Exceptionally preserved fossils,such as those from Cambrian Burgess Shale-type fossil-Lagerstatten are critical because of their unique contributions to knowledge of the phylogenetic radiation and palaeoecological exp...Exceptionally preserved fossils,such as those from Cambrian Burgess Shale-type fossil-Lagerstatten are critical because of their unique contributions to knowledge of the phylogenetic radiation and palaeoecological expansion of metazoans during the Cambrian explosion.Critically,these deposits provide information that is usually unobtainable from shelly and skeletonized fossils alone.The Guanshan Biota(Cambrian Series 2,Stage 4)in the Yunnan Province of South China,has produced abundant and diverse,exquisitely preserved fossils that often retain soft tissues and organs.To date,most fossils from the Guanshan Biota have been collected from localities such as Gaoloufang and Gangtoucun,which have become inaccessible due to new urban expansions and constructions of residential buildings.Here we present the first report of soft bodied fossils from a new section at Kanfuqing,close to the Wulongqing village in Malong County,approximately 3 km east of the Wulongqing Formation stratotype section.Fossils retain soft morphology,and include brachiopods with delicate marginal setae,priapulids with well-preserved sclerites and vetulicolians with entire sections of body.In addition,this fauna includes rare occurrences of trilobites preserved with soft tissues replicated as pyrite pseudomorphs after weathering.This discovery represents an important palaeogeographical extension of soft-bodied fossils of the Guanshan fauna to the east of the Xiaojiang Fault(related to Tsinning tectonic movements ca.700 Ma).The fauna from the new Kanfuqing section is similar to that reported from the Wulongqing Formation west of the Xiaojiang Fault,and thus has significant implications for early Cambrian palaeogeography,faunal successions and palaeoenvironments of eastern Yunnan.展开更多
Thyroid hormone receptors(THRs),a crucial nuclear receptor protein family,primarily consist of two categories:a receptors and b receptors.Among them,THRb is the primary subtype of thyroid hormone that confers benefits...Thyroid hormone receptors(THRs),a crucial nuclear receptor protein family,primarily consist of two categories:a receptors and b receptors.Among them,THRb is the primary subtype of thyroid hormone that confers benefits to the liver.In the last two decades,there have been efforts to develop THRb agonists that selectively yield beneficial effects on the liver,such as lowering triglycerides and cholesterol,while reducing adverse effects on the heart,muscle,and bone.This paper systematically reviews strategies to enhance the safety of THRb agonists for the treatment of MASH,with a focus on improving the selectivity of THRa and increasing the distribution of the drug in the liver.Additionally,we explore the potential application of this target in addressing other medical indications.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.41425008,41890844,41720104002,41621003 and 41772002)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB26000000)+1 种基金the Overseas Expertise Introduction Centre for Discipline Innovation(111 project:D17013)the Postgraduate Creation Program of Northwest University(YZZ15001)
文摘Exceptionally preserved fossils,such as those from Cambrian Burgess Shale-type fossil-Lagerstatten are critical because of their unique contributions to knowledge of the phylogenetic radiation and palaeoecological expansion of metazoans during the Cambrian explosion.Critically,these deposits provide information that is usually unobtainable from shelly and skeletonized fossils alone.The Guanshan Biota(Cambrian Series 2,Stage 4)in the Yunnan Province of South China,has produced abundant and diverse,exquisitely preserved fossils that often retain soft tissues and organs.To date,most fossils from the Guanshan Biota have been collected from localities such as Gaoloufang and Gangtoucun,which have become inaccessible due to new urban expansions and constructions of residential buildings.Here we present the first report of soft bodied fossils from a new section at Kanfuqing,close to the Wulongqing village in Malong County,approximately 3 km east of the Wulongqing Formation stratotype section.Fossils retain soft morphology,and include brachiopods with delicate marginal setae,priapulids with well-preserved sclerites and vetulicolians with entire sections of body.In addition,this fauna includes rare occurrences of trilobites preserved with soft tissues replicated as pyrite pseudomorphs after weathering.This discovery represents an important palaeogeographical extension of soft-bodied fossils of the Guanshan fauna to the east of the Xiaojiang Fault(related to Tsinning tectonic movements ca.700 Ma).The fauna from the new Kanfuqing section is similar to that reported from the Wulongqing Formation west of the Xiaojiang Fault,and thus has significant implications for early Cambrian palaeogeography,faunal successions and palaeoenvironments of eastern Yunnan.
基金the National Natural Science Foundation of China(82130105,22337003,and 82121005 to Hong Liu,and 82322063,22177124 to Jiang Wang)the Lingang Laboratory(LG-GG-202403-01 to Jiang Wang,China)Program of Shanghai Academic Research Leader(23XD1460300 to Jiang Wang,China).
文摘Thyroid hormone receptors(THRs),a crucial nuclear receptor protein family,primarily consist of two categories:a receptors and b receptors.Among them,THRb is the primary subtype of thyroid hormone that confers benefits to the liver.In the last two decades,there have been efforts to develop THRb agonists that selectively yield beneficial effects on the liver,such as lowering triglycerides and cholesterol,while reducing adverse effects on the heart,muscle,and bone.This paper systematically reviews strategies to enhance the safety of THRb agonists for the treatment of MASH,with a focus on improving the selectivity of THRa and increasing the distribution of the drug in the liver.Additionally,we explore the potential application of this target in addressing other medical indications.
