Micro-/mesopore structures in carbon anode are highly desirable for increasing active sites and accelerating ion migration,favoring high capacity and rate performance.However,some structure-performance relationships s...Micro-/mesopore structures in carbon anode are highly desirable for increasing active sites and accelerating ion migration,favoring high capacity and rate performance.However,some structure-performance relationships still need to be clarified,and an in-depth understanding of how pore size and volume affect capacity and rate performance has rarely been mentioned.Herein,a series of carbon nanosheets with different micro-/mesopore sizes and volumes are precisely prepared.Detailed experimental analyses demonstrate that micropore volume rather than size is tightly responsible for capacity,resulting from its“accommodation effect”for ions.Conversely,mesopore size instead of volume is closely related to rate performance,which can be ascribed to its“channels effect”for ions.Capacity and rate performance first increase and then decrease with increasing micropore volume and mesopore size.In this work,the sample featured with the optimal micropore volume(1.6 cm^(3)·g^(-1))and mesopore size(2.55 nm)delivers the highest capacity(453 mAh·g^(-1)at 0.5 A·g^(-1))and excellent rate performance(235.1 mAh·g^(-1)at 2 A·g^(-1)).This work provides a new insight into the understanding of micro-/mesopore parameters and their effect on capacity and rate performance.展开更多
Severe fever with thrombocytopenia virus(SFTSV),an emerging tick-borne bandavirus,poses a significant public health threat in rural China.Since 2021,an increase of local cases has been noted in the rural-urban fringe ...Severe fever with thrombocytopenia virus(SFTSV),an emerging tick-borne bandavirus,poses a significant public health threat in rural China.Since 2021,an increase of local cases has been noted in the rural-urban fringe of Beijing.This study aimed to assess the formation of natural foci in urban areas by conducting a field survey of ticks and hedgehogs from the second to fifth ring roads of Beijing.Our survey revealed a diverse tick population in city parks,including the major SFTSV vector,Haemaphysalis longicornis.Parthenogenetic H.longicornis,known for its role in the rapid spread of SFTSV,was identified in key locations such as Beihai Park and Taoranting Park,near the Forbidden City.Notably,high SFTSV seroprevalence and RNA prevalence were found in hedgehogs and parasitic ticks in the center of Beijing.Phylogenetic analyses of SFTSV RNA and mitochondrial sequences of parthenogenetic H.longicornis ticks revealed the existence of diverse lineages of SFTSV and H.longicornis ticks within Beijing,suggesting multiple invasion events happened.These findings reveal the circulation of SFTSV in central Beijing,highlighting the need for urgent attention and enhanced surveillance measures.展开更多
目的探讨甲状腺术后出血的危险因素及常见出血部位,为预防术后出血提供临床依据。方法回顾性分析2010年11月至2017年11月期间四川大学华西医院的21例甲状腺术后出血和63例非出血患者的临床资料,探索术后出血的影响因素。结果单因素分析...目的探讨甲状腺术后出血的危险因素及常见出血部位,为预防术后出血提供临床依据。方法回顾性分析2010年11月至2017年11月期间四川大学华西医院的21例甲状腺术后出血和63例非出血患者的临床资料,探索术后出血的影响因素。结果单因素分析结果显示,合并高血压、肿瘤最大径、淋巴结转移、喉返神经浸润、T分期、N分期、甘油三酯和血清高密度脂蛋白(high density lipoprotein,HDL)水平与术后出血有关(P<0.05);多因素分析结果显示,淋巴结转移(OR=16.219,P=0.002)和血清HDL水平(OR=0.035,P=0.006)为术后出血的影响因素。术后出血的患者中,最常见的5个出血部位依次为:带状肌及胸锁乳突肌(均占19.2%)、食管气管表面血管(11.5%)、甲状腺床(7.7%)及喉返神经旁小血管(7.7%)。结论淋巴结转移和低血清HDL水平为甲状腺术后出血的危险因素。术后出血的好发部位主要为颈部肌肉。展开更多
A 62-year-old woman was admitted to our hospital in2011 because of recurrent abdominal pain,nausea and constipation for six months.Computed tomography enterography(CTE)showed tortuous thread-like calcifications in the...A 62-year-old woman was admitted to our hospital in2011 because of recurrent abdominal pain,nausea and constipation for six months.Computed tomography enterography(CTE)showed tortuous thread-like calcifications in the ileocolic vein and right colic vein,while colonoscopy revealed purple-blue mucosa extending from the cecum to the splenic flexure.Based on the results of these tests,the patient was diagnosed with idiopathic mesenteric phlebosclerosis(IMP).She had a history of Chinese medical liquor intake for one and a half years and her symptoms subsided after conservative treatment.In 2013,a 63-year-old male patient who presented with recurrent lower right abdominal pain,bloating,melena and diarrhea for fifteen months was admitted to our institution.Colonoscopy and CTE led to the diagnosis of IMP.He also used Chinese medical liquor for approximately 12 years.The patient underwent total colectomy and the postoperative course was uneventful.We searched for previously published reports on similar cases and analyzed the clinical data of 50 cases identified in PubMed.As some of these patients admitted use of Chinese medicines,we hypothesize that Chinese medicines may play a role in the pathogenesis of IMP.展开更多
Severe fever with thrombocytopenia syndrome virus （SFTSV） is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of ...Severe fever with thrombocytopenia syndrome virus （SFTSV） is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses. The virus particles are internalized into host cell endosomes through the clathrin-dependent pathway, where the low pH activates the fusion of the virus with the cell membrane. With information from studies on other bunyaviruses, herein we will review our knowledge of the entry process of SFTSV.展开更多
In the prediction of the end-point molten steel temperature of the ladle furnace, the influence of some factors is nonlinear. The prediction accuracy will be affected by directly inputting these nonlinear factors into...In the prediction of the end-point molten steel temperature of the ladle furnace, the influence of some factors is nonlinear. The prediction accuracy will be affected by directly inputting these nonlinear factors into the data-driven model. To solve this problem, an improved case-based reasoning model based on heat transfer calculation(CBR-HTC) was established through the nonlinear processing of these factors with software Ansys. The results showed that the CBR-HTC model improves the prediction accuracy of end-point molten steel temperature by5.33% and 7.00% compared with the original CBR model and 6.66% and 5.33% compared with the back propagation neural network(BPNN)model in the ranges of [-3, 3] and [-7, 7], respectively. It was found that the mean absolute error(MAE) and root-mean-square error(RMSE)values of the CBR-HTC model are also lower. It was verified that the prediction accuracy of the data-driven model can be improved by combining the mechanism model with the data-driven model.展开更多
Background Interleukin （IL）-10, IL-6 and their ratio （IL-6/IL-10） play an important role in the risk of developing coronary artery disease, and may correlate with its outcomes. Few clinical trials have investigate...Background Interleukin （IL）-10, IL-6 and their ratio （IL-6/IL-10） play an important role in the risk of developing coronary artery disease, and may correlate with its outcomes. Few clinical trials have investigated the prognostic impact of these factors on long-term car- diovascular events in patients presented with chest pain. Methods A prospective study was performed on 566 patients admitted with chest pain and identified mild to moderate coronary artery lesions. 1L-10, IL-6 and IL-6/IL-10 were measured. Results A total of 511 patients com- pleted the follow-up. The median follow-up time was 74 months. Kaplan-Meier analysis demonstrated a clear increase of the incidence of major adverse cardiac events during the follow-up period in patients with below-median levels of IL-10 （P = 0.006） and above-median levels of IL-6/IL-10 （P = 0.012）. Multivariate Cox proportional hazards analysis indicated the IL-10 levels to be strong independent predictors after adjustment for underlying confounders. Conclusions Elevated IL-10 levels are associated with a more favorable long-term prognosis in patients with chest pain and mild to moderate coronary artery lesions. IL-10 could be used for early risk assessment of long-term prognosis.展开更多
Potassium-ion batteries(KIBs)are regarded as one of the most promising replacements for lithium-ion batteries because of their low cost and high performance.Exploring suitable anode materials to stably and effectively...Potassium-ion batteries(KIBs)are regarded as one of the most promising replacements for lithium-ion batteries because of their low cost and high performance.Exploring suitable anode materials to stably and effectively store potassium is critical for the development of KIBs.Given their high theoretical specific capacity,cobalt-based compounds have been extensively investigated as an anode material in recent years;however,specific reviews summarizing the research progress in the application of cobaltbased compounds as anode materials for high-performance KIBs are lacking.Consequently,this review systematically summarizes the recent states of cobalt-based anode materials in KIBs starting at the potassium storage mechanism,followed by strategies and applications to improve the electrochemical performance.The current challenges are also discussed,and corresponding prospects are proposed.This work may facilitate the realization of various applications of cobalt-based compound anodes for highperformance rechargeable batteries and is expected to provide some guidance for developing other metal-based compounds for KIBs anodes.展开更多
Background In patients with acute ST-segment elevation myocardial infarction(STEMI)who undergo primary percutaneous coronary intervention(PCI),approximately 10%are concomitant with a chronic total occlusion(CTO)in a n...Background In patients with acute ST-segment elevation myocardial infarction(STEMI)who undergo primary percutaneous coronary intervention(PCI),approximately 10%are concomitant with a chronic total occlusion(CTO)in a non-culprit vessel.However,the impact of staged CTO recanalization on prognosis in this cohort remains disputable.This study aimed to compare the long-term outcomes of staged CTO recanalization versus medical therapy in patients with STEMI after primary PCI.Methods Between January 2005 and December 2016,a total of 287 patients were treated with staged CTO-PCI(n=91)or medical therapy(n=196)after primary PCI in our center.The primary endpoint was major adverse cardiovascular and cerebrovascular event(MACCE),defined as a composite of all-cause death,nonfatal myocardial infarction(MI),stroke or unplanned revascularization.After propensity-score matching,77 pairs of well-balanced patients were identified.Results The mean follow-up period was 6.06 years.Overall,the incidence of the primary endpoint of MACCE was significantly lower in staged CTO-PCI group than that in medical therapy group in both overall population(22.0%vs.46.9%;hazard ratio(HR)=0.48,95%CI:0.29-0.77)and propensity-matched cohorts(22.1%vs.42.9%;HR:0.48,95%CI:0.27-0.86).In addition,staged CTO-PCI was also associated with reduced risk of the composite of cardiac death,nonfatal MI or stroke compared with medical therapy in both overall population(9.9%vs.26.5%;hazard ratio(HR)=0.39,95%CI:0.19-0.79)and propensity-matched cohorts(9.1%vs.22.1%;HR:0.40,95%CI:0.16-0.96).After correction of the possible confounders,staged CTO-PCI was independently associated with reduced risks of MACCE(adjusted HR:0.46,95%CI:0.28-0.75),the composite of cardiac death,nonfatal MI or stroke(adjusted HR:0.45,95%CI:0.22-0.94)and all-cause mortality(adjusted HR:0.32,95%CI:0.13-0.83).Moreover,the results of sensitivity analysis were almost concordant with the overall analysis.Conclusions In patients with STEMI and a concurrent CTO who undergo primary PCI,successful staged recanalization of CTO in the non-culprit vessels is associated with better clinical outcomes during long-term follow-up.展开更多
Objective: Tumor cells rely heavily on glycolysis regardless of oxygen tension, a phenomenon called the Warburg effect. Hexokinase II(HKII) catalyzes the first irreversible step of glycolysis and is often overexpresse...Objective: Tumor cells rely heavily on glycolysis regardless of oxygen tension, a phenomenon called the Warburg effect. Hexokinase II(HKII) catalyzes the first irreversible step of glycolysis and is often overexpressed in tumor cells. Mitochondrial HKII couples glycolysis and oxidative phosphorylation while maintaining mitochondrial membrane integrity. In this study, we investigated the role of HKII in promoting the Warburg effect in cancer cells.Methods: HKII-mediated phosphorylation of the alpha subunit of pyruvate dehydrogenase(PDHA1) was tested in HEK293 T cells and clear cell renal cell carcinoma(cc RCC) specimens using gene knockdown, western blotting,immunohistochemistry, and immunofluorescence.Results: It was determined that HKII could not only transform glucose into glucose-6-phosphate, but also transfer the phosphate group of ATP onto PDHA1. In addition, it was found that HKII increased the phosphorylation of Ser293 on PDHA1, decreasing pyruvate dehydrogenase(PDH) complex activity and thus rerouting the metabolic pathway and promoting the Warburg effect. The overexpression of HKII correlated with the phosphorylation of PDHA1 and disease progression in cc RCC.Conclusions: The data presented here suggest that HKII is an important biomarker in the evaluation and treatment of cancer.展开更多
Anomalous characteristics of the atmospheric water cycle structure are highly significant to the mechanisms of seasonal-scale meteorological droughts.They also play an important role in the identification of indicativ...Anomalous characteristics of the atmospheric water cycle structure are highly significant to the mechanisms of seasonal-scale meteorological droughts.They also play an important role in the identification of indicative predictors of droughts.To better understand the causes of seasonal meteorological droughts in the middle and lower reaches of the Yangtze River(MLRYR),characteristics of the atmospheric water cycle structure at different drought stages were determined using standardized anomalies.The results showed that the total column water vapor(TCWV)was anomalously low during drought occurrence periods.In contrast,there were no anomalous signals at the drought persistence and recovery stages in the MLRYR.Moreover,there was no significant temporal correlation between the TCWV anomaly and seasonal-scale drought index(the 3-month standardized precipitation index(SPI_(3))).During drought events,water vapor that mainly originated from the Bay of Bengal was transported southwest of the MLRYR.Meanwhile,the anomalous signal of water vapor transport was negative at the drought appearance stage.At the drought persistence stage,the negative anomalous signal was the most significant.Water vapor flux divergence in the MLRYR showed significant positive anomalous signals during drought events,and the signal intensity shifted from an increasing to a decreasing trend at different drought stages.In addition,a significant positive correlation existed between the anomaly of water vapor flux divergence and regional SPI_(3).Overall,water vapor flux divergence is more predictive of droughts in the MLRYR.展开更多
The leaching of chromium from stainless steel dust （SSD） is deleterious to the environment. To address this issue, the reduction of SSD briquettes can be employed to effectively extract chromium. The recovery rates ...The leaching of chromium from stainless steel dust （SSD） is deleterious to the environment. To address this issue, the reduction of SSD briquettes can be employed to effectively extract chromium. The recovery rates of iron, chromium, and nickel via ironbath reduction of SSD briquettes were determined using X-ray fluorescence spectroscopy, X-ray diffraction, and scanning electron microscopy measurements. First, the effects of basicity and contents of silicon, iron, CaF2, and carbon on the recovery rates of the three metals were analyzed using the slag amount prediction model, which was originally established from the A1203 balance of corundum crucible erosion behavior. Second, the effect of feeding mode, i.e., whether steel scrap and SSD briquettes were simultaneously added, on the recovery rates was discussed in detail. Third, the iron-bath reduction of SSD briquettes was thermodynamically analyzed. The results indicated that the recovery rates of the three metals are greater than 95% those of using a basicity of 1.5 and 6.0% CaF2, 15% carbon, and 7% ferrosilicon. The recovery rate of chromium increases twofold with the addition of ferrosilicon. The feeding mode of adding briquettes and steel scrap simultaneously is better for recovery of metals and separation of the metal and slag than the feeding mode of adding steel scrap firstly and then briquettes.展开更多
The Palmer drought severity index(PDSI) is physically based with multivariate concepts, but requires complicated calibration and cannot easily be used for multiscale comparison. Standardized drought indices(SDIs), suc...The Palmer drought severity index(PDSI) is physically based with multivariate concepts, but requires complicated calibration and cannot easily be used for multiscale comparison. Standardized drought indices(SDIs), such as the standardized precipitation index(SPI) and standardized precipitation evapotranspiration index(SPEI), are multiscalar and convenient for spatiotemporal comparison, but they are still challenged by their lack of physical basis. In this study, a hybrid multiscalar indicator, the standardized Palmer drought index(SPDI), was used to examine drought properties of two meteorological stations(the Beijing and Guangzhou stations) in China, which have completely different drought climatologies. The results of our case study show that the SPDI is correlated with the well-established drought indices(SPI, SPEI, and PDSI) and presents generally consistent drought/wetness conditions against multiple indicators and literature records. Relative to the PDSI, the SPDI demonstrates invariable statistical characteristics and better comparable drought/wetness frequencies over time and space. Moreover,characteristics of major drought events(drought class, and onset and end times) indicated by the SPDI are generally comparable to those detected by the PDSI. As a physically-based standardized multiscalar drought indicator, the SPDI can be regarded as an effective development of the Palmer drought indices, providing additional choices and tools for practical drought monitoring and assessment.展开更多
Background It is still controversial whether percutaneous coronary intervention with drug-eluting stent （DES） is safe and effective compared to coronary artery bypass graft surgery （CABG） for unprotected left main...Background It is still controversial whether percutaneous coronary intervention with drug-eluting stent （DES） is safe and effective compared to coronary artery bypass graft surgery （CABG） for unprotected left main coronary artery （ULMCA） disease at long-term follow up （≥3 years）. Methods Eligible studies were selected by searching PubMed, EMBASE, and Cochrane Library up to December 6, 2016. The primary endpoint was a composite of death, myocardial infarction （MI） or stroke during the longest follow-up. Death, cardiac death, MI, stroke and repeat revascularization were the secondary outcomes. Results Four randomized controlled trials and twelve adjusted observational studies involving 14,130 patients were included. DES was comparable to CABG regarding the occurrence of the primary endpoint （FIR = 0.94, 95% CI： 0.86-1.03）. Besides, DES was significantly associated with higher incidence of MI （HR = 1.56, 95% CI： 1.09-2.22） and repeat revascularization （HR = 3.09, 95% CI： 2.33-4.10） compared with CABG, while no difference was found between the two strategies regard as the rate of death, cardiac death and stroke. Furthermore, DES can reduce the risk of the composite endpoint of death, MI or stroke （HR = 0.80, 95% CI： 0.67-0.95） for ULMCA lesions with SYNTAX score ≤32. Conclusions Although with higher risk of repeat revascularization, PCI with DES appears to be as safe as CABG for ULMCA disease at long-term follow up. In addition, treatment with DES could be an alternative interventional strategy to CABG for ULMCA lesions with low to intermediate anatomic complexity.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52002111 and 52474318)the Natural Science Foundation of Hebei Province(Nos.E2024208054,E2024208087 and B2022208006)+3 种基金the S&T Program of Hebei(Nos.242Q4402Z)the Science Foundation of University of Hebei Province(No.JZX2024025)Beijing Nova Program(No.Z211100002121082)the Interdisciplinary Research Project for Young Teachers of USTB,Fundamental Research Funds for the Central Universities(No.FRF-IDRY-GD23-005).
文摘Micro-/mesopore structures in carbon anode are highly desirable for increasing active sites and accelerating ion migration,favoring high capacity and rate performance.However,some structure-performance relationships still need to be clarified,and an in-depth understanding of how pore size and volume affect capacity and rate performance has rarely been mentioned.Herein,a series of carbon nanosheets with different micro-/mesopore sizes and volumes are precisely prepared.Detailed experimental analyses demonstrate that micropore volume rather than size is tightly responsible for capacity,resulting from its“accommodation effect”for ions.Conversely,mesopore size instead of volume is closely related to rate performance,which can be ascribed to its“channels effect”for ions.Capacity and rate performance first increase and then decrease with increasing micropore volume and mesopore size.In this work,the sample featured with the optimal micropore volume(1.6 cm^(3)·g^(-1))and mesopore size(2.55 nm)delivers the highest capacity(453 mAh·g^(-1)at 0.5 A·g^(-1))and excellent rate performance(235.1 mAh·g^(-1)at 2 A·g^(-1)).This work provides a new insight into the understanding of micro-/mesopore parameters and their effect on capacity and rate performance.
基金supported by the National Key R&D Program of China(2021YFC2300903 and 2022YFC2601603)the Open Research Fund Program of State Key Laboratory of Integrated Pest Management(IPM2315).
文摘Severe fever with thrombocytopenia virus(SFTSV),an emerging tick-borne bandavirus,poses a significant public health threat in rural China.Since 2021,an increase of local cases has been noted in the rural-urban fringe of Beijing.This study aimed to assess the formation of natural foci in urban areas by conducting a field survey of ticks and hedgehogs from the second to fifth ring roads of Beijing.Our survey revealed a diverse tick population in city parks,including the major SFTSV vector,Haemaphysalis longicornis.Parthenogenetic H.longicornis,known for its role in the rapid spread of SFTSV,was identified in key locations such as Beihai Park and Taoranting Park,near the Forbidden City.Notably,high SFTSV seroprevalence and RNA prevalence were found in hedgehogs and parasitic ticks in the center of Beijing.Phylogenetic analyses of SFTSV RNA and mitochondrial sequences of parthenogenetic H.longicornis ticks revealed the existence of diverse lineages of SFTSV and H.longicornis ticks within Beijing,suggesting multiple invasion events happened.These findings reveal the circulation of SFTSV in central Beijing,highlighting the need for urgent attention and enhanced surveillance measures.
文摘目的探讨甲状腺术后出血的危险因素及常见出血部位,为预防术后出血提供临床依据。方法回顾性分析2010年11月至2017年11月期间四川大学华西医院的21例甲状腺术后出血和63例非出血患者的临床资料,探索术后出血的影响因素。结果单因素分析结果显示,合并高血压、肿瘤最大径、淋巴结转移、喉返神经浸润、T分期、N分期、甘油三酯和血清高密度脂蛋白(high density lipoprotein,HDL)水平与术后出血有关(P<0.05);多因素分析结果显示,淋巴结转移(OR=16.219,P=0.002)和血清HDL水平(OR=0.035,P=0.006)为术后出血的影响因素。术后出血的患者中,最常见的5个出血部位依次为:带状肌及胸锁乳突肌(均占19.2%)、食管气管表面血管(11.5%)、甲状腺床(7.7%)及喉返神经旁小血管(7.7%)。结论淋巴结转移和低血清HDL水平为甲状腺术后出血的危险因素。术后出血的好发部位主要为颈部肌肉。
文摘A 62-year-old woman was admitted to our hospital in2011 because of recurrent abdominal pain,nausea and constipation for six months.Computed tomography enterography(CTE)showed tortuous thread-like calcifications in the ileocolic vein and right colic vein,while colonoscopy revealed purple-blue mucosa extending from the cecum to the splenic flexure.Based on the results of these tests,the patient was diagnosed with idiopathic mesenteric phlebosclerosis(IMP).She had a history of Chinese medical liquor intake for one and a half years and her symptoms subsided after conservative treatment.In 2013,a 63-year-old male patient who presented with recurrent lower right abdominal pain,bloating,melena and diarrhea for fifteen months was admitted to our institution.Colonoscopy and CTE led to the diagnosis of IMP.He also used Chinese medical liquor for approximately 12 years.The patient underwent total colectomy and the postoperative course was uneventful.We searched for previously published reports on similar cases and analyzed the clinical data of 50 cases identified in PubMed.As some of these patients admitted use of Chinese medicines,we hypothesize that Chinese medicines may play a role in the pathogenesis of IMP.
基金funded by the National Key Plan for Scientific Research and Development of China (2016YFD0500300)the Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) (XDB11030800)the Natural Science Foundation of China (L1524009)
文摘Severe fever with thrombocytopenia syndrome virus （SFTSV） is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses. The virus particles are internalized into host cell endosomes through the clathrin-dependent pathway, where the low pH activates the fusion of the virus with the cell membrane. With information from studies on other bunyaviruses, herein we will review our knowledge of the entry process of SFTSV.
基金financially supported by the National Natural Science Foundation of China (No.51674030)the Fundamental Research Funds for the Central Universities (Nos.FRF-TP-18-097A1 and FRF-BD-19-022A)。
文摘In the prediction of the end-point molten steel temperature of the ladle furnace, the influence of some factors is nonlinear. The prediction accuracy will be affected by directly inputting these nonlinear factors into the data-driven model. To solve this problem, an improved case-based reasoning model based on heat transfer calculation(CBR-HTC) was established through the nonlinear processing of these factors with software Ansys. The results showed that the CBR-HTC model improves the prediction accuracy of end-point molten steel temperature by5.33% and 7.00% compared with the original CBR model and 6.66% and 5.33% compared with the back propagation neural network(BPNN)model in the ranges of [-3, 3] and [-7, 7], respectively. It was found that the mean absolute error(MAE) and root-mean-square error(RMSE)values of the CBR-HTC model are also lower. It was verified that the prediction accuracy of the data-driven model can be improved by combining the mechanism model with the data-driven model.
文摘Background Interleukin （IL）-10, IL-6 and their ratio （IL-6/IL-10） play an important role in the risk of developing coronary artery disease, and may correlate with its outcomes. Few clinical trials have investigated the prognostic impact of these factors on long-term car- diovascular events in patients presented with chest pain. Methods A prospective study was performed on 566 patients admitted with chest pain and identified mild to moderate coronary artery lesions. 1L-10, IL-6 and IL-6/IL-10 were measured. Results A total of 511 patients com- pleted the follow-up. The median follow-up time was 74 months. Kaplan-Meier analysis demonstrated a clear increase of the incidence of major adverse cardiac events during the follow-up period in patients with below-median levels of IL-10 （P = 0.006） and above-median levels of IL-6/IL-10 （P = 0.012）. Multivariate Cox proportional hazards analysis indicated the IL-10 levels to be strong independent predictors after adjustment for underlying confounders. Conclusions Elevated IL-10 levels are associated with a more favorable long-term prognosis in patients with chest pain and mild to moderate coronary artery lesions. IL-10 could be used for early risk assessment of long-term prognosis.
基金financially supported by the National Natural Science Foundation of China(Nos.22008053 and 52002111)Key Research and Development Program of Hebei Province(Nos.20310601D and 205A4401D)+3 种基金the Natural Science Foundation of Hebei Province(No.B2021208061)the High Level Talents Funding of Hebei Province(No.A202005006)the Science Foundation of University of Hebei Province(Nos.BJ2020026 and BJ2021001)Liaoning Revitalization Talents Program(No.XLYC2008014)。
文摘Potassium-ion batteries(KIBs)are regarded as one of the most promising replacements for lithium-ion batteries because of their low cost and high performance.Exploring suitable anode materials to stably and effectively store potassium is critical for the development of KIBs.Given their high theoretical specific capacity,cobalt-based compounds have been extensively investigated as an anode material in recent years;however,specific reviews summarizing the research progress in the application of cobaltbased compounds as anode materials for high-performance KIBs are lacking.Consequently,this review systematically summarizes the recent states of cobalt-based anode materials in KIBs starting at the potassium storage mechanism,followed by strategies and applications to improve the electrochemical performance.The current challenges are also discussed,and corresponding prospects are proposed.This work may facilitate the realization of various applications of cobalt-based compound anodes for highperformance rechargeable batteries and is expected to provide some guidance for developing other metal-based compounds for KIBs anodes.
基金funded by the Ministry of Science and Technology of the People’s Republic of China,State Science and Technology Support Program (No.2011BAI11B05)Beijing Lab for Cardiovascular Precision Medicine, Beijing, China (PXM2019_014226_000023)
文摘Background In patients with acute ST-segment elevation myocardial infarction(STEMI)who undergo primary percutaneous coronary intervention(PCI),approximately 10%are concomitant with a chronic total occlusion(CTO)in a non-culprit vessel.However,the impact of staged CTO recanalization on prognosis in this cohort remains disputable.This study aimed to compare the long-term outcomes of staged CTO recanalization versus medical therapy in patients with STEMI after primary PCI.Methods Between January 2005 and December 2016,a total of 287 patients were treated with staged CTO-PCI(n=91)or medical therapy(n=196)after primary PCI in our center.The primary endpoint was major adverse cardiovascular and cerebrovascular event(MACCE),defined as a composite of all-cause death,nonfatal myocardial infarction(MI),stroke or unplanned revascularization.After propensity-score matching,77 pairs of well-balanced patients were identified.Results The mean follow-up period was 6.06 years.Overall,the incidence of the primary endpoint of MACCE was significantly lower in staged CTO-PCI group than that in medical therapy group in both overall population(22.0%vs.46.9%;hazard ratio(HR)=0.48,95%CI:0.29-0.77)and propensity-matched cohorts(22.1%vs.42.9%;HR:0.48,95%CI:0.27-0.86).In addition,staged CTO-PCI was also associated with reduced risk of the composite of cardiac death,nonfatal MI or stroke compared with medical therapy in both overall population(9.9%vs.26.5%;hazard ratio(HR)=0.39,95%CI:0.19-0.79)and propensity-matched cohorts(9.1%vs.22.1%;HR:0.40,95%CI:0.16-0.96).After correction of the possible confounders,staged CTO-PCI was independently associated with reduced risks of MACCE(adjusted HR:0.46,95%CI:0.28-0.75),the composite of cardiac death,nonfatal MI or stroke(adjusted HR:0.45,95%CI:0.22-0.94)and all-cause mortality(adjusted HR:0.32,95%CI:0.13-0.83).Moreover,the results of sensitivity analysis were almost concordant with the overall analysis.Conclusions In patients with STEMI and a concurrent CTO who undergo primary PCI,successful staged recanalization of CTO in the non-culprit vessels is associated with better clinical outcomes during long-term follow-up.
文摘Objective: Tumor cells rely heavily on glycolysis regardless of oxygen tension, a phenomenon called the Warburg effect. Hexokinase II(HKII) catalyzes the first irreversible step of glycolysis and is often overexpressed in tumor cells. Mitochondrial HKII couples glycolysis and oxidative phosphorylation while maintaining mitochondrial membrane integrity. In this study, we investigated the role of HKII in promoting the Warburg effect in cancer cells.Methods: HKII-mediated phosphorylation of the alpha subunit of pyruvate dehydrogenase(PDHA1) was tested in HEK293 T cells and clear cell renal cell carcinoma(cc RCC) specimens using gene knockdown, western blotting,immunohistochemistry, and immunofluorescence.Results: It was determined that HKII could not only transform glucose into glucose-6-phosphate, but also transfer the phosphate group of ATP onto PDHA1. In addition, it was found that HKII increased the phosphorylation of Ser293 on PDHA1, decreasing pyruvate dehydrogenase(PDH) complex activity and thus rerouting the metabolic pathway and promoting the Warburg effect. The overexpression of HKII correlated with the phosphorylation of PDHA1 and disease progression in cc RCC.Conclusions: The data presented here suggest that HKII is an important biomarker in the evaluation and treatment of cancer.
基金supported by the National Key Research and Development Program of China(Grants No.2019YFC0409000,2017YFC1502403,and 2018YFC0407701)the Fundamental Research Funds for the Central Universities(Grant No.B200204045).
文摘Anomalous characteristics of the atmospheric water cycle structure are highly significant to the mechanisms of seasonal-scale meteorological droughts.They also play an important role in the identification of indicative predictors of droughts.To better understand the causes of seasonal meteorological droughts in the middle and lower reaches of the Yangtze River(MLRYR),characteristics of the atmospheric water cycle structure at different drought stages were determined using standardized anomalies.The results showed that the total column water vapor(TCWV)was anomalously low during drought occurrence periods.In contrast,there were no anomalous signals at the drought persistence and recovery stages in the MLRYR.Moreover,there was no significant temporal correlation between the TCWV anomaly and seasonal-scale drought index(the 3-month standardized precipitation index(SPI_(3))).During drought events,water vapor that mainly originated from the Bay of Bengal was transported southwest of the MLRYR.Meanwhile,the anomalous signal of water vapor transport was negative at the drought appearance stage.At the drought persistence stage,the negative anomalous signal was the most significant.Water vapor flux divergence in the MLRYR showed significant positive anomalous signals during drought events,and the signal intensity shifted from an increasing to a decreasing trend at different drought stages.In addition,a significant positive correlation existed between the anomaly of water vapor flux divergence and regional SPI_(3).Overall,water vapor flux divergence is more predictive of droughts in the MLRYR.
基金This research was supported by the National Natural Science Foundation of China （Grant No. 51304053）, Jiangxi University of Science and Technology Doctoral Start-up Fund （No. 3401223181）.
文摘The leaching of chromium from stainless steel dust （SSD） is deleterious to the environment. To address this issue, the reduction of SSD briquettes can be employed to effectively extract chromium. The recovery rates of iron, chromium, and nickel via ironbath reduction of SSD briquettes were determined using X-ray fluorescence spectroscopy, X-ray diffraction, and scanning electron microscopy measurements. First, the effects of basicity and contents of silicon, iron, CaF2, and carbon on the recovery rates of the three metals were analyzed using the slag amount prediction model, which was originally established from the A1203 balance of corundum crucible erosion behavior. Second, the effect of feeding mode, i.e., whether steel scrap and SSD briquettes were simultaneously added, on the recovery rates was discussed in detail. Third, the iron-bath reduction of SSD briquettes was thermodynamically analyzed. The results indicated that the recovery rates of the three metals are greater than 95% those of using a basicity of 1.5 and 6.0% CaF2, 15% carbon, and 7% ferrosilicon. The recovery rate of chromium increases twofold with the addition of ferrosilicon. The feeding mode of adding briquettes and steel scrap simultaneously is better for recovery of metals and separation of the metal and slag than the feeding mode of adding steel scrap firstly and then briquettes.
基金supported by the National Natural Science Foundation of China(Grant No.41701022)the Open Foundation of State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering(Grant No.2017491011)the Scientific and Technical Innovation Team Foundation for Universities of Henan Province(Grant No.18IRTSTHN009)
文摘The Palmer drought severity index(PDSI) is physically based with multivariate concepts, but requires complicated calibration and cannot easily be used for multiscale comparison. Standardized drought indices(SDIs), such as the standardized precipitation index(SPI) and standardized precipitation evapotranspiration index(SPEI), are multiscalar and convenient for spatiotemporal comparison, but they are still challenged by their lack of physical basis. In this study, a hybrid multiscalar indicator, the standardized Palmer drought index(SPDI), was used to examine drought properties of two meteorological stations(the Beijing and Guangzhou stations) in China, which have completely different drought climatologies. The results of our case study show that the SPDI is correlated with the well-established drought indices(SPI, SPEI, and PDSI) and presents generally consistent drought/wetness conditions against multiple indicators and literature records. Relative to the PDSI, the SPDI demonstrates invariable statistical characteristics and better comparable drought/wetness frequencies over time and space. Moreover,characteristics of major drought events(drought class, and onset and end times) indicated by the SPDI are generally comparable to those detected by the PDSI. As a physically-based standardized multiscalar drought indicator, the SPDI can be regarded as an effective development of the Palmer drought indices, providing additional choices and tools for practical drought monitoring and assessment.
文摘Background It is still controversial whether percutaneous coronary intervention with drug-eluting stent （DES） is safe and effective compared to coronary artery bypass graft surgery （CABG） for unprotected left main coronary artery （ULMCA） disease at long-term follow up （≥3 years）. Methods Eligible studies were selected by searching PubMed, EMBASE, and Cochrane Library up to December 6, 2016. The primary endpoint was a composite of death, myocardial infarction （MI） or stroke during the longest follow-up. Death, cardiac death, MI, stroke and repeat revascularization were the secondary outcomes. Results Four randomized controlled trials and twelve adjusted observational studies involving 14,130 patients were included. DES was comparable to CABG regarding the occurrence of the primary endpoint （FIR = 0.94, 95% CI： 0.86-1.03）. Besides, DES was significantly associated with higher incidence of MI （HR = 1.56, 95% CI： 1.09-2.22） and repeat revascularization （HR = 3.09, 95% CI： 2.33-4.10） compared with CABG, while no difference was found between the two strategies regard as the rate of death, cardiac death and stroke. Furthermore, DES can reduce the risk of the composite endpoint of death, MI or stroke （HR = 0.80, 95% CI： 0.67-0.95） for ULMCA lesions with SYNTAX score ≤32. Conclusions Although with higher risk of repeat revascularization, PCI with DES appears to be as safe as CABG for ULMCA disease at long-term follow up. In addition, treatment with DES could be an alternative interventional strategy to CABG for ULMCA lesions with low to intermediate anatomic complexity.
