Pyroptosis is a form of programmed cell death.Excessive or uncontrolled pyroptosis and the production of pro-inflammatory cytokines can lead to organ damage,circulatory failure,and even death.Gasdermin D(GSDMD)is the ...Pyroptosis is a form of programmed cell death.Excessive or uncontrolled pyroptosis and the production of pro-inflammatory cytokines can lead to organ damage,circulatory failure,and even death.Gasdermin D(GSDMD)is the primary executor of pyroptosis in macrophages.Upon cleavage,the N-terminal domain of GSDMD(GSDMD-N)is activated and oligomerizes to form pore-like structures in the plasma membrane,triggering pyroptosis and resulting in the release of pro-inflammatory cytokines such as interleukin-1β(IL-1β).As a key executioner molecule of pyroptosis,Gasdermin D plays a crucial role in pathogen-induced pyroptosis in macrophages.With in-depth research on the function and regulatory mechanisms of GSDMD,its role in pathogen-induced macrophage pyroptosis has gradually been revealed.This article elaborates on the mechanism of GSDMD in pathogen-induced macrophage pyroptosis,providing insights for exploring pyroptosis in the prevention and control of bacterial diseases,and identifying new therapeutic targets for bacterial infections.展开更多
This paper analyzes the spread of the COVID-19 epidemic in China,establishes a SEIR^(+CAQ)epidemiologic model that classifies the diagnosed population into asymptomatic,mild,and severe,and considers the condition of a...This paper analyzes the spread of the COVID-19 epidemic in China,establishes a SEIR^(+CAQ)epidemiologic model that classifies the diagnosed population into asymptomatic,mild,and severe,and considers the condition of an isolated population.First of all,we theoretically analyzed the key problems of the disease-free equilibrium,stability,and basic reproduction number of the model.Then,combined with the actual data,the development trend of the epidemic situation is simulated and compared,and the influence of some important parameters is discussed in the model evaluation part.Finally,based on the theoretical analysis and numerical simulation results,we forecast the future development of the COVID-19 epidemic and put forward some reasonable scientific suggestions for the government to formulate a future epidemic prevention policy.展开更多
基金Foshan High-Level Talent and Lingnan Scholar Research Initiation Project(Project No.:CGZ07001)Foshan Science and Technology Innovation Project(Project No.:2420001004253)Foshan Self-Funded Science and Technology Innovation Project(Project No.:2420001004253)。
文摘Pyroptosis is a form of programmed cell death.Excessive or uncontrolled pyroptosis and the production of pro-inflammatory cytokines can lead to organ damage,circulatory failure,and even death.Gasdermin D(GSDMD)is the primary executor of pyroptosis in macrophages.Upon cleavage,the N-terminal domain of GSDMD(GSDMD-N)is activated and oligomerizes to form pore-like structures in the plasma membrane,triggering pyroptosis and resulting in the release of pro-inflammatory cytokines such as interleukin-1β(IL-1β).As a key executioner molecule of pyroptosis,Gasdermin D plays a crucial role in pathogen-induced pyroptosis in macrophages.With in-depth research on the function and regulatory mechanisms of GSDMD,its role in pathogen-induced macrophage pyroptosis has gradually been revealed.This article elaborates on the mechanism of GSDMD in pathogen-induced macrophage pyroptosis,providing insights for exploring pyroptosis in the prevention and control of bacterial diseases,and identifying new therapeutic targets for bacterial infections.
基金This work is supported by the National College Students’s Innovation and Entrepreneurship Training Program(S202010619021)School of Science College Student Innovation Fund Project of Southwest University of Science and Tech-nology+1 种基金Application Basic Project of Sichuan Science and Technology Department(2017JY0336)Longshan Academic Talent Research Support Program of Southwest University of Science and Technology(17LZX670,18LZX622).
文摘This paper analyzes the spread of the COVID-19 epidemic in China,establishes a SEIR^(+CAQ)epidemiologic model that classifies the diagnosed population into asymptomatic,mild,and severe,and considers the condition of an isolated population.First of all,we theoretically analyzed the key problems of the disease-free equilibrium,stability,and basic reproduction number of the model.Then,combined with the actual data,the development trend of the epidemic situation is simulated and compared,and the influence of some important parameters is discussed in the model evaluation part.Finally,based on the theoretical analysis and numerical simulation results,we forecast the future development of the COVID-19 epidemic and put forward some reasonable scientific suggestions for the government to formulate a future epidemic prevention policy.
