The thermal deformation behavior of FV520B stainless steel is investigated.Isothermal compression tests were conducted at temperatures ranging from 600 to 900℃ and strain rates from 0.001 to 10 s^(−1).The true stress...The thermal deformation behavior of FV520B stainless steel is investigated.Isothermal compression tests were conducted at temperatures ranging from 600 to 900℃ and strain rates from 0.001 to 10 s^(−1).The true stress–strain curves were corrected for friction and temperature due to the drum shape and adiabatic heating.The comparison shows that there is a large difference between the stress before and after the correction,which proves that the correction is necessary.Five constitutive models were developed:the original Arrhenius model,the strain correction Arrhenius model,a new modified Arrhenius model,the back propagation neural network model(BPNN)and the dandelion optimization BPNN model(DO-BPNN).The DO-BPNN model showed the highest prediction accuracy though it was more computationally intensive than the other models.The new modified Arrhenius model performed a better predictive capacity than the strain correction version,while it showed a negligible increase in the number of parameters and computational time.Although artificial neural network-based models exhibit superior accuracy compared to the Arrhenius models,their application in finite element simulations still faces notable challenges.展开更多
Backgrounds:As cancer progresses through various stages of malignancy,metastasis,and drug resistance,the Wnt/-catenin signaling is frequently dysregulated.Despite advancements in medical technology and therapeutic str...Backgrounds:As cancer progresses through various stages of malignancy,metastasis,and drug resistance,the Wnt/-catenin signaling is frequently dysregulated.Despite advancements in medical technology and therapeutic strategies,the prognosis for numerous gastric cancer patients remains unfavorable.Methods:For the analysis of prognostic signature genes associated with Wnt signaling in GC,we used LASSO(least absolute shrinkage and selection operator)regression.To explore the function,cell specificity,and transcriptional regulation of the signature gene Carboxypeptidase Z(CPZ),we conducted co-expression analysis,single-cell RNA sequencing data analysis,transcription factor prediction,and dual luciferase reporter assay.The knockdown and overexpression experiments were also performed to observe the changes in the downstream gene expression,as well as the influence on the biological functions of GC cells.Results:We identified a five-gene signature,including CPZ,Collagen Triple Helix Repeat Containing-1(CTHRC1),Dickkopf-1(DKK1),Epidermal Growth Factor(EGF),and Glypican Proteoglycan-3(GPC3),with risk scores predictive of the prognosis of GC patients.We found that the adipocyte enhancer binding protein 1(AEBP1)and transcription factor 3(TCF3)could interact in the nucleus and synergistically enhance the expression of Wnt signaling-associated genes,including WNT2/FZD2(Wnt family member 2/frizzled class receptor 2)and VIM(vimentin),thus promoting the invasion,migration,and malignant metastasis of GC.Conclusions:Our study offers a precise gene-signature prediction method for the prognosis of GC.We discovered the synergistic effect of AEBP1 and TCF3 in the nucleus on GC metastasis.GC may benefit from the identification of this potential therapeutic target.展开更多
Fluid flow in fractures controls subsurface heat and mass transport,which is essential for developing enhanced geothermal systems and radioactive waste disposal.Fracture permeability is controlled by fracture microstr...Fluid flow in fractures controls subsurface heat and mass transport,which is essential for developing enhanced geothermal systems and radioactive waste disposal.Fracture permeability is controlled by fracture microstructure(e.g.aperture,roughness,and tortuosity),but in situ values and their anisotropy have not yet been estimated.Recent advances in geophysical techniques allow the detection of changes in electrical conductivity due to changes in crustal stress and these techniques can be used to predict subsurface fluid flow.However,the paucity of data on fractured rocks hinders the quantitative interpretation of geophysical monitoring data in the field.Therefore,considering different shear displacements and chemical erosions,an investigation was conducted into the hydraulic-electric relationship as an elevated stress change in fractures.The simulation of fracture flows was achieved using the lattice Boltzmann method,while the electrical properties were calculated through the finite element method,based on synthetic faults incorporating elastic-plastic deformation.Numerical results show that the hydraulic and electrical properties depend on the rock's geometric properties(i.e.fracture length,roughness,and shear displacement).The permeability anisotropy in the direction parallel or perpendicular to the shear displacement is also notable in high stress conditions.Conversely,the permeability econductivity(i.e.,formation factor)relationship is unique under all conditions and follows a linear trend in logarithmic coordinates.However,both matrix porosity and fracture spacing alter this relationship.Both increase the slope of the linear trend,thereby changing the sensitivity of electrical observations to permeability changes.展开更多
Bacterial cellulose/polyacrylic acid (BC/PAA) pH-responsive hydrogels were prepared by free-radical polymerization (in situ) using BC as the raw material and AA as the monomer. The hydrogels were loaded with curcumin ...Bacterial cellulose/polyacrylic acid (BC/PAA) pH-responsive hydrogels were prepared by free-radical polymerization (in situ) using BC as the raw material and AA as the monomer. The hydrogels were loaded with curcumin (Cur) to prepare pH-responsive intelligent medical dressings. The preparation process of the hydrogels was optimized by a single factor and response surface experiment using their swelling degree as an index. The structures of BC/PAA pH-responsive hydrogels were characterized by scanning electron microscope (SEM), Fourier Transform Infrared spectrometer (FTIR), X-ray diffraction (XRD), and tensile tester, and the swelling properties, mechanical properties, bacteriostatic properties, and drug release behavior were investigated. The results showed that the BC/PAA pH-responsive hydrogel has a three-dimensional network structure with the swelling rate up to 1600 g/g, compressive strength of up to 8 KPa, and good mechanical properties, and the drug release behavior was in line with the logistic dynamics model, and it has good inhibitory effects on common pathogens of wound infection: E. coli, S. aureus, and P. aeruginosa.展开更多
Bone tissue engineering has emerged as a promising alternative therapy for patients who suffer bone fractures or defects caused by trauma,congenital diseases or tumours.However,the reconstruction of bone defects combi...Bone tissue engineering has emerged as a promising alternative therapy for patients who suffer bone fractures or defects caused by trauma,congenital diseases or tumours.However,the reconstruction of bone defects combined with osteoporosis remains a great challenge for clinicians and researchers.Based on our previous study,Ca–Si-based bioceramics(MSCs)showed enhanced bone formation capabilities under normal conditions,and strontium was demonstrated to be therapeutic in promoting bone quality in osteoporosis patients.Therefore,in the present study,we attempted to enlarge the application range of MSCs with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes.In vitro readout suggested that Sr-incorporated MSC scaffolds could enhance the expression level of osteogenic and angiogenic markers of osteoporotic bone mesenchymal stem cells(OVX BMSCs).Animal experiments showed a larger new bone area;in particular,there was a tendency for blood vessel formation to be enhanced in the Sr-MSC scaffold group,showing its positive osteogenic capacity in bone regeneration.This study systematically illustrated the effective delivery of a low-cost therapeutic Sr agent in an osteoporotic model and provided new insight into the treatment of bone defects in osteoporosis patients.展开更多
The thread rolling process has been widely applied to manufacture high-performance thread parts.In this process,the evolutions of surface and subsurface are frequently introduced,which affect the working performance o...The thread rolling process has been widely applied to manufacture high-performance thread parts.In this process,the evolutions of surface and subsurface are frequently introduced,which affect the working performance of manufactured parts.In this study,an axial-infeed thread rolling process(ATRP)is employed,and the macro-meso surface characteristics under different lubrications and operating conditions are investigated.Moreover,the distributions of microstructure and hardness on the subsurface of formed tooth are analyzed in detail,along with the study of stress state and yield strength change.It is found that the MoS_(2)grease is more effective in reducing the surface roughness and defects than the lubrication oil and water-base graphite during the ATRP process.Increasing rolling speed improves the quality of surface morphology and can reduce the surface roughness.On the subsurface of bottom and flank,intensive shear stress occurs in a narrow region,resulting in the elongation and refinement of the grains and increasing the low angle grain boundary fraction.Based on the grain size and plastic strain,the yield strength is predicted.The maximum yield strength and hardness on the bottom of formed tooth are improved by 41.2% and 39.4%,respectively.展开更多
In spinal cord injuries,external forces from various directions occur at various velocities.Therefore,it is important to physically evaluate whether the spinal cord is susceptible to damage and an increase in internal...In spinal cord injuries,external forces from various directions occur at various velocities.Therefore,it is important to physically evaluate whether the spinal cord is susceptible to damage and an increase in internal stress for external forces.We hypothesized that the spinal cord has mechanical features that vary under stress depending on the direction and velocity of injury.However,it is difficult to perform experiment because the spinal cord is very soft.There are no reports on the effects of multiple external forces.In this study,we used bovine spinal cord white matter to test and analyze the anisotropy and velocity dependence of the spinal cord.Tensile-vertical,tensile-parallel,shear-vertical,and shear-parallel tests were performed on the white matter in the fibrous direction(cranial to caudal).Strain rate in the experiment was 0.1,1,10,and 100/s.We calculated the Young’s modulus of the spinal cord.Results of the tensile and shear tests revealed that stress tended to increase when external forces were applied parallel to the direction of axon fibers,such as in tensile-vertical and shear-vertical tests.However,external forces those tear against the fibrous direction and vertically,such as in tensile-parallel and shear-parallel tests,were less likely to increase stress even with increased velocity.We found that the spinal cord was prone to external forces,especially in the direction of the fibers,and to be under increased stress levels when the velocity of external forces increased.From these results,we confirmed that the spinal cord has velocity dependence and anisotropy.The Institutional Animal Care and Use Committee of Yamaguchi University waived the requirement for ethical approval.展开更多
The spinal cord is composed of gray matter and white matter.It is well known that the properties of these two tissues differ considerably.Spinal diseases often present with symptoms that are caused by spinal cord comp...The spinal cord is composed of gray matter and white matter.It is well known that the properties of these two tissues differ considerably.Spinal diseases often present with symptoms that are caused by spinal cord compression.Understanding the mechanical properties of gray and white matter would allow us to gain a deep understanding of the injuries caused to the spinal cord and provide information on the pathological changes to these distinct tissues in several disorders.Previous studies have reported on the physical properties of gray and white matter,however,these were focused on longitudinal tension tests.Little is known about the differences between gray and white matter in terms of their response to compression.We therefore performed mechanical compression test of the gray and white matter of spinal cords harvested from cows and analyzed the differences between them in response to compression.We conducted compression testing of gray matter and white matter to detect possible differences in the collapse rate.We found that increased compression(especially more than 50%compression)resulted in more severe injuries to both the gray and white matter.The present results on the mechanical differences between gray and white matter in response to compression will be useful when interpreting findings from medical imaging in patients with spinal conditions.展开更多
BACKGROUND Early detection of advanced cystic mucinous neoplasms[(A-cMNs),defined as high-grade dysplasia or malignancy]of the pancreas is of great significance.As a simple and feasible detection method,serum tumor ma...BACKGROUND Early detection of advanced cystic mucinous neoplasms[(A-cMNs),defined as high-grade dysplasia or malignancy]of the pancreas is of great significance.As a simple and feasible detection method,serum tumor markers(STMs)may be used to predict advanced intraductal papillary mucinous neoplasms(IPMNs)and mucinous cystic neoplasms(MCNs).However,there are few studies on the usefulness of STMs other than carbohydrate antigen(CA)19-9 for early detection of A-cMNs.AIM To study the ability of five STMs-CA19-9,carcinoembryonic antigen(CEA),CA125,CA724,and CA242 to predict A-cMNs and distinguish IPMNs and MCNs.METHODS We mainly measured the levels of each STM in patients pathologically diagnosed with cMNs.The mean levels of STMs and the number of A-cMN subjects with a higher STM level than the cutoff were compared respectively to identify the ability of STMs to predict A-cMNs and distinguish MCNs from IPMNs.A receiver operating characteristic curve with the area under curve(AUC)was also created to identify the performance of the five STMs.RESULTS A total of 187 patients with cMNs were identified and 72 of them showed AcMNs.We found that CA19-9 exhibited the highest sensitivity(SE)(54.2%)and accuracy(76.5%)and a moderate ability(AUC=0.766)to predict A-cMNs.In predicting high-grade dysplasia IPMNs,the SE of CA19-9 decreased to 38.5%.The ability of CEA,CA125,and CA724 to predict A-cMNs was low(AUC=0.651,0.583,and 0.618,respectively).The predictive ability of CA242 was not identified.The combination of STMs improved the SE to 62.5%.CA125 may be specific to the diagnosis of advanced MCNs.CONCLUSION CA19-9 has a moderate ability,and CEA,CA125,and CA724 have a low ability to predict A-cMNs.The combination of STM testing could improve SE in predicting A-cMNs.展开更多
Production prediction is an important factor influencing the realization of an intelligent agricultural supply chain.In an Internet of Things(IoT)environment,accurate yield prediction is one of the prerequisites for a...Production prediction is an important factor influencing the realization of an intelligent agricultural supply chain.In an Internet of Things(IoT)environment,accurate yield prediction is one of the prerequisites for achieving an efficient response in an intelligent agricultural supply chain.As an example,this study applied a conventional prediction method and deep learning prediction model to predict the yield of a characteristic regional fruit(the Shatian pomelo)in a comparative study.The root means square error(RMSE)values of regression analysis,exponential smoothing,grey prediction,grey neural network,support vector regression(SVR),and long short-term memory(LSTM)neural network methods were 53.715,6.707,18.440,1.580,and 1.436,respectively.Among these,the mean square error(MSE)values of the grey neural network,SVR,and LSTM neural network methods were 2.4979,31.652,and 2.0618,respectively;and theirRvalues were 0.99905,0.94,and 0.94501,respectively.The results demonstrated that the RMSE of the deep learning model is generally lower than that of a traditional prediction model,and the prediction results are more accurate.The prediction performance of the grey neural network was shown to be superior to that of SVR,and LSTM neural network,based on the comparison of parameters.展开更多
From a global perspective, local awareness and People Standard in three ways, conditions to establish and improve a social security system covering urban and rural areas has matured its localization requirements have ...From a global perspective, local awareness and People Standard in three ways, conditions to establish and improve a social security system covering urban and rural areas has matured its localization requirements have become more evident. Therefore, to explore the social security system with Chinese characteristics model, not only is the key to solve China＇s current social conflicts, as well as building a socialist harmonious society and a necessary step in the inevitable choice. Globalization and global governance movement accelerated economic globalization, social security, face the opportunities and challenges, China should establish a “China model” of pension security.展开更多
Diesel poisoning is a rare clinical condition.On September 27,2021,a 55-year-old male who mistakenly inhaled 20 mL of diesel through a siphon was admitted to our hospital.The main symptoms were cough and asthma.Chest ...Diesel poisoning is a rare clinical condition.On September 27,2021,a 55-year-old male who mistakenly inhaled 20 mL of diesel through a siphon was admitted to our hospital.The main symptoms were cough and asthma.Chest computed tomography(CT)showed both lungs scattered with patchy consolidation,ground-glass shadow,exudation,and pleural effusion.After 61 days of lung rehabilitation training and other supportive treatment,including oxygen therapy,postural drainage,ventilator support,bronchoalveolar lavage,hemoperfusion,continuous renal replacement therapy(CRRT),hormones,and antibiotics,the patient’s condition improved,and the patient was discharged.Through literature review,we found that lung consolidation,ground-glass shadow,nodular lesions,and pleural effusion can be observed on chest images of patients with lipoid pneumonia,with severe cases showing diffuse lesions involving both lungs,possibly secondary to respiratory failure.Children with acute critical illness deteriorates rapidly and have poor prognosis,whereas adults or patients with chronic poisoning have better prognosis after active treatment.展开更多
Grid impedance and phase-locked loop(PLL)are critical factors for the stability of the grid-connected inverters(GCIs)in a weak grid.They are the positive feedback control loops formed by PLL in the GCI with grid imped...Grid impedance and phase-locked loop(PLL)are critical factors for the stability of the grid-connected inverters(GCIs)in a weak grid.They are the positive feedback control loops formed by PLL in the GCI with grid impedance.It is prone to GCI instability,especially in the case of the higher PLL bandwidth.A novel impedance-phase and magnitude control strategy is proposed to improve stability of GCI with different grid impedance.Moreover,a detailed design of control loop and parameter calculation for the impedance-phase and magnitude control strategy are introduced.First,PLL output impedance is reshaped to broaden the frequency range of the GCI phase-frequency characteristic curve above the−90°line towards the low-frequency band.In addition,current loop output impedance is reshaped to maintain the phase margin(PM)of the GCI near to 45°.Meanwhile,the magnitude of GCI output impedance is also increased significantly.Stability of the GCI in a weak grid is enhanced by adopting the proposed control strategy.Simulation and experimental results verify the analysis and the proposed method.展开更多
Elevated atmospheric carbon dioxide(CO_(2)) concentrations have caused global climate change such as global warming and more frequent climate extremes. Countries worldwide have proposed carbon neutrality strategies to...Elevated atmospheric carbon dioxide(CO_(2)) concentrations have caused global climate change such as global warming and more frequent climate extremes. Countries worldwide have proposed carbon neutrality strategies to curb the rising CO_(2) concentrations. To investigate the impact of China's carbon neutrality goal on atmospheric CO_(2) concentrations, we conducted a series of ideal simulations from 2015 to 2019 using a global 3D chemistry transport model, Goddard Earth Observing System Chemistry(GEOS-Chem). Compared with the column-averaged dry-air mole fraction of atmospheric CO_(2) (XCO_(2) ) from Orbiting Carbon Observatory-2(OCO-2) and surface CO_(2) measurements in Obs Pack, we find that GEOS-Chem effectively reproduces the spatiotemporal variability of CO_(2) . The model exhibits a root mean square error(RMSE) of 1.51 ppm(R^(2)=0.89) for OCO-2 XCO_(2) in China and 2.65 ppm(R^(2)=0.75) for surface CO_(2) concentrations at the WLG station. Further, compared to 2.83 ppm yr^(-1)in the control experiment, we suggest that net-zero CO_(2) emissions in China decelerate the increasing trends of XCO_(2) to 1.81 ppm yr^(-1),making a decrease of approximately 35.89%. Meanwhile, the seasonal cycle amplitude(SCA) of XCO_(2) is moderately reduced from 7.39±0.81 to 6.75±0.70 ppm, representing a relative reduction of 9.91%. Spatially, net-zero CO_(2) emissions induce a more significant decrease in XCO_(2) trends over northern and southern China, while their impact on SCA is more evident in northern and northeastern China. Moreover, ideal experiments demonstrate that zero fossil CO_(2) emissions lead to a greater attenuation of the linear trends of XCO_(2) by 40.81%, while the absence of terrestrial CO_(2) sinks largely diminishes the SCA by 16.61%. Additionally,trends and SCA in surface CO_(2) concentrations exhibit almost identical decreasing responses to net-zero CO_(2) emissions but display greater sensitivities compared to XCO_(2) . Overall, our study underscores the potential of China's carbon neutrality goal in mitigating global warming, underscoring the need for concerted and collaborative efforts from nations worldwide.展开更多
Inflammatory bowel diseases(IBD)are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence.Although the pathomechanism of IBD has been extensively investigated,several as...Inflammatory bowel diseases(IBD)are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence.Although the pathomechanism of IBD has been extensively investigated,several aspects of its pathogenesis remain unclear.Long non-coding RNAs(lncRNAs)are transcripts with more than 200 nucleotides in length that have potential protein-coding functions.LncRNAs play important roles in biological processes such as epigenetic modification,transcriptional regulation and posttranscriptional regulation.In this review,we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment,as well as their potential roles as immune regulators,diagnostic biomarkers and therapeutic targets or agents for IBD.展开更多
Hydrothermal carbonization(HTC)has been regarded as a promising technique for turning wet biomass into hydrochar due to its low energy consumption,low exhaust gas emissions,etc.In addition,hydrochar is an important so...Hydrothermal carbonization(HTC)has been regarded as a promising technique for turning wet biomass into hydrochar due to its low energy consumption,low exhaust gas emissions,etc.In addition,hydrochar is an important source of dissolved organic matter(DOM),which plays a crucial part in the migration and destiny of pollutants in the environmental medium.However,there are limited studies that focus on the factors that influence the formation of DOM in hydrochar,such as hydrothermal temperature.Therefore,the current study comprehensively characterized the optical properties of DOM within hydrochar derived from sawdust(HDOM)under different hydrothermal temperatures(150-300℃)by Ultraviolet-visible(UV-Vis)and fluorescence spectroscopy,as well as its complexation characteristic with Cu(II).The findings revealed that the organic carbon content of HDOM reached a peak of 37.3 mg L^(−1)when the temperature rose to 240℃and then decreased as the temperature increased.UV-Vis spectroscopy analysis showed that the absorption capacity of HDOM at 275 nm increases with temperature and reaches a maximum value at 240℃,indicating that high temperature promotes the formation of monocyclic aromatic compounds.High temperature enhances the aromaticity,hydrophobicity,and humification degree of HDOM,thus improving its stability and aromaticity.The E3/E4 ratios are all greater than 3.5,confirming that the main component of HDOM is fulvic acid,which corresponds to 3D-EEM and Pearson’s correlation coefficient analysis.The humification index(HIX)of HDOM increased with the rise in hydrothermal temperature(150-240℃),as observed by the three-dimensional excitation-emission matrix spectroscopy(3D-EEMs).After reaching its peak at 240℃,the HIX value gradually dropped in line with the trend of the DOC change.Moreover,the bioavailability(BIX)value of DOM was all high and greater than 1,indicating all the HDOM are readily bioavailable.Two microbial humic substances(C1 and C4),a humic-like substance(C2),and a protein-like substance(C3)were discovered in DOM by integrating 3D-EEMs with parallel factor analysis(PARAFAC).Their fluorescence intensity decreases as the Cu(II)concentration increases,indicating the formation of complexes with Cu(II).As the temperature rises,the binding ability of DOM and Cu(II)changes significantly,reaching the optimum at 300℃.Meanwhile,the substance C2 has the strongest binding ability with Cu(II).This research emphasizes the significance of spectroscopy analysis in determining the evolution of hydrochar-derived DOM,the potential for heavy metal binding and migration,and its characteristics and features.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52275373)the National Natural Science Foundation of China(Grant No.52105397)the Open Foundation of National Key Laboratory of Metal Forming Technology and Heavy Equipment(Grant No.S2308100.W08).
文摘The thermal deformation behavior of FV520B stainless steel is investigated.Isothermal compression tests were conducted at temperatures ranging from 600 to 900℃ and strain rates from 0.001 to 10 s^(−1).The true stress–strain curves were corrected for friction and temperature due to the drum shape and adiabatic heating.The comparison shows that there is a large difference between the stress before and after the correction,which proves that the correction is necessary.Five constitutive models were developed:the original Arrhenius model,the strain correction Arrhenius model,a new modified Arrhenius model,the back propagation neural network model(BPNN)and the dandelion optimization BPNN model(DO-BPNN).The DO-BPNN model showed the highest prediction accuracy though it was more computationally intensive than the other models.The new modified Arrhenius model performed a better predictive capacity than the strain correction version,while it showed a negligible increase in the number of parameters and computational time.Although artificial neural network-based models exhibit superior accuracy compared to the Arrhenius models,their application in finite element simulations still faces notable challenges.
基金funded by the Natural Science Research Project of Anhui Educational Committee(2023AH050650)the Research Fund Program of Anhui Medical University(2023xkj176).
文摘Backgrounds:As cancer progresses through various stages of malignancy,metastasis,and drug resistance,the Wnt/-catenin signaling is frequently dysregulated.Despite advancements in medical technology and therapeutic strategies,the prognosis for numerous gastric cancer patients remains unfavorable.Methods:For the analysis of prognostic signature genes associated with Wnt signaling in GC,we used LASSO(least absolute shrinkage and selection operator)regression.To explore the function,cell specificity,and transcriptional regulation of the signature gene Carboxypeptidase Z(CPZ),we conducted co-expression analysis,single-cell RNA sequencing data analysis,transcription factor prediction,and dual luciferase reporter assay.The knockdown and overexpression experiments were also performed to observe the changes in the downstream gene expression,as well as the influence on the biological functions of GC cells.Results:We identified a five-gene signature,including CPZ,Collagen Triple Helix Repeat Containing-1(CTHRC1),Dickkopf-1(DKK1),Epidermal Growth Factor(EGF),and Glypican Proteoglycan-3(GPC3),with risk scores predictive of the prognosis of GC patients.We found that the adipocyte enhancer binding protein 1(AEBP1)and transcription factor 3(TCF3)could interact in the nucleus and synergistically enhance the expression of Wnt signaling-associated genes,including WNT2/FZD2(Wnt family member 2/frizzled class receptor 2)and VIM(vimentin),thus promoting the invasion,migration,and malignant metastasis of GC.Conclusions:Our study offers a precise gene-signature prediction method for the prognosis of GC.We discovered the synergistic effect of AEBP1 and TCF3 in the nucleus on GC metastasis.GC may benefit from the identification of this potential therapeutic target.
基金supported in part by the Japan Society for the Promotion of Science (JSPS)under JSPS KAKENHI (Grant Nos.JP22K14635 and JP22H05303)a supporting program titled“Program to Support Research and Investigation on Important Basic Technologies Related to Radioactive Waste (2023 FY)”under the contract with the Ministry of Economy,Trade and Industry,Japan.
文摘Fluid flow in fractures controls subsurface heat and mass transport,which is essential for developing enhanced geothermal systems and radioactive waste disposal.Fracture permeability is controlled by fracture microstructure(e.g.aperture,roughness,and tortuosity),but in situ values and their anisotropy have not yet been estimated.Recent advances in geophysical techniques allow the detection of changes in electrical conductivity due to changes in crustal stress and these techniques can be used to predict subsurface fluid flow.However,the paucity of data on fractured rocks hinders the quantitative interpretation of geophysical monitoring data in the field.Therefore,considering different shear displacements and chemical erosions,an investigation was conducted into the hydraulic-electric relationship as an elevated stress change in fractures.The simulation of fracture flows was achieved using the lattice Boltzmann method,while the electrical properties were calculated through the finite element method,based on synthetic faults incorporating elastic-plastic deformation.Numerical results show that the hydraulic and electrical properties depend on the rock's geometric properties(i.e.fracture length,roughness,and shear displacement).The permeability anisotropy in the direction parallel or perpendicular to the shear displacement is also notable in high stress conditions.Conversely,the permeability econductivity(i.e.,formation factor)relationship is unique under all conditions and follows a linear trend in logarithmic coordinates.However,both matrix porosity and fracture spacing alter this relationship.Both increase the slope of the linear trend,thereby changing the sensitivity of electrical observations to permeability changes.
文摘Bacterial cellulose/polyacrylic acid (BC/PAA) pH-responsive hydrogels were prepared by free-radical polymerization (in situ) using BC as the raw material and AA as the monomer. The hydrogels were loaded with curcumin (Cur) to prepare pH-responsive intelligent medical dressings. The preparation process of the hydrogels was optimized by a single factor and response surface experiment using their swelling degree as an index. The structures of BC/PAA pH-responsive hydrogels were characterized by scanning electron microscope (SEM), Fourier Transform Infrared spectrometer (FTIR), X-ray diffraction (XRD), and tensile tester, and the swelling properties, mechanical properties, bacteriostatic properties, and drug release behavior were investigated. The results showed that the BC/PAA pH-responsive hydrogel has a three-dimensional network structure with the swelling rate up to 1600 g/g, compressive strength of up to 8 KPa, and good mechanical properties, and the drug release behavior was in line with the logistic dynamics model, and it has good inhibitory effects on common pathogens of wound infection: E. coli, S. aureus, and P. aeruginosa.
基金This work has been jointly supported by the National Natural Science Foundation of China(No.81900970 and 81921002)Young Elite Scientists Sponsorship Program CAST(2018QNRC001)Shanghai Sailing Program(19YF1426000).
文摘Bone tissue engineering has emerged as a promising alternative therapy for patients who suffer bone fractures or defects caused by trauma,congenital diseases or tumours.However,the reconstruction of bone defects combined with osteoporosis remains a great challenge for clinicians and researchers.Based on our previous study,Ca–Si-based bioceramics(MSCs)showed enhanced bone formation capabilities under normal conditions,and strontium was demonstrated to be therapeutic in promoting bone quality in osteoporosis patients.Therefore,in the present study,we attempted to enlarge the application range of MSCs with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes.In vitro readout suggested that Sr-incorporated MSC scaffolds could enhance the expression level of osteogenic and angiogenic markers of osteoporotic bone mesenchymal stem cells(OVX BMSCs).Animal experiments showed a larger new bone area;in particular,there was a tendency for blood vessel formation to be enhanced in the Sr-MSC scaffold group,showing its positive osteogenic capacity in bone regeneration.This study systematically illustrated the effective delivery of a low-cost therapeutic Sr agent in an osteoporotic model and provided new insight into the treatment of bone defects in osteoporosis patients.
基金supported by the Shaanxi Province Key Research and Development Program(2021GXLH-Z-049,2020GY-168)the Joint Fund for Aerospace Advanced Manufacturing Technology Research Key Program(U1937203)+3 种基金the State Scholarship Fund from the China Scholarship Council(CSC)the Talent Project of Bright Pearl of the Yellow Sea of Yanchengsupport of Institute of Engineering Research at Seoul National Universitygrant from NRF(No.2022R1A2C2009315)。
文摘The thread rolling process has been widely applied to manufacture high-performance thread parts.In this process,the evolutions of surface and subsurface are frequently introduced,which affect the working performance of manufactured parts.In this study,an axial-infeed thread rolling process(ATRP)is employed,and the macro-meso surface characteristics under different lubrications and operating conditions are investigated.Moreover,the distributions of microstructure and hardness on the subsurface of formed tooth are analyzed in detail,along with the study of stress state and yield strength change.It is found that the MoS_(2)grease is more effective in reducing the surface roughness and defects than the lubrication oil and water-base graphite during the ATRP process.Increasing rolling speed improves the quality of surface morphology and can reduce the surface roughness.On the subsurface of bottom and flank,intensive shear stress occurs in a narrow region,resulting in the elongation and refinement of the grains and increasing the low angle grain boundary fraction.Based on the grain size and plastic strain,the yield strength is predicted.The maximum yield strength and hardness on the bottom of formed tooth are improved by 41.2% and 39.4%,respectively.
基金This work was supported by the Japan Society for the Promotion of Science(KARENHI grant number JP 15K20002)by the Yamaguchi University Hospital(a translational promotion grant).
文摘In spinal cord injuries,external forces from various directions occur at various velocities.Therefore,it is important to physically evaluate whether the spinal cord is susceptible to damage and an increase in internal stress for external forces.We hypothesized that the spinal cord has mechanical features that vary under stress depending on the direction and velocity of injury.However,it is difficult to perform experiment because the spinal cord is very soft.There are no reports on the effects of multiple external forces.In this study,we used bovine spinal cord white matter to test and analyze the anisotropy and velocity dependence of the spinal cord.Tensile-vertical,tensile-parallel,shear-vertical,and shear-parallel tests were performed on the white matter in the fibrous direction(cranial to caudal).Strain rate in the experiment was 0.1,1,10,and 100/s.We calculated the Young’s modulus of the spinal cord.Results of the tensile and shear tests revealed that stress tended to increase when external forces were applied parallel to the direction of axon fibers,such as in tensile-vertical and shear-vertical tests.However,external forces those tear against the fibrous direction and vertically,such as in tensile-parallel and shear-parallel tests,were less likely to increase stress even with increased velocity.We found that the spinal cord was prone to external forces,especially in the direction of the fibers,and to be under increased stress levels when the velocity of external forces increased.From these results,we confirmed that the spinal cord has velocity dependence and anisotropy.The Institutional Animal Care and Use Committee of Yamaguchi University waived the requirement for ethical approval.
基金supported by JSPS KAKENHI(No.JP 15K20002)Yamaguchi University School of Medicine Affiliated Hospital:Translational Promotion Grant and President of Yamaguchi University Strategic Expenses:Young Researcher Support Project(all to NN)
文摘The spinal cord is composed of gray matter and white matter.It is well known that the properties of these two tissues differ considerably.Spinal diseases often present with symptoms that are caused by spinal cord compression.Understanding the mechanical properties of gray and white matter would allow us to gain a deep understanding of the injuries caused to the spinal cord and provide information on the pathological changes to these distinct tissues in several disorders.Previous studies have reported on the physical properties of gray and white matter,however,these were focused on longitudinal tension tests.Little is known about the differences between gray and white matter in terms of their response to compression.We therefore performed mechanical compression test of the gray and white matter of spinal cords harvested from cows and analyzed the differences between them in response to compression.We conducted compression testing of gray matter and white matter to detect possible differences in the collapse rate.We found that increased compression(especially more than 50%compression)resulted in more severe injuries to both the gray and white matter.The present results on the mechanical differences between gray and white matter in response to compression will be useful when interpreting findings from medical imaging in patients with spinal conditions.
基金National Natural Science Foundation of China,No.81770642the Shanghai Association for Science and Technology,China,No.19411951602.
文摘BACKGROUND Early detection of advanced cystic mucinous neoplasms[(A-cMNs),defined as high-grade dysplasia or malignancy]of the pancreas is of great significance.As a simple and feasible detection method,serum tumor markers(STMs)may be used to predict advanced intraductal papillary mucinous neoplasms(IPMNs)and mucinous cystic neoplasms(MCNs).However,there are few studies on the usefulness of STMs other than carbohydrate antigen(CA)19-9 for early detection of A-cMNs.AIM To study the ability of five STMs-CA19-9,carcinoembryonic antigen(CEA),CA125,CA724,and CA242 to predict A-cMNs and distinguish IPMNs and MCNs.METHODS We mainly measured the levels of each STM in patients pathologically diagnosed with cMNs.The mean levels of STMs and the number of A-cMN subjects with a higher STM level than the cutoff were compared respectively to identify the ability of STMs to predict A-cMNs and distinguish MCNs from IPMNs.A receiver operating characteristic curve with the area under curve(AUC)was also created to identify the performance of the five STMs.RESULTS A total of 187 patients with cMNs were identified and 72 of them showed AcMNs.We found that CA19-9 exhibited the highest sensitivity(SE)(54.2%)and accuracy(76.5%)and a moderate ability(AUC=0.766)to predict A-cMNs.In predicting high-grade dysplasia IPMNs,the SE of CA19-9 decreased to 38.5%.The ability of CEA,CA125,and CA724 to predict A-cMNs was low(AUC=0.651,0.583,and 0.618,respectively).The predictive ability of CA242 was not identified.The combination of STMs improved the SE to 62.5%.CA125 may be specific to the diagnosis of advanced MCNs.CONCLUSION CA19-9 has a moderate ability,and CEA,CA125,and CA724 have a low ability to predict A-cMNs.The combination of STM testing could improve SE in predicting A-cMNs.
基金This work was supported by the 2021‘Cultivation plan for thousands of young andmiddle-aged backbone teachers in Guangxi Colleges and universities’by the Project of Humanities and Social Sciences in‘Research on Collaborative Integration of Logistics Service Supply Chain under High-QualityDevelopmentGoals’(2021QGRW044)In addition,the studywas supported by the 2019 National Social Science Project in‘Research on the Integration of Transnational Supply Chains under the Belt and Road Initiative(19BJY184)’This paper was also supported by Guangxi Philosophy and Social Science Planning Office Project:Research on the DynamicMechanism and Model Innovation of the Cross-border Integration Growth of Guangxi Logistics Enterprises(18BGL010).
文摘Production prediction is an important factor influencing the realization of an intelligent agricultural supply chain.In an Internet of Things(IoT)environment,accurate yield prediction is one of the prerequisites for achieving an efficient response in an intelligent agricultural supply chain.As an example,this study applied a conventional prediction method and deep learning prediction model to predict the yield of a characteristic regional fruit(the Shatian pomelo)in a comparative study.The root means square error(RMSE)values of regression analysis,exponential smoothing,grey prediction,grey neural network,support vector regression(SVR),and long short-term memory(LSTM)neural network methods were 53.715,6.707,18.440,1.580,and 1.436,respectively.Among these,the mean square error(MSE)values of the grey neural network,SVR,and LSTM neural network methods were 2.4979,31.652,and 2.0618,respectively;and theirRvalues were 0.99905,0.94,and 0.94501,respectively.The results demonstrated that the RMSE of the deep learning model is generally lower than that of a traditional prediction model,and the prediction results are more accurate.The prediction performance of the grey neural network was shown to be superior to that of SVR,and LSTM neural network,based on the comparison of parameters.
文摘From a global perspective, local awareness and People Standard in three ways, conditions to establish and improve a social security system covering urban and rural areas has matured its localization requirements have become more evident. Therefore, to explore the social security system with Chinese characteristics model, not only is the key to solve China＇s current social conflicts, as well as building a socialist harmonious society and a necessary step in the inevitable choice. Globalization and global governance movement accelerated economic globalization, social security, face the opportunities and challenges, China should establish a “China model” of pension security.
文摘Diesel poisoning is a rare clinical condition.On September 27,2021,a 55-year-old male who mistakenly inhaled 20 mL of diesel through a siphon was admitted to our hospital.The main symptoms were cough and asthma.Chest computed tomography(CT)showed both lungs scattered with patchy consolidation,ground-glass shadow,exudation,and pleural effusion.After 61 days of lung rehabilitation training and other supportive treatment,including oxygen therapy,postural drainage,ventilator support,bronchoalveolar lavage,hemoperfusion,continuous renal replacement therapy(CRRT),hormones,and antibiotics,the patient’s condition improved,and the patient was discharged.Through literature review,we found that lung consolidation,ground-glass shadow,nodular lesions,and pleural effusion can be observed on chest images of patients with lipoid pneumonia,with severe cases showing diffuse lesions involving both lungs,possibly secondary to respiratory failure.Children with acute critical illness deteriorates rapidly and have poor prognosis,whereas adults or patients with chronic poisoning have better prognosis after active treatment.
基金supported in part by the Leading talents of scientific and technological innovation in Hunan Province under Grant(No.2019RS3014)the National Natural Science Foundation of China under Grant(No.51907057)。
文摘Grid impedance and phase-locked loop(PLL)are critical factors for the stability of the grid-connected inverters(GCIs)in a weak grid.They are the positive feedback control loops formed by PLL in the GCI with grid impedance.It is prone to GCI instability,especially in the case of the higher PLL bandwidth.A novel impedance-phase and magnitude control strategy is proposed to improve stability of GCI with different grid impedance.Moreover,a detailed design of control loop and parameter calculation for the impedance-phase and magnitude control strategy are introduced.First,PLL output impedance is reshaped to broaden the frequency range of the GCI phase-frequency characteristic curve above the−90°line towards the low-frequency band.In addition,current loop output impedance is reshaped to maintain the phase margin(PM)of the GCI near to 45°.Meanwhile,the magnitude of GCI output impedance is also increased significantly.Stability of the GCI in a weak grid is enhanced by adopting the proposed control strategy.Simulation and experimental results verify the analysis and the proposed method.
基金supported by the National Key Research and Development Program of China (Grant No. 2022YFB3904801)the National Natural Science Foundation of China (Grant No. 42475129)+2 种基金the Natural Science Foundation of Jiangsu Province, China (Grant No. BK20221449)the Xizang Science and Technology Innovation Base Construction Project (Grant No. XZ202401YD0008)the National Key Scientific and Technological Infrastructure project “Earth System Numerical Simulation Facility” (Grant No. 2023-EL-ZD-00022)。
文摘Elevated atmospheric carbon dioxide(CO_(2)) concentrations have caused global climate change such as global warming and more frequent climate extremes. Countries worldwide have proposed carbon neutrality strategies to curb the rising CO_(2) concentrations. To investigate the impact of China's carbon neutrality goal on atmospheric CO_(2) concentrations, we conducted a series of ideal simulations from 2015 to 2019 using a global 3D chemistry transport model, Goddard Earth Observing System Chemistry(GEOS-Chem). Compared with the column-averaged dry-air mole fraction of atmospheric CO_(2) (XCO_(2) ) from Orbiting Carbon Observatory-2(OCO-2) and surface CO_(2) measurements in Obs Pack, we find that GEOS-Chem effectively reproduces the spatiotemporal variability of CO_(2) . The model exhibits a root mean square error(RMSE) of 1.51 ppm(R^(2)=0.89) for OCO-2 XCO_(2) in China and 2.65 ppm(R^(2)=0.75) for surface CO_(2) concentrations at the WLG station. Further, compared to 2.83 ppm yr^(-1)in the control experiment, we suggest that net-zero CO_(2) emissions in China decelerate the increasing trends of XCO_(2) to 1.81 ppm yr^(-1),making a decrease of approximately 35.89%. Meanwhile, the seasonal cycle amplitude(SCA) of XCO_(2) is moderately reduced from 7.39±0.81 to 6.75±0.70 ppm, representing a relative reduction of 9.91%. Spatially, net-zero CO_(2) emissions induce a more significant decrease in XCO_(2) trends over northern and southern China, while their impact on SCA is more evident in northern and northeastern China. Moreover, ideal experiments demonstrate that zero fossil CO_(2) emissions lead to a greater attenuation of the linear trends of XCO_(2) by 40.81%, while the absence of terrestrial CO_(2) sinks largely diminishes the SCA by 16.61%. Additionally,trends and SCA in surface CO_(2) concentrations exhibit almost identical decreasing responses to net-zero CO_(2) emissions but display greater sensitivities compared to XCO_(2) . Overall, our study underscores the potential of China's carbon neutrality goal in mitigating global warming, underscoring the need for concerted and collaborative efforts from nations worldwide.
基金supported by the National Natural Science Foundation of China (Grants No.82270011 and 81960513)the Scientific Research Foundation of the Affiliated Hospital of Xuzhou Medical University (Grant No.2020KA010)+2 种基金the Priority Academic Program Development of jiangsu Higher Education Institutions (PAPD),and Postgraduate Research&Practice Innovation Program of Jiangsu Province (Grant No.KYCX22_2815)the Natural Science Foundation of Guizhou Provincial Scientific and Technology Department Grant (Grant No. (2022)626)Scientific Research Foundation of Wenzhou Institute,University of Chinese Academy of Sciences.
文摘Inflammatory bowel diseases(IBD)are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence.Although the pathomechanism of IBD has been extensively investigated,several aspects of its pathogenesis remain unclear.Long non-coding RNAs(lncRNAs)are transcripts with more than 200 nucleotides in length that have potential protein-coding functions.LncRNAs play important roles in biological processes such as epigenetic modification,transcriptional regulation and posttranscriptional regulation.In this review,we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment,as well as their potential roles as immune regulators,diagnostic biomarkers and therapeutic targets or agents for IBD.
基金supported by the Outstanding Youth Research Project in Anhui Provincial Scientific Research Plan Project(2022AH020089)Anhui Province University Top Talent Funding Project(gxbjZD2021069)+1 种基金Excellent Scientific Research and Innovation Team of Universities in Anhui Province(2023AH010062)Commissioned R&D project(ZHEP2021001,BOFA202007).
文摘Hydrothermal carbonization(HTC)has been regarded as a promising technique for turning wet biomass into hydrochar due to its low energy consumption,low exhaust gas emissions,etc.In addition,hydrochar is an important source of dissolved organic matter(DOM),which plays a crucial part in the migration and destiny of pollutants in the environmental medium.However,there are limited studies that focus on the factors that influence the formation of DOM in hydrochar,such as hydrothermal temperature.Therefore,the current study comprehensively characterized the optical properties of DOM within hydrochar derived from sawdust(HDOM)under different hydrothermal temperatures(150-300℃)by Ultraviolet-visible(UV-Vis)and fluorescence spectroscopy,as well as its complexation characteristic with Cu(II).The findings revealed that the organic carbon content of HDOM reached a peak of 37.3 mg L^(−1)when the temperature rose to 240℃and then decreased as the temperature increased.UV-Vis spectroscopy analysis showed that the absorption capacity of HDOM at 275 nm increases with temperature and reaches a maximum value at 240℃,indicating that high temperature promotes the formation of monocyclic aromatic compounds.High temperature enhances the aromaticity,hydrophobicity,and humification degree of HDOM,thus improving its stability and aromaticity.The E3/E4 ratios are all greater than 3.5,confirming that the main component of HDOM is fulvic acid,which corresponds to 3D-EEM and Pearson’s correlation coefficient analysis.The humification index(HIX)of HDOM increased with the rise in hydrothermal temperature(150-240℃),as observed by the three-dimensional excitation-emission matrix spectroscopy(3D-EEMs).After reaching its peak at 240℃,the HIX value gradually dropped in line with the trend of the DOC change.Moreover,the bioavailability(BIX)value of DOM was all high and greater than 1,indicating all the HDOM are readily bioavailable.Two microbial humic substances(C1 and C4),a humic-like substance(C2),and a protein-like substance(C3)were discovered in DOM by integrating 3D-EEMs with parallel factor analysis(PARAFAC).Their fluorescence intensity decreases as the Cu(II)concentration increases,indicating the formation of complexes with Cu(II).As the temperature rises,the binding ability of DOM and Cu(II)changes significantly,reaching the optimum at 300℃.Meanwhile,the substance C2 has the strongest binding ability with Cu(II).This research emphasizes the significance of spectroscopy analysis in determining the evolution of hydrochar-derived DOM,the potential for heavy metal binding and migration,and its characteristics and features.
