Introduction:Transfusion-transmitted infections(TTIs)pose significant public health challenges.Screening potential blood donors for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),and T...Introduction:Transfusion-transmitted infections(TTIs)pose significant public health challenges.Screening potential blood donors for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),and Treponema pallidum(TP),along with ongoing monitoring of epidemiological data on TTIs among donors,is essential to ensure blood safety.Methods:This study conducted a retrospective analysis of the seroprevalence of HBsAg,anti-HCV,anti-HIV,and anti-TP among 3,111,265 blood donation events in Guangzhou from 2014 to 2023,investigating their relationships with demographic characteristics such as gender,age,and donation status.Results:The findings indicated that the overall seroprevalence of TTIs among blood donations was 866.21 per 100,000,demonstrating a declining trend over the ten-year period.Seroprevalence rates of transfusion-transmissible infections also exhibited a downward trend across various demographic groups.Notably,male donors,first-time donors,and older donors demonstrated higher seroprevalence rates for TTIs.Conclusions:While the overall seroprevalence rate of transfusion-transmissible infections among blood donors remains relatively low,significant disparities exist among different demographic groups.It is necessary of sustained TTIs monitoring among blood donors to guide public health interventions and donor screening practices.展开更多
基金supported by the Medical Scientific Research Foundation of Guangdong Province(A2024391)Science and Technology Projects in Guangzhou(2023A03J0544,2023A03J0550,2024A03J0447,2023A03J0552,2024A03J0150)The Key Medical Disciplines and Specialties Program of Guangzhou(2025-2027).
文摘Introduction:Transfusion-transmitted infections(TTIs)pose significant public health challenges.Screening potential blood donors for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),and Treponema pallidum(TP),along with ongoing monitoring of epidemiological data on TTIs among donors,is essential to ensure blood safety.Methods:This study conducted a retrospective analysis of the seroprevalence of HBsAg,anti-HCV,anti-HIV,and anti-TP among 3,111,265 blood donation events in Guangzhou from 2014 to 2023,investigating their relationships with demographic characteristics such as gender,age,and donation status.Results:The findings indicated that the overall seroprevalence of TTIs among blood donations was 866.21 per 100,000,demonstrating a declining trend over the ten-year period.Seroprevalence rates of transfusion-transmissible infections also exhibited a downward trend across various demographic groups.Notably,male donors,first-time donors,and older donors demonstrated higher seroprevalence rates for TTIs.Conclusions:While the overall seroprevalence rate of transfusion-transmissible infections among blood donors remains relatively low,significant disparities exist among different demographic groups.It is necessary of sustained TTIs monitoring among blood donors to guide public health interventions and donor screening practices.
