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Revealing inheritance of a Xinjiang isolate BGTB-1 of Puccinia striiformis f.sp.tritici and the shift of pathogenicity from avirulence to virulence at heterozygous AvrYr5 locus
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作者 Lin Wang fei liu +3 位作者 Yumeng Bian Mudi Sun Zhensheng Kang Jie Zhao 《Journal of Integrative Agriculture》 2026年第2期744-755,共12页
In China,Xinjiang is a relatively independent epidemic region of wheat stripe rust,caused by Puccinia striiformis f.sp.tritici,due to great population genetic divergence of Xinjiang with other inland epidemic regions.... In China,Xinjiang is a relatively independent epidemic region of wheat stripe rust,caused by Puccinia striiformis f.sp.tritici,due to great population genetic divergence of Xinjiang with other inland epidemic regions.In this region,race evolution was usually slower than inland populations.However,many new races have recently been found,and therefore,it is necessary for more understanding of the virulence evolution of the Xinjiang population.So,in this study,a 65 sexual progenies,derived from a Xinjiang single-urediospore isolate BGTB-1 of P.striiformis f.sp.tritici by selfing on alternate host barberry(Berberis aggregata).It was phenotyped on the 25 single Yr lines,and genotyped by 19 kompetitive allele-specific PCRsingle nucleotide polymorphism(KASP-SNP) markers.As a result,the 65 progenies were identified as 56 various virulence patterns(VPs),and neither of which was identical to the parental isolate,showed 100% virulence variation.Compared with the parental isolate,of all progenies,39(60.0%) had increased virulence,and 18(27.7%) had decreased virulence.All progenies exhibited avirulence to Yr10,Yr15,Yr32,and YrTr1 loci,and avirulence and virulence segregation at the remaining 21 Yr resistance loci.The results showed avirulence to Yr5,Yr7,and Yr76(A:V≈3:1) loci is controlled by a single dominant gene,and that to Yr6,Yr25,and Yr44(A:V≈1:3) loci by a single recessive gene.However,avirulence to the remaining 15 resistant loci including Yr1,Yr2,Yr3,Yr4,Yr8,Yr9,Yr17,Yr26(=Yr24),Yr28,Yr29,Yr43,YrSP,Yr27,YrA,and YrExp2,with various avirulence and virulence segregation ratios,is controlled by two genes with different gene effects,indicating complex genetic traits of the parental isolate.Totally,65 dissimilar genotypes detected among progenies using overall molecular markers,by which a linkage map was constructed,with a genetic distance of 441.0 cM.Interestingly,although the parental isolate was avirulent to Yr5,but 17 progenies showed virulence,showing the change of pathogenicity from avirulence to virulence at this resistance locus.It was for the first time to report that progenies with virulence to Yr5 produced sexually from avirulent parental isolate at this resistance locus.To our knowledge,this study offers an insight into inheritance,sexual reproduction and virulence variation of P.striiformis f.sp.tritici in Xinjiang,facilitating us to understand evolution of the rust pathogen in this region and accounting for Xinjiang population distinguished form other inland populations.Additionally,it is necessary to further confirm the roles of sexual reproduction in the emergence of new races and affecting population genetic diversity of P.striiformis f.sp.tritici under natural conditions in Xinjiang. 展开更多
关键词 wheat yellow rust Puccinia striiformis f.sp.tritici sexual reproduction virulence variation new race SNP Yr5 XINJIANG
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Advancing Asian Monsoon Climate Prediction under Global Change:Progress,Challenges,and Outlook
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作者 Bin WANG fei liu +9 位作者 Renguang WU Qinghua DING Shaobo QIAO Juan LI Zhiwei WU Keerthi SASIKUMAR Jianping LI Qing BAO Haishan CHEN Yuhang XIANG 《Advances in Atmospheric Sciences》 2026年第1期1-29,共29页
Predicting monsoon climate is one of the major endeavors in climate science and is becoming increasingly challenging due to global warming. The accuracy of monsoon seasonal predictions significantly impacts the lives ... Predicting monsoon climate is one of the major endeavors in climate science and is becoming increasingly challenging due to global warming. The accuracy of monsoon seasonal predictions significantly impacts the lives of billions who depend on or are affected by monsoons, as it is essential for the water cycle, food security, ecology, disaster prevention, and the economy of monsoon regions. Given the extensive literature on Asian monsoon climate prediction, we limit our focus to reviewing the seasonal prediction and predictability of the Asian Summer Monsoon (ASM). However, much of this review is also relevant to monsoon predictions in other seasons and regions. Over the past two decades, considerable progress has been made in the seasonal forecasting of the ASM, driven by an enhanced understanding of the sources of predictability and the dynamics of seasonal variability, along with advanced development in sophisticated models and technologies. This review centers on advances in understanding the physical foundation for monsoon climate prediction (section 2), significant findings and insights into the primary and regional sources of predictability arising from feedback processes among various climate components (sections 3 and 4), the effects of global warming and external forcings on predictability (section 5), developments in seasonal prediction models and techniques (section 6), the challenges and limitations of monsoon climate prediction (section 7), and emerging research trends with suggestions for future directions (section 8). We hope this review will stimulate creative activities to enhance monsoon climate prediction. 展开更多
关键词 Asian summer monsoon monsoon climate prediction climate predictability predictability sources seasonal prediction models seasonal prediction techniques artificial intelligence
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Laparoscopic liver resection is superior to open liver resection for hepatocellular carcinoma patients with BCLC stage 0-A hepatocellular carcinoma and portal hypertension
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作者 Wu-Gui Yang Bin Liang +5 位作者 Yu-Fu Peng Yu-Bo Yang Ya-Ni liu Bo Li Yong-Gang Wei fei liu 《Hepatobiliary & Pancreatic Diseases International》 2026年第1期32-41,共10页
Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hyperten... Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P<0.001),and fewer postoperative complications(33.9%vs.57.6%,P<0.001),including lower rates of postoperative liver decompensation(16.9%vs.28.0%,P=0.043),postoperative ascites(18.6%vs.31.4%,P=0.024)and pulmonary infections(12.7%vs.29.7%,P=0.001).The long-term follow-up showed that overall survival(P=0.154)and recurrence-free survival(P=0.376)were comparable between the two groups.In subgroup analysis,patients with PLT≤75×10^(9)/L suffered more postoperative liver decompensation(PLD)and ascites than patiens with PLT>75×10^(9)/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH. 展开更多
关键词 Laparoscopic liver resection Hepatocellular carcinoma Clinically significant portal hypertension BCLC stage
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《电力系统分析》课程教学资源建设与实践课程探索 被引量:2
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作者 刘飞 陈鹏伟 +2 位作者 郝振洋 江军 王世山 《教育教学研究前沿》 2025年第2期152-154,共3页
《电力系统分析》是南京航空航天大学电气工程及其自动化专业的一门必修课程。本文分析了课程的教学设置现状,针对课程配置的不均衡问题,提出建立完备的《电力系统分析》课程教学资源,实现理论结合实践的混合教学方式升级,从而更快地适... 《电力系统分析》是南京航空航天大学电气工程及其自动化专业的一门必修课程。本文分析了课程的教学设置现状,针对课程配置的不均衡问题,提出建立完备的《电力系统分析》课程教学资源,实现理论结合实践的混合教学方式升级,从而更快地适应迅速发展的电力工程事业,服务于高素质电气人才培养和一流电气工程学科的建设。 展开更多
关键词 《电力系统分析》 教学资源 实践课程
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Analysis of Chinese Citizens’Perception and Its Differences of City Spirit:A Case Study of Hefei City
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作者 Zhiguo Yao fei liu Min Xiang 《Journal of Geographical Research》 2022年第3期41-48,共8页
City spirit is the soul of the city.The spread of city spirit not only could establish a civilized specimen for citizens,but also create a good cultural atmosphere for the city.Hefei residents’perception of city spir... City spirit is the soul of the city.The spread of city spirit not only could establish a civilized specimen for citizens,but also create a good cultural atmosphere for the city.Hefei residents’perception of city spirit is extensive,and most of Hefei citizens consider the expression words of city spirit are very appropriate,which is enlightened,open-minded,actual and innovate.Great majority of Hefei citizens willing to support the propaganda and promotion of the city spirit,and they think the promotion of the city spirit plays a key role in the way of city’s development.In addition,significant differences in the perception of urban spirituality emerge among residents with different economic and social characteristics.There are four aspects about how to enhance the public perception of city spirit,which including increasing dissemination channels and means,strengthening guidance according to the difference of residents,encouraging participation of community residents,and building good atmosphere depending on the city’s advantages. 展开更多
关键词 City spirit Hefei City PERCEPTION
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Active polarization high-resolution imaging through complex scattering media 被引量:2
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作者 Meng Xiang Xue Dong +6 位作者 Tianyu Wang Sen Wang Jingjing Ge Jinpeng liu Qianqian liu fei liu Xiaopeng Shao 《Advanced Photonics Nexus》 2025年第1期127-137,共11页
High-resolution seeing through complex scattering media such as turbid water,biological tissues,and mist is a significant challenge because the strong scattering scrambles the light paths and forms the scattering wall... High-resolution seeing through complex scattering media such as turbid water,biological tissues,and mist is a significant challenge because the strong scattering scrambles the light paths and forms the scattering wall.We propose an active polarized iterative optimization approach for high-resolution imaging through complex scattering media.By acquiring a series of sub-polarized images,we can capture the diverse pattern-illuminated images with various high-frequency component information caused by the Brownian motion of complex scattering materials,which are processed using the common-mode rejection of polarization characteristics to extract target information from scattering medium information.Following that,our computational reconstruction technique employs an iterative optimization algorithm that commences with patternilluminated Fourier ptychography for reconstructing the high-resolution scene.It is extremely important that our approach for high-resolution imaging through complex scattering media is not limited by priori information and optical memory effect.The proposed approach is suitable for not only dynamic but also static scattering media,which may find applications in the biomedicine field,such as skin abnormalities,non-invasive blood flow,and superficial tumors. 展开更多
关键词 complex scattering media iterative optimization POLARIZATION Fourier ptychography.
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Comparative modelling of retrogressive landslide runout:2D and 3D random large-deformation analyses using coupled Eulerian-Lagrangian method 被引量:1
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作者 Xuejian Chen Shunping Ren +4 位作者 Xingsen Guo Yueying Wang fei liu Hoang Nguyen Rita Leal Sousa 《International Journal of Mining Science and Technology》 2025年第11期2011-2030,共20页
Retrogressive landslides in sensitive clays pose significant risks to nearby infrastructure,as natural toe erosion or localized disturbances can trigger progressive block failures.While prior studies have largely reli... Retrogressive landslides in sensitive clays pose significant risks to nearby infrastructure,as natural toe erosion or localized disturbances can trigger progressive block failures.While prior studies have largely relied on two-dimensional(2D)large-deformation analyses,such models overlook key three-dimensional(3D)failure mechanisms and variability effects.This study develops a 3D probabilistic framework by integrating the Coupled Eulerian–Lagrangian(CEL)method with random field theory to simulate retrogressive landslides in spatially variable clay.Using Monte Carlo simulations,we compare 2D and 3D random large-deformation models to evaluate failure modes,runout distances,sliding velocities,and influence zones.The 3D analyses captured more complex failure modes—such as lateral retrogression and asynchronous block mobilization across slope width.Additionally,the 3D analyses predict longer mean runout distances(13.76 vs.11.92 m),wider mean influence distance(11.35 vs.8.73 m),and higher mean sliding velocities(4.66 vs.3.94 m/s)than their 2D counterparts.Moreover,3D models exhibit lower coefficients of variation(e.g.,0.10 for runout distance)due to spatial averaging across slope width.Probabilistic hazard assessment shows that 2D models significantly underpredict near-field failure probabilities(e.g.,48.8%vs.89.9%at 12 m from the slope toe).These findings highlight the limitations of 2D analyses and the importance of multi-directional spatial variability for robust geohazard assessments.The proposed 3D framework enables more realistic prediction of landslide mobility and supports the design of safer,risk-informed infrastructure. 展开更多
关键词 Retrogressive landslide Coupled Eulerian-Lagrangian approach Spatial variability Runout dynamics Progressive failure Hazard assessment
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Evolution of undeformed chip thickness and grinding forces in grinding of K4002 nickel-based superalloy using corundum abrasive wheels 被引量:1
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作者 Yang CAO Biao ZHAO +6 位作者 Wenfeng DING Xiaofeng JIA Bangfu WU fei liu Yanfang ZHU Qi liu Dongdong XU 《Chinese Journal of Aeronautics》 2025年第1期131-146,共16页
The undeformed chip thickness and grinding force are key parameters for revealing the material removal mechanism in the grinding process.However,they are difficult to be well expressed due to the ununiformed protrusio... The undeformed chip thickness and grinding force are key parameters for revealing the material removal mechanism in the grinding process.However,they are difficult to be well expressed due to the ununiformed protrusion height and random position distribution of abrasive grains on the abrasive wheel surface.This study investigated the distribution of undeformed chip thickness and grinding force considering the non-uniform characteristics of abrasive wheel in the grinding of K4002 nickel-based superalloy.First,a novel grinding force model was established through a kinematic-geometric analysis and a grain-workpiece contact analysis.Then,a series of grinding experiments were conducted for verifying the model.The results indicate that the distribution of undeformed chip thickness is highly consistent with the Gaussian distribution formula.The increase in the grinding depth mainly leads to an increase in the average value of Gaussian distribution.On the contrary,the increase in the workpiece infeed speed or the decrease in the grinding speed mainly increases the standard deviation of Gaussian distribution.The average and maximum errors of the grinding force model are 4.9%and 14.6%respectively,indicating that the model is of high predication accuracy. 展开更多
关键词 K4002 nickel-based superalloy Grinding force Material removal mechanism Undeformed chip thickness Quantity of active abrasive grains
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Inhibiting creep in fine-grained Mg-Al alloys through grain boundary stabilization 被引量:1
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作者 Lingbao Ren Yurong Zhao +5 位作者 Jinjin Li fei liu Boyu liu Ge Wu Carl J.Boehlert Zhiwei Shan 《Journal of Magnesium and Alloys》 2025年第5期2072-2083,共12页
The limited creep resistance of wrought Mg-Al alloys restricts their lightweight applications at intermediate temperatures due to the softening effect of discontinuous precipitation(DP)on the dislocation-controlled cr... The limited creep resistance of wrought Mg-Al alloys restricts their lightweight applications at intermediate temperatures due to the softening effect of discontinuous precipitation(DP)on the dislocation-controlled creep.Here,we developed a creep-resistant wrought Mg-Al alloy through microalloying of Y and Ca.The resulting alloy exhibited an order of magnitude enhancement in the creep resistance at 125℃/50±100 MPa.In contrast to the grain boundary instabilities by DP in the previously reported wrought Mg-Al alloys,we show that the addition of 0.21Y+0.15Ca wt%produces a(Zn+Ca)co-segregation at the grain boundaries as a result of their segregation energy and the activation energy of grain boundary migration,thereby stabilizing the grain boundaries.The(Zn+Ca)co-segregation inhibits the dynamic DP and promotes the formation of intragranular Al-enriched clusters,which favorthe formation of Al_(2)Y,Mg_(17)Al_(12)nano precipitates,thereby impeding intragranular dislocation motion during creep.Furthermore,the addition of 0.21Y+0.15Ca wt%facilitates the formation of a fine and uniform recrystallization structure in the microalloyed alloys compared to AZ80 due to the high activation energy of mobility for the(Zn+Ca)segregated grain boundary.Therefore,the microalloyed alloys exhibit good tensile properties with 380 MPa tensile strength and 18%elongation.Our constitutive analysis revealed that the(Y+Ca)microalloying decreased the creep stress exponent by 29%and increased the creep resistance in the medium to high-stress range.Microalloying provides a promising way to develop low-cost creep-resistant wrought Mg-Al alloys. 展开更多
关键词 CREEP Wrought Mg alloys Discontinuous precipitation MICROALLOYING SEGREGATION
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高原阿尔茨海默病患者脑白质微结构与脑血流改变的多模态MR研究
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作者 乔玉玲 张永海 +1 位作者 刘飞 茹宝根 《阿尔茨海默病及相关病杂志》 2025年第6期403-410,共8页
目的:旨在探讨高原阿尔茨海默病患者脑白质微结构与脑血流改变的多模态MR变化。方法:前瞻性纳入青海省人民医院18例久居高原AD患者和20名健康受试者,使用3.0T MRI扫描仪采集DTI序列、T1序列和ASL序列,利用DPABI Pro后处理软件获取基于... 目的:旨在探讨高原阿尔茨海默病患者脑白质微结构与脑血流改变的多模态MR变化。方法:前瞻性纳入青海省人民医院18例久居高原AD患者和20名健康受试者,使用3.0T MRI扫描仪采集DTI序列、T1序列和ASL序列,利用DPABI Pro后处理软件获取基于纤维束示踪技术的纤维束空间统计(TBSS)图像和感兴趣区(ROI)图像,并结合脑血流量(CBF)及认知量表综合分析高原AD患者脑白质微结构变化的特征。结果:1.TBSS结果显示高原AD患者在白质纤维束损伤区域基本与平原AD患者一致。ROI结果与NC组比较,发现AD组的轴向扩散率(AD)、平均扩散率(MD)及径向扩散率(RD)在多个脑区均显著升高(P<0.05)。2.高原AD患者在颞叶、放射冠、顶叶、楔前叶、扣带回、前额叶及丘脑等区域的CBF降低与DTI异常并存;3.高原AD患者扣带回的AD值、MD值与ADL评分呈正相关;丘脑的AD值、MD值与MMSE评分呈显著负相关;海马的RD值与MMSE评分呈负相关。结论:高原AD患者全脑白质及纤维束普遍显著损伤,且表现出以视觉区、丘脑和运动区广泛受累的区域特异性,另高原AD患者CBF降低与DTI指数异常区域存在较多重叠,反映了脑神经血管偶联(NVC)损伤导致的“血流-微结构”协同破坏机制可能加剧高原AD病理进程,并与整体认知功能和日常生活能力密切相关。 展开更多
关键词 高原阿尔茨海默病 扩散张量成像 脑血流量 脑白质
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Enhanced hydrogen evolution in neutral media via proximity effect of Ru/RuO_(2)-TiO_(2) nanocatalysts 被引量:1
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作者 Yifan Yang Lixiong Xu +5 位作者 Chenyue Li Rongqian Ning Jun Ma Mengqin Yao Shuo Geng fei liu 《Journal of Materials Science & Technology》 2025年第9期173-181,共9页
Ru-based nanomaterials have been demonstrated to be highly active electrocatalysts for hydrogen evo-lution reaction(HER),yet weak water adsorption and splitting ability in neutral media thus it is rather difficult for... Ru-based nanomaterials have been demonstrated to be highly active electrocatalysts for hydrogen evo-lution reaction(HER),yet weak water adsorption and splitting ability in neutral media thus it is rather difficult for the intermediates to adsorb on the active site.Herein,we introduce a concept of the prox-imity effect,com prising adjacent Ru and RuO_(2) nanoparticles coupled on TiO_(2)(Ru/RuO_(2)-TiO_(2)),for the synergic promotion of water molecule adsorption and splitting,significantly enhancing HER electrocatal-ysis performance.The in-situ spectroscopy experiments and density function theory(DFT)simulations demonstrated that the proximity effect between the adjacent Ru nanoparticles and RuO_(2) nanoparticles can accelerate water adsorption and splitting.As a result,the as-made Ru/RuO_(2)-TiO_(2) only need overpo-tentials of 52.7,16.0,and 16.4 mV to achieve the current density of 10 mA cm-2 in neutral,acid,and alkaline media,respectively.The mass activity of Ru/RuO_(2)-TiO_(2) in neutral media is 320 and 117 times higher than that of commercial Ru/C and Pt/C at the overpotential of 100 mV,respectively.This work emphasizes the proximity effect for activation of reactants which can be extended to other electrocat-alytic reactions. 展开更多
关键词 Hydrogen evolution reaction Water activation Proximity effect RUTHENIUM
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The fourth exon confers antagonistic activity of OsMFT1 and OsMFT2 in rice pre-harvest sprouting 被引量:1
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作者 Jialing Zhang fei liu +3 位作者 Yang Kuang Ming Luo Chengcai Chu Fan Xu 《The Crop Journal》 2025年第1期135-144,共10页
Pre-harvest sprouting(PHS)describes the germination of physiologically mature grains in spikes prior to harvest in cereal crops.PHS could seriously decrease grain yield and quality,which makes it a major constraint to... Pre-harvest sprouting(PHS)describes the germination of physiologically mature grains in spikes prior to harvest in cereal crops.PHS could seriously decrease grain yield and quality,which makes it a major constraint to cereal production worldwide.A number of PHS-associated genes in cereals have been reported;however,the molecular mechanisms underlying PHS remain largely elusive.Here,we report a CRISPRCas9 mutant with severe PHS in a paddy field.The mutated gene OsMFT2 encodes a phosphatidylethanolamine-binding protein(PEBP).Intriguingly,the OsMFT1,in the same PEBP family,had the opposite effect in controlling rice PHS as does OsMFT2.Germination tests of seeds of chimeric protein-expressing plants revealed that the fourth exon conferred the antagonistic activity of OsMFT1 and OsMFT2 in rice PHS.Additionally,two lines of these plants showed elevated grain numbers per panicle,implying that chimeric protein has potential to significantly increase yield.Moreover,transcriptome analysis and genetic studies indicated that OsMFT1 and OsMFT2 performed opposing functions in rice PHS owing to three co-regulated genes that being contrastingly affected by OsMFT1 and OsMFT2.Overall,it seemed that the proper combination of PEBP family members could obtain optimal PHS resistance and high yield. 展开更多
关键词 RICE Pre-harvest sprouting PEBP MFT
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重组Ⅲ型胶原蛋白对皮肤光老化的改善作用研究
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作者 刘菲 王倩 +3 位作者 刘慧 杨素珍 韩婷婷 武涛 《日用化学工业(中英文)》 北大核心 2025年第11期1452-1459,共8页
为探究重组Ⅲ型胶原蛋白(RHC-Ⅲ)对皮肤光老化的改善作用。采用原代皮肤细胞和离体皮肤组织模型,通过结晶紫染色法、酶联免疫吸附测定法和免疫荧光法等检测皮肤中光老化标志物的变化情况。细胞实验结果显示,与空白对照组相比,RHC-Ⅲ可增... 为探究重组Ⅲ型胶原蛋白(RHC-Ⅲ)对皮肤光老化的改善作用。采用原代皮肤细胞和离体皮肤组织模型,通过结晶紫染色法、酶联免疫吸附测定法和免疫荧光法等检测皮肤中光老化标志物的变化情况。细胞实验结果显示,与空白对照组相比,RHC-Ⅲ可增加NHDFs细胞的粘附能力;与模型对照组相比,RHC-Ⅲ可降低细胞内ROS水平和MMPs分泌量并提高CAT酶活力;离体皮肤组织模型实验结果显示,与模型对照组相比,RHC-Ⅲ可提高COL-Ⅳ、COL-Ⅶ、COL-ⅩⅦ、整合素α6亚单位、COL-Ⅰ、COL-Ⅲ和弹性蛋白的含量。以上结果表明,RHC-Ⅲ改善皮肤光老化的机制可能与促进成纤维细胞粘附,减少皮肤细胞氧化应激,减少细胞外基质(ECM)的降解,促进DEJ结构相关蛋白的表达,提高真皮层细胞外基质关键蛋白的含量有关。 展开更多
关键词 重组Ⅲ型胶原蛋白 光老化 离体皮肤 氧化应激 真表皮连接
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Effect of tantalum doping on the microstructure and photoelectrical properties of transparent conductive zinc oxide films
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作者 Kai Yi Hongxu Jiang +3 位作者 Yanbo Cai Guangwei Wang fei liu Deliang Wang 《中国科学技术大学学报》 北大核心 2025年第4期49-57,48,I0002,共11页
ZnO thin films with varying Ta concentrations were fabricated through magnetron sputtering.The crystallinity and surface morphology of the ZnO films are significantly influenced by the incorporation of Ta,as evidenced... ZnO thin films with varying Ta concentrations were fabricated through magnetron sputtering.The crystallinity and surface morphology of the ZnO films are significantly influenced by the incorporation of Ta,as evidenced by the X-ray diffraction and scanning electron microscopy results.The lattice constants,as determined by X-ray diffraction,contradict the disparity in Ta and Zn ion radii,which is attributed to the impact of interstitial defects.This inconsistency introduces variations in carrier concentration in this experiment compared with prior studies.Subsequent exploration of the luminescent characteristics and emission mechanism of defect levels in Ta-doped ZnO films was conducted through photoluminescence.Furthermore,the factors influencing the bandgap are discussed. 展开更多
关键词 tantalum-doped zinc oxide RF magnetron sputtering MICROSTRUCTURE PHOTOLUMINESCENCE
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基于牙体牙髓、牙周及功能健康的显微微创牙体预备 被引量:22
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作者 于海洋 赵雨薇 +17 位作者 李俊颖 罗天 高静 刘洪臣 刘伟才 刘峰 赵克 fei liu 马楚凡 JuergenManfred Setz 梁珊珊 范琳 高姗姗 朱卓立 沈颉飞 王剑 朱智敏 周学东 《华西口腔医学杂志》 CAS CSCD 北大核心 2019年第3期229-235,共7页
牙体预备技术是口腔美学修复治疗必知必会的核心操作,通过一定量的牙修复体组织的磨除,为目标修复体提供容纳空间、粘接面与完成线等。如何在完成高质量牙体预备的同时还能保存牙体、保护活髓和牙周组织是美学修复牙体预备中亟需解决的... 牙体预备技术是口腔美学修复治疗必知必会的核心操作,通过一定量的牙修复体组织的磨除,为目标修复体提供容纳空间、粘接面与完成线等。如何在完成高质量牙体预备的同时还能保存牙体、保护活髓和牙周组织是美学修复牙体预备中亟需解决的难题。本文就微创牙体预备的概念及核心要素,显微牙体预备涉及的解剖生理学、显微牙体预备术前设计进行介绍,并总结了显微牙体预备技术临床路径,提出了显微牙体预备核心因素量与形的新认知。 展开更多
关键词 牙体预备 显微牙科预备 微创牙科 目标修复体空间 瓷美学修复体
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高血压脑出血立体定向颅内血肿清除术中不同麻醉方式的血流动力学及应激反应 被引量:21
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作者 赵广平 刘盼盼 +3 位作者 刘飞 李炜 陈永学 张凯 《昆明医科大学学报》 CAS 2022年第5期117-122,共6页
目的探讨高血压脑出血立体定向颅内血肿清除术中不同麻醉方式对血流动力学及应激反应的影响。方法选取2020年4月至2021年12月在邯郸市中心医院及河北医科大学第二医院接受立体定向颅内血肿清除术的80例高血压脑出血患者纳入研究对象,按... 目的探讨高血压脑出血立体定向颅内血肿清除术中不同麻醉方式对血流动力学及应激反应的影响。方法选取2020年4月至2021年12月在邯郸市中心医院及河北医科大学第二医院接受立体定向颅内血肿清除术的80例高血压脑出血患者纳入研究对象,按随机数字表法分为观察组与对照组,各40例。观察组患者在立体定向颅内血肿清除术前给予头皮神经阻滞麻醉,对照组患者在立体定向颅内血肿清除术前给予局部浸润麻醉。比较2组患者在麻醉前(T0)、切头皮时(T1)、钻孔时(T2)、缝合时(T3)的平均动脉压(MAP)、心率(HR)、皮质醇(Cor)、去甲肾上腺素(NE)、肾上腺素(E),比较2组患者术后1 h、6 h、12 h的疼痛程度,比较2组患者手术前后的格拉斯哥昏迷评分(GCS)评分、神经功能缺损评分(CCS)评分。结果对照组在T1、T2、T3时点MAP、HR显著高于T0时(P<0.05),观察组在T1、T2、T3时点MAP、HR显著低于对照组(P<0.05);观察组在T1、T2、T3时点Cor、NE、E显著低于对照组(P<0.05),对照组在T1、T2、T3时点Cor、NE、E显著高于T0时(P<0.05);观察组在术后1 h、6 h、12 h的疼痛数字评价量表(NRS)评分均显著低于对照组(P<0.05);2组术后3 d的GCS评分显著高于术前,CCS评分显著低于术前(P<0.05)。结论高血压脑出血患者立体定向颅内血肿清除术中采用头皮神经阻滞麻醉血流动力学更稳定,应激反应程度更轻。 展开更多
关键词 高血压脑出血 立体定向颅内血肿清除术 麻醉 血流动力学 应激反应
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Gab2-Akt-ARK5通路在胶质瘤侵袭中的研究 被引量:5
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作者 孙磊 刘雨清 +4 位作者 李小龙 刘菲 张丽娜 李洪利 张宝刚 《中国肿瘤临床》 CAS CSCD 北大核心 2014年第9期551-554,共4页
目的:探讨Gab2-Akt-ARK5通路在胶质瘤侵袭中的意义。方法:采用免疫组织化学SP法检测90例胶质瘤组织中ARK5及Gab2表达。采用小RNA干扰转染LN-229细胞株,Western Blot检测瞬时转染后ARK5及Gab2表达。体外侵袭实验检测转染后侵袭能力变化及... 目的:探讨Gab2-Akt-ARK5通路在胶质瘤侵袭中的意义。方法:采用免疫组织化学SP法检测90例胶质瘤组织中ARK5及Gab2表达。采用小RNA干扰转染LN-229细胞株,Western Blot检测瞬时转染后ARK5及Gab2表达。体外侵袭实验检测转染后侵袭能力变化及Western Blot检测Gab2下降后Akt和ARK5的磷酸化。结果:胶质瘤组织中ARK5和Gab2免疫组织化学阳性结果呈正相关且在高级别胶质瘤(WHO分级为Ⅲ、Ⅳ级)中表达明显高于低级别胶质瘤(WHO分级为Ⅰ、Ⅱ级)。转染ARK5、Gab2、ARK5-Gab2及SCR质粒的LN-229细胞分别称siARK5/LN-229、siGab2/LN-229、siARK5-siGab2/LN-229和SCR/LN-229。其中siARK5干扰效率为70%,siGab2的干扰效率为75%。转染后,与SCR/LN-229相比,siARK5/LN-229中ARK5表达降低,siGab2/LN-229中Gab2表达降低,siARK5-siGab2/LN-229中ARK5和Gab2表达均降低。siARK5/LN-229和siGab2/LN-229侵袭并穿透Matrigel膜基质的细胞数均比对照组少(P<0.01),且siARK5-siGab2/LN-229细胞数减少更显著(P<0.01)。在IGF-1刺激下,siGab2/LN-229中Akt和ARK5的磷酸化减弱。结论:应用小RNA干扰技术降低ARK5或Gab2表达使LN-229细胞侵袭转移能力降低,同时Gab2表达降低抑制ARK5和Akt磷酸化,提示Gab2-Akt-ARK5通路参与胶质瘤细胞的侵袭。 展开更多
关键词 胶质瘤 ARK5 Gab2 LN-229细胞 小RNA干扰 侵袭
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选择性胆管造影在诊治复杂肝内胆管结石中的临床应用 被引量:8
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作者 史力军 刘飞 +6 位作者 杨玉龙 马跃峰 李婧伊 林美举 张洪威 张诚 祁春春 《中国内镜杂志》 2019年第1期10-15,共6页
目的探讨胆道镜引导下选择性肝内胆管造影在复杂肝内胆管结石治疗中的临床价值。方法回顾性分析该科2010年8月-2017年7月收治的复杂肝内胆管结石术后T管造影及胆道镜未发现结石的患者96例,在胆道镜引导下对可疑胆管行选择性胆管造影以... 目的探讨胆道镜引导下选择性肝内胆管造影在复杂肝内胆管结石治疗中的临床价值。方法回顾性分析该科2010年8月-2017年7月收治的复杂肝内胆管结石术后T管造影及胆道镜未发现结石的患者96例,在胆道镜引导下对可疑胆管行选择性胆管造影以确定狭窄胆管及结石部位,同时行取石和解除狭窄治疗。结果肝内胆管狭窄伴结石组88例,86例经胆管球囊扩张、Cook网篮取石等结石全部取净,操作时间为(58.4±11.5)min,2例取石失败,结束手术。肝内胆管狭窄不伴结石组8例,直接行胆道镜下高频电切术。两组肝内狭窄胆管的位置分布比较,差异无统计学意义(P>0.05);取石和电切过程中共出血8例,采取针状刀高频电凝成功止血,术后发生胆管炎9例,迟发性胆道出血4例,均给予对症治疗,两组并发症发生率比较,差异无统计学意义(P>0.05)。随访6~24个月,肝内胆管结石复发15例,采取经皮经肝胆管穿刺引流及经皮经肝胆道镜治疗,术中发现17处胆管狭窄。结论针对复杂肝内胆管结石或结石合并狭窄,规范的选择性胆管造影技术不失为一种准确、安全、有效的诊治方法。 展开更多
关键词 选择性胆管造影 肝内胆管结石 球囊扩张
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吸收倒刺线在双镜联合保胆取石术中的临床应用 被引量:7
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作者 李婧伊 刘飞 +2 位作者 马跃峰 祁春春 史力军 《中国现代医学杂志》 CAS 2020年第2期85-89,共5页
目的探讨可吸收倒刺线在腹腔镜联合胆道镜(以下简称双镜联合)保胆取石术中的临床应用。方法回顾性分析2015年6月-2018年1月在大连大学附属中山医院胆石病微创外科成功行双镜联合保胆取石手术治疗的209例患者临床资料。其中,128例采用可... 目的探讨可吸收倒刺线在腹腔镜联合胆道镜(以下简称双镜联合)保胆取石术中的临床应用。方法回顾性分析2015年6月-2018年1月在大连大学附属中山医院胆石病微创外科成功行双镜联合保胆取石手术治疗的209例患者临床资料。其中,128例采用可吸收倒刺线缝合胆囊者作为倒刺线组,81例采用普通可吸收缝线者作为普通组。结果两组基线资料比较,差异无统计学意义(P>0.05)。两组术中出血量、住院时间比较,差异无统计学意义(P>0.05)。倒刺线组胆囊缝合时间(5.52±1.32)min、手术时间(64.87±16.36)min低于普通组胆囊缝合时间(6.19±1.64)min、手术时间(72.80±25.09)min(P<0.05)。倒刺线组无术后胆漏,普通组术后胆漏发生率为6.17%(P <0.05)。3例术后胆漏在积极保守治疗后缓解,2例在行内镜下鼻胆管引流治疗后缓解。术后随访3~6个月,结石复发13例,6例给予腹腔镜下胆囊切除;7例行内镜下乳头括约肌切开/内镜下乳头括约肌球囊扩张+鼻胆管引流等治疗。无死亡病例。结论可吸收倒刺线用于双镜联合保胆取石术中一期缝合胆囊安全可行,其可降低腹腔镜下胆囊缝合难度、缩短胆囊缝合时间及手术时间,降低术后胆漏发生率,临床优势明显。 展开更多
关键词 胆结石 腹腔镜检查 治疗结果 随访研究
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Fluorine distribution,health risk,and geological and anthropogenic controlling factors in central Guizhou Province,Southwest China
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作者 Xiu-jin liu Li Zhang +6 位作者 Zhi-zhuo liu Ya-long Zhou Shi-qi Tang fei liu Min Peng Hang-xin Cheng Yan-fei Qi 《China Geology》 2025年第3期586-597,共12页
Fluorine(F)-enriched soils,resulting from geogenic processes or superimposed by anthropogenic activities,have raised significant concerns due to their phytotoxicity and potential threats to human health.Soils in centr... Fluorine(F)-enriched soils,resulting from geogenic processes or superimposed by anthropogenic activities,have raised significant concerns due to their phytotoxicity and potential threats to human health.Soils in central Guizhou Province exhibit F enrichment,with a mean F concentration of 1067 mg/kg.However,the associated human health risks and geochemical mechanisms driving F enrichment in these soils remain insufficiently understood.In areas with a natural geological background,the average concentrations of F in rice,vegetables,drinking water,and ambient air are 1.54 mg/kg,0.54 mg/kg,0.16 mg/L,and 0.29μg/m^(3),respectively.In contrast,samples collected near phosphorous chemical plants demonstrate elevated F concentrations:1.78 mg/kg in rice,1.53 mg/kg in vegetables,0.20 mg/L in drinking water,and 11.98μg/m^(3) in ambient air.Fluorine in soils was immobilized by apatite and clay minerals,and hardly transferred into water and crops.The fixation of F-by Ca^(2+)in water and by Fe/Al hydroxides and clay minerals in bottom sediment further reduces F concentrations in water.As a result,hazard quotient(HQ)values below 1.0 indicate negligible fluorine-related health risk in geological background regions.However,ambient air near phosphorous chemical plant exhibited a 41.3-fold increase in F concentration compared to geological background regions.Fluorine-laden emissions can be directly inhaled or deposited on vegetable leaves and orally ingested into human bodies.Improvement of F-rich waste gas disposal and restricted leafy vegetable cultivation are effective measures to reduce F health risks in phosphorous chemical plant regions. 展开更多
关键词 Soil fluorine Drinking water fluorine Ambient air fluorine Rice fluorine Vegetable fluorine Health risk Apatite and clay minerals Geological background Phosphorus chemical plants Guizhou Province Sustainable Development Goals(SDG 3) Environmental geological survey engineering
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