BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer worldwide.Among patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to mortality.In recent years,immunother...BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer worldwide.Among patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to mortality.In recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including CRC.We present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of CRLM.CASE SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as pT4N2aM0.The patient has been receiving a combination treatment of Western and Traditional Chinese Medicine.Regular assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its coating.The patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies failed.Since the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced CRC.CONCLUSION This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.展开更多
BACKGROUND Aging is an inevitable aspect of human life,characterized by the gradual decline in the function of individual cells and structural components,including bones,muscles,and ligaments.AIM To evaluate the clini...BACKGROUND Aging is an inevitable aspect of human life,characterized by the gradual decline in the function of individual cells and structural components,including bones,muscles,and ligaments.AIM To evaluate the clinical effects of radiofrequency technology in treating facial skin wrinkles and laxity.METHODS This study included 60 female patients,aged 36-58 years(mean age 47.71±1.56 years),who received focused radiofrequency technology treatment for facial wrinkles and laxity in the Department of Medical Cosmetology at our hospital between January 2021 and June 2022.Each patient underwent three treatment sessions,one every two months.Facial photographs were taken before treatment and one week after the final session.A single physician assessed wrinkle severity using a standardized wrinkle severity scale,and patients completed a satisfaction questionnaire one week after the last treatment.RESULTS After three consecutive radiofrequency treatments,performed every two months,patients exhibited significantly reduced wrinkles and skin laxity compared to baseline.One week after the third treatment,the mean facial wrinkle severity score had significantly decreased from 3.00±0.79 to 2.71±0.47(t=2.58,P<0.05).Additionally,88.24%of patients reported noticeable improvements in facial wrinkles and skin laxity.No serious adverse reactions occurred during or follow-ing treatment.CONCLUSION Radiofrequency technology demonstrates significant clinical efficacy in improving facial skin wrinkles and laxity.展开更多
The mechanical properties of cemented paste backfill(CPB)determine its control effect on the goaf roof.In this study,the mechanical strength of polymer-modified cemented paste backfill(PCPB)samples was tested by uniax...The mechanical properties of cemented paste backfill(CPB)determine its control effect on the goaf roof.In this study,the mechanical strength of polymer-modified cemented paste backfill(PCPB)samples was tested by uniaxial compression tests,and the failure characteristics of PCPB under the compression were analyzed.Besides,acoustic emission(AE)technology was used to monitor and record the cracking process of the PCPB sample with a curing age of 28 d,and two AE indexes(rise angle and average frequency)were used to classify the failure modes of samples under different loading processes.The results show that waterborne epoxy resin can significantly enhance the mechanical strength of PCPB samples(when the mass ratio of polymer to powder material is 0.30,the strength of PCPB samples with a curing age of 28 d is increased by 102.6%);with the increase of polymer content,the mechanical strength of PCPB samples is improved significantly in the early and middle period of curing.Under uniaxial load,the macro cracks of PCPB samples are mostly generated along the axial direction,the main crack runs through the sample,and a large number of small cracks are distributed around the main crack.The AE response of PCPB samples during the whole loading process can be divided into four periods:quiet period,slow growth period,rapid growth period,and remission period,corresponding to the micro-pore compaction stage,elastic deformation stage,plastic deformation stage,and failure instability stage of the stress-strain curve.The AE events are mainly concentrated in the plastic deformation stage;both shear failure and tensile failure occur in the above four stages,while tensile failure is dominant for PCPB samples.This study provides a reference for the safety of coal pillar recovery in pillar goaf.展开更多
针对海量数据处理难度大,传统方法效率低、异常值导致模型参数估计不准确等问题,提出了一种基于高斯过程回归(Gaussian process regression,GPR)和粒子滤波(Particle filtering,PF)的光伏电站监测数据修复方法。首先用数学语言描述GPR...针对海量数据处理难度大,传统方法效率低、异常值导致模型参数估计不准确等问题,提出了一种基于高斯过程回归(Gaussian process regression,GPR)和粒子滤波(Particle filtering,PF)的光伏电站监测数据修复方法。首先用数学语言描述GPR数据监测过程,并进行数据预处理;在训练样本集中通过高斯过程回归建立状态空间方程,采用粒子滤波算法对当前量测值进行估计,对估计值和量测值的残差进行分析;其次,检测异常值并进行修复,并对修正后的光伏电站数据重新建立高斯过程回归预测模型。最后,测试结果验证了模型和方法的正确性。展开更多
Dear Editor,The ongoing pandemic of coronavirus disease 2019(COVID-19)has reshaped our daily life and caused>4 million deaths worldwide(https://covid19.who.int/).Although lockdown and vaccination have improved the ...Dear Editor,The ongoing pandemic of coronavirus disease 2019(COVID-19)has reshaped our daily life and caused>4 million deaths worldwide(https://covid19.who.int/).Although lockdown and vaccination have improved the situation in many countries,imported cases and sporadic outbreaks pose a constant stress to the prevention and control of COVID-19.展开更多
Creating a specific shape with hierarchically porous structure of metal-organic frameworks represents an effective strategy to enhance the adsorption and photocatalytic performance yet remains rather challenging.Herei...Creating a specific shape with hierarchically porous structure of metal-organic frameworks represents an effective strategy to enhance the adsorption and photocatalytic performance yet remains rather challenging.Herein,we present a facile linker competitive coordination induced interface assembly strategy to synthesize a series of star-concave metalorganic frameworks(MOFs)(Fe-MIL-101)with rich hierarchical pores.This strategy of star-concave Fe-MIL-101 depends on the electronegativity difference of the two linkers to produce an in-situ oriented growth with controllable kinetics nucleation and structural evolution.As a result,the optimized star-concave Fe-MIL-101-2 with multiple physical-chemical effects endows enhanced visible-light trapping,preferred charge separation,and optimized the local electronic structure.In comparison with the slightly concave Fe-MIL-101 and solid octahedron Fe-MIL-101-NH_(2),the star-concave Fe-MIL-101-2 displays a clear superiority in the adsorption-photoreduction of Cr(VI)under visible-light irradiation.Furthermore,the X-ray absorption fine structure spectroscopy,finite element method,and density functional theory calculations are performed to reveal the local electronic structure of star-concave Fe-MIL-101-2,understanding the mechanisms behind the boosting synergistic adsorption-photoreduction of Cr(VI)removal performance.This work provides a new perspective for the rational construction of MOFs-based photocatalysts with high activity for Cr(VI)removal through shape engineering.展开更多
基金Supported by the National Key R and D Program of China,No.2022YFC3500200 and No.2022YFC3500204Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine,No.ZYYCXTD-C-202208+3 种基金NATCM’s Project of Highlevel Construction of Key TCM Disciplines,No.[2023]85Qing Lan Project of Jiangsu Higher Education Institutions,No.[2023]27Jiangsu Postgraduate Practice Innovation Plan,No.SJCX22_0706General Project of Universities’Philosophy and Social Science in Jiangsu Province,No.2024SJYB0564.
文摘BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer worldwide.Among patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to mortality.In recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including CRC.We present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of CRLM.CASE SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as pT4N2aM0.The patient has been receiving a combination treatment of Western and Traditional Chinese Medicine.Regular assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its coating.The patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies failed.Since the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced CRC.CONCLUSION This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.
文摘BACKGROUND Aging is an inevitable aspect of human life,characterized by the gradual decline in the function of individual cells and structural components,including bones,muscles,and ligaments.AIM To evaluate the clinical effects of radiofrequency technology in treating facial skin wrinkles and laxity.METHODS This study included 60 female patients,aged 36-58 years(mean age 47.71±1.56 years),who received focused radiofrequency technology treatment for facial wrinkles and laxity in the Department of Medical Cosmetology at our hospital between January 2021 and June 2022.Each patient underwent three treatment sessions,one every two months.Facial photographs were taken before treatment and one week after the final session.A single physician assessed wrinkle severity using a standardized wrinkle severity scale,and patients completed a satisfaction questionnaire one week after the last treatment.RESULTS After three consecutive radiofrequency treatments,performed every two months,patients exhibited significantly reduced wrinkles and skin laxity compared to baseline.One week after the third treatment,the mean facial wrinkle severity score had significantly decreased from 3.00±0.79 to 2.71±0.47(t=2.58,P<0.05).Additionally,88.24%of patients reported noticeable improvements in facial wrinkles and skin laxity.No serious adverse reactions occurred during or follow-ing treatment.CONCLUSION Radiofrequency technology demonstrates significant clinical efficacy in improving facial skin wrinkles and laxity.
基金supported by the National Natural Science Foundation of China (Nos.52022107,52174128,and 52104103)the Natural Science Foundation of Jiangsu Province (Nos.BK20190031 and BK20210499)+2 种基金the“Tianshan Innovation Team Plan”Project (No.2021D14016)the Xinjiang Key Research and Development Special Project (No.2022B03028-3)the Xinjiang Central Guidance Local Fund Project。
文摘The mechanical properties of cemented paste backfill(CPB)determine its control effect on the goaf roof.In this study,the mechanical strength of polymer-modified cemented paste backfill(PCPB)samples was tested by uniaxial compression tests,and the failure characteristics of PCPB under the compression were analyzed.Besides,acoustic emission(AE)technology was used to monitor and record the cracking process of the PCPB sample with a curing age of 28 d,and two AE indexes(rise angle and average frequency)were used to classify the failure modes of samples under different loading processes.The results show that waterborne epoxy resin can significantly enhance the mechanical strength of PCPB samples(when the mass ratio of polymer to powder material is 0.30,the strength of PCPB samples with a curing age of 28 d is increased by 102.6%);with the increase of polymer content,the mechanical strength of PCPB samples is improved significantly in the early and middle period of curing.Under uniaxial load,the macro cracks of PCPB samples are mostly generated along the axial direction,the main crack runs through the sample,and a large number of small cracks are distributed around the main crack.The AE response of PCPB samples during the whole loading process can be divided into four periods:quiet period,slow growth period,rapid growth period,and remission period,corresponding to the micro-pore compaction stage,elastic deformation stage,plastic deformation stage,and failure instability stage of the stress-strain curve.The AE events are mainly concentrated in the plastic deformation stage;both shear failure and tensile failure occur in the above four stages,while tensile failure is dominant for PCPB samples.This study provides a reference for the safety of coal pillar recovery in pillar goaf.
文摘针对海量数据处理难度大,传统方法效率低、异常值导致模型参数估计不准确等问题,提出了一种基于高斯过程回归(Gaussian process regression,GPR)和粒子滤波(Particle filtering,PF)的光伏电站监测数据修复方法。首先用数学语言描述GPR数据监测过程,并进行数据预处理;在训练样本集中通过高斯过程回归建立状态空间方程,采用粒子滤波算法对当前量测值进行估计,对估计值和量测值的残差进行分析;其次,检测异常值并进行修复,并对修正后的光伏电站数据重新建立高斯过程回归预测模型。最后,测试结果验证了模型和方法的正确性。
基金supported by the Key Program of Chinese Academy of Sciences(KJZD-SW-L11 to Z.L.S.)the National Natural Science Foundation of China(32070180 to X.L.Y.)Youth Innovation Promotion Association of CAS(2019328 to X.L.Y.)
文摘Dear Editor,The ongoing pandemic of coronavirus disease 2019(COVID-19)has reshaped our daily life and caused>4 million deaths worldwide(https://covid19.who.int/).Although lockdown and vaccination have improved the situation in many countries,imported cases and sporadic outbreaks pose a constant stress to the prevention and control of COVID-19.
基金supported by the National Natural Science Foundation of China(No.21501003)the Open Fund of Anhui Institute of Urban-Rural Green Development and Urban Renewal(No.2304001).
文摘Creating a specific shape with hierarchically porous structure of metal-organic frameworks represents an effective strategy to enhance the adsorption and photocatalytic performance yet remains rather challenging.Herein,we present a facile linker competitive coordination induced interface assembly strategy to synthesize a series of star-concave metalorganic frameworks(MOFs)(Fe-MIL-101)with rich hierarchical pores.This strategy of star-concave Fe-MIL-101 depends on the electronegativity difference of the two linkers to produce an in-situ oriented growth with controllable kinetics nucleation and structural evolution.As a result,the optimized star-concave Fe-MIL-101-2 with multiple physical-chemical effects endows enhanced visible-light trapping,preferred charge separation,and optimized the local electronic structure.In comparison with the slightly concave Fe-MIL-101 and solid octahedron Fe-MIL-101-NH_(2),the star-concave Fe-MIL-101-2 displays a clear superiority in the adsorption-photoreduction of Cr(VI)under visible-light irradiation.Furthermore,the X-ray absorption fine structure spectroscopy,finite element method,and density functional theory calculations are performed to reveal the local electronic structure of star-concave Fe-MIL-101-2,understanding the mechanisms behind the boosting synergistic adsorption-photoreduction of Cr(VI)removal performance.This work provides a new perspective for the rational construction of MOFs-based photocatalysts with high activity for Cr(VI)removal through shape engineering.
