Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are...Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,展开更多
Winter fiber flax has been planted in a large area in Yunnan Province, the southwestern part of China, and other areas of the world, but little is known about the influence of fertilization on the fiber yield and qual...Winter fiber flax has been planted in a large area in Yunnan Province, the southwestern part of China, and other areas of the world, but little is known about the influence of fertilization on the fiber yield and quality. For that, a two-factor experiment in random block designed was carried out by specifying nitrogen (N), phosphorus (P) and potassium (K) as factor A, boron (B), manganese (Mn), copper (Cu), zinc (Zn) and molybdenum (Mo) as factor B each in four levels and their complete combinations. With the increase of N, P and K fertilizers, the yields of long-fiber and total-fiber obviously increased resulting from the increased straw yield, although the portion of retted-stem in straw, contents of longfiber and total-fiber decreased. The fiber tensile strength and flexibility increased as well. The micronutrients application increased the yields of straw, long-fiber and total-fiber, but gave no influence to fiber content and the fiber qualities. Combinations of the macronutrients and micronutrients gave obvious influences to the yields of straw and fiber, contents of long-fiber and total-fiber, fiber fineness and tensile strength, but little influence to the fiber flexibility. The fertilizers formula A2B2, i.e. N-P2O5-K2O 172.8, 28.8 172.8 kg/hm2, Zn-Cu-B-M-Mo 2363, 1654, 236, 2363,165 g/hm2, was the best, yielding most in the straw, long-fiber and total-fiber, with synchronous improvement of the three quality indices.展开更多
Seeds of three Anemone species were collected from the suburban areas of Kunming and planted in a nursery for three and a half years at Kunming, Yunnan Province, China. Leaf gas exchange measurement indicated that the...Seeds of three Anemone species were collected from the suburban areas of Kunming and planted in a nursery for three and a half years at Kunming, Yunnan Province, China. Leaf gas exchange measurement indicated that these species had similar one-peak diurnal trends of net photosynthetic rate (PN), although A. rivularis had lower transpiration rate (TR), stomatal conductance (gs) and intercellular CO2 concentration (Ci), and higher stomatal limit in the afternoon. Species differences in response of PN to photosynthetically active radiation (PAR) were observed, especially under strong light. A. rivularis had the highest PN and Ci under strong light which corresponded with its highest gs and TR. A. rivularis had the highest light saturation point (LSP) (1000 mol m-2 s-1) and light compensation point (LCP) (69 mol m-2 s-1), while A. hupehensis var. japonica had the lowest LSP (800 ?mol m-2 s-1) and a lower LCP (53 mol m-2 s-1). But the three species responded similarly to the change of CO2 concentration in the air from 0 to 350 ?mol (CO2) mol-1, and their observed CO2 compensation point showed little difference (47, 53 and 56 ?mol (CO2) mol-1). Moreover, A. rivularis had the highest apparent quantum yield (0.032), carboxylation efficiency (0.049), PN (11.68 ?mol (CO2) m-2 s-1) and TR (5.36 mmol (H2O) m-2 s-1) based on the PN -PAR response. The results implied that A. rivularis is able to grow well under higher radiation, while A. hupehensis var. japonica is the best one to grow under partial shade.展开更多
基金supported by the project of Science Fund for Creative Research Groups of the National Natural Science Foundation of China(81221002)Rational Medication Application Patterns of Schizophrenia(BMU20140430) of Peking University Health Science Center
文摘Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,
文摘Winter fiber flax has been planted in a large area in Yunnan Province, the southwestern part of China, and other areas of the world, but little is known about the influence of fertilization on the fiber yield and quality. For that, a two-factor experiment in random block designed was carried out by specifying nitrogen (N), phosphorus (P) and potassium (K) as factor A, boron (B), manganese (Mn), copper (Cu), zinc (Zn) and molybdenum (Mo) as factor B each in four levels and their complete combinations. With the increase of N, P and K fertilizers, the yields of long-fiber and total-fiber obviously increased resulting from the increased straw yield, although the portion of retted-stem in straw, contents of longfiber and total-fiber decreased. The fiber tensile strength and flexibility increased as well. The micronutrients application increased the yields of straw, long-fiber and total-fiber, but gave no influence to fiber content and the fiber qualities. Combinations of the macronutrients and micronutrients gave obvious influences to the yields of straw and fiber, contents of long-fiber and total-fiber, fiber fineness and tensile strength, but little influence to the fiber flexibility. The fertilizers formula A2B2, i.e. N-P2O5-K2O 172.8, 28.8 172.8 kg/hm2, Zn-Cu-B-M-Mo 2363, 1654, 236, 2363,165 g/hm2, was the best, yielding most in the straw, long-fiber and total-fiber, with synchronous improvement of the three quality indices.
文摘Seeds of three Anemone species were collected from the suburban areas of Kunming and planted in a nursery for three and a half years at Kunming, Yunnan Province, China. Leaf gas exchange measurement indicated that these species had similar one-peak diurnal trends of net photosynthetic rate (PN), although A. rivularis had lower transpiration rate (TR), stomatal conductance (gs) and intercellular CO2 concentration (Ci), and higher stomatal limit in the afternoon. Species differences in response of PN to photosynthetically active radiation (PAR) were observed, especially under strong light. A. rivularis had the highest PN and Ci under strong light which corresponded with its highest gs and TR. A. rivularis had the highest light saturation point (LSP) (1000 mol m-2 s-1) and light compensation point (LCP) (69 mol m-2 s-1), while A. hupehensis var. japonica had the lowest LSP (800 ?mol m-2 s-1) and a lower LCP (53 mol m-2 s-1). But the three species responded similarly to the change of CO2 concentration in the air from 0 to 350 ?mol (CO2) mol-1, and their observed CO2 compensation point showed little difference (47, 53 and 56 ?mol (CO2) mol-1). Moreover, A. rivularis had the highest apparent quantum yield (0.032), carboxylation efficiency (0.049), PN (11.68 ?mol (CO2) m-2 s-1) and TR (5.36 mmol (H2O) m-2 s-1) based on the PN -PAR response. The results implied that A. rivularis is able to grow well under higher radiation, while A. hupehensis var. japonica is the best one to grow under partial shade.
