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Development of a Magnetically-Actuated Capsule Robot for Biopsy Sampling Using SMA
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作者 Hao Zhang Keding Luo +3 位作者 feihao wang Shishi Li Xianghe Meng Hui Xie 《Journal of Bionic Engineering》 2025年第4期1609-1621,共13页
Capsule Robots(CRs)with active locomotion improve on the inefficiency of passive locomotion in capsule endoscopes,showing great potential for clinical use.However,despite the development of various CR types,efficient ... Capsule Robots(CRs)with active locomotion improve on the inefficiency of passive locomotion in capsule endoscopes,showing great potential for clinical use.However,despite the development of various CR types,efficient locomotion and functional integration remain challenges due to space limitations and increasing demands.Additionally,many CRs are overly complex,so simplifying their structure while maintaining functionality is essential.This paper presents a novel magnetically actuated CR with two internal permanent magnets for oscillating locomotion and anchoring,along with a Shape Memory Alloy(SMA)-driven actuator for biopsy sampling.Compared to existing CRs,this design simplifies the structure while ensuring biopsy functionality and leaving space for a micro-CCD.The robot’s dynamics are modeled to guide its structural design and locomotion strategy.SMA characteristics are also examined to optimize the biopsy module’s parameters,improving efficiency and success rates.The CR undergoes experiments to assess safety,locomotion performance,and functionality,with results showing stable steering,and advantages in driving height,speed,and accuracy.Finally,the CR’s biopsy capabilities are validated in a gastric model and ex vivo stomach.This work offers a novel solution for gastrointestinal disease diagnosis and treatment,enhancing the application of CRs in biomedical engineering. 展开更多
关键词 Capsule Robot(CR) Magnetic guidance Shape memory alloy(SMA) Oscillating locomotion Biopsy sampling
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纤维素/海藻酸钠/明胶复合水凝胶的制备与性能 被引量:12
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作者 王斐昊 许波 +1 位作者 王平 王强 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2024年第3期133-142,共10页
纤维素作为一种来源丰富的天然高分子材料,具有优异的生物相容性和可降解性,但其难溶特性限制了其应用。文中采用离子液体1-烯丙基-3-甲基咪唑氯化物(AmimCl)溶解纤维素(Cel),海藻酸钠(SA)与明胶(Gel)混合水溶液作为凝固浴进行纤维素再... 纤维素作为一种来源丰富的天然高分子材料,具有优异的生物相容性和可降解性,但其难溶特性限制了其应用。文中采用离子液体1-烯丙基-3-甲基咪唑氯化物(AmimCl)溶解纤维素(Cel),海藻酸钠(SA)与明胶(Gel)混合水溶液作为凝固浴进行纤维素再生,进一步通过浸泡氯化钙(CaCl_(2))溶液交联海藻酸钠,制备了一种透明、高强度的复合水凝胶。分别探究了纤维素浓度(3%,4%,5%,6%,7%和8%)及不同的海藻酸钠/明胶质量比(0:10,2:8,4:6,6:4,8:2和10:0)对水凝胶性能的影响。利用傅里叶变换红外光谱、扫描电子显微镜、X射线衍射仪、紫外可见分光光度计和万能材料试验机对水凝胶进行了表征。结果表明,水凝胶中各组分之间的氢键作用及海藻酸钠与Ca^(2+)之间的离子相互作用赋予水凝胶优异的力学性能,相比于纯水作为凝固浴制备的再生纤维素水凝胶,强度提高了26.36%。随着纤维素浓度的增加,水凝胶的结晶度和网络结构的致密性增加,水凝胶的力学性能显著提升。此外,海藻酸钠/明胶的比例也对水凝胶的力学性能有显著影响,当海藻酸钠与明胶质量比为6:4时,水凝胶力学性能最好,最高达到2.349 MPa。生物降解性分析表明,水凝胶具有良好的生物降解性,在食品包装和生物医药领域具有潜在应用价值。 展开更多
关键词 纤维素 海藻酸钠 明胶 水凝胶 离子液体
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