The proliferation of low-altitude economic activities has precipitated a significant expansion in the application domains of Unmanned Aerial Vehicle(UAV),transcending the constraints of singular platform operation.Mul...The proliferation of low-altitude economic activities has precipitated a significant expansion in the application domains of Unmanned Aerial Vehicle(UAV),transcending the constraints of singular platform operation.Multi-UAV cooperative online remote sensing image stitching involves several challenges,including image blurriness and deformation caused by platform vibrations,as well as managing vast amounts of data and addressing transmission delays.This paper introduces a real-time system for multi-UAV video stitching that integrates hardware acceleration,pose-guided ROI filtering,and temporal consistency constraints.Data from the onboard GPS and Inertial Measurement Unit(IMU)are used to estimate the overlap between two aerial images.Subsequently,the Graphics Processing Unit(GPU)within an edge computing platform is tasked with swiftly detecting SIFT features within the overlapping image sectors.Feature point matching is performed using a position-guided matching algorithm to compute the homography matrix.The results demonstrate that the RK3588-based edge computing platform exhibits rapid image decoding and stitching capabilities,with an average stitching latency of 36.43ms.Furthermore,this study developed a ground-based human-machine interaction system to present stitched video streams in realtime,thereby improving the operational efficiency and visual quality of multi-UAV aerial surveillance.展开更多
For a class of time-delay discrete-time linear systems with external disturbance and measurement noise, the interval estimation problems of state and measurement noise are investigated in this paper. First, the system...For a class of time-delay discrete-time linear systems with external disturbance and measurement noise, the interval estimation problems of state and measurement noise are investigated in this paper. First, the system state together with the time-delay term and measurement noise is augmented as a new state, and a singular system is then constructed. Subsequently, a kind of decoupling technique is employed to eliminate the effect of external disturbance, and an observer is designed to simultaneously estimate the system state and measurement noise. Based on the estimated state and measurement noise, the interval estimations of system state and measurement noise are obtained by reachability analysis technique. Finally, the effectiveness of the proposed method is verified by a four-tank liquid level system.展开更多
Real-time health monitoring and ongoing evaluation of physiological conditions are becoming increasingly vital for the advancement of future medical diagnostics and personalized healthcare solutions.Given that certain...Real-time health monitoring and ongoing evaluation of physiological conditions are becoming increasingly vital for the advancement of future medical diagnostics and personalized healthcare solutions.Given that certain illnesses necessitate prompt and accessible detection methods,wearable chemical sensors have garnered considerable interest for their capability to monitor health through physiological signals and chemical indicators.This review delivers a thorough examination of recent developments in four primary categories of wearable chemical sensors:biosensors,humidity sensors,gas sensors,and ion sensors.We explore the representative materials,device structures,operating mechanisms,and various application scenarios for each type of sensor.By investigating the latest innovations in these technologies,we aim to provide a detailed overview of the current research landscape,highlight existing challenges,and present potential future directions of wearable chemical sensors in healthcare monitoring.展开更多
In this work,we have systematically investigated the post-thermal annealing-induced enhancement in photovoltaic performance of a 2,4-bis[4-(N,N-diisobutylamino)-2,6-dihydroxyphenyl]squaraine(DIBSQ)/C60 planar heteroju...In this work,we have systematically investigated the post-thermal annealing-induced enhancement in photovoltaic performance of a 2,4-bis[4-(N,N-diisobutylamino)-2,6-dihydroxyphenyl]squaraine(DIBSQ)/C60 planar heterojunction(PHJ)organic solar cells(OSCs).An increased power conversion efficiency(PCE)of 3.28%has been realized from a DIBSQ/C60 device with thermal annealing at 100°C for 4 min,which is about 33%enhancement compared with that of the as-cast device.The improvement of the device performance may be mainly ascribed to the crystallinity of the DIBSQ film with post-thermal annealing,which will change the DIBSQ donor and C60 acceptor interface from^PHJ to hybrid planar-mixed heterojunction.This new donor-acceptor heterojunction structure will significantly improve the charge separation and charge collection efficiency,as well as the open circuit voltage(Voc)of the device,leading to an enhanced PCE.This work provides an effective strategy to improve the photovoltaic performance of SQ-based OSCs.展开更多
Enhancer of zeste homolog 2(EZH2),an enzymatic subunit of PRC2 complex,plays an important role in tumor development and progression through its catalytic and noncatalytic activities.Overexpression or gain-of-function ...Enhancer of zeste homolog 2(EZH2),an enzymatic subunit of PRC2 complex,plays an important role in tumor development and progression through its catalytic and noncatalytic activities.Overexpression or gain-of-function mutations of EZH2 have been significantly associated with tumor cell proliferation of triple-negative breast cancer(TNBC)and diffuse large B-cell lymphoma(DLBCL).As a result,it has gained interest as a potential therapeutic target.The currently available EZH2 inhibitors,such as EPZ6438 and GSK126,are of benefit for clinical using or reached clinical trials.However,certain cancers are resistant to these enzymatic inhibitors due to its noncatalytic or transcriptional activity through modulating nonhistone proteins.Thus,it may be more effective to synergistically degrade EZH2 in addition to enzymatic inhibition.Here,through a rational design and chemical screening,we discovered a new irreversible EZH2 inhibitor,IHMT-337,which covalently bounds to and degrades EZH2 via the E3 ligase CHIP-mediated ubiquitination pathway.Moreover,we revealed that IHMT-337 affects cell cycle progression in TNBC cells through targeting transcriptional regulating of CDK4,a novel PRC2 complex-and enzymatic activity-independent function of EZH2.More significantly,our compound inhibits both DLBCL and TNBC cell proliferation in different preclinical models in vitro and in vivo.Taken together,our findings demonstrate that in addition to enzymatic inhibition,destroying of EZH2 by IHMT-337 could be a promising therapeutic strategy for TNBC and other malignancies that are independent of EZH2 enzymatic activity.展开更多
基金funded by Graduate innovation program of National University of Defense Technology,grant number:XJZH2024016.
文摘The proliferation of low-altitude economic activities has precipitated a significant expansion in the application domains of Unmanned Aerial Vehicle(UAV),transcending the constraints of singular platform operation.Multi-UAV cooperative online remote sensing image stitching involves several challenges,including image blurriness and deformation caused by platform vibrations,as well as managing vast amounts of data and addressing transmission delays.This paper introduces a real-time system for multi-UAV video stitching that integrates hardware acceleration,pose-guided ROI filtering,and temporal consistency constraints.Data from the onboard GPS and Inertial Measurement Unit(IMU)are used to estimate the overlap between two aerial images.Subsequently,the Graphics Processing Unit(GPU)within an edge computing platform is tasked with swiftly detecting SIFT features within the overlapping image sectors.Feature point matching is performed using a position-guided matching algorithm to compute the homography matrix.The results demonstrate that the RK3588-based edge computing platform exhibits rapid image decoding and stitching capabilities,with an average stitching latency of 36.43ms.Furthermore,this study developed a ground-based human-machine interaction system to present stitched video streams in realtime,thereby improving the operational efficiency and visual quality of multi-UAV aerial surveillance.
基金supported in part by the National Nature Science Foundation of China(No.61973105)the Natural Science Foundation of Henan Province(No.232300420147)the Fundamental Research Funds for the Universities of Henan Province(No.NSFRF180335).
文摘For a class of time-delay discrete-time linear systems with external disturbance and measurement noise, the interval estimation problems of state and measurement noise are investigated in this paper. First, the system state together with the time-delay term and measurement noise is augmented as a new state, and a singular system is then constructed. Subsequently, a kind of decoupling technique is employed to eliminate the effect of external disturbance, and an observer is designed to simultaneously estimate the system state and measurement noise. Based on the estimated state and measurement noise, the interval estimations of system state and measurement noise are obtained by reachability analysis technique. Finally, the effectiveness of the proposed method is verified by a four-tank liquid level system.
基金supported by the Shandong Excellent Young Scientists Fund Program(Overseas)(2023HWYQ-035)the Taishan Scholar Program of Shandong Province(tsqn202306078)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(2024A1515011635)the Natural Science Foundation of Shandong Province(ZR2023MF108)the Jinan Central Hospital(1190022050)。
文摘Real-time health monitoring and ongoing evaluation of physiological conditions are becoming increasingly vital for the advancement of future medical diagnostics and personalized healthcare solutions.Given that certain illnesses necessitate prompt and accessible detection methods,wearable chemical sensors have garnered considerable interest for their capability to monitor health through physiological signals and chemical indicators.This review delivers a thorough examination of recent developments in four primary categories of wearable chemical sensors:biosensors,humidity sensors,gas sensors,and ion sensors.We explore the representative materials,device structures,operating mechanisms,and various application scenarios for each type of sensor.By investigating the latest innovations in these technologies,we aim to provide a detailed overview of the current research landscape,highlight existing challenges,and present potential future directions of wearable chemical sensors in healthcare monitoring.
基金This work was financially supported by the National Natural Science Foundation of China(Grant No.61604093)the Natural Science Foundation of Shanghai(Grant Nos.16ZR1411000 and 18ZR1413800)the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20180978).
文摘In this work,we have systematically investigated the post-thermal annealing-induced enhancement in photovoltaic performance of a 2,4-bis[4-(N,N-diisobutylamino)-2,6-dihydroxyphenyl]squaraine(DIBSQ)/C60 planar heterojunction(PHJ)organic solar cells(OSCs).An increased power conversion efficiency(PCE)of 3.28%has been realized from a DIBSQ/C60 device with thermal annealing at 100°C for 4 min,which is about 33%enhancement compared with that of the as-cast device.The improvement of the device performance may be mainly ascribed to the crystallinity of the DIBSQ film with post-thermal annealing,which will change the DIBSQ donor and C60 acceptor interface from^PHJ to hybrid planar-mixed heterojunction.This new donor-acceptor heterojunction structure will significantly improve the charge separation and charge collection efficiency,as well as the open circuit voltage(Voc)of the device,leading to an enhanced PCE.This work provides an effective strategy to improve the photovoltaic performance of SQ-based OSCs.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.82104198,32171479,82104239)the Natural Science Foundation of Anhui Province(Grant Nos.2008085MH274,2108085QH377)+4 种基金the China Postdoctoral Science Foundation(Grant No.2020M671916)the Frontier Science Key Research Program of CAS(Grant No.QYZDB-SSW-SLH037)the Collaborative Innovation Program of Hefei Science Center,CAS(Grant No.2021HSC-CIP014)the CASHIPS Director’s Found(Grant Nos.BJPY2019A03,YZJJZX202011,YZJJ2021QN38)We are also grateful for the support of the Youth Innovation Promotion Association of CAS support(No.2019437)for H.W.A portion of this work was supported by the High Magnetic Field Laboratory of Anhui Province.
文摘Enhancer of zeste homolog 2(EZH2),an enzymatic subunit of PRC2 complex,plays an important role in tumor development and progression through its catalytic and noncatalytic activities.Overexpression or gain-of-function mutations of EZH2 have been significantly associated with tumor cell proliferation of triple-negative breast cancer(TNBC)and diffuse large B-cell lymphoma(DLBCL).As a result,it has gained interest as a potential therapeutic target.The currently available EZH2 inhibitors,such as EPZ6438 and GSK126,are of benefit for clinical using or reached clinical trials.However,certain cancers are resistant to these enzymatic inhibitors due to its noncatalytic or transcriptional activity through modulating nonhistone proteins.Thus,it may be more effective to synergistically degrade EZH2 in addition to enzymatic inhibition.Here,through a rational design and chemical screening,we discovered a new irreversible EZH2 inhibitor,IHMT-337,which covalently bounds to and degrades EZH2 via the E3 ligase CHIP-mediated ubiquitination pathway.Moreover,we revealed that IHMT-337 affects cell cycle progression in TNBC cells through targeting transcriptional regulating of CDK4,a novel PRC2 complex-and enzymatic activity-independent function of EZH2.More significantly,our compound inhibits both DLBCL and TNBC cell proliferation in different preclinical models in vitro and in vivo.Taken together,our findings demonstrate that in addition to enzymatic inhibition,destroying of EZH2 by IHMT-337 could be a promising therapeutic strategy for TNBC and other malignancies that are independent of EZH2 enzymatic activity.
