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石香膏促进大鼠慢性难愈性创面愈合机制的代谢组学分析
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作者 王艳 张开伟 +3 位作者 刘曼 费冀 朱旭 倪云涛 《中国组织工程研究》 北大核心 2026年第17期4325-4336,共12页
背景:前期研究已证实石香膏可促进慢性难愈性创面的愈合,但其代谢组学方面的作用机制尚未挖掘。目的:运用非靶向代谢组学和免疫学方法探讨石香膏对慢性难愈性创面代谢的影响。方法:选取36只SD大鼠建立慢性难愈合创面模型(2 cm×2 c... 背景:前期研究已证实石香膏可促进慢性难愈性创面的愈合,但其代谢组学方面的作用机制尚未挖掘。目的:运用非靶向代谢组学和免疫学方法探讨石香膏对慢性难愈性创面代谢的影响。方法:选取36只SD大鼠建立慢性难愈合创面模型(2 cm×2 cm正方形全层皮肤缺损+金黄色葡萄球菌覆盖创面),造模成功后第2天随机分3组干预:模型组(n=12)用生理盐水湿敷后用干纱布覆盖创面,石香膏组(n=12)涂覆石香膏后用干纱布覆盖创面,贝复济组(n=12)喷洒贝复济(主要成分为重组碱性成纤维细胞生长因子)喷雾剂后用干纱布覆盖创面,每隔24 h换药1次,连续给药14 d。给药后3,7,14 d收集创面分泌物,Elisa法检测纤连蛋白水平,通过液相色谱-质谱技术分析石香膏组代谢产物变化,采用主成分分析、偏最小二乘-判别分析等方法筛选和鉴定差异代谢物,并进行差异代谢产物的KEGG富集分析、Veen关联分析。结果与结论:①随着给药时间的延长,3组创面面积均减小,其中模型组创面恢复最慢、石香膏组创面恢复最快;石香膏组给药后7,14 d的纤连蛋白水平高于模型组(P<0.05)。②给药后7 d与给药后3 d的比较中筛选出118个独特差异代谢物,给药后14 d与给药后3 d的比较中筛选出129个独特差异代谢物,给药后14 d与给药后7 d的比较中筛选出30个独特差异代谢物;KEGG富集分析显示,石香膏通过调节多个代谢通路增强了创面愈合效果,特别是ABC转运蛋白通路、cAMP信号通路和mTOR信号通路,这些通路在细胞增殖、迁移、免疫反应和抗氧化等过程中发挥着至关重要的作用;Veen关联分析显示,给药后3,7,14 d共有甲氧沙林和5’-甲硫腺苷2个差异代谢物。③结果表明,石香膏可能通过调控甲氧沙林和5’-甲硫腺苷的表达优化ABC转运蛋白、cAMP信号通路及mTOR信号通路,从而发挥抗炎、抗氧化和促进细胞增殖的作用,加速创面愈合。 展开更多
关键词 石香膏 慢性难愈性创面 甲氧沙林 5’-甲硫腺苷 创面分泌物 差异代谢产物 工程化组织构建
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有限元分析肱骨外展与前屈运动中冈上肌腱及盂肱关节的受力变化
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作者 郑汪杨 费冀 +4 位作者 杨砥 赵浪 王伶俐 刘鹏 李海洋 《中国组织工程研究》 北大核心 2026年第9期2199-2207,共9页
背景:肩关节是人体复杂且活动度大的关节,其正常运作对日常生活至关重要,但也易发生损伤,肩袖损伤、盂唇损伤和脱位等疾病较为常见。了解肩关节生物力学特性对预防和治疗相关疾病意义重大,而有限元分析为研究提供了有力工具。目的:采用... 背景:肩关节是人体复杂且活动度大的关节,其正常运作对日常生活至关重要,但也易发生损伤,肩袖损伤、盂唇损伤和脱位等疾病较为常见。了解肩关节生物力学特性对预防和治疗相关疾病意义重大,而有限元分析为研究提供了有力工具。目的:采用有限元法分析肱骨外展与前屈运动中冈上肌腱及盂肱关节的受力变化。方法:构建肩关节三维有限元模型,在Mimics软件中提取肱骨与肩胛骨三维模型,于Geomagic软件处理并实体化。在SolidWorks软件装配、建立不同角度模型,构建冈上肌腱和关节软骨。于Ansys软件设置材料属性、接触关系等,观察并分析冈上肌腱和关节软骨应力变化。结果与结论:①Ⅰ型肩峰形态在肱骨外展角≤90°时未诱发肩峰下撞击征;②冈上肌腱应力随肱骨外展角度呈非线性递增趋势;③盂肱关节软骨应力与外展/前屈角度呈显著正相关性;④外展状态下关节软骨应力负荷显著高于前屈状态(P<0.01);⑤通过有限元分析首次揭示了Ⅰ型肩峰在0°-90°外展范围的生物力学安全性特征,量化了冈上肌腱及盂肱关节的应力-角度动态关系;但因模型简化和静态分析,结论需多模态体内实验验证,但研究结论仍可为相关病症干预策略奠定理论基础。 展开更多
关键词 肩关节 生物力学 冈上肌腱 盂肱关节 有限元分析
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Deep learning aided underwater acoustic OFDM receivers: Model-driven or data-driven?
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作者 Hao Zhao Miaowen Wen +3 位作者 fei ji Yaokun Liang Hua Yu Cui Yang 《Digital Communications and Networks》 2025年第3期866-877,共12页
The Underwater Acoustic(UWA)channel is bandwidth-constrained and experiences doubly selective fading.It is challenging to acquire perfect channel knowledge for Orthogonal Frequency Division Multiplexing(OFDM)communica... The Underwater Acoustic(UWA)channel is bandwidth-constrained and experiences doubly selective fading.It is challenging to acquire perfect channel knowledge for Orthogonal Frequency Division Multiplexing(OFDM)communications using a finite number of pilots.On the other hand,Deep Learning(DL)approaches have been very successful in wireless OFDM communications.However,whether they will work underwater is still a mystery.For the first time,this paper compares two categories of DL-based UWA OFDM receivers:the DataDriven(DD)method,which performs as an end-to-end black box,and the Model-Driven(MD)method,also known as the model-based data-driven method,which combines DL and expert OFDM receiver knowledge.The encoder-decoder framework and Convolutional Neural Network(CNN)structure are employed to establish the DD receiver.On the other hand,an unfolding-based Minimum Mean Square Error(MMSE)structure is adopted for the MD receiver.We analyze the characteristics of different receivers by Monte Carlo simulations under diverse communications conditions and propose a strategy for selecting a proper receiver under different communication scenarios.Field trials in the pool and sea are also conducted to verify the feasibility and advantages of the DL receivers.It is observed that DL receivers perform better than conventional receivers in terms of bit error rate. 展开更多
关键词 Deep learning Doubly-selective channels DATA-DRIVEN Model-driven Underwater acoustic communication OFDM
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The Effect of Binaural Beamforming Technology on Mandarin Speech Recognition in Babble Noise for Bimodal Hearing CI users
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作者 Aiting Chen Mengdi Hong +17 位作者 jianan Li Qian Wang Nan Li Lumeng Han Qian Wu Haihong Liu Yidi Liu Yue Long Fangxia Hu jianfen Luo Lei Xu Zhaomin Fan Peng Lin Wei Wang Yue Wang Yu Chen Zhaohui Hou fei ji 《Journal of Otology》 2025年第3期157-161,共5页
PurposeThe purpose of the study was to investigate the effect of bimodal beamforming on speech recognition and comfort for cochlear implant (CI) users with the bimodal hearing solution made up by linking a hearing aid... PurposeThe purpose of the study was to investigate the effect of bimodal beamforming on speech recognition and comfort for cochlear implant (CI) users with the bimodal hearing solution made up by linking a hearing aid to the CI sound processor.Methods19 subjects participated in this study. Speech tests were conducted in quiet and in noisy environments, with the target speech presented from 0° and the noise signal from 45°. Speech recognition thresholds (SRTs) were compared among the previously used bimodal hearing configuration (baseline, any CI sound processor plus any hearing aid), the Naída Bimodal Hearing Solution with omnidirectional microphone, and with directional microphone (so called StereoZoom) switched on. In addition, the study participants provided subjective feedback on their hearing impressions.ResultsThe SRT results showed no significant difference among the three hearing conditions in the quiet environment. No significant improvement was reported when using Naída bimodal system with omnidirectional microphone in noise compared to the baseline (p=0.27). When applying StereoZoom, SRT in noise showed significant improvements compared to omnidirectional settings (p<0.05). Subjective feedback showed that 13 participants were satisfied with Naída Bimodal Hearing Solution, and wanted to continue using it after the trial.ConclusionThe Naída Bimodal Hearing Solution with the same pre-processing algorithm can provide satisfying hearing performance. Beamforming technology can further improve speech perception in noisy environments. 展开更多
关键词 BIMODAL Cochlear Implant speech recognition beamforming directional microphone
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基于“筋先骨随”理念探讨肩脊平衡功在肩袖损伤防治中的应用
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作者 陈昌勇 张开伟 +1 位作者 费冀 刘晨力 《中医正骨》 2025年第4期73-76,共4页
肩袖损伤是骨伤科常见疾病,传统治疗多侧重于肩袖局部干预,而忽视了肩部与脊柱之间的整体关联。肩脊平衡功融合了中医整体观、筋骨平衡观和生物力学原理,是治疗慢性肩袖损伤的有效方法。本文基于“筋先骨随”理念,对肩脊平衡功进行了概... 肩袖损伤是骨伤科常见疾病,传统治疗多侧重于肩袖局部干预,而忽视了肩部与脊柱之间的整体关联。肩脊平衡功融合了中医整体观、筋骨平衡观和生物力学原理,是治疗慢性肩袖损伤的有效方法。本文基于“筋先骨随”理念,对肩脊平衡功进行了概述,介绍了其功法动作及注意事项,并对其防治肩袖损伤的作用机制进行了探讨,以期为临床提供参考。 展开更多
关键词 肩袖损伤 运动疗法 筋先骨随 肩脊平衡功
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Asymmetric Drying and Wetting Trends in Eastern and Western China 被引量:1
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作者 Wen WU fei ji +1 位作者 Shujuan HU Yongli HE 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第2期221-232,共12页
As an important factor that directly affects agricultural production, the social economy, and policy implementation,observed changes in dry/wet conditions have become a matter of widespread concern. However, previous ... As an important factor that directly affects agricultural production, the social economy, and policy implementation,observed changes in dry/wet conditions have become a matter of widespread concern. However, previous research has mainly focused on the long-term linear changes of dry/wet conditions, while the detection and evolution of the non-linear trends related to dry/wet changes have received less attention. The non-linear trends of the annual aridity index, obtained by the Ensemble Empirical Mode Decomposition(EEMD) method, reveal that changes in dry/wet conditions in China are asymmetric and can be characterized by contrasting features in both time and space in China. Spatially, most areas in western China have experienced transitions from drying to wetting, while opposite changes have occurred in most areas of eastern China. Temporally, the transitions occurred earlier in western China compared to eastern China. Research into the asymmetric spatial characteristics of dry/wet conditions compensates for the inadequacies of previous studies, which focused solely on temporal evolution;at the same time, it remedies the inadequacies of traditional research on linear trends over centennial timescales. Analyzing the non-linear trend also provides for a more comprehensive understanding of the drying/wetting changes in China. 展开更多
关键词 aridity index EEMD dry/wet conditions asymmetric evolution
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Joint computation offloading and parallel scheduling to maximize delay-guarantee in cooperative MEC systems
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作者 Mian Guo Mithun Mukherjee +3 位作者 Jaime Lloret Lei Li Quansheng Guan fei ji 《Digital Communications and Networks》 SCIE CSCD 2024年第3期693-705,共13页
The growing development of the Internet of Things(IoT)is accelerating the emergence and growth of new IoT services and applications,which will result in massive amounts of data being generated,transmitted and pro-cess... The growing development of the Internet of Things(IoT)is accelerating the emergence and growth of new IoT services and applications,which will result in massive amounts of data being generated,transmitted and pro-cessed in wireless communication networks.Mobile Edge Computing(MEC)is a desired paradigm to timely process the data from IoT for value maximization.In MEC,a number of computing-capable devices are deployed at the network edge near data sources to support edge computing,such that the long network transmission delay in cloud computing paradigm could be avoided.Since an edge device might not always have sufficient resources to process the massive amount of data,computation offloading is significantly important considering the coop-eration among edge devices.However,the dynamic traffic characteristics and heterogeneous computing capa-bilities of edge devices challenge the offloading.In addition,different scheduling schemes might provide different computation delays to the offloaded tasks.Thus,offloading in mobile nodes and scheduling in the MEC server are coupled to determine service delay.This paper seeks to guarantee low delay for computation intensive applica-tions by jointly optimizing the offloading and scheduling in such an MEC system.We propose a Delay-Greedy Computation Offloading(DGCO)algorithm to make offloading decisions for new tasks in distributed computing-enabled mobile devices.A Reinforcement Learning-based Parallel Scheduling(RLPS)algorithm is further designed to schedule offloaded tasks in the multi-core MEC server.With an offloading delay broadcast mechanism,the DGCO and RLPS cooperate to achieve the goal of delay-guarantee-ratio maximization.Finally,the simulation results show that our proposal can bound the end-to-end delay of various tasks.Even under slightly heavy task load,the delay-guarantee-ratio given by DGCO-RLPS can still approximate 95%,while that given by benchmarked algorithms is reduced to intolerable value.The simulation results are demonstrated the effective-ness of DGCO-RLPS for delay guarantee in MEC. 展开更多
关键词 Edge computing Computation offloading Parallel scheduling Mobile-edge cooperation Delay guarantee
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The effect of right versus left long-term single-sided deafness on sound source localization
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作者 Qingqing Xia Shuoshuo Kang +6 位作者 Qian Wang Mengdi Hong Aiting Chen Wei Chen fei ji jianan Li Shiming Yang 《Journal of Otology》 CAS CSCD 2024年第3期158-162,共5页
Purpose: To analyze the effect of right versus left long-term single-sided deafness(SSD) on sound source localization(SSL), discuss the necessity of intervention and treatment for SSD patients, and analyze the therape... Purpose: To analyze the effect of right versus left long-term single-sided deafness(SSD) on sound source localization(SSL), discuss the necessity of intervention and treatment for SSD patients, and analyze the therapeutic effect of long-term unilateral cochlear implantation(UCI) from the perspective of SSL.Methods: This study included 25 patients with SSD, 11 patients with UCI, and 30 participants with normal hearing(NH). Their SSL ability was tested by obtaining their average root mean square(RMS) error values of SSL test.Results: The results showed that the RMS error value of SSD, UCI and NH groups were 52.26 ± 20.25°, 69.84 ±12.14° and 4.27 ± 2.66°, respectively. The ability of SSL was better in the SSD-L group than that in the SSD-R group, and no significant difference existed in the SSD-R and the UCI group.Conclusion: When bilateral deafness patients select unilateral treatment, right-side cochlear implantation may be more beneficial in terms of SSL, which means that the central auditory cortex in long-term SSD patients is affected differently based on which side their deafness occurs. 展开更多
关键词 Single-sided deafness Cochlear implantation Sound source localization Treatment
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A Pre-Selection-Based Ant Colony System for Integrated Resources Scheduling Problem at Marine Container Terminal
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作者 Rong Wang Xinxin Xu +2 位作者 Zijia Wang fei ji Nankun Mu 《Computers, Materials & Continua》 SCIE EI 2024年第8期2363-2385,共23页
Marine container terminal(MCT)plays a key role in the marine intelligent transportation system and international logistics system.However,the efficiency of resource scheduling significantly influences the operation pe... Marine container terminal(MCT)plays a key role in the marine intelligent transportation system and international logistics system.However,the efficiency of resource scheduling significantly influences the operation performance of MCT.To solve the practical resource scheduling problem(RSP)in MCT efficiently,this paper has contributions to both the problem model and the algorithm design.Firstly,in the problem model,different from most of the existing studies that only consider scheduling part of the resources in MCT,we propose a unified mathematical model for formulating an integrated RSP.The new integrated RSP model allocates and schedules multiple MCT resources simultaneously by taking the total cost minimization as the objective.Secondly,in the algorithm design,a pre-selection-based ant colony system(PACS)approach is proposed based on graphic structure solution representation and a pre-selection strategy.On the one hand,as the RSP can be formulated as the shortest path problem on the directed complete graph,the graphic structure is proposed to represent the solution encoding to consider multiple constraints and multiple factors of the RSP,which effectively avoids the generation of infeasible solutions.On the other hand,the pre-selection strategy aims to reduce the computational burden of PACS and to fast obtain a higher-quality solution.To evaluate the performance of the proposed novel PACS in solving the new integrated RSP model,a set of test cases with different sizes is conducted.Experimental results and comparisons show the effectiveness and efficiency of the PACS algorithm,which can significantly outperform other state-of-the-art algorithms. 展开更多
关键词 Resource scheduling problem(RSP) ant colony system(ACS) marine container terminal(MCT) pre-selection strategy
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Effect analysis of unilateral deaf adults wearing bone-conduction hearing aids:A case report
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作者 Chenchen Xiang Yi Wang +6 位作者 Xiaozhu Cao Weiman Xv jing Liu Nan Li Lumeng Han QIan Wang fei ji 《Journal of Otology》 CAS CSCD 2024年第4期207-213,共7页
The prevalence of unilateral deafness(SSD)or asymmetric hearing loss(AHL)among patients with hearing impairments ranges from 7.2%to 15.0%,indicating a relatively significant proportion.However,these individuals often ... The prevalence of unilateral deafness(SSD)or asymmetric hearing loss(AHL)among patients with hearing impairments ranges from 7.2%to 15.0%,indicating a relatively significant proportion.However,these individuals often overlook their hearing loss,resulting in delayed or inadequate treatment.This oversight can lead to a lack of binaural summation and squelch effect,as well as the head shadow effect,which can significantly impact their speech recognition and sound localization abilities,especially in noisy environments.Recently,a groundbreaking Sound Bite™Pinyin® Bone Conduction Hearing Aid(HA)device has been has been introduced as a viable alternative to traditional percutaneous stimulation hearing assistance devices.This innovative device harnesses bone conduction technology to convey sound vibrations directly to the inner ear via the bones of the jaw and skull,effectively bypassing the air conduction pathway that is commonly compromised in individuals with hearing loss.This report details the evaluation and adjustment process of a HA device worn by a 31-year-old female patient who suffers from a congenital ossicular chain deformity in her right ear,while maintaining normal hearing in her left ear.The report comprehensively covers the hearing thresholds of the 31-year-old female patient on the day of fitting the hearing aid and one month later.It also presents assessments of the hearing aid’s performance through the Abbreviated Profile of Hearing Aid Benefit(APHAB)questionnaire,conducted three days after adjustment,one month later,and one year later.Furthermore,the report details the evaluation of the patient’s sound localization ability,comparing her performance before and after wearing the hearing aid device.Additionally,it includes measurements of her speech recognition ability for monosyllabic words and Yang Yang Ge words,which are specific tests in the Chinese language,conducted two years after the initial fitting of the hearing aid.The discovery that bone-anchored hearing devices can significantly enhance hearing thresholds in patients with unilateral conductive hearing loss represents a significant milestone.These devices not only improve speech recognition ability but also enhance sound localization in noisy environments.This improvement is accompanied by a high level of subjective satisfaction among patients,indicating a positive impact on their overall quality of life. 展开更多
关键词 Bone conduction hearing aid Abbreviated profile of hearing aid benefit Speech audiometry
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中药石香膏对糖尿病大鼠慢性难愈合创面RAGE/NF-κBp65/eNOS mRNA表达影响的研究 被引量:9
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作者 凌一鸣 费冀 +2 位作者 张开伟 周一夫 沈冯君 《中国中医基础医学杂志》 CAS CSCD 北大核心 2019年第7期913-917,共5页
目的:研究中药石香膏对于糖尿病大鼠慢性难愈合创面的晚期糖基化终末产物受体(RAGE)/转录因子-κBp65(NF-κBp65)/内皮型一氧化氮合酶(e NOS) mRNA表达的影响。方法:将50只SD级清洁大鼠按随机数字表法分为正常组、正常对照组、难愈合组... 目的:研究中药石香膏对于糖尿病大鼠慢性难愈合创面的晚期糖基化终末产物受体(RAGE)/转录因子-κBp65(NF-κBp65)/内皮型一氧化氮合酶(e NOS) mRNA表达的影响。方法:将50只SD级清洁大鼠按随机数字表法分为正常组、正常对照组、难愈合组、贝复济组、石香膏组5组,每组每时间点(7 d/14 d) 5只。造模成功后,贝复济组创面外用贝复济溶液,石香膏组创面外敷石香膏。第7/14天取大鼠背部创面肉芽组织标本,荧光定量PCR法检测RAGE/NF-κBp65/e NOS mRNA表达水平。结果:干预7 d后,与难愈合组比较,贝复济组和石香膏组中RAGE/NF-κBp65 mRNA相对表达量降低,e NOS mRNA相对表达量升高,差异有统计学意义。与贝复济组比较,石香膏组中RAGE/NF-κBp65 mRNA相对表达量降低,e NOS mRNA升高,差异有统计学意义。干预14 d后,与贝复济组比较,石香膏组RAGE/NF-κBp65 mRNA相对表达量降低,差异有统计学意义。结论:石香膏可抑制糖尿病大鼠慢性难愈合创面中RAGE/NF-κBp65 mRNA表达,促进e NOS mRNA的表达,对于创面修复具有显著作用。 展开更多
关键词 石香膏 慢性难愈合创面 RAGE/NF-κBp65/e NOS mRNA
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Performance Analysis of NOMA-Based Cooperative Networks with Relay Selection 被引量:9
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作者 Ronglan Huang Dehuan Wan +4 位作者 fei ji Hua Qing jie Li Hua Yu Fangjiong Chen 《China Communications》 SCIE CSCD 2020年第11期111-119,共9页
Non-orthogonal multiple access(NOMA)technique is an expert on channel differences exploiting.In this paper,a dual-hop NOMA-based cooperative relaying network where a best relay is selected as an active node to accompl... Non-orthogonal multiple access(NOMA)technique is an expert on channel differences exploiting.In this paper,a dual-hop NOMA-based cooperative relaying network where a best relay is selected as an active node to accomplish the communication between a source and a destination is discussed.We assume that both decode-and-forward(DF)and amplify-and-forward(AF)protocols are applied to the selected relay.The metrics that ergodic sum-rate and outage probability are investigated,and the closed-form expressions of the latter for DF and AF protocols are derived.Numerical and simulation results are conducted to verify the validity of the theoretical analysis,in which we can see that the NOMA based DF relaying is better than the NOMA based AF relaying and other existing NOMA-based cooperative communication schemes. 展开更多
关键词 non-orthogonal multiple access(NOMA) decode-and-forward(DF) amplify-and-forward(AF) relay selection ergodic sum-rate outage probability
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石香膏对糖尿病慢性难愈合创面模型大鼠创面组织血管内皮细胞黏附分子1、核因子κB p65表达的影响 被引量:6
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作者 凌一鸣 费冀 +2 位作者 张开伟 周一夫 沈冯君 《中医杂志》 CSCD 北大核心 2020年第7期619-625,共7页
目的探讨石香膏治疗糖尿病慢性难愈合创面的可能作用机制。方法将50只SD大鼠按7、14天两个时间点分为正常组、创面对照组、难愈合组、贝复济组、石香膏组,每个时间点每组5只。除正常组和创面对照组外,其余各组采用腹腔注射链脲佐菌素溶... 目的探讨石香膏治疗糖尿病慢性难愈合创面的可能作用机制。方法将50只SD大鼠按7、14天两个时间点分为正常组、创面对照组、难愈合组、贝复济组、石香膏组,每个时间点每组5只。除正常组和创面对照组外,其余各组采用腹腔注射链脲佐菌素溶液制备糖尿病大鼠模型,造模后用手术器械剪去标记圆形区域全层皮肤直至显露肌筋膜,形成大鼠全层皮肤缺损创面模型;创面对照组亦建立皮肤缺损创面模型。造模成功后石香膏组创面外敷石香膏厚度约2 mm,贝复济组创面外用贝复济约0. 2 ml,均保证药物完全覆盖创面,创面对照组和难愈合组均不使用药物覆盖创面,正常组不作处理。创面造模后第7、14天,观察大鼠创面组织生长情况,Western Blot法检测创面组织血管内皮细胞黏附分子1 (VCAM-1)、核因子κB p65 (NF-κB p65)、磷酸化核因子κB p65 (p-NF-κB p65)表达情况,荧光定量PCR法检测VCAM-1 mRNA表达水平。结果造模后第14天难愈合组可见创面未见明显修复,成纤维细胞数量较少;石香膏组创面已基本修复。造模后第7天,与难愈合组比较,石香膏组中VCAM-1蛋白表达,贝复济组和石香膏组NF-κB p65、p-NF-κB p65蛋白及VCAM-1 mRNA表达降低(P <0. 05或P <0. 01);与贝复济组比较,石香膏组中VCAM-1 mRNA相对表达量降低(P <0. 01)。造模后第14天,与难愈合组比较,贝复济组和石香膏组中VCAM-1、NF-κB p65、p-NF-κB p65蛋白及VCAM-1 mRNA相对表达量降低(P <0. 05或P <0. 01)。与贝复济组比较,石香膏组中VCAM-1、NF-κB p65蛋白及VCAM-1 mRNA相对表达量降低(P <0. 05或P <0. 01)。结论石香膏可以促进糖尿病慢性难愈合创面修复,抑制创面中VCAM-1、NF-κB p65、p-NF-κB p65及VCAM-1 mRNA表达可能是其作用机制之一。 展开更多
关键词 糖尿病 慢性难愈合创面 石香膏 血管内皮细胞黏附分子1 核因子ΚB p65
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Sudden sensorineural hearing loss(SSHL) following a local anesthetic dental procedure 被引量:5
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作者 Yi Wang Jun-Kai Cao +3 位作者 Hui-Xin Yang jin Feng Qi-you Zhou fei ji 《Journal of Otology》 CSCD 2019年第2期67-72,共6页
Acute sensorineural hearing loss is an uncommon phenomenon in dentistry.We describe the case of a 79-year-old male who presented with acute sensorineural hearing loss occurring 2 days after a tooth extraction procedur... Acute sensorineural hearing loss is an uncommon phenomenon in dentistry.We describe the case of a 79-year-old male who presented with acute sensorineural hearing loss occurring 2 days after a tooth extraction procedure under local anesthesia.Possible mechanisms are discussed.He was treated with vasodilators(Ginaton and Alprostadil Injection)and Mecobalamin injection with benefit.High dose oral steroids(1 mg/kg)and low molecular weight dextran were used. 展开更多
关键词 SUDDEN SENSORINEURAL HEARING LOSS DENTAL PROCEDURE Acute HEARING LOSS
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Radio-Acoustic Integrated Network for Ocean Information Transmission:Framework and Enabling Technologies 被引量:5
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作者 Fangjiong Chen Zilong jiang +3 位作者 fei ji Hua Yu Quansheng Guan Feng Liu 《China Communications》 SCIE CSCD 2021年第9期62-70,共9页
An important vision of next generation mobile system is to provide global internet access.The Space-Terrestrial Integrated Network(STIN)has been proposed and intensively studied to tackle this challenge.Due to the sev... An important vision of next generation mobile system is to provide global internet access.The Space-Terrestrial Integrated Network(STIN)has been proposed and intensively studied to tackle this challenge.Due to the severe attenuation of radio signals in water,the STIN cannot be directly applied in underwater scenarios.In this paper we envision a framework of integrated radio-acoustic network arming at high-efficient data transmission in underwater scenarios,where acoustic signal is for underwater communication and radio signal is for surface and air communications.Since radio links have much higher data transmission rate and lower delay,in the integrated radio-acoustic network,the acoustic links easily become congested,at the same time the radio links are not fully utilized.We therefore propose that the integrated radio-acoustic network should be properly designed to minimize the hop count of acoustic links,as well as the signaling overhead in the acoustic subnetwork.We then present a novel network framework and the relative technologies to help moving the signaling overhead to the radio subnetwork. 展开更多
关键词 integrated network acoustic communication network protocols ocean engineering
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Improvement of the global prediction system of the COVID-19 pandemic based on the ensemble empirical mode decomposition(EEMD)and autoregressive moving average(ARMA)model in a hybrid approach 被引量:5
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作者 Chuwei Liu jianping Huang +4 位作者 fei ji Li Zhang Xiaoyue Liu Yun Wei Xinbo Lian 《Atmospheric and Oceanic Science Letters》 CSCD 2021年第4期52-57,共6页
In 2020,the COVID-19 pandemic spreads rapidly around the world.To accurately predict the number of daily new cases in each country,Lanzhou University has established the Global Prediction System of the COVID-19 Pandem... In 2020,the COVID-19 pandemic spreads rapidly around the world.To accurately predict the number of daily new cases in each country,Lanzhou University has established the Global Prediction System of the COVID-19 Pandemic(GPCP).In this article,the authors use the ensemble empirical mode decomposition(EEMD)model and autoregressive moving average(ARMA)model to improve the prediction results of GPCP.In addition,the authors also conduct direct predictions for those countries with a small number of confirmed cases or are in the early stage of the disease,whose development trends of the pandemic do not fully comply with the law of infectious diseases and cannot be predicted by the GPCP model.Judging from the results,the absolute values of the relative errors of predictions in countries such as Cuba have been reduced significantly and their prediction trends are closer to the real situations through the method mentioned above to revise the prediction results out of GPCP.For countries such as El Salvador with a small number of cases,the absolute values of the relative errors of prediction become smaller.Therefore,this article concludes that this method is more effective for improving prediction results and direct prediction. 展开更多
关键词 COVID-19 PREDICTION hybrid EEMDARMA method historical data
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Distributed Cooperative OFDM-IM System 被引量:4
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作者 Hua Qing Hua Yu +3 位作者 Yun Liu Wei Duan Miaowen Wen fei ji 《China Communications》 SCIE CSCD 2020年第9期167-176,共10页
This paper considered a multi-relay distributed cooperative system in which not only the source communicates with the destination,but also the relays have communication requests with the destination.In order to achiev... This paper considered a multi-relay distributed cooperative system in which not only the source communicates with the destination,but also the relays have communication requests with the destination.In order to achieve the requirements of simultaneous communication for the source and relays,we propose a distributed cooperative system based on orthogonal frequency division multiplexing with index modulation(OFDM-IM).In this system,the relay can communicate with the destination by superimposing its own signal over the inactive subcarriers on the decoded OFDM-IM signal.Upper bounds on the bit error rates of the source and the active relay are both derived in closed form,whose tightness is verified through simulation results. 展开更多
关键词 OFDM index modulation(IM) maximum-likelihood(ML) decode-and-forward(DF) bit error rate(BER)
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Rational design of Sn_(4)P_(3)/Ti_(3)C_(2)Tx composite anode with enhanced performance for potassium-ion battery 被引量:4
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作者 jie Zhao Chao-Lin Li +4 位作者 Gang Chen fei ji Yi-Yong Shen Juan Peng Wen-Hui Wang 《Rare Metals》 SCIE EI CAS CSCD 2022年第7期2259-2267,共9页
The potential application of high-capacity Sn_(4)P_(3)anode for potassium-ion batteries(PIBs)is hindered by the poor cycle stability mainly rooted from the huge volume changes upon cycling and low electronic conduc-ti... The potential application of high-capacity Sn_(4)P_(3)anode for potassium-ion batteries(PIBs)is hindered by the poor cycle stability mainly rooted from the huge volume changes upon cycling and low electronic conduc-tivity.To address the above issues,sandwich-like struc-tured Sn_(4)P_(3)/Ti_(3)C_(2)T_(x)was designed and synthesized as anode material for PIBs.As a result,Sn_(4)P_(3)/Ti_(3)C_(2)T_(x)pre-sents superior cycle stability(retains a capacity of 103.2 mAh·g^(-1)even after 300 cycles at 1000 mA·g^(-1))and rate capability(delivers 60.7 mAh·g^(-1)at high current density of 2000 mA·g^(-1)).The excellent electrochemical perfor-mance of sandwich-like structured Sn_(4)P_(3)/Ti_(3)C_(2)Tx is orig-inated from the synergistic effect between Sn_(4)P_(3)and Ti_(3)C_(2)T_(x),where Ti_(3)C_(2)T_(x)acts as a conductive matrix to facilitate electron transfer and buffer the volume change of Sn_(4)P_(3)particles upon cycling,while Sn_(4)P_(3)serves as pillars to prevent the collapse and stacking of Ti_(3)C_(2)T_(x)sheets.Moreover,significant capacitive contribution is demonstrated as a major contributor to the excellent rate capability. 展开更多
关键词 Sn_(4)P_(3) Ti_(3)C_(2) TxAnode material Potassium-ion battery
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Saccades of video head impulse test in Meniere's disease and Vestibular Migraine: What can we learn from? 被引量:3
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作者 Yi Du Xingjian Liu +4 位作者 Lili Ren Yu Wang fei ji Weiwei Guo Ziming Wu 《Journal of Otology》 CSCD 2023年第2期79-84,共6页
Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This stud... Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side. 展开更多
关键词 Meniere's disease Vestibular migraine SACCADES Video head impulse test Differential diagnosis
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