Three-way control combiner valves(TCCVs)are critical components used in nuclear power plants to regulate the concentration of boron acid for neutron absorption and reactor safety.However,current TCCV designs often suf...Three-way control combiner valves(TCCVs)are critical components used in nuclear power plants to regulate the concentration of boron acid for neutron absorption and reactor safety.However,current TCCV designs often suffer from suboptimal control performance and high flow resistance,leading to control deviations and reduced operational efficiency.In this paper,a numerical model based on the standard K–ωturbulence model is established and validated against experimental data to analyze the flow characteristics and local flow resistance of a TCCV.A parametric design method for the throttling windows is proposed,establishing relationships between shape parameters and performance indexes,including control performance and flow resistance.The adaptive non-dominated sorting genetic algorithm(ANSGA-II)is used to optimize the shape parameters of the throttling windows.The optimization results show an improvement in the performance indexes of the TCCV,with the adjustable operating range increasing by 31.0%and the maximum local resistance decreasing by 18.3%.We also introduce the concepts of effective and controllable domains to characterize the inlet backflow phenomena and regulation dead zones,which are crucial for ensuring the reliability and effectiveness of control valves.These findings provide insights for enhancing the design and performance of TCCVs in nuclear power plants.展开更多
Complex diseases do not always follow gradual progressions.Instead,they may experience sudden shifts known as critical states or tipping points,where a marked qualitative change occurs.Detecting such a pivotal transit...Complex diseases do not always follow gradual progressions.Instead,they may experience sudden shifts known as critical states or tipping points,where a marked qualitative change occurs.Detecting such a pivotal transition or pre-deterioration state holds paramount importance due to its association with severe disease deterioration.Nevertheless,the task of pinpointing the pre-deterioration state for complex diseases remains an obstacle,especially in scenarios involving high-dimensional data with limited samples,where conventional statistical methods frequently prove inadequate.In this study,we introduce an innovative quantitative approach termed sample-specific causality network entropy(SCNE),which infers a sample-specific causality network for each individual and effectively quantifies the dynamic alterations in causal relations among molecules,thereby capturing critical points or pre-deterioration states of complex diseases.We substantiated the accuracy and efficacy of our approach via numerical simulations and by examining various real-world datasets,including single-cell data of epithelial cell deterioration(EPCD)in colorectal cancer,influenza infection data,and three different tumor cases from The Cancer Genome Atlas(TCGA)repositories.Compared to other existing six single-sample methods,our proposed approach exhibits superior performance in identifying critical signals or pre-deterioration states.Additionally,the efficacy of computational findings is underscored by analyzing the functionality of signaling biomarkers.展开更多
基金supported by the National Natural Science Foundation of China(No.52422506).
文摘Three-way control combiner valves(TCCVs)are critical components used in nuclear power plants to regulate the concentration of boron acid for neutron absorption and reactor safety.However,current TCCV designs often suffer from suboptimal control performance and high flow resistance,leading to control deviations and reduced operational efficiency.In this paper,a numerical model based on the standard K–ωturbulence model is established and validated against experimental data to analyze the flow characteristics and local flow resistance of a TCCV.A parametric design method for the throttling windows is proposed,establishing relationships between shape parameters and performance indexes,including control performance and flow resistance.The adaptive non-dominated sorting genetic algorithm(ANSGA-II)is used to optimize the shape parameters of the throttling windows.The optimization results show an improvement in the performance indexes of the TCCV,with the adjustable operating range increasing by 31.0%and the maximum local resistance decreasing by 18.3%.We also introduce the concepts of effective and controllable domains to characterize the inlet backflow phenomena and regulation dead zones,which are crucial for ensuring the reliability and effectiveness of control valves.These findings provide insights for enhancing the design and performance of TCCVs in nuclear power plants.
基金supported by National Natural Science Foundation of China(nos.T2341022,12322119,62172164,and 12271180)Guangdong Provincial Key Laboratory of Human Digital Twin(2022B1212010004)+2 种基金Educational Commission of Guangdong Province of China(2023KQNCX073)the Natural Science Foundation of Guangdong Province of China(2022A-1515110759,and 2023A1515110558)Fundamental Research Funds for the Central Universities(2023ZYGXZR077).
文摘Complex diseases do not always follow gradual progressions.Instead,they may experience sudden shifts known as critical states or tipping points,where a marked qualitative change occurs.Detecting such a pivotal transition or pre-deterioration state holds paramount importance due to its association with severe disease deterioration.Nevertheless,the task of pinpointing the pre-deterioration state for complex diseases remains an obstacle,especially in scenarios involving high-dimensional data with limited samples,where conventional statistical methods frequently prove inadequate.In this study,we introduce an innovative quantitative approach termed sample-specific causality network entropy(SCNE),which infers a sample-specific causality network for each individual and effectively quantifies the dynamic alterations in causal relations among molecules,thereby capturing critical points or pre-deterioration states of complex diseases.We substantiated the accuracy and efficacy of our approach via numerical simulations and by examining various real-world datasets,including single-cell data of epithelial cell deterioration(EPCD)in colorectal cancer,influenza infection data,and three different tumor cases from The Cancer Genome Atlas(TCGA)repositories.Compared to other existing six single-sample methods,our proposed approach exhibits superior performance in identifying critical signals or pre-deterioration states.Additionally,the efficacy of computational findings is underscored by analyzing the functionality of signaling biomarkers.
