High-entropy alloys(HEAs) are an important research direction in the materials science field and engineering field.Different from traditional alloys which usually contain only one basic element and infrequently two,HE...High-entropy alloys(HEAs) are an important research direction in the materials science field and engineering field.Different from traditional alloys which usually contain only one basic element and infrequently two,HEAs are made up of many major elements in much larger numbers.With impressive mechanical properties,impressive corrosion resistance and superior thermal stability,HEAs offer overwhelming advantages over conventional alloys.HEAs have received a lot of attention due to its unique concept and performance.In recent years,many researchers have prepared HEAs at the nanometer level,and the obtained high-entropy nanoparticles(HEA-NPs) have been extensively used in multifarious fields.This paper reviews the main characteristics,core effects,conventional synthesis methods and their applications in various fields of HEA-NPs.Furthermore,the vast space to be explored is discussed and the future development direction and outlook are outlined productively.展开更多
Photodynamic therapy(PDT)has emerged as a significant cancer therapy option.Currently,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scien...Photodynamic therapy(PDT)has emerged as a significant cancer therapy option.Currently,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after cationization.However,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some circumstances.Herein,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor cells.Further,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor growth.Accordingly,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.展开更多
A series of white phosphorescent OLED devices with buffer layer and multiple dopant structure is investigated in order to obtain better electro-optic performances and color stability. The color coordinate and color st...A series of white phosphorescent OLED devices with buffer layer and multiple dopant structure is investigated in order to obtain better electro-optic performances and color stability. The color coordinate and color stability are related to the location of multiple dopants layer, and the optimized location can compensate for the change of the blue emission intensity under a high voltage and stabilize the spectrum. The electro-optic performances and color stability can be further improved by changing the composition and thickness of the buffer layer between the emitting layer and the electron transport layer.In device B2, the distance from multiple dopant layer to buffer layer is 2 nm and the thickness of buffer layer is 5 nm,the maximum luminance, current density, and power efficiency can reach 9091 cd/m^2, 364.5 mA/cm^2, and 26.74 lm/W,respectively. The variation of international commission on the illumination（CIE） coordinate of device B2 with voltage increasing from 4 V to 7 V is only（0.006, 0.004）.展开更多
For specific drug research and development,a drug-screening strategy(DSS)plays an indispensable role in the biomedical field.Unfortunately,traditional strategies are complicated and insufficiently accurate due to the ...For specific drug research and development,a drug-screening strategy(DSS)plays an indispensable role in the biomedical field.Unfortunately,traditional strategies are complicated and insufficiently accurate due to the widely used single-target screening method.Herein,a simple dual-target-based drug-screening strategy(dt-DSS)is proposed to screen highly effective drugs by fluorescence imaging.As a proof of concept,we utilized a dual-responsive fluorescence probe to screen drugs for diabetic cardiomyopathy(DCM).We first developed and took advantage of a dual-response probe HDB to detect reactive oxygen species(ROS)and mitophagy levels in cellular starvation and high glucose models.Based on this,HDB was utilized to study the effects of different drugs in the mitophagy process caused by the high-glucose cell model for DCM.Combined with Western blotting assays,we found that Drp-1 inhibitors could fundamentally reduce mitophagy caused by the high-glucose cells model.Compared with commercial single-target antioxidant drugs,the drugs with simultaneous antioxidant capacity and Drp-1 inhibition screened by dt-DSS,such as resveratrol and icariin,could treat DCM better.Therefore,HDB as an effective tool could accurately and quickly screen high-potency drugs for DCM.We believe that this work provides an attractive strategy to explore the pathogenesis of diabetic cardiomyopathy and precisely screen for highly effective drugs.展开更多
基金financially supported by the National Natural Science Foundation of China (No. U1904215)the Natural Science Foundation of Jiangsu Province (No. BK20200044)Changjiang Scholars Program of the Ministry of Education (No. Q2018270)。
文摘High-entropy alloys(HEAs) are an important research direction in the materials science field and engineering field.Different from traditional alloys which usually contain only one basic element and infrequently two,HEAs are made up of many major elements in much larger numbers.With impressive mechanical properties,impressive corrosion resistance and superior thermal stability,HEAs offer overwhelming advantages over conventional alloys.HEAs have received a lot of attention due to its unique concept and performance.In recent years,many researchers have prepared HEAs at the nanometer level,and the obtained high-entropy nanoparticles(HEA-NPs) have been extensively used in multifarious fields.This paper reviews the main characteristics,core effects,conventional synthesis methods and their applications in various fields of HEA-NPs.Furthermore,the vast space to be explored is discussed and the future development direction and outlook are outlined productively.
基金supported by the National Science Foundation of China(No.21890744)the National Key R&D Program of China(No.2019YFA0210100).
文摘Photodynamic therapy(PDT)has emerged as a significant cancer therapy option.Currently,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after cationization.However,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some circumstances.Herein,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor cells.Further,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor growth.Accordingly,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.
文摘A series of white phosphorescent OLED devices with buffer layer and multiple dopant structure is investigated in order to obtain better electro-optic performances and color stability. The color coordinate and color stability are related to the location of multiple dopants layer, and the optimized location can compensate for the change of the blue emission intensity under a high voltage and stabilize the spectrum. The electro-optic performances and color stability can be further improved by changing the composition and thickness of the buffer layer between the emitting layer and the electron transport layer.In device B2, the distance from multiple dopant layer to buffer layer is 2 nm and the thickness of buffer layer is 5 nm,the maximum luminance, current density, and power efficiency can reach 9091 cd/m^2, 364.5 mA/cm^2, and 26.74 lm/W,respectively. The variation of international commission on the illumination（CIE） coordinate of device B2 with voltage increasing from 4 V to 7 V is only（0.006, 0.004）.
基金supported by the National Key R&D Program of China(2019YFA0210100)the National Science Foundation of China(21890744,22004033).
文摘For specific drug research and development,a drug-screening strategy(DSS)plays an indispensable role in the biomedical field.Unfortunately,traditional strategies are complicated and insufficiently accurate due to the widely used single-target screening method.Herein,a simple dual-target-based drug-screening strategy(dt-DSS)is proposed to screen highly effective drugs by fluorescence imaging.As a proof of concept,we utilized a dual-responsive fluorescence probe to screen drugs for diabetic cardiomyopathy(DCM).We first developed and took advantage of a dual-response probe HDB to detect reactive oxygen species(ROS)and mitophagy levels in cellular starvation and high glucose models.Based on this,HDB was utilized to study the effects of different drugs in the mitophagy process caused by the high-glucose cell model for DCM.Combined with Western blotting assays,we found that Drp-1 inhibitors could fundamentally reduce mitophagy caused by the high-glucose cells model.Compared with commercial single-target antioxidant drugs,the drugs with simultaneous antioxidant capacity and Drp-1 inhibition screened by dt-DSS,such as resveratrol and icariin,could treat DCM better.Therefore,HDB as an effective tool could accurately and quickly screen high-potency drugs for DCM.We believe that this work provides an attractive strategy to explore the pathogenesis of diabetic cardiomyopathy and precisely screen for highly effective drugs.
