Hepatocellular carcinoma ranks as the sixth most common cancer globally,with portal vein tumor thrombus(PVTT)being a frequent complication associated with intrahepatic metastasis,distant dissemination,and poor prognos...Hepatocellular carcinoma ranks as the sixth most common cancer globally,with portal vein tumor thrombus(PVTT)being a frequent complication associated with intrahepatic metastasis,distant dissemination,and poor prognosis.The significance of PVTT has been widely recognized,prompting the utilization of various treatment modalities such as surgery,transarterial chemoembolization,radiotherapy,targeted therapy,and immune checkpoint inhibitors.However,the efficacy of these approaches is often hampered by the impact of hepatitis B virus infection and the compromised physical condition of late-stage patients,limiting their effectiveness in achieving desirable therapeutic outcomes.This article delineates the treatment modalities available for PVTT patients and the challenges they encounter in clinical management.展开更多
基金Sponsored by Beijing Nova Program(20230484372)Young Elite Scientists Sponsorship Program by CAST(2023QNRC001)+2 种基金Capital’s Funds for Health Improvement and Research(CFH 2024-4-5026,2022-2-5021)Young Elite Scientists Sponsorship Program by BAST(No.BYESS2024001)National Key Research and Development Program of China(2022YFC2407402,2022YFC2407403).
文摘Hepatocellular carcinoma ranks as the sixth most common cancer globally,with portal vein tumor thrombus(PVTT)being a frequent complication associated with intrahepatic metastasis,distant dissemination,and poor prognosis.The significance of PVTT has been widely recognized,prompting the utilization of various treatment modalities such as surgery,transarterial chemoembolization,radiotherapy,targeted therapy,and immune checkpoint inhibitors.However,the efficacy of these approaches is often hampered by the impact of hepatitis B virus infection and the compromised physical condition of late-stage patients,limiting their effectiveness in achieving desirable therapeutic outcomes.This article delineates the treatment modalities available for PVTT patients and the challenges they encounter in clinical management.
