PATIENTS with chronic heart failure(CHF)have a high incidence of atrial/ventricular arrhythmias which seriously affect life span and quality of life.Cardiac resynchronization therapy(CRT)can improve cardiac function a...PATIENTS with chronic heart failure(CHF)have a high incidence of atrial/ventricular arrhythmias which seriously affect life span and quality of life.Cardiac resynchronization therapy(CRT)can improve cardiac function and reverse myocardial remodeling,therefore improving the quality of life and reducing mortality.CRT with Home-Monitoring(HM)can be used to monitor cardiac arrhythmias and other展开更多
Copper matrix composites consisting of chromium （Cr） or ferrochrome （Cr-Fe） as strengthening elements and molybdenum disulfide as a lubricant had been sintered in nitrogen and hydrogen atmosphere, respectively. Th...Copper matrix composites consisting of chromium （Cr） or ferrochrome （Cr-Fe） as strengthening elements and molybdenum disulfide as a lubricant had been sintered in nitrogen and hydrogen atmosphere, respectively. Their morphology and energy-dispersive X-ray spectrometry （EDS） analysis showed that serious interaction occurred between MoS2 and Cr （or Cr-Fe） particles when the samples were sintered in hydrogen atmosphere. Chromium sulfide compound （CrxSy） was formed as a reaction product, which decreased the density and strength of the composites remarkably. This interaction was inhibited when the samples were sintered in nitrogen atmosphere; thus, the mechanical properties of the composites were improved.展开更多
NiFe layered double hydroxides(NiFe LDHs)have been intensively developed for the oxygen evolution reaction(OER)in alkaline media;however,their unsatisfactory hydrogen evolution reaction(HER)performance limits their pr...NiFe layered double hydroxides(NiFe LDHs)have been intensively developed for the oxygen evolution reaction(OER)in alkaline media;however,their unsatisfactory hydrogen evolution reaction(HER)performance limits their practical application in overall water splitting.Herein,a simple and efficient one-step electrodeposition method is used to accomplish in situ growth of NiFe LDHsNiFe alloy gradient hybrid coatings on a carbon cloth(CC).Within the binder-free electrode,NiFe LDHs nanosheets with a low-crystalline nature exhibit highly active bifunctional OER/HER activities,and the NiFe alloy acts as a stable electron highway and strong skeleton bridge between NiFe LDHs and the CC.When the electrodes are simultaneously employed as the cathode and anode for overall water splitting,they require low cell potentials of 1.441 V at10 mA·cm^(-2)and 1.703 V at 100 mA·cm^(-2),respectively,and they demonstrate outstanding stability at a current density greater than 100 mA·cm^(-2)for more than 100 h.This is one of the best bifunctional OER and HER catalysts for overall water splitting.Both lattice defects and surface reconstructions crucially contribute to the bifunctional OER/HER activities of NiFe LDHs.This simple and scalable synthesis approach presents an intriguing paradigm for industrial production,and the fabricated electrode has potential application in high-current-density water splitting.展开更多
Due to the extremely complex geological conditions in the Bohai Strait, active faults is very developed and earthquake activity occurs frequently. It is of great importance to evaluate the regional crustal stability f...Due to the extremely complex geological conditions in the Bohai Strait, active faults is very developed and earthquake activity occurs frequently. It is of great importance to evaluate the regional crustal stability for the planning and construction of the Trans-straits Passage. In this study, the authors carry out the evaluation by means of buffer analysis, topology analysis and overlay analysis based on ArcGIS software. The evaluation mainly analyzed six assessment factors of Bohai Strait including neotectonic activity, active faults distribution, seismicity, tectonic stress fields, Bouguer gravity anomaly and geological disasters. In brief, the crustal stability of the eastern North Yellow Sea Basin is best, while that of the Bohai Basin and southwest Bohai Strait is poor. Meanwhile, small and frequent earthquakes in the southern Strait and geological disasters developed in the northern and central Strait such as tidal ridge and shallow gas which may adversely impact on the Trans-straits Passage construction.展开更多
Electrocatalysis of CO_(2)reduction reaction is an effective way to convert CO_(2)into high value-added products,but the selectivity of Cu-based catalysts for C2+products needs to be improved due to the high energy ba...Electrocatalysis of CO_(2)reduction reaction is an effective way to convert CO_(2)into high value-added products,but the selectivity of Cu-based catalysts for C2+products needs to be improved due to the high energy barrier of C-C coupling.Therefore,a viable catalyst design strategy to decrease energy barrier of C-C coupling should be put forward.Here,a nanocavity-enriched CuPd single atom alloy(CuPd SAA)catalyst is designed to promote CC coupling process.The faradaic efficiency of CuPd SAA for ethylene and C_(2+)reaches 75.6%and 85.7%at-0.7 V versus reversible hydrogen electrode(RHE),respectively.Based on the results given by in situ characterization,the porous hollow structure dramatically increases the ratio of the linear-bond*CO,thus enhancing the faradaic efficiency for ethylene.Density functional theory(DFT)calculation reveals that the Pd doping can regulate the electronic structure of neighboring Cu atoms to decrease the energy barrier of C-C coupling,further improving the faradaic efficiency.This work provides a new idea for designing catalyst with high selectivity for ethylene.展开更多
Owing to the significant potential of alkalin seawater electrolysis for converting surplus power into eco friendly hydrogen fuel,we developed bifunctional elec trodes that integrate low-crystalline NiFe LDHs and amorp...Owing to the significant potential of alkalin seawater electrolysis for converting surplus power into eco friendly hydrogen fuel,we developed bifunctional elec trodes that integrate low-crystalline NiFe LDHs and amorphous NiFe alloy on a Ni foam(NF)substrate to enhance this process.Driven by the battery-like charac teristics of NiFe LDHs,an anti-corrosive and active oute layer of NiFe^(vac)OOH continuously forms over time in th hybrid on the anode for the oxygen evolution reaction(OER),effectively mitigating powder shedding caused by corrosion induced by multiple anions in seawater.Mean while,the strong bond between the hybrid and the NF substrate maintains intact hybrid coatings to ensure a rel atively high overall conductivity of the electrodes,signif icantly reducing the negative effects of structura degradation during the OER and hydrogen evolution reaction(HER),as well as the accumulation of contami nants on the electrode surfaces.In long-term tests,thes bifunctionalhybridelectrodesmaintained stable performance,even at a high current density o500 mA·cm^(-2).The cell voltage increased by only 88 m V over 1000 h to 1.970 V during saline electrolysis and by103 mV over 500 h to 2.062 V during seawater electroly sis.Hence,this study provides valuable insights into efficient and stable seawater electrolysis using NiFe LDHs–NiFe alloy hybrids.展开更多
Long non-coding RNAs(lnc RNAs), a newly discovered class of nc RNA molecules, have been widely accepted as crucial regulators of various diseases including cancer. Increasing numbers of studies have demonstrated that ...Long non-coding RNAs(lnc RNAs), a newly discovered class of nc RNA molecules, have been widely accepted as crucial regulators of various diseases including cancer. Increasing numbers of studies have demonstrated that lnc RNAs are involved in diverse physiological and pathophysiological processes, such as cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Aberrant expression of lnc RNAs frequently occurs in gastrointestinal cancer and plays emerging roles in cancer metastasis. In this review, we focus on and outline the regulatory functions of recently identified metastasis-associated lnc RNAs, and evaluate the p o t e n t i a l r o l e s o f l n c R N A s a s n o v e l d i a g n o s t i c biomarkers and therapeutic targets in gastrointestinal cancer.展开更多
Background:Climate change profoundly shapes the population health at the global scale.However,there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease...Background:Climate change profoundly shapes the population health at the global scale.However,there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease(CKD).Methods:In the present study,we studied the association of heat exposure with hospitalizations for cause-specific CKD using a national inpatient database in China during the study period of hot season from 2015 to 2018.Standard time-series regression models and random-effects Meta-analysis were developed to estimate the city-specific and national averaged associations at a 7 lag-day span,respectively.Results:A total of 768,129 hospitalizations for CKD was recorded during the study period.The results showed that higher temperature was associated with elevated risk of hospitalizations for CKD,especially in sub-tropical cities.With a 1℃ increase in daily mean temperature,the cumulative relative risks(RR)over lag 0-7 d were 1.008[95% confidence interval(CI)1.003-1.012]for nationwide.The attributable fraction of CKD hospitalizations due to high temperatures was 5.50%.Stronger associations were observed among younger patients and those with obstructive nephropathy.Our study also found that exposure to heatwaves was associated with added risk of hospitalizations for CKD compared to non-heatwave days(RR=1.116,95%CI 1.069-1.166)above the effect of daily mean temperature.Conclusions:Short-term heat exposure may increase the risk of hospitalization for CKD.Our findings provide insights into the health effects of climate change and suggest the necessity of guided protection strategies against the adverse effects of high temperatures.展开更多
Electrochemical nitrite(NO_(2)^(−))reduction offers a sustainable route for ammonia(NH_(3))synthesis while simultaneously removing contaminants in wastewater.However,its efficiency is often limited by low catalytic ef...Electrochemical nitrite(NO_(2)^(−))reduction offers a sustainable route for ammonia(NH_(3))synthesis while simultaneously removing contaminants in wastewater.However,its efficiency is often limited by low catalytic efficiency and the competitive hydrogen evolution reaction at low NO_(2)^(−)concentrations.Herein,we report an intermittent pulsed electrolysis(IPE)strategy using copper oxide(Cu_(x)O)nanowires,which significantly enhances the NH3 yield rate and Faradaic efficiency(FE)at lower reactant concentrations.In situ experiments and theoretical calculations reveal that alternating between open-circuit and cathodic potentials modulates the copper oxidation states,stabilizing the catalytically active cuprous oxide(Cu_(2)O).Consequently,the IPE approach provides an outstanding NH3 yield rate of 115.10 mg·h^(−1)·cm^(−2)and FE of 91.14%in the presence of 25 mM NO_(2)^(−),markedly outperforming conventional constant potential electrolysis.展开更多
Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory infertility.Inadequate understanding of the ovulation drivers hinders PCOS intervention.Herein,we report that follicle stimulating hormone(FSH)control...Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory infertility.Inadequate understanding of the ovulation drivers hinders PCOS intervention.Herein,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine ovulation.Murine ovulation starts from FF-exposing granulosa cell(GC)apoptosis.FF glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients FF.High-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS traits.Mechanistically,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic pathway.FSH and glutamine inhibit the rapture of cultured murine follicles.Glutamine removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or EsR1-KO.These suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.展开更多
The Global Stratotype Section and Point(GSSP)of the base-Wuchiapingian Stage was formally ratified at the Penglaitan section in South China in 2005.However,the riverside GSSP section at Penglaitan and its auxiliary se...The Global Stratotype Section and Point(GSSP)of the base-Wuchiapingian Stage was formally ratified at the Penglaitan section in South China in 2005.However,the riverside GSSP section at Penglaitan and its auxiliary section at Tieqiao have been permanently flooded since 2020.We herein designate an excavated section at Penglaitan as the new GSSP and the Fengshan section as a new Standard Auxiliary Boundary Stratotype(SABS).In addition,we revised the original definition based on a detailed restudy of the conodont succession from the two sections.We define the GSSP of the base-Wuchiapingian by the First Appearance Datum(FAD)of Clarkina postbitteri within the lineage Jinogondolella granti→Clarkina postbitteri→C.dukouensis.It represents a major evolutionary turnover in conodonts from Jinogondolella to Clarkina and marks the end-Guadalupian extinction event.The U-Pb date of 259.51±0.21 Ma from the uppermost part of the Emeishan basalt is adopted for the GLB age.δ13Ccarb chemostratigraphy at the SABS exhibits several excursions between 3‰and 5‰across the GLB interval.Carbonate 87Sr/86Sr ratio is 0.707244 at the GLB.Remarkably,the SABS contains six normal and six reverse geomagnetic polarity zones in the uppermost Capitanian and three in the lowest Wuchiapingian.展开更多
In dimensional affect recognition, the machine learning methods, which are used to model and predict affect, are mostly classification and regression. However, the annotation in the dimensional affect space usually ta...In dimensional affect recognition, the machine learning methods, which are used to model and predict affect, are mostly classification and regression. However, the annotation in the dimensional affect space usually takes the form of a continuous real value which has an ordinal property. The aforementioned methods do not focus on taking advantage of this important information. Therefore, we propose an affective rating ranking framework for affect recognition based on face images in the valence and arousal dimensional space. Our approach can appropriately use the ordinal information among affective ratings which are generated by discretizing continuous annotations.Specifically, we first train a series of basic cost-sensitive binary classifiers, each of which uses all samples relabeled according to the comparison results between corresponding ratings and a given rank of a binary classifier. We obtain the final affective ratings by aggregating the outputs of binary classifiers. By comparing the experimental results with the baseline and deep learning based classification and regression methods on the benchmarking database of the AVEC 2015 Challenge and the selected subset of SEMAINE database, we find that our ordinal ranking method is effective in both arousal and valence dimensions.展开更多
Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS patients.Many studies have reported that aut...Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS patients.Many studies have reported that autophagy and apoptosis,which are closely related to mitochondrial function,play important roles in the development of NAFLD.Therefore,in this study,we aimed to explore the role of mitochondrial dysfunction caused by liver apoptosis and autophagy imbalance in the development of NAFLD in a PCOS mouse model.Methods:We used a dihydrotestosterone(DHT)-induced PCOS model to mimic the pathological process of hyperandrogenism.Hematoxylin and eosin and Oil Red O staining assays were used to observe the pathological changes in the liver.Western blotting and quantitative real-time polymerase chain reaction were used to perform mitochondrion-related assays.Results:Hepatic steatosis and different degrees of inflammation were observed in the DHT-treated mice.The expression of molecules involved in the respiratory chain and aerobic respiration process was altered.The levels of the key molecules associated with apoptosis and autophagy were abnormal.Conclusions:Androgens may play a role in the process of hepatic steatosis development by affecting mitochondrial function and subsequently inducing apoptosis and autophagy.Such phenomena might be involved in the pathogenesis of NAFLD in women with PCOS.展开更多
Hormone therapy,assisted reproductive technology,and regenerative medicine have been used to treat infertility due to premature ovarian insufficiency(POI),with limited success.It is timely to survey the field by outli...Hormone therapy,assisted reproductive technology,and regenerative medicine have been used to treat infertility due to premature ovarian insufficiency(POI),with limited success.It is timely to survey the field by outlining the controversies and promising prospects of evolving stem cell(SC)therapy for patients with POI.We first discuss several strategies of tissue-derived SC therapy and induced/engineered SC therapy and then enumerate mechanisms,including cellular regenerability induced in reproductive tissues and paracrine effects induced by various chemokines.Next,we evaluate the potential benefits of SC-based tissue engineering in reversing ovarian aging.Finally,we discuss the clinical feasibility of SC therapy and generalized regenerative medicine for the treatment of POI.In summary,SCs and SC-derived exosomes,induced pluripotent SCs,engineered SCs,and tissue engineering could start a new chapter for fertility rehabilitation in patients with POI.Uncovering the underlying molecular mechanisms and biological efficacy could be facilitated not only by animal experiments but also by security screening and clinical trials to validate SC-based therapy for POI.展开更多
Objective::Altered bile acid transformation induces low-grade chronic inflammation and may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS). Liquiritincan regulate bile acid metabolism...Objective::Altered bile acid transformation induces low-grade chronic inflammation and may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS). Liquiritincan regulate bile acid metabolism and anti-inflammatory properties;however, limited information is available regarding its therapeutic potential in PCOS.Methods::Female C57BL/6 mice were randomly assigned into four groups ( n = 6 mice/group): the control, letrozole or dehydroepiandrosterone-induced PCOS groups, PCOS + 20 mg/kg liquiritin group, and control + liquiritin groups. After 21 days of treatment, the mice were euthanized, and the associated metabolism indications were investigated. Ovarian histological examinations were performed, and serum hormone concentration was measured. The expression of key genes involved in steroid hormone synthesis, ovarian follicle development, and ovulation was assessed. Results::Liquiritin reduced fasting blood glucose levels and increased insulin sensitivity compared to the PCOS group. Liquiritin also significantly decreased serum levels of total testosterone ( P < 0.001) and dehydroepiandrosterone sulfate ( P < 0.05) in the PCOS group. Histomorphological inspection of ovaries from the liquiritin group revealed fewer cystic dilated follicles than in the PCOS group. Moreover, liquiritinsignificantly ( P < 0.01) decreased Cyp17a1, Cyp19a1, Fshr, Hsd3b2, Runx2, and Ccn2 mRNA expression compared to letrozole-induced PCOS. Conclusion::Liquiritin may be safe and helpful in ameliorating PCOS-associated hyperandrogenemia and hyperglycemia. However, clinical trials investigating different liquiritin dosages are needed to confirm these findings.展开更多
文摘PATIENTS with chronic heart failure(CHF)have a high incidence of atrial/ventricular arrhythmias which seriously affect life span and quality of life.Cardiac resynchronization therapy(CRT)can improve cardiac function and reverse myocardial remodeling,therefore improving the quality of life and reducing mortality.CRT with Home-Monitoring(HM)can be used to monitor cardiac arrhythmias and other
基金financially supported by the Key Project of the National Eleventh-Five Year Research Program of China (No.2009BAG12A07)
文摘Copper matrix composites consisting of chromium （Cr） or ferrochrome （Cr-Fe） as strengthening elements and molybdenum disulfide as a lubricant had been sintered in nitrogen and hydrogen atmosphere, respectively. Their morphology and energy-dispersive X-ray spectrometry （EDS） analysis showed that serious interaction occurred between MoS2 and Cr （or Cr-Fe） particles when the samples were sintered in hydrogen atmosphere. Chromium sulfide compound （CrxSy） was formed as a reaction product, which decreased the density and strength of the composites remarkably. This interaction was inhibited when the samples were sintered in nitrogen atmosphere; thus, the mechanical properties of the composites were improved.
基金financially supported by the Fundamental Research Funds for the Central Universities,JLU(No.45122031B004)。
文摘NiFe layered double hydroxides(NiFe LDHs)have been intensively developed for the oxygen evolution reaction(OER)in alkaline media;however,their unsatisfactory hydrogen evolution reaction(HER)performance limits their practical application in overall water splitting.Herein,a simple and efficient one-step electrodeposition method is used to accomplish in situ growth of NiFe LDHsNiFe alloy gradient hybrid coatings on a carbon cloth(CC).Within the binder-free electrode,NiFe LDHs nanosheets with a low-crystalline nature exhibit highly active bifunctional OER/HER activities,and the NiFe alloy acts as a stable electron highway and strong skeleton bridge between NiFe LDHs and the CC.When the electrodes are simultaneously employed as the cathode and anode for overall water splitting,they require low cell potentials of 1.441 V at10 mA·cm^(-2)and 1.703 V at 100 mA·cm^(-2),respectively,and they demonstrate outstanding stability at a current density greater than 100 mA·cm^(-2)for more than 100 h.This is one of the best bifunctional OER and HER catalysts for overall water splitting.Both lattice defects and surface reconstructions crucially contribute to the bifunctional OER/HER activities of NiFe LDHs.This simple and scalable synthesis approach presents an intriguing paradigm for industrial production,and the fabricated electrode has potential application in high-current-density water splitting.
基金This work was supported by the National Natural Science Foundation of China (41506119,41276060)the Geological Investigation Project of China Geological Survey (201200504,DD20191003). Thanks Prof. Xu Jie,Zhang Lifang and other anonymous reviewers for their comments and suggestions,which significantly improved the quality of the manuscript.
文摘Due to the extremely complex geological conditions in the Bohai Strait, active faults is very developed and earthquake activity occurs frequently. It is of great importance to evaluate the regional crustal stability for the planning and construction of the Trans-straits Passage. In this study, the authors carry out the evaluation by means of buffer analysis, topology analysis and overlay analysis based on ArcGIS software. The evaluation mainly analyzed six assessment factors of Bohai Strait including neotectonic activity, active faults distribution, seismicity, tectonic stress fields, Bouguer gravity anomaly and geological disasters. In brief, the crustal stability of the eastern North Yellow Sea Basin is best, while that of the Bohai Basin and southwest Bohai Strait is poor. Meanwhile, small and frequent earthquakes in the southern Strait and geological disasters developed in the northern and central Strait such as tidal ridge and shallow gas which may adversely impact on the Trans-straits Passage construction.
基金financially supported by the National Natural Science Foundation of China(Nos.50835002 and 51105102)。
文摘Electrocatalysis of CO_(2)reduction reaction is an effective way to convert CO_(2)into high value-added products,but the selectivity of Cu-based catalysts for C2+products needs to be improved due to the high energy barrier of C-C coupling.Therefore,a viable catalyst design strategy to decrease energy barrier of C-C coupling should be put forward.Here,a nanocavity-enriched CuPd single atom alloy(CuPd SAA)catalyst is designed to promote CC coupling process.The faradaic efficiency of CuPd SAA for ethylene and C_(2+)reaches 75.6%and 85.7%at-0.7 V versus reversible hydrogen electrode(RHE),respectively.Based on the results given by in situ characterization,the porous hollow structure dramatically increases the ratio of the linear-bond*CO,thus enhancing the faradaic efficiency for ethylene.Density functional theory(DFT)calculation reveals that the Pd doping can regulate the electronic structure of neighboring Cu atoms to decrease the energy barrier of C-C coupling,further improving the faradaic efficiency.This work provides a new idea for designing catalyst with high selectivity for ethylene.
基金supported by the National Natural Science Foundation of China(No.22209054)the Natural Science Foundation of Hunan Province(Nos.2023JJ30017 and 2023JJ30030)the Natural Science Foundation of Changsha(No.kq2208223)。
文摘Owing to the significant potential of alkalin seawater electrolysis for converting surplus power into eco friendly hydrogen fuel,we developed bifunctional elec trodes that integrate low-crystalline NiFe LDHs and amorphous NiFe alloy on a Ni foam(NF)substrate to enhance this process.Driven by the battery-like charac teristics of NiFe LDHs,an anti-corrosive and active oute layer of NiFe^(vac)OOH continuously forms over time in th hybrid on the anode for the oxygen evolution reaction(OER),effectively mitigating powder shedding caused by corrosion induced by multiple anions in seawater.Mean while,the strong bond between the hybrid and the NF substrate maintains intact hybrid coatings to ensure a rel atively high overall conductivity of the electrodes,signif icantly reducing the negative effects of structura degradation during the OER and hydrogen evolution reaction(HER),as well as the accumulation of contami nants on the electrode surfaces.In long-term tests,thes bifunctionalhybridelectrodesmaintained stable performance,even at a high current density o500 mA·cm^(-2).The cell voltage increased by only 88 m V over 1000 h to 1.970 V during saline electrolysis and by103 mV over 500 h to 2.062 V during seawater electroly sis.Hence,this study provides valuable insights into efficient and stable seawater electrolysis using NiFe LDHs–NiFe alloy hybrids.
基金Supported by the National Natural Science Foundation of China,No.81272762 and No.81201635the Guangdong Natural Science Funds for Distinguished Young Scholar,No.S20120011334
文摘Long non-coding RNAs(lnc RNAs), a newly discovered class of nc RNA molecules, have been widely accepted as crucial regulators of various diseases including cancer. Increasing numbers of studies have demonstrated that lnc RNAs are involved in diverse physiological and pathophysiological processes, such as cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Aberrant expression of lnc RNAs frequently occurs in gastrointestinal cancer and plays emerging roles in cancer metastasis. In this review, we focus on and outline the regulatory functions of recently identified metastasis-associated lnc RNAs, and evaluate the p o t e n t i a l r o l e s o f l n c R N A s a s n o v e l d i a g n o s t i c biomarkers and therapeutic targets in gastrointestinal cancer.
基金This study was supported by the National Natural Science Foundation of China(82003529,72125009)the National Key Research and Development Program of the Ministry of Science and Technology of China(2019YFC2005000)+4 种基金the Chinese Scientific and Technical Innovation Project 2030(2018AAA0102100)the National High Level Hospital Clinical Research Funding(“Star of Outlook”Scientific Research Project of Peking University First Hospital,2022XW06)the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-046)the Young Elite Scientists Sponsorship Program by CAST(2022QNRC001)the PKU-Baidu Fund(2020BD004,2020BD005 and 2020BD032).
文摘Background:Climate change profoundly shapes the population health at the global scale.However,there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease(CKD).Methods:In the present study,we studied the association of heat exposure with hospitalizations for cause-specific CKD using a national inpatient database in China during the study period of hot season from 2015 to 2018.Standard time-series regression models and random-effects Meta-analysis were developed to estimate the city-specific and national averaged associations at a 7 lag-day span,respectively.Results:A total of 768,129 hospitalizations for CKD was recorded during the study period.The results showed that higher temperature was associated with elevated risk of hospitalizations for CKD,especially in sub-tropical cities.With a 1℃ increase in daily mean temperature,the cumulative relative risks(RR)over lag 0-7 d were 1.008[95% confidence interval(CI)1.003-1.012]for nationwide.The attributable fraction of CKD hospitalizations due to high temperatures was 5.50%.Stronger associations were observed among younger patients and those with obstructive nephropathy.Our study also found that exposure to heatwaves was associated with added risk of hospitalizations for CKD compared to non-heatwave days(RR=1.116,95%CI 1.069-1.166)above the effect of daily mean temperature.Conclusions:Short-term heat exposure may increase the risk of hospitalization for CKD.Our findings provide insights into the health effects of climate change and suggest the necessity of guided protection strategies against the adverse effects of high temperatures.
基金supported in part by the National Key R&D Program of China(No.2024YFA1509400)the National Natural Science Foundation of China(No.52302094)Natural Science Foundation of Jiangxi,China(No.20232ACB203002).
文摘Electrochemical nitrite(NO_(2)^(−))reduction offers a sustainable route for ammonia(NH_(3))synthesis while simultaneously removing contaminants in wastewater.However,its efficiency is often limited by low catalytic efficiency and the competitive hydrogen evolution reaction at low NO_(2)^(−)concentrations.Herein,we report an intermittent pulsed electrolysis(IPE)strategy using copper oxide(Cu_(x)O)nanowires,which significantly enhances the NH3 yield rate and Faradaic efficiency(FE)at lower reactant concentrations.In situ experiments and theoretical calculations reveal that alternating between open-circuit and cathodic potentials modulates the copper oxidation states,stabilizing the catalytically active cuprous oxide(Cu_(2)O).Consequently,the IPE approach provides an outstanding NH3 yield rate of 115.10 mg·h^(−1)·cm^(−2)and FE of 91.14%in the presence of 25 mM NO_(2)^(−),markedly outperforming conventional constant potential electrolysis.
基金State Key Development Programs of China(Nos.2018YFA0800300)(S.M.Z),2018YFA0801300(W.X)National Natural Science Foundation of China(Nos.92253305)(S.M.Z),31821002(S.M.Z),32230054(S.M.Z),31930062(S.M.Z),91857000(S.M.Z),92157001(S.M.Z),32171298(W.X),81971449(Y.Y.Y),82171672(Y.Y.Y)+1 种基金Program of Shanghai Academic Research Leader(21XD1423000)(W.X)China postdoctoral science foundation(2022M721954)(K.H.Z).
文摘Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory infertility.Inadequate understanding of the ovulation drivers hinders PCOS intervention.Herein,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine ovulation.Murine ovulation starts from FF-exposing granulosa cell(GC)apoptosis.FF glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients FF.High-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS traits.Mechanistically,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic pathway.FSH and glutamine inhibit the rapture of cultured murine follicles.Glutamine removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or EsR1-KO.These suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.
基金supported by the National Natural Science Foundation of China(42293280,42272031,42250104,42261144668)Strategic Priority Research Program(B)of the Chinese Academy of Sciences(XDB26000000).
文摘The Global Stratotype Section and Point(GSSP)of the base-Wuchiapingian Stage was formally ratified at the Penglaitan section in South China in 2005.However,the riverside GSSP section at Penglaitan and its auxiliary section at Tieqiao have been permanently flooded since 2020.We herein designate an excavated section at Penglaitan as the new GSSP and the Fengshan section as a new Standard Auxiliary Boundary Stratotype(SABS).In addition,we revised the original definition based on a detailed restudy of the conodont succession from the two sections.We define the GSSP of the base-Wuchiapingian by the First Appearance Datum(FAD)of Clarkina postbitteri within the lineage Jinogondolella granti→Clarkina postbitteri→C.dukouensis.It represents a major evolutionary turnover in conodonts from Jinogondolella to Clarkina and marks the end-Guadalupian extinction event.The U-Pb date of 259.51±0.21 Ma from the uppermost part of the Emeishan basalt is adopted for the GLB age.δ13Ccarb chemostratigraphy at the SABS exhibits several excursions between 3‰and 5‰across the GLB interval.Carbonate 87Sr/86Sr ratio is 0.707244 at the GLB.Remarkably,the SABS contains six normal and six reverse geomagnetic polarity zones in the uppermost Capitanian and three in the lowest Wuchiapingian.
基金supported by the National Natural Science Foundation of China(Nos.61272211 and 61672267)the Open Project Program of the National Laboratory of Pattern Recognition(No.201700022)+1 种基金the China Postdoctoral Science Foundation(No.2015M570413)and the Innovation Project of Undergraduate Students in Jiangsu University(No.16A235)
文摘In dimensional affect recognition, the machine learning methods, which are used to model and predict affect, are mostly classification and regression. However, the annotation in the dimensional affect space usually takes the form of a continuous real value which has an ordinal property. The aforementioned methods do not focus on taking advantage of this important information. Therefore, we propose an affective rating ranking framework for affect recognition based on face images in the valence and arousal dimensional space. Our approach can appropriately use the ordinal information among affective ratings which are generated by discretizing continuous annotations.Specifically, we first train a series of basic cost-sensitive binary classifiers, each of which uses all samples relabeled according to the comparison results between corresponding ratings and a given rank of a binary classifier. We obtain the final affective ratings by aggregating the outputs of binary classifiers. By comparing the experimental results with the baseline and deep learning based classification and regression methods on the benchmarking database of the AVEC 2015 Challenge and the selected subset of SEMAINE database, we find that our ordinal ranking method is effective in both arousal and valence dimensions.
基金This work was supported by the National Natural Science Foundation of China(No.81673766 and 81973945 to YF,No.81572555 to XL)the Chinese Special Fund for Postdocs(No.2014T70392)+1 种基金the Swedish Medical Research Council(No.10380)the Swedish Federal Government under the LUA/ALF agreement(No.ALFGBG-147791 to HB and LS).
文摘Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS patients.Many studies have reported that autophagy and apoptosis,which are closely related to mitochondrial function,play important roles in the development of NAFLD.Therefore,in this study,we aimed to explore the role of mitochondrial dysfunction caused by liver apoptosis and autophagy imbalance in the development of NAFLD in a PCOS mouse model.Methods:We used a dihydrotestosterone(DHT)-induced PCOS model to mimic the pathological process of hyperandrogenism.Hematoxylin and eosin and Oil Red O staining assays were used to observe the pathological changes in the liver.Western blotting and quantitative real-time polymerase chain reaction were used to perform mitochondrion-related assays.Results:Hepatic steatosis and different degrees of inflammation were observed in the DHT-treated mice.The expression of molecules involved in the respiratory chain and aerobic respiration process was altered.The levels of the key molecules associated with apoptosis and autophagy were abnormal.Conclusions:Androgens may play a role in the process of hepatic steatosis development by affecting mitochondrial function and subsequently inducing apoptosis and autophagy.Such phenomena might be involved in the pathogenesis of NAFLD in women with PCOS.
文摘Hormone therapy,assisted reproductive technology,and regenerative medicine have been used to treat infertility due to premature ovarian insufficiency(POI),with limited success.It is timely to survey the field by outlining the controversies and promising prospects of evolving stem cell(SC)therapy for patients with POI.We first discuss several strategies of tissue-derived SC therapy and induced/engineered SC therapy and then enumerate mechanisms,including cellular regenerability induced in reproductive tissues and paracrine effects induced by various chemokines.Next,we evaluate the potential benefits of SC-based tissue engineering in reversing ovarian aging.Finally,we discuss the clinical feasibility of SC therapy and generalized regenerative medicine for the treatment of POI.In summary,SCs and SC-derived exosomes,induced pluripotent SCs,engineered SCs,and tissue engineering could start a new chapter for fertility rehabilitation in patients with POI.Uncovering the underlying molecular mechanisms and biological efficacy could be facilitated not only by animal experiments but also by security screening and clinical trials to validate SC-based therapy for POI.
基金This work was supported by the Shanghai Commission of Science and Technology Planning(22ZR1409100)to F.Zthe Shanghai Municipal Commission of Health and Family Planning(2017ZZ01016)to C.X.
文摘Objective::Altered bile acid transformation induces low-grade chronic inflammation and may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS). Liquiritincan regulate bile acid metabolism and anti-inflammatory properties;however, limited information is available regarding its therapeutic potential in PCOS.Methods::Female C57BL/6 mice were randomly assigned into four groups ( n = 6 mice/group): the control, letrozole or dehydroepiandrosterone-induced PCOS groups, PCOS + 20 mg/kg liquiritin group, and control + liquiritin groups. After 21 days of treatment, the mice were euthanized, and the associated metabolism indications were investigated. Ovarian histological examinations were performed, and serum hormone concentration was measured. The expression of key genes involved in steroid hormone synthesis, ovarian follicle development, and ovulation was assessed. Results::Liquiritin reduced fasting blood glucose levels and increased insulin sensitivity compared to the PCOS group. Liquiritin also significantly decreased serum levels of total testosterone ( P < 0.001) and dehydroepiandrosterone sulfate ( P < 0.05) in the PCOS group. Histomorphological inspection of ovaries from the liquiritin group revealed fewer cystic dilated follicles than in the PCOS group. Moreover, liquiritinsignificantly ( P < 0.01) decreased Cyp17a1, Cyp19a1, Fshr, Hsd3b2, Runx2, and Ccn2 mRNA expression compared to letrozole-induced PCOS. Conclusion::Liquiritin may be safe and helpful in ameliorating PCOS-associated hyperandrogenemia and hyperglycemia. However, clinical trials investigating different liquiritin dosages are needed to confirm these findings.
