Verticillin A is a diketopiperazine compound which was previously isolated from Amanita flavorubescens Aik(containing parasitic fungi Hypomyces hyalines(Schw.)Tul.).Here,we initially found,by wound healing assay and T...Verticillin A is a diketopiperazine compound which was previously isolated from Amanita flavorubescens Aik(containing parasitic fungi Hypomyces hyalines(Schw.)Tul.).Here,we initially found,by wound healing assay and Tran swell assay in vitro,that verticilli n A possesses an inhibitory effect agai nst the migrati on and in vasion of the human colon cancer cell.Subsequently,c-mesenchymal,epithelial transition factor(c-Met)was identified as a molecular target of verticillin A by screening key genes related to cell migration.Verticillin A-mediated c-Met suppress!on is at the transcriptio nal level.Further study dem on strated that verticilli n A suppressed c-MET phosphorylation and decreased c-MET protein level.In addition,verticillin A inhibited the phosphorylation of c-MET downstream molecules including rat sarcoma(Ras)-associated factor(Raf),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT).Overexpression of Erk partially reversed the verticillin A-mediated anti-metastasis action in the human colon cancer cell.More importantly,verticillin A also inhibited cancer cell metastasis in vivo.Thus,verticillin A can significantly inhibit the migration and invasion of colon cancer cells by targeting c-Met and inhibiting Ras/Raf/mitogen-activated extracellular signal-regulated kinase(MEK)/ERK signaling pathways.Therefore,we determined that verticillin A is a natural compound that can be further developed as an anti-metastatic drug in human cancers.展开更多
In this paper,we investigate a(2+1)-dimensional variable-coefficient modified dispersive waterwave system in fluid mechanics.We prove the Painlevéintegrability for that system via the Painlevéanalysis.We fin...In this paper,we investigate a(2+1)-dimensional variable-coefficient modified dispersive waterwave system in fluid mechanics.We prove the Painlevéintegrability for that system via the Painlevéanalysis.We find some auto-B?cklund transformations for that system via the truncated Painlevéexpansions.Bilinear forms and N-soliton solutions are constructed,where N is a positive integer.We discuss the inelastic interactions,elastic interactions and soliton resonances for the two solitons.We also graphically demonstrate that the velocities of the solitons are affected by the variable coefficient of that system.展开更多
The nonlocal symmetries are derived for the Korteweg–de Vries–negative-order Korteweg–de Vries equation from the Painlevétruncation method.The nonlocal symmetries are localized to the classical Lie point symme...The nonlocal symmetries are derived for the Korteweg–de Vries–negative-order Korteweg–de Vries equation from the Painlevétruncation method.The nonlocal symmetries are localized to the classical Lie point symmetries for the enlarged system by introducing new dependent variables.The corresponding similarity reduction equations are obtained with different constant selections.Many explicit solutions for the integrable equation can be presented from the similarity reduction.展开更多
基金Zhejiang Provincial Natural Science Foundation of China(No.LY20H160039)the National Natural Science Foundation of China(No.31570811)Siyuan Foundation,Hongkong,China。
文摘Verticillin A is a diketopiperazine compound which was previously isolated from Amanita flavorubescens Aik(containing parasitic fungi Hypomyces hyalines(Schw.)Tul.).Here,we initially found,by wound healing assay and Tran swell assay in vitro,that verticilli n A possesses an inhibitory effect agai nst the migrati on and in vasion of the human colon cancer cell.Subsequently,c-mesenchymal,epithelial transition factor(c-Met)was identified as a molecular target of verticillin A by screening key genes related to cell migration.Verticillin A-mediated c-Met suppress!on is at the transcriptio nal level.Further study dem on strated that verticilli n A suppressed c-MET phosphorylation and decreased c-MET protein level.In addition,verticillin A inhibited the phosphorylation of c-MET downstream molecules including rat sarcoma(Ras)-associated factor(Raf),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT).Overexpression of Erk partially reversed the verticillin A-mediated anti-metastasis action in the human colon cancer cell.More importantly,verticillin A also inhibited cancer cell metastasis in vivo.Thus,verticillin A can significantly inhibit the migration and invasion of colon cancer cells by targeting c-Met and inhibiting Ras/Raf/mitogen-activated extracellular signal-regulated kinase(MEK)/ERK signaling pathways.Therefore,we determined that verticillin A is a natural compound that can be further developed as an anti-metastatic drug in human cancers.
基金the National Natural Science Foundation of China under Grant No.11772017the Fundamental Research Funds for the Central Universities
文摘In this paper,we investigate a(2+1)-dimensional variable-coefficient modified dispersive waterwave system in fluid mechanics.We prove the Painlevéintegrability for that system via the Painlevéanalysis.We find some auto-B?cklund transformations for that system via the truncated Painlevéexpansions.Bilinear forms and N-soliton solutions are constructed,where N is a positive integer.We discuss the inelastic interactions,elastic interactions and soliton resonances for the two solitons.We also graphically demonstrate that the velocities of the solitons are affected by the variable coefficient of that system.
基金Project supported by the National Natural Science Foundation of China(Grant No.11471215)。
文摘The nonlocal symmetries are derived for the Korteweg–de Vries–negative-order Korteweg–de Vries equation from the Painlevétruncation method.The nonlocal symmetries are localized to the classical Lie point symmetries for the enlarged system by introducing new dependent variables.The corresponding similarity reduction equations are obtained with different constant selections.Many explicit solutions for the integrable equation can be presented from the similarity reduction.
