Stretchable and flexible electronics represent emerging and exciting directions for future electronics,while transfer printing plays an essential and mainstream role in integrating electronics onto application substra...Stretchable and flexible electronics represent emerging and exciting directions for future electronics,while transfer printing plays an essential and mainstream role in integrating electronics onto application substrates.However,existing transfer printing approaches have restrictions for electronics in terms of stiffness and dimensionality,as well as limitations for substrates in terms of surface and adhesion.Here,we report a versatile soap bubble transfer printing technique that,through a volume modulation strategy,enables the adhesion-independent,damage-free,and lowcontamination integration of rigid,flexible,and three-dimensional curved electronics onto substrates with complex surfaces and challenging adhesion.To demonstrate the versatility and compatibility of the soap bubble transfer printing technique,we performed not only special behaviors such as wraplike,multilayer,selective,and interior printing,but also integrated flexible electronics onto various human organ models,which holds promise for health monitoring in both noninvasive and invasive manners.展开更多
1 Introduction Humanity has entered a new phase of space exploration in which long-term orbital habitats are becoming routine.Within these permanently inhabited,hermetically sealed modules,microbial safety has emerged...1 Introduction Humanity has entered a new phase of space exploration in which long-term orbital habitats are becoming routine.Within these permanently inhabited,hermetically sealed modules,microbial safety has emerged as a pivotal determinant of crew health and mission reliability.Closed circulation of air and water,together with the altered physiology and virulence of microorgan-isms in micro-gravity,renders conventional,Earth-based control measures insufficient and calls for space-specific innovations.Against this backdrop,China’s rapid progress in astronautics,exemplified by the successful assembly and sustained operation of the Tiangong Space Station,has become a powerful catalyst for the development of next-generation microbial monitoring and abatement technologies.展开更多
Ultrahigh dose-rate(FLASH)radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity.However,tumor recurrence largely impede the effectiveness of FLASH therapy.Overcoming tum...Ultrahigh dose-rate(FLASH)radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity.However,tumor recurrence largely impede the effectiveness of FLASH therapy.Overcoming tumor recurrence is crucial for practical FLASH applications.Here,we prepared an agarose-based thermosensitive hydrogel containing a mild photothermal agent(TPE-BBT)and a glutaminase inhibitor(CB-839).Within nanoparticles,TPE-BBT exhibits aggregation-induced emission peaked at 900 nm,while the unrestricted molecular motions endow TPE-BBT with a mild photothermy generation ability.The balanced photothermal effect and photoluminescence are ideal for phototheranostics.Upon 660-nm laser irradiation,the temperature-rising effect softens and hydrolyzes the hydrogel to release TPE-BBT and CB-839 into the tumor site for concurrent mild photothermal therapy and chemotherapy,jointly inhibiting homologous recombination repair of DNA.The enhanced FLASH radiotherapy efficiently kills the tumor tissue without recurrence and obvious systematic toxicity.This work deciphers the unrestricted molecular motions in bright organic fluorophores as a source of photothermy,and provides novel recurrence-resistant radiotherapy without adverse side effects.展开更多
基金supported by the National Natural Science Foundation of China(12272079,12172189,11921002)fundamental research funds for the central universities(DUT21YG213)。
文摘Stretchable and flexible electronics represent emerging and exciting directions for future electronics,while transfer printing plays an essential and mainstream role in integrating electronics onto application substrates.However,existing transfer printing approaches have restrictions for electronics in terms of stiffness and dimensionality,as well as limitations for substrates in terms of surface and adhesion.Here,we report a versatile soap bubble transfer printing technique that,through a volume modulation strategy,enables the adhesion-independent,damage-free,and lowcontamination integration of rigid,flexible,and three-dimensional curved electronics onto substrates with complex surfaces and challenging adhesion.To demonstrate the versatility and compatibility of the soap bubble transfer printing technique,we performed not only special behaviors such as wraplike,multilayer,selective,and interior printing,but also integrated flexible electronics onto various human organ models,which holds promise for health monitoring in both noninvasive and invasive manners.
文摘1 Introduction Humanity has entered a new phase of space exploration in which long-term orbital habitats are becoming routine.Within these permanently inhabited,hermetically sealed modules,microbial safety has emerged as a pivotal determinant of crew health and mission reliability.Closed circulation of air and water,together with the altered physiology and virulence of microorgan-isms in micro-gravity,renders conventional,Earth-based control measures insufficient and calls for space-specific innovations.Against this backdrop,China’s rapid progress in astronautics,exemplified by the successful assembly and sustained operation of the Tiangong Space Station,has become a powerful catalyst for the development of next-generation microbial monitoring and abatement technologies.
基金supported by the National Natural Science Foundation of China (21788102 and 82303797)the Research Grants Council of Hong Kong (16306620,16303221,N_HKUST609/19,and C6014-20W)+4 种基金the Research Grants Council of the Hong Kong Special Administrative Region,China (HKUST PDFS2324-6S01)the Innovation and Technology Commission (ITC-CNERC14SC01 and ITCPD/17-9)the Science Technology Innovation Commission of Shenzhen Municipality (KQTD20210811090142053 and GJHZ20210705141810031)the Science and Technology Plan of Shenzhen (JCYJ20200109110608167 and JCYJ20220818103007014)the Guangxi Natural Science Foundation (2023GXNSFBA026137).
文摘Ultrahigh dose-rate(FLASH)radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity.However,tumor recurrence largely impede the effectiveness of FLASH therapy.Overcoming tumor recurrence is crucial for practical FLASH applications.Here,we prepared an agarose-based thermosensitive hydrogel containing a mild photothermal agent(TPE-BBT)and a glutaminase inhibitor(CB-839).Within nanoparticles,TPE-BBT exhibits aggregation-induced emission peaked at 900 nm,while the unrestricted molecular motions endow TPE-BBT with a mild photothermy generation ability.The balanced photothermal effect and photoluminescence are ideal for phototheranostics.Upon 660-nm laser irradiation,the temperature-rising effect softens and hydrolyzes the hydrogel to release TPE-BBT and CB-839 into the tumor site for concurrent mild photothermal therapy and chemotherapy,jointly inhibiting homologous recombination repair of DNA.The enhanced FLASH radiotherapy efficiently kills the tumor tissue without recurrence and obvious systematic toxicity.This work deciphers the unrestricted molecular motions in bright organic fluorophores as a source of photothermy,and provides novel recurrence-resistant radiotherapy without adverse side effects.
