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以肌张力障碍为首发症状的疑似克-雅病1例报告
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作者 简文佳 申少珍 +2 位作者 杨贺 甄飞 窦金娟 《阿尔茨海默病及相关病杂志》 2025年第4期248-252,共5页
目的:研究散发型克-雅病(sCJD)的疾病特征,增加临床医师对该病的认知。方法:通过分析1例疑似sCJD病例,探讨其临床资料、影像学及实验室检验结果,并结合文献复习。结果:该患者表现为肢体僵硬、不自主运动、肌阵挛、言语障碍、快速进展的... 目的:研究散发型克-雅病(sCJD)的疾病特征,增加临床医师对该病的认知。方法:通过分析1例疑似sCJD病例,探讨其临床资料、影像学及实验室检验结果,并结合文献复习。结果:该患者表现为肢体僵硬、不自主运动、肌阵挛、言语障碍、快速进展的认知障碍,后期出现自主神经功能障碍,并在发病8个月死亡。结论:sCJD早期症状不典型,症状异质性大,病情进展快,致死率高,诊断中需要注意与多种疾病的鉴别,并动态检查脑脊液,头颅核磁,脑电图,甚至活检,以避免误诊漏诊。 展开更多
关键词 克-雅病 诊断 鉴别诊断
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High-throughput development of genome-wide locus-specific informative SSR markers in wheat 被引量:5
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作者 Lei Li Fayu Sun +4 位作者 Di Wu fei zhen Guihua Bai Derong Gao Tao Li 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第6期671-673,共3页
Dear Editor,Although simple sequence repeat(SSR)markers are not new,they are still useful and often used markers in molecular mapping and marker-assisted breeding,particularly in developing countries.However,locus-s... Dear Editor,Although simple sequence repeat(SSR)markers are not new,they are still useful and often used markers in molecular mapping and marker-assisted breeding,particularly in developing countries.However,locus-specific SSR markers could be more useful and informative in wheat breeding and genetic studies.In the present study,221,911 locus-specific SSR markers were designed.Verification of polymorphisms showed that the proportion of polymorphic markers increases with an increase in SSR size. 展开更多
关键词 locus wheat informative breeding polymorphic throughput SSRs Aegilops primer Triticum
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