Background:Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer(CRC).However,as the molecular mechanism associated is still unclear,our study aimed to explore the ...Background:Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer(CRC).However,as the molecular mechanism associated is still unclear,our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC.Methods:HT29 and SW480 cells were treated with curcumin or/and Doxycycline(DOX),and cell viability,colony forming ability,migration and invasion were confirmed by cell counting kit-8(CCK-8),colony forming,Transwell assays.And Yes-associated protein 1(YAP)and PDZ-binding motif(TAZ)signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR(RT-qPCR),western blot,and immunofluorescence assays.Then nude mice xenograft tumor model was constructed,YAP and Ki67 expressions were tested by immunohistochemistry(IHC)staining.Results:In our study,we proved that curcumin significantly inhibited the CRC cell viability,cell migration,and cell invasion abilities.In addition,curcumin inhibited YAP and Transcriptional coactivator with TAZ or the YAP/TAZ signaling axis in CRC cells.Further,in the nude mice model,curcumin treatment significantly decreased the size and weight of xenotransplant tumors.Conclusion:Therefore,curcumin significantly inhibited CRC development and invasion by regulating the YAP/TAZ signaling axis.展开更多
This study aims to explore the mechanism by which flavonoids in Crataegus pinnatifida fruit improve Alzheimer’s disease(AD)through network pharmacology and molecular docking technology.The flavonoid components presen...This study aims to explore the mechanism by which flavonoids in Crataegus pinnatifida fruit improve Alzheimer’s disease(AD)through network pharmacology and molecular docking technology.The flavonoid components present in Crataegus pinnatifida fruit were gathered from the HERB,HIT,and ETCM databases,and were further supplemented by relevant published literature.The PubChem and SwissTargetPrediction databases were utilized to predict potential targets,and a“Crataegus pinnatifida fruit-active ingredient-target”network was constructed using Cytoscape 3.9.0 software.The GeneCards database was utilized to identify targets associated with AD,which were subsequently intersected with the active targets of Crataegus pinnatifi da fruit.A protein-protein interaction(PPI)network was constructed using the STRING platform.KEGG enrichment analysis of the core targets was conducted on an online bioinformatics mapping platform,while molecular docking of the primary active components and core targets was executed using AutoDock software.Eight flavonoids and 160 potential targets were identifi ed from Crataegus pinnatifi da fruit,of which 147 targets were linked to AD.The results of the“Crataegus pinnatifi da fruit-active ingredient-target”network indicated that quercetin was the principal flavonoid active ingredient.PPI analysis revealed that SRC and EGFR were the key targets,and KEGG analysis identifi ed the main enrichment pathways as Pathways in cancer,PI3K/Akt signaling pathway,and Proteoglycans in cancer.Molecular docking confi rmed the strong binding affi nity between the core targets and the primary active ingredient.The interaction of quercetin with the key targets SRC and EGFR may represent a signifi cant mechanism by which flavonoids from Crataegus pinnatifi da fruit contribute to the improvement of AD.展开更多
Quasi-solid-state composite electrolytes(QSCEs)show promise for high-performance solid-state batteries,while they still struggle with interfacial stability and cycling performance.Herein,a F-grafted QSCE(F-QSCE)was de...Quasi-solid-state composite electrolytes(QSCEs)show promise for high-performance solid-state batteries,while they still struggle with interfacial stability and cycling performance.Herein,a F-grafted QSCE(F-QSCE)was developed via copolymerizing the F monomers and ionic liquid monomers.The F-QSCE demonstrates better overall performance,such as high ionic conductivity of 1.21 mS cm^(-1)at 25℃,wide electrochemical windows of 5.20 V,and stable cycling stability for Li//Li symmetric cells over 4000 h.This is attributed to the significant electronegativity difference between C and F in the fluorinated chain(-CF_(2)-CF-CF_(3)),which causes the electron cloud to shift toward the F atom,surrounding it with a negative charge and producing the inductive effect.Furthermore,the interactions between Li^(+)and F,TFSI~-,and C are enhanced,reducing ion pair aggregation(Li^(+)-TFSI~--Li^(+))and promoting Li^(+)transport.Besides,-CF_(2)-CF-CF_(3)decomposes to form Li F preferentially over TFSI~-,resulting in better interfacial stability for F-QSCE.This work provides a pathway to enable the development of high-performance Li metal batteries.展开更多
Novel water-based nanolubricants using TiO2 nanoparticles(NPs)were synthesised by adding sodium dodecyl benzene sulfonate(SDBS)and glycerol,which exhibited excellent dispersion stability and wettability.The tribologic...Novel water-based nanolubricants using TiO2 nanoparticles(NPs)were synthesised by adding sodium dodecyl benzene sulfonate(SDBS)and glycerol,which exhibited excellent dispersion stability and wettability.The tribological performance of the synthesised nanolubricants was investigated using an Rtec ball-on-disk tribometer,and their application in hot steel rolling was evaluated on a 2-high Hille 100 experimental rolling mill,in comparison to those without SDBS.The water-based nanolubricant containing 4 wt%TiO2 and 0.4 wt%SDBS demonstrated superior tribological performance by decreasing coefficient of friction and ball wear up to 70.5%and 84.3%,respectively,compared to those of pure water.In addition to the lubrication effect,the suspensions also had significant effect on polishing of the work roll surface.The resultant surface improvement thus enabled the decrease in rolling force up to 8.3%under a workpiece reduction of 30%at a rolling temperature of 850◦C.The lubrication mechanisms were primarily ascribed to the formation of lubricating film and ball-bearing effect of the TiO2 NPs.展开更多
The attention is a scarce resource in decentralized autonomous organizations(DAOs),as their self-governance relies heavily on the attention-intensive decision-making process of“proposal and voting”.To prevent the ne...The attention is a scarce resource in decentralized autonomous organizations(DAOs),as their self-governance relies heavily on the attention-intensive decision-making process of“proposal and voting”.To prevent the negative effects of pro-posers’attention-capturing strategies that contribute to the“tragedy of the commons”and ensure an efficient distribution of attention among multiple proposals,it is necessary to establish a market-driven allocation scheme for DAOs’attention.First,the Harberger tax-based attention markets are designed to facilitate its allocation via continuous and automated trading,where the individualized Harberger tax rate(HTR)determined by the pro-posers’reputation is adopted.Then,the Stackelberg game model is formulated in these markets,casting attention to owners in the role of leaders and other competitive proposers as followers.Its equilibrium trading strategies are also discussed to unravel the intricate dynamics of attention pricing.Moreover,utilizing the single-round Stackelberg game as an illustrative example,the existence of Nash equilibrium trading strategies is demonstrated.Finally,the impact of individualized HTR on trading strategies is investigated,and results suggest that it has a negative correlation with leaders’self-accessed prices and ownership duration,but its effect on their revenues varies under different conditions.This study is expected to provide valuable insights into leveraging attention resources to improve DAOs’governance and decision-making process.展开更多
The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds ...The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds the utmost importance in determining thenecessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is acollaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence,aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontictherapy in patients with compromised overall health.展开更多
THE Lebanese wireless device explosion incident has drawn widespread attention,involving devices such as pagers,walkie-talkies,and other common devices[1].This event has revealed and highlighted the security vulnerabi...THE Lebanese wireless device explosion incident has drawn widespread attention,involving devices such as pagers,walkie-talkies,and other common devices[1].This event has revealed and highlighted the security vulnerabilities in global supply chains from raw material manufacturing and distribution to the usage of devices and equipment,signaling the onset of a new wave of"supply chain warfare"[2].展开更多
BACKGROUND The intensive care unit(ICU)is a specialized hospital department.Awake patients in the ICU frequently encounter adverse psychological states,such as anxiety and fear,often accompanied by poor sleep quality....BACKGROUND The intensive care unit(ICU)is a specialized hospital department.Awake patients in the ICU frequently encounter adverse psychological states,such as anxiety and fear,often accompanied by poor sleep quality.This situation has garnered significant attention within the medical community.AIM To investigate the impact of prospective nursing intervention strategies on the sleep quality and negative emotional state of conscious ICU patients.METHODS One hundred and twenty ICU awake patients admitted to our hospital were selected and randomly divided into control(n=60)and observation(n=60)groups.Patients in the control group were cared for using the conventional nursing model,while patients in the observation group were cared for using the prospective nursing model.Sleep improvement was assessed using the International Standardized Sleep Efficiency Formula and Pittsburgh Sleep Quality Index(PSQI).The PSQI,Generalized Anxiety Disorder 7-item(GAD-7)scale,Self-Depression Scale(SDS),and satisfaction before and after treatment were used to assess the negative emotional states of patients under the two care models.RESULTS Patient satisfaction in the observation group was significantly higher than in the control group.The GAD-7 and SDS scores in the observation group were significantly lower than those in the control group,and the total effective rate of sleep improvement in the observation group was significantly higher than in the control group.After treatment,the PSQI scores of the two groups significantly decreased(P<0.05).The decrease in the observation group was more significan than that in the control group,and the difference between the two groups was statistically significant.CONCLUSION Prospective nursing interventions can improve sleep quality and psychological levels and significantly affect conscious patients in the ICU,which is worthy of clinical application.展开更多
基金This work was financially supported by the Second Batch of Medical and Health Science and Technology Plan(self-financing)Projects in Shantou in 2020,Shantou Science and Technology Bureau Document Shantou([2020]No.58).
文摘Background:Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer(CRC).However,as the molecular mechanism associated is still unclear,our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC.Methods:HT29 and SW480 cells were treated with curcumin or/and Doxycycline(DOX),and cell viability,colony forming ability,migration and invasion were confirmed by cell counting kit-8(CCK-8),colony forming,Transwell assays.And Yes-associated protein 1(YAP)and PDZ-binding motif(TAZ)signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR(RT-qPCR),western blot,and immunofluorescence assays.Then nude mice xenograft tumor model was constructed,YAP and Ki67 expressions were tested by immunohistochemistry(IHC)staining.Results:In our study,we proved that curcumin significantly inhibited the CRC cell viability,cell migration,and cell invasion abilities.In addition,curcumin inhibited YAP and Transcriptional coactivator with TAZ or the YAP/TAZ signaling axis in CRC cells.Further,in the nude mice model,curcumin treatment significantly decreased the size and weight of xenotransplant tumors.Conclusion:Therefore,curcumin significantly inhibited CRC development and invasion by regulating the YAP/TAZ signaling axis.
基金supported by National Natural Science Foundation of China(No.82374333,No.82173961)LiaoNing Revitalization Talents Program(XLYC2203200)+5 种基金SPU Excellent Youth Program(YQ202310)SPU Youth Career Development plan(ZQN202211)Key Laboratory of polysaccharide bioactivity evaluation of TCM of Liaoning Province-Liaoning Distinguished Professor Project for Ying Jia(2017)High-level innovation and entrepreneurship team of Liaoning Province(XLYC2008029)Liaoning Provincial Department of Education Fund(LJ212410163006,LJ212410163018)Postgraduate Education and Teaching Reform Research Project of Liaoning Province in 2024(LNYJG2024251).
文摘This study aims to explore the mechanism by which flavonoids in Crataegus pinnatifida fruit improve Alzheimer’s disease(AD)through network pharmacology and molecular docking technology.The flavonoid components present in Crataegus pinnatifida fruit were gathered from the HERB,HIT,and ETCM databases,and were further supplemented by relevant published literature.The PubChem and SwissTargetPrediction databases were utilized to predict potential targets,and a“Crataegus pinnatifida fruit-active ingredient-target”network was constructed using Cytoscape 3.9.0 software.The GeneCards database was utilized to identify targets associated with AD,which were subsequently intersected with the active targets of Crataegus pinnatifi da fruit.A protein-protein interaction(PPI)network was constructed using the STRING platform.KEGG enrichment analysis of the core targets was conducted on an online bioinformatics mapping platform,while molecular docking of the primary active components and core targets was executed using AutoDock software.Eight flavonoids and 160 potential targets were identifi ed from Crataegus pinnatifi da fruit,of which 147 targets were linked to AD.The results of the“Crataegus pinnatifi da fruit-active ingredient-target”network indicated that quercetin was the principal flavonoid active ingredient.PPI analysis revealed that SRC and EGFR were the key targets,and KEGG analysis identifi ed the main enrichment pathways as Pathways in cancer,PI3K/Akt signaling pathway,and Proteoglycans in cancer.Molecular docking confi rmed the strong binding affi nity between the core targets and the primary active ingredient.The interaction of quercetin with the key targets SRC and EGFR may represent a signifi cant mechanism by which flavonoids from Crataegus pinnatifi da fruit contribute to the improvement of AD.
基金conducted in a project within M-ERA.NET 3 with support from the European Union’s Horizon 2020 research,innovation program under grant agreement No.958174,Vinnova(Swedish Governmental Agency for Innovation Systems)the financial support from the LTU CREATERNITY program+1 种基金the J.Gust Richert Foundationthe National Natural Science Foundation of China(No.U23A20122)。
文摘Quasi-solid-state composite electrolytes(QSCEs)show promise for high-performance solid-state batteries,while they still struggle with interfacial stability and cycling performance.Herein,a F-grafted QSCE(F-QSCE)was developed via copolymerizing the F monomers and ionic liquid monomers.The F-QSCE demonstrates better overall performance,such as high ionic conductivity of 1.21 mS cm^(-1)at 25℃,wide electrochemical windows of 5.20 V,and stable cycling stability for Li//Li symmetric cells over 4000 h.This is attributed to the significant electronegativity difference between C and F in the fluorinated chain(-CF_(2)-CF-CF_(3)),which causes the electron cloud to shift toward the F atom,surrounding it with a negative charge and producing the inductive effect.Furthermore,the interactions between Li^(+)and F,TFSI~-,and C are enhanced,reducing ion pair aggregation(Li^(+)-TFSI~--Li^(+))and promoting Li^(+)transport.Besides,-CF_(2)-CF-CF_(3)decomposes to form Li F preferentially over TFSI~-,resulting in better interfacial stability for F-QSCE.This work provides a pathway to enable the development of high-performance Li metal batteries.
基金The authors acknowledge the financial supports from Baosteel-Australia Joint Research&Development Center(BAJC)under the project of BA17004 and Australian Research Council(ARC)under Linkage Project Program(LP150100591)。
文摘Novel water-based nanolubricants using TiO2 nanoparticles(NPs)were synthesised by adding sodium dodecyl benzene sulfonate(SDBS)and glycerol,which exhibited excellent dispersion stability and wettability.The tribological performance of the synthesised nanolubricants was investigated using an Rtec ball-on-disk tribometer,and their application in hot steel rolling was evaluated on a 2-high Hille 100 experimental rolling mill,in comparison to those without SDBS.The water-based nanolubricant containing 4 wt%TiO2 and 0.4 wt%SDBS demonstrated superior tribological performance by decreasing coefficient of friction and ball wear up to 70.5%and 84.3%,respectively,compared to those of pure water.In addition to the lubrication effect,the suspensions also had significant effect on polishing of the work roll surface.The resultant surface improvement thus enabled the decrease in rolling force up to 8.3%under a workpiece reduction of 30%at a rolling temperature of 850◦C.The lubrication mechanisms were primarily ascribed to the formation of lubricating film and ball-bearing effect of the TiO2 NPs.
基金supported by the National Natural Science Foundation of China(62103411)the Science and Technology Development Fund of Macao SAR(0093/2023/RIA2,0050/2020/A1)。
文摘The attention is a scarce resource in decentralized autonomous organizations(DAOs),as their self-governance relies heavily on the attention-intensive decision-making process of“proposal and voting”.To prevent the negative effects of pro-posers’attention-capturing strategies that contribute to the“tragedy of the commons”and ensure an efficient distribution of attention among multiple proposals,it is necessary to establish a market-driven allocation scheme for DAOs’attention.First,the Harberger tax-based attention markets are designed to facilitate its allocation via continuous and automated trading,where the individualized Harberger tax rate(HTR)determined by the pro-posers’reputation is adopted.Then,the Stackelberg game model is formulated in these markets,casting attention to owners in the role of leaders and other competitive proposers as followers.Its equilibrium trading strategies are also discussed to unravel the intricate dynamics of attention pricing.Moreover,utilizing the single-round Stackelberg game as an illustrative example,the existence of Nash equilibrium trading strategies is demonstrated.Finally,the impact of individualized HTR on trading strategies is investigated,and results suggest that it has a negative correlation with leaders’self-accessed prices and ownership duration,but its effect on their revenues varies under different conditions.This study is expected to provide valuable insights into leveraging attention resources to improve DAOs’governance and decision-making process.
基金supported by the National Natural Science Foundation of China(82370947)the Natural Science Foundation of Sichuan Province(2023NSFSC1505)。
文摘The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds the utmost importance in determining thenecessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is acollaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence,aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontictherapy in patients with compromised overall health.
基金partly supported by the Science and Technology Development Fund,Macao Special Administrative Region(SAR)(0093/2023/RIA2,0145/2023/RIA3)The National Natural Science Foundation of China(62103411)。
文摘THE Lebanese wireless device explosion incident has drawn widespread attention,involving devices such as pagers,walkie-talkies,and other common devices[1].This event has revealed and highlighted the security vulnerabilities in global supply chains from raw material manufacturing and distribution to the usage of devices and equipment,signaling the onset of a new wave of"supply chain warfare"[2].
文摘BACKGROUND The intensive care unit(ICU)is a specialized hospital department.Awake patients in the ICU frequently encounter adverse psychological states,such as anxiety and fear,often accompanied by poor sleep quality.This situation has garnered significant attention within the medical community.AIM To investigate the impact of prospective nursing intervention strategies on the sleep quality and negative emotional state of conscious ICU patients.METHODS One hundred and twenty ICU awake patients admitted to our hospital were selected and randomly divided into control(n=60)and observation(n=60)groups.Patients in the control group were cared for using the conventional nursing model,while patients in the observation group were cared for using the prospective nursing model.Sleep improvement was assessed using the International Standardized Sleep Efficiency Formula and Pittsburgh Sleep Quality Index(PSQI).The PSQI,Generalized Anxiety Disorder 7-item(GAD-7)scale,Self-Depression Scale(SDS),and satisfaction before and after treatment were used to assess the negative emotional states of patients under the two care models.RESULTS Patient satisfaction in the observation group was significantly higher than in the control group.The GAD-7 and SDS scores in the observation group were significantly lower than those in the control group,and the total effective rate of sleep improvement in the observation group was significantly higher than in the control group.After treatment,the PSQI scores of the two groups significantly decreased(P<0.05).The decrease in the observation group was more significan than that in the control group,and the difference between the two groups was statistically significant.CONCLUSION Prospective nursing interventions can improve sleep quality and psychological levels and significantly affect conscious patients in the ICU,which is worthy of clinical application.
