskites to achieve high-performance optoelectronic devices.In this review,the working mechanisms of PeSCs and PeLEDs are first demonstrated with the discussion on the factors which determine the device performance.We then examine the optoelectronic properties of perovskites with structures modulated from 3D,2D,1D to 0D,and analyze the corresponding structure-property relationships in terms of photo-electric and electric-photo conversion processes.Based on the unique optoelectronic properties of structurally modulated perovskites,we put forward the concept of structural assembling engineering that integrate the merits of different types of perovskites within one matrix and elaborate their excellent properties for applications of both PeSCs and PeLEDs.Finally,we discuss the potential challenges and provide our perspectives on the structural assembling engineering of perovskites for future optoelectronic applications.
基金supported by grants from the National Natural Science Foundation of China,China(81672749,81772993,81971551,82302954,and K2918001)Natural Science Foundation of Fujian Province,China(2024J08346)+4 种基金Xiamen Municipal Bureau of Ocean Development,China(16PYY007SF17 and 23YYZP022QCB33)Xiamen Science&Technology Department,China(3502Z20231022,3502Z20193004,3502Z20150007,and 2023CXY0107)National Key R&D Program of China,China(2020YFA0112900)the Postdoctoral Science Foundation of China(2023M732956)fund from NucMito Pharmaceuticals Co.,Ltd.,China.
文摘Hepatic stellate cells(HSCs)are the primary fibrogenic cells in the liver,and their activation plays a crucial role in the development and progression of hepatic fibrosis.Here,we report that retinoid X receptor-alpha(RXRα),a unique member of the nuclear receptor superfamily,is a key modulator of HSC activation and liver fibrosis.RXRαexerts its effects by modulating calcium/calmodulin-dependent protein kinase kinaseβ(CaMKKβ)-mediated activation of AMP-activated protein kinase-alpha(AMPKα).In addition,we demonstrate that K-80003,which binds RXRαby a unique mechanism,effectively suppresses HSC activation,proliferation,and migration,thereby inhibiting liver fibrosis in the CCl4 and amylin liver NASH(AMLN)diet animal models.The effect is mediated by AMPKαactivation,promoting mitophagy in HSCs.Mechanistically,K-80003 activates AMPKαby inducing RXRαto form condensates with CaMKKβand AMPKαvia a two-phase process.The formation of RXRαcondensates is driven by its N-terminal intrinsic disorder region and requires phosphorylation by CaMKKβ.Our results reveal a crucial role of RXRαin liver fibrosis regulation through modulating mitochondrial activities in HSCs.Furthermore,they suggest that K-80003 and related RXRαmodulators hold promise as therapeutic agents for fibrosis-related diseases.
基金Funding for this research was provided by the Science and Technology Program of Jiangxi Provincial Health and Wellness Commission(202312001).
文摘Scrub typhus poses a serious public health risk globally.Forecasting the occurrence of the disease is essential for policymakers to develop prevention and control strategies.This study investigated the application of modelling techniques to predict the occurrence of scrub typhus and establishes an early warning system aimed at providing a foundational reference for its effective prevention and control.In this study,the monthly occurrence of scrub typhus in Ganzhou City from January 2008 to December 2022 was utilized as the training set for the first part of the analysis,while the data from January 2008 to December 2019 served as the training set for the second part.Based1 on these data,the SARIMA model,the BPNN model,and the combined SARIMA-BPNN model were developed and validated using data from January to December 2023.The most effective model was then selected to predict the number of occurrences of scrub typhus for the years 2024 and 2025,respectively.The root mean square error(RMSE)and mean absolute error(MAE)of the BPNN(3-9-1)model,developed using data from January 2008 to December 2022,were 8.472 and 6.4,respectively.In contrast,the RMSE and MAE of the combined SARIMA-BPNN(1-9-1)model,constructed using data from January 2008 to December 2019,were 19.361 and 16.178,respectively.In addition,the BPNN(3-9-1)model predicted 284 cases of scrub typhus in Ganzhou City for 2024,and 163 cases for 2025.The BPNN(3-9-1)model demonstrated strong applicability in predicting the monthly occurrence of scrub typhus.Furthermore,incorporating three years of data on the occurrence of new crown outbreaks when developing a predictive model for infectious diseases can substantially enhance prediction accuracy.
基金support of the National Natural Science Foundation of China[grant number 52472411,52272397]the Key Research&Development and Achievement Transformation Program of Wuhu[grant number 2023YF010].
文摘This paper proposes an adaptive-neural-network based robust hierarchical path-tracking controller for autonomous fourwheel-independent-drive electric vehicles(4WID-EVs)with parametric uncertainties and external disturbances.Firstly,considering the uncertain tire cornering stiffness and longitudinal speed,a control-oriented mismatched norm bounded uncertain system model of 4WID-EVs is established by using Takagi–Sugeno(T–S)fuzzy modeling approach.Secondly,an adaptive integral sliding mode controller combined with radial basis function neural network(RBFNN)is proposed,in which an improved RBFNN is used to approximate uncertain dynamics to improve tracking performance and reduce chattering.A sufficient condition for the asymptotic stability of sliding mode dynamics is given based on linear matrix inequality.According to Lyapunov theory,it has been proved that the estimation errors are bounded and finally converge near the origin.Further,a novel torque vectoring algorithm is introduced to allocate longitudinal driving force and additional yaw moment,aiming to reduce tire load rate and slip energy consumption,in which the weights assigned to the two objective functions are determined by taking into account the customized vehicle stability index and slip rate.Finally,the simulation results conducted on the CarSim-Simulink platform confirm the outstanding tracking and energy-efficient performance of the proposed controller.
