Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role...Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear.展开更多
基金This work was supported by the National Natural Science Foundation(81972146 to Chengqi He)the Department of Science and Technology of Sichuan Province(20YYJC3320,2020YJ0210 to Chengqi He)+1 种基金West China Hospital of Sichuan University(ZYGD18018 and HX-20l9-nCoV-011to Chengqi He)West China Nursing Discipline Development Special Fund Project,Sichuan University(HXHL20001 to Chengqi He).
文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear.
